Human LBP DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human LBP DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: LBP

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human LBP DuoSet ELISA, 5 Plate

• LBP
• lipopolysaccharide binding protein
• lipopolysaccharide-binding protein
• LPS-binding protein
• MGC22233

Background

Lipopolysaccharide-binding protein (LBP), a 58kDa glycoprotein synthesized in hepatocytes, belongs to a family of lipid-binding proteins that includes bactericidal/permeability increasing protein (BPI), phospholipid ester transfer protein (PLTP), and cholesterol ester transfer protein (CETP). LBP binds to the lipidA portion of lipopolysaccharide (LPS) to facilitate the process of LPS monomerization, catalyzes the binding of LPS monomers to CD14, and promotes LPS-induced immune response.

Publications for LBP (DY870-05)(52)

Publications using DY870-05

• Riedel, S;de Buys, K;Tshivhase, AM;Mendham, AE;Venter, P;Hoosen, F;Dugas, LR;D'Alton, C;Rusch, JA;Southon, B;Pheiffer, CP;Johnson, R;Reddy, T;Yende-Zuma, N;Muller, CJF;Dave, JA;Goedecke, JH; Effects of Baobab fruit powder on gut and cardiometabolic health in obesity-Protocol for a randomised placebo-controlled trial PloS one 2025-08-13 [PMID: 40802664] (Human)
• Orban, B;Simon, D;Erd?-Bonyár, S;Berki, T;Molnár, T;Závori, L;Schwarcz, A;Péterfi, Z;Csécsei, P; Effects of Aneurysmal Subarachnoid Hemorrhage in Patients Without In-Hospital Infection on FABP-I, LBP, and sCD-14 International journal of molecular sciences 2025-01-08 [PMID: 39859200] (Human)
• Malindisa, EK;Dika, H;Rehman, AM;Kweka, B;Todd, J;Olsen, MF;Krogh-Madsen, R;Frikke-Schmidt, R;Friis, H;Faurholt-Jepsen, D;Kelly, P;Filteau, S;PrayGod, G; Associations between dietary patterns and intestinal inflammation among HIV-infected and uninfected adults: A cross-sectional study in Tanzania PloS one 2024-12-30 [PMID: 39775265] (Human)
• Sturgeon, JP;Mutasa, K;Bwakura-Dangarembizi, M;Amadi, B;Ngosa, D;Dzikiti, A;Chandwe, K;Besa, E;Mutasa, B;Murch, SH;Hill, S;Playford, RJ;VanBuskirk, K;Kelly, P;Prendergast, AJ;TAME Trial Team, ; Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration EBioMedicine 2024-12-10 [PMID: 39662176] (Human)
• Custers, E;van der Burgh, YGR;Vreeken, D;Schuren, F;van den Broek, TJ;Verschuren, L;de Blaauw, I;Bouwens, M;Kleemann, R;Kiliaan, AJ;Hazebroek, EJ; Gastrointestinal complaints after Roux-en-Y gastric bypass surgery. Impact of microbiota and its metabolites Heliyon 2024-11-15 [PMID: 39559236] (Human)
• Seidel, F;Vreeken, D;Custers, E;Wiesmann, M;Özsezen, S;van Duyvenvoorde, W;Caspers, M;Menke, A;Morrison, MC;Verschuren, L;Duering, M;Hazebroek, EJ;Kiliaan, AJ;Kleemann, R; Metabolic dysfunction-associated steatotic liver disease is associated with effects on cerebral perfusion and white matter integrity Heliyon 2024-10-15 [PMID: 39391513] (Human)
• Tamme, K;Acosta, S;Biloslavo, A;Björck, M;Casian, D;Damaskos, D;Forbes, A;Kase, K;Kisand, K;Lakbar, I;Mihnovitš, V;Murruste, M;Mändul, M;Nuzzo, A;Padar, M;Starkopf, J;Visconti, D;Reintam Blaser, A; Biomarkers In Prediction of Acute Mesenteric Ischaemia: a prospective multicentre study (BIPAMI study): a study protocol BMC surgery 2024-07-03 [PMID: 38961419] (Human)
• Shantaram, D;Hoyd, R;Blaszczak, AM;Antwi, L;Jalilvand, A;Wright, VP;Liu, J;Smith, AJ;Bradley, D;Lafuse, W;Liu, Y;Williams, NF;Snyder, O;Wheeler, C;Needleman, B;Brethauer, S;Noria, S;Renton, D;Perry, KA;Nagareddy, P;Wozniak, D;Mahajan, S;Rana, PSJB;Pietrzak, M;Schlesinger, LS;Spakowicz, DJ;Hsueh, WA; Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils Nature communications 2024-06-27 [PMID: 38937454] (Human)
• Runtuwene, LR;Parbie, PK;Mizutani, T;Ishizaka, A;Matsuoka, S;Abana, CZ;Kushitor, D;Bonney, EY;Ofori, SB;Kiyono, H;Ishikawa, K;Ampofo, WK;Matano, T; Longitudinal analysis of microbiome composition in Ghanaians living with HIV-1 Frontiers in microbiology 2024-02-15 [PMID: 38426062] (Human)
• Li, JZ;Melberg, M;Kittilson, A;Abdel-Mohsen, M;Li, Y;Aga, E;Bosch, RJ;Wonderlich, ER;Kinslow, J;Giron, LB;Di Germanio, C;Pilkinton, M;MacLaren, L;Keefer, M;Fox, L;Barr, L;Acosta, E;Ananworanich, J;Coombs, R;Mellors, J;Deeks, S;Gandhi, RT;Busch, M;Landay, A;Macatangay, B;Smith, DM;AIDS Clinical Trials Group A5345 Study Team, ; Predictors of HIV rebound differ by timing of antiretroviral therapy initiation JCI insight 2024-02-08 [PMID: 38329130] (Human)
• Wiche Salinas, TR;Zhang, Y;Gosselin, A;Do Rosario, NF;El-Far, M;Filali-Mouhim, A;Routy, JP;Chartrand-Lefebvre, C;Landay, AL;Durand, M;Tremblay, CL;Ancuta, P;Canadian HIV and Aging Cohort Study (CHACS), ; A Blood Immunological Signature of Subclinical Coronary Artery Atherosclerosis in People Living with HIV-1 Receiving Antiretroviral Therapy bioRxiv : the preprint server for biology 2023-12-18 [PMID: 38187644] (Human)
• Li, W;Xia, Y;Yang, J;Sanyal, AJ;Shah, VH;Chalasani, NP;Yu, Q; Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis medRxiv : the preprint server for health sciences 2023-12-17 [PMID: 38168393] (Human)
• Mweetwa, MN;Haritunians, T;Dube, S;Chandwe, K;Amadi, B;Zyambo, K;Liu, TC;McGovern, D;Kelly, P; Genetic variation in environmental enteropathy and stunting in Zambian children: A pilot genome wide association study using the H3Africa chip PloS one 2023-09-27 [PMID: 37756315] (Human)
• Pokala, A;Quarles, WR;Ortega-Anaya, J;Jimenez-Flores, R;Cao, S;Zeng, M;Hodges, JK;Bruno, RS; Milk-Fat-Globule-Membrane-Enriched Dairy Milk Compared with a Soy-Lecithin-Enriched Beverage Did Not Adversely Affect Endotoxemia or Biomarkers of Gut Barrier Function and Cardiometabolic Risk in Adults with Metabolic Syndrome: A Randomized Controlled Crossover Trial Nutrients 2023-07-23 [PMID: 37513677] (Human)
• Coufal, S;Kverka, M;Kreisinger, J;Thon, T;Rob, F;Kolar, M;Reiss, Z;Schierova, D;Kostovcikova, K;Roubalova, R;Bajer, L;Jackova, Z;Mihula, M;Drastich, P;Tresnak Hercogova, J;Novakova, M;Vasatko, M;Lukas, M;Tlaskalova-Hogenova, H;Jiraskova Zakostelska, Z; Serum TGF-?1 and CD14 Predicts Response to Anti-TNF-? Therapy in IBD Journal of immunology research 2023-06-20 [PMID: 37383609] (Human)
• Metz, CN;Xue, X;Chatterjee, PK;Adelson, R;Brines, M;Tracey, KJ;Gregersen, PK;Pavlov, VA; Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia bioRxiv : the preprint server for biology 2023-05-22 [PMID: 37293028] (Human)
• Gaspard Kerner, Anna-Lena Neehus, Quentin Philippot, Jonathan Bohlen, Darawan Rinchai, Nacim Kerrouche et al. Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe Cell Genomics 2023-02-08 [PMID: 36819665] (Human)
• L Blöbaum, M Witkowski, M Wegner, S Lammel, PA Schencke, K Jakobs, M Puccini, D Rei beta ner, D Steffens, U Landmesser, U Rauch, J Friebel Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation Biomedicines, 2023-01-10;11(1):. 2023-01-10 [PMID: 36672684] (Human)
• J Parantaine, G Barreto, R Koivuniemi, H Kautiainen, D Nordström, E Moilanen, M Hämäläinen, M Leirisalo-, K Nurmi, KK Eklund The biological activity of serum bacterial lipopolysaccharides associates with disease activity and likelihood of achieving remission in patients with rheumatoid arthritis Arthritis Research & Therapy, 2022-11-21;24(1):256. 2022-11-21 [PMID: 36411473] (Human)
• ML Sarangam, R Namazzi, D Datta, C Bond, CPB Vanderpool, RO Opoka, CC John, AL Conroy Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria MBio, 2022-09-07;0(0):e0132522. 2022-09-07 [PMID: 36069443] (Human)
• H Kared, AS Wolf, A Alirezayla, A Ravussin, G Solum, TT Tran, F Lund-Johan, JT Vaage, LS Nissen-Mey, UC Nygaard, O Hungnes, AH Robertson, LM Næss, L Trogstad, P Magnus, LA Munthe, S Mjaaland Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults Nature Communications, 2022-07-18;13(1):4165. 2022-07-18 [PMID: 35851055] (Human)
• D Reljic, W Dieterich, HJ Herrmann, MF Neurath, Y Zopf "HIIT the Inflammation": Comparative Effects of Low-Volume Interval Training and Resistance Exercises on Inflammatory Indices in Obese Metabolic Syndrome Patients Undergoing Caloric Restriction Nutrients, 2022-05-10;14(10):. 2022-05-10 [PMID: 35631137] (Human)
• H Ranaivo, Z Zhang, M Alligier, L Van Den Be, M Sothier, S Lambert-Po, N Feugier, C Cuerq, C Machon, AM Neyrinck, B Seethaler, J Rodriguez, M Roumain, GG Muccioli, V Maquet, M Laville, SC Bischoff, J Walter, NM Delzenne, JA Nazare Chitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial Scientific Reports, 2022-05-25;12(1):8830. 2022-05-25 [PMID: 35614185] (Human)
• C Amadieu, L Maccioni, S Leclercq, AM Neyrinck, NM Delzenne, P de Timary, P Stärkel Liver alterations are not improved by inulin supplementation in alcohol use disorder patients during alcohol withdrawal: A pilot randomized, double-blind, placebo-controlled study EBioMedicine, 2022-04-28;80(0):104033. 2022-04-28 [PMID: 35490461] (Human)
• M Franck, J de Toro-Ma, T V Varin, V Garneau, G Pilon, D Roy, P Couture, C Couillard, A Marette, MC Vohl Gut Microbial Signatures of Distinct Trimethylamine N-Oxide Response to Raspberry Consumption Nutrients, 2022-04-15;14(8):. 2022-04-15 [PMID: 35458219] (Human)
• AJ Riviere, KS Smith, MN Schaberg, MW Greene, AD Frugé Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention: secondary analysis of a randomized control crossover trial BMC gastroenterology, 2022-04-12;22(1):184. 2022-04-12 [PMID: 35413837] (Human)
• AI Amaruddin, JPR Koopman, M Muhammad, K Lenaerts, HMH van Eijk, EAT Brienen, AR Geelen, L van Liesho, S Wahyuni, EJ Kuijper, RD Zwittink, F Hamid, E Sartono, M Yazdanbakh Intestinal permeability before and after albendazole treatment in low and high socioeconomic status schoolchildren in Makassar, Indonesia Scientific Reports, 2022-03-01;12(1):3394. 2022-03-01 [PMID: 35233023] (Human)
• HS Kim, J Son, D Lee, J Tsai, D Wang, ES Chocron, S Jeong, P Kittrell, CF Murchison, RE Kennedy, A Tobon, CE Jackson, AM Pickering Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset BMC neurology, 2022-02-21;22(1):62. 2022-02-21 [PMID: 35189854] (Human)
• S Hong, KH Park, YE Lee, JE Lee, YM Kim, E Joo, I Cho Antibody microarray analysis of amniotic fluid proteomes in women with cervical insufficiency and short cervix, and their association with pregnancy latency length PLoS ONE, 2022-02-07;17(2):e0263586. 2022-02-07 [PMID: 35130326] (Human)
• AQ Atwater, LC Immergluck, AJ Davidson, O Castanon-C Shift Work Predicts Increases in Lipopolysaccharide-Binding Protein, Interleukin-10, and Leukocyte Counts in a Cross-Sectional Study of Healthy Volunteers Carrying Low-Grade Systemic Inflammation International Journal of Environmental Research and Public Health, 2021-12-14;18(24):. 2021-12-14 [PMID: 34948768] (Human)
• N Zhang, Y Gou, S Liang, N Chen, Y Liu, Q He, J Zhang Dysbiosis of Gut Microbiota Promotes Hepatocellular Carcinoma Progression by Regulating the Immune Response Journal of Immunology Research, 2021-10-20;2021(0):4973589. 2021-10-20 [PMID: 34722779] (Human)
• HE Ho, L Radigan, G Bongers, A El-Shamy, C Cunningham Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency JCI Insight, 2021-10-08;6(19):. 2021-10-08 [PMID: 34622805] (Human)
• CM Mitchell, BM Davy, MA Ponder, RP McMillan, MD Hughes, MW Hulver, AP Neilson, KP Davy Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial Nutrients, 2021-09-17;13(9):. 2021-09-17 [PMID: 34579112] (Human)
• SK Aune, J Cwikiel, A Flaa, H Arnesen, S Solheim, A Awoyemi, M Trøseid, I Seljeflot, R Helseth Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease Cells, 2021-08-25;10(9):. 2021-08-25 [PMID: 34571843] (Human)
• B Amadi, K Zyambo, K Chandwe, E Besa, C Mulenga, S Mwakamui, S Siyumbwa, S Croft, R Banda, M Chipunza, K Chifunda, L Kazhila, K VanBuskirk, P Kelly Adaptation of the small intestine to microbial enteropathogens in Zambian children with stunting Nature Microbiology, 2021-02-15;0(0):. 2021-02-15 [PMID: 33589804] (Human)
• EK Ha, JH Kim, DK Yon, SW Lee, MA Kim, KS Lee, M Sung, HM Jee, YH Shin, MY Han Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children Scientific Reports, 2021-01-25;11(1):2143. 2021-01-25 [PMID: 33495502] (Human)
• DR Beers, W Zhao, DW Neal, JR Thonhoff, AD Thome, A Faridar, S Wen, J Wang, SH Appel Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis Scientific Reports, 2020-09-17;10(1):15295. 2020-09-17 [PMID: 32943739] (Human)
• D Kantamala, J Praparatta, S Taejaroenk, S Srithep, R Yoosupap, K Supparatpi High microbial translocation limits gut immune recovery during short-term HAART in the area with high prevalence of foodborne infection Cytokine, 2020-08-26;136(0):155257. 2020-08-26 [PMID: 32861144] (Human)
• A Haidmayer, P Bosch, A Lackner, M D'Orazio, J Fessler, MH Stradner Effects of Probiotic Strains on Disease Activity and Enteric Permeability in Psoriatic Arthritis-A Pilot Open-Label Study Nutrients, 2020-08-05;12(8):. 2020-08-05 [PMID: 32764250] (Human)
• SP Polster, A Sharma, C Tanes, AT Tang, P Mericko, Y Cao, J Carrión-Pe, R Girard, J Koskimäki, D Zhang, A Stadnik, SG Romanos, SB Lyne, R Shenkar, K Yan, C Lee, A Akers, L Morrison, M Robinson, A Zafar, K Bittinger, H Kim, JA Gilbert, ML Kahn, L Shen, IA Awad Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma Nat Commun, 2020-05-27;11(1):2659. 2020-05-27 [PMID: 32461638] (Human)
• LB Giron, CE Tanes, MH Schleimann, PA Engen, LM Mattei, A Anzurez, M Damra, H Zhang, K Bittinger, F Bushman, A Kossenkov, PW Denton, H Tateno, A Keshavarzi, AL Landay, M Abdel-Mohs Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection Mucosal Immunol, 2020-03-09;0(0):. 2020-03-09 [PMID: 32152415] (Human)
• A Horvath, B Leber, N Feldbacher, M Steinwende, I Komarova, F Rainer, A Blesl, V Stadlbauer The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study Sci Rep, 2020-02-17;10(1):2723. 2020-02-17 [PMID: 32066847] (Human)
• F Ciregia, D Baiwir, G Cobraivill, T Dewael, G Mazzucchel, V Badot, S Di Romana, P Sidiras, T Sokolova, P Durez, MG Malaise, D de Seny Glycosylation deficiency of lipopolysaccharide-binding protein and corticosteroid-binding globulin associated with activity and response to treatment for rheumatoid arthritis J Transl Med, 2020-01-06;18(1):8. 2020-01-06 [PMID: 31907043] (Human)
• S Coufal, N Galanova, L Bajer, Z Gajdarova, D Schierova, Z Jiraskova, K Kostovciko, Z Jackova, Z Stehlikova, P Drastich, H Tlaskalova, M Kverka Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response Cells, 2019-07-13;8(7):. 2019-07-13 [PMID: 31337064] (Human)
• RM Naimi, M Hvistendah, N Nerup, R Ambrus, MP Achiam, LB Svendsen, H Grønbæk, HJ Møller, H Vilstrup, A Steensberg, PB Jeppesen Effects of glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, on markers of liver status in patients with short bowel syndrome: findings from a randomised phase 2 trial EBioMedicine, 2019-07-17;0(0):. 2019-07-17 [PMID: 31326433] (Human)
• HC Steel, WDF Venter, AJ Theron, R Anderson, C Feldman, L Kwofie, T Cronjé, N Arullapan, TM Rossouw Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants Mediators Inflamm., 2018-12-09;2018(0):8357109. 2018-12-09 [PMID: 30622435] (Human)
• C Petes, V Mintsopoul, RL Finnen, BW Banfield, K Gee The effects of CD14 and IL-27 on induction of endotoxin tolerance in human monocytes and macrophages J. Biol. Chem., 2018-09-21;0(0):. 2018-09-21 [PMID: 30242126] (Human)
• A Awoyemi, M Trøseid, H Arnesen, S Solheim, I Seljeflot Markers of metabolic endotoxemia as related to metabolic syndrome in an elderly male population at high cardiovascular risk: a cross-sectional study Diabetol Metab Syndr, 2018-07-21;10(0):59. 2018-07-21 [PMID: 30038669] (Human)
• Y Kong, Z Li, T Tang, H Wu, J Liu, L Gu, T Zhao, Q Huang The level of lipopolysaccharide-binding protein is elevated in adult patients with obstructive sleep apnea BMC Pulm Med, 2018-05-29;18(1):90. 2018-05-29 [PMID: 29843666] (Human)
• E Sinkala, K Zyambo, E Besa, P Kaonga, B Nsokolo, V Kayamba, M Vinikoor, R Zulu, M Bwalya, GR Foster, P Kelly Rifaximin Reduces Markers of Inflammation and Bacterial 16S rRNA in Zambian Adults with Hepatosplenic Schistosomiasis: A Randomized Control Trial Am. J. Trop. Med. Hyg., 2018-02-08;0(0):. 2018-02-08 [PMID: 29436337] (Human)
• D Paquin-Pro, C Ching, I Vujkovic-C, D Fadrosh, L Loh, Y Huang, M Somsouk, SV Lynch, PW Hunt, DF Nixon, D SenGupta Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection Mucosal Immunol, 2016-04-06;0(0):. 2016-04-06 [PMID: 27049061] (Human)
• Nystrom J, Stenkvist J, Haggblom A, Weiland O, Nowak P Low levels of microbial translocation marker LBP are associated with sustained viral response after anti-HCV treatment in HIV-1/HCV co-infected patients. PLoS ONE, 2015-03-18;10(3):e0118643. 2015-03-18 [PMID: 25785448] (Human)

FAQs for LBP (DY870-05). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: LBP