TGF-beta RII Antibody [Unconjugated]


Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, Hep3B human hepatocellular carcinoma cell line, U‑118‑MG human glioblastoma/astrocytoma cell line, HT1080 human fibrosarcoma cell more
Recombinant Human TGF‑ beta 1 (Catalog # 240-B) inhibits Recombinant Human IL‑4 (Catalog # 204-IL) induced proliferation in the TF‑1 human erythroleukemic cell line in a dose-dependent manner (orange line). more
TGF-beta RII was detected in immersion fixed paraffin-embedded sections of human pituitary using Goat Anti-Human TGF-beta RII Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-241-NA) at 15 µg/mL overnight more
Human blood-derived lymphocytes were labeled with Goat Anti-Human TGF-beta RII Antigen Affinity-purified Poly­clonal Antibody (Catalog #AF‑241‑NA, filled histogram) or control antibody (Catalog #AB‑108‑C, more

Product Details

Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, B/N, CyTOF-ready, ELISA(Cap)

TGF-beta RII Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant human TGF‑ beta  RII
Accession # P37173.2
Detects human TGF-beta RII in direct ELISAs and Western blots.
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Flow Cytometry 1 ug/10^6 cells
  • Immunohistochemistry 5-15 ug/mL
  • Neutralization 5-20 ug/mL
  • Western Blot 2 ug/mL
Application Notes
ELISA Capture: Human TGF-beta RII Antibody (Catalog # AF-241-NA)
ELISA Detection: Human TGF-beta RII Biotinylated Antibody (Catalog # BAF241)
Standard: Recombinant Human TGF-beta RII (Catalog # 241-R2)
Read Publications using
AF-241-NA in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta RII Antibody [Unconjugated]

  • AAT3
  • EC 2.7.11
  • EC
  • FAA3
  • HNPCC6
  • LDS1B
  • LDS2B
  • MFS2
  • RIIC
  • TAAD2
  • tbetaR-II
  • TGF-beta receptor type II
  • TGF-beta receptor type IIB
  • TGF-beta receptor type-2
  • TGF-beta RII
  • TGF-beta type II receptor
  • TGFbetaRII
  • TGFbeta-RII
  • TGFBR2
  • TGF-bRII
  • TGFR-2
  • transforming growth factor beta receptor type IIC
  • transforming growth factor, beta receptor II (70/80kDa) isoform 1
  • transforming growth factor, beta receptor II (70/80kDa) isoform 2
  • transforming growth factor, beta receptor II (70/80kDa)
  • transforming growth factor, beta receptor II (70-80kD)
  • Transforming growth factor-beta receptor type II


TGF-beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex thattransduces TGF beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the Nterminus of the mature protein has also been described.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TGF-beta RII Antibody (AF-241-NA)(18)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Feline, Rabbit.

We have publications tested in 7 applications: Bioassay, Blocking, Cell Culture, IHC, IHC-P, Neutralization, Western Blot.

Filter By Application
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Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using AF-241-NA Applications Species
N Zimmer, FK Krebs, S Zimmer, H Mitzel-Rin, EJ Kumm, K Jurk, S Grabbe, C Loquai, A Tuettenber Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis Cancers, 2020;12(12):. 2020 [PMID: 33291452] (Cell Culture, Human) Cell Culture Human
C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells Hum Vaccin Immunother, 2018;0(0):0. 2018 [PMID: 29420117] (Western Blot, Human) Western Blot Human
OE Olsen, A Skjærvik, BF Størdal, A Sundan, T Holien TGF-? contamination of purified recombinant GDF15 PLoS ONE, 2017;12(11):e0187349. 2017 [PMID: 29161287] (Neutralization, Human) Neutralization Human
24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats PLoS ONE, 2016;11(8):e0161782. 2016 [PMID: 27575371] (Blocking, Rat) Blocking Rat
Clathrin light chains&#039; role in selective endocytosis influences antibody isotype switching Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27540116] (Bioassay, Human) Bioassay Human
Kenny H, Chiang C, White E, Schryver E, Habis M, Romero I, Ladanyi A, Penicka C, George J, Matlin K, Montag A, Wroblewski K, Yamada S, Mazar A, Bowtell D, Lengyel E Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest, 2014;124(10):4614-28. 2014 [PMID: 25202979] (Neutralization, Human) Neutralization Human
Gate D, Danielpour M, Rodriguez J, Kim G, Levy R, Bannykh S, Breunig J, Kaech S, Flavell R, Town T T-cell TGF-beta signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A, 2014;111(33):E3458-66. 2014 [PMID: 25082897] (IHC, Human) IHC Human
Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest, 2014;124(8):3295-310. 2014 [PMID: 24983314] (Neutralization, Mouse) Neutralization Mouse
Miller M, Petty C, Tompkins M, Fogle J CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism. Virol J, 2014;11(0):7. 2014 [PMID: 24438223] (Neutralization, Feline) Neutralization Feline
Allen M, Thomas G, Clark S, Dawoud M, Vallath S, Payne S, Gomm J, Dreger S, Dickinson S, Edwards D, Pennington C, Sestak I, Cuzick J, Marshall J, Hart I, Jones J Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of alphavbeta6 integrin in DCIS identifies high-risk patients and predicts recurrence. Clin Cancer Res, 2014;20(2):344-57. 2014 [PMID: 24150233] (Neutralization, Mouse) Neutralization Mouse
Show All 18 Publications.

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 700 FAB2411N
Alexa Fluor 700 FAB2411N
Allophycocyanin FAB2411A
Allophycocyanin FAB2411A
Biotin BAF241
Fluorescein FAB2411F
Fluorescein FAB2411F
Phycoerythrin FAB2411P
Phycoerythrin FAB2411P

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Gene Symbol TGFBR2