Hu, Mu, RtApplications:
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, ICC/IF
Host: Rabbit Polyclonal
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide.
Research Areas for MD-2
Find related products by research area and learn more about each of the different research areas below.Signal Transduction
Bioinformatics Tool for MD-2
Discover related pathways, diseases and genes to MD-2. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.