Integrin alpha 8 Antibody (CL7304) - BSA Free

Western Blot: Integrin alpha 8 Antibody (CL7304) [NBP2-76482] - Analysis in human cell line HEK 293.

Immunohistochemistry-Paraffin: Integrin alpha 8 Antibody (CL7304) [NBP2-76482] - Staining of human prostate shows moderate to strong positivity in smooth muscle cells.

Immunohistochemistry-Paraffin: Integrin alpha 8 Antibody (CL7304) [NBP2-76482] - Analysis in human lung and pancreas tissues. Corresponding ITGA8 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: Integrin alpha 8 Antibody (CL7304) [NBP2-76482] - Staining of human lung shows strong membranous positivity in pneumocytes.

Immunohistochemistry-Paraffin: Integrin alpha 8 Antibody (CL7304) [NBP2-76482] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: CL7304
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

Integrin alpha 8 Antibody (CL7304) - BSA Free Summary

• Immunogen: This antibody was developed using a recombinant protein derived from P53708, with the exact immunogen sequence remaining proprietary.
• Predicted Species: Mouse (91%), Rat (91%). Backed by our 100% Guarantee.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGA8
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
  • Western Blot 1 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.2, containing 40% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Protein A purified

Alternate Names for Integrin alpha 8 Antibody (CL7304) - BSA Free

• Integrin alpha 8
• integrin alpha-8
• integrin, alpha 8
• ITGA8

Background

ITGA8 is a gene that codes for a protein that functions in the genesis of kidneys and other organs by facilitating the recruitment of mesenchymal cells into epithelial structures as well as working as a neuronal receptor for TNC to regulate neurite outgrowth, and is made up of 1063 amino acids, weighs approximately 117 kDa. Studies are being conducted on several diseases and disorders including keratopathy, carcinoma, kidney disease, laryngitis, Parkinson's disease, glomerulonephritis, Alzheimer's disease, melanoma, hepatitis, and neuronitis. ITGA8 has also been shown to have interactions with FN1, ITGB1, ITGA3, NPNT, and VNT in pathways such as the CDK5, Tec kinases signaling, integrin-mediated cell adhesion, signal transduction, and hypertrophic cardiomyopathy pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ITGA8