MD-2 Products

Antibodies
MD-2 Antibody
MD-2 Antibody
NB100-56655
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
MD-2 Antibody
MD-2 Antibody
NBP1-77201
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
MD-2 Antibody (1A2E3)
MD-2 Antibody (1A2E3)
NBP1-75513
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
MD-2 Overexpression Lysate (D ...
MD-2 Overexpression Lysate (Denatu...
H00023643-T01
Species: Hu
Applications: WB
MD-2 Overexpression Lysate (N ...
MD-2 Overexpression Lysate (Native)
NBL1-12751
Applications: WB
Proteins
MD-2 Recombinant Protein
MD-2 Recombinant Protein
H00023643-P01
Species: Hu
Applications: WB, ELISA, PA
MD-2 Peptide
MD-2 Peptide
NBP1-77201PEP
Species: Hu
Applications: AC
RNAi
MD-2 RNAi
MD-2 RNAi
H00023643-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 23643
Alternate Names
  • MD2
  • Ly-96
  • ESOP-1
  • ESOP1
  • Protein MD-2
  • myeloid differentiation protein-2
  • MD-2
  • ly-96
  • lymphocyte antigen 96

Research Areas for MD-2

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

Bioinformatics Tool for MD-2

Discover related pathways, diseases and genes to MD-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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