TGF-beta RII Antibody [Unconjugated]


Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, Hep3B human hepatocellular carcinoma cell line, U‑118‑MG human glioblastoma/astrocytoma cell line, HT1080 human fibrosarcoma cell more
Human blood-derived lymphocytes were labeled with Goat Anti-Human TGF-beta RII Antigen Affinity-purified Poly­clonal Antibody (Catalog #AF‑241‑NA, filled histogram) or control antibody (Catalog #AB‑108‑C, more
TGF-beta RII was detected in immersion fixed paraffin-embedded sections of human pituitary using Goat Anti-Human TGF-beta RII Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-241-NA) at 15 µg/mL overnight more
Recombinant Human TGF‑ beta 1 (Catalog # 240-B) inhibits Recombinant Human IL‑4 (Catalog # 204-IL) induced proliferation in the TF‑1 human erythroleukemic cell line in a dose-dependent manner (orange line). more

Product Details

Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, B/N, CyTOF-ready, ELISA(Cap)

TGF-beta RII Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant human TGF‑ beta  RII
Accession # P37173.2
Detects human TGF-beta RII in direct ELISAs and Western blots.
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Flow Cytometry 1 ug/10^6 cells
  • Immunohistochemistry 5-15 ug/mL
  • Neutralization 5-20 ug/mL
  • Western Blot 2 ug/mL
Application Notes
ELISA Capture: Human TGF-beta RII Antibody (Catalog # AF-241-NA)
ELISA Detection: Human TGF-beta RII Biotinylated Antibody (Catalog # BAF241)
Standard: Recombinant Human TGF-beta RII (Catalog # 241-R2)
Read Publications using
AF-241-NA in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta RII Antibody [Unconjugated]

  • AAT3
  • EC 2.7.11
  • EC
  • FAA3
  • HNPCC6
  • LDS1B
  • LDS2B
  • MFS2
  • RIIC
  • TAAD2
  • tbetaR-II
  • TGF-beta receptor type II
  • TGF-beta receptor type IIB
  • TGF-beta receptor type-2
  • TGF-beta RII
  • TGF-beta type II receptor
  • TGFbetaRII
  • TGFbeta-RII
  • TGFBR2
  • TGF-bRII
  • TGFR-2
  • transforming growth factor beta receptor type IIC
  • transforming growth factor, beta receptor II (70/80kDa) isoform 1
  • transforming growth factor, beta receptor II (70/80kDa) isoform 2
  • transforming growth factor, beta receptor II (70/80kDa)
  • transforming growth factor, beta receptor II (70-80kD)
  • Transforming growth factor-beta receptor type II


TGF-beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex thattransduces TGF beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the Nterminus of the mature protein has also been described.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TGF-beta RII Antibody (AF-241-NA)(24)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Feline, Rabbit.

We have publications tested in 10 applications: Bioassay, Blocking, Cell Culture, CyTof, Functional Assay, ICC, IHC, IHC-P, Neutralization, Western Blot.

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Showing Publications 1 - 10 of 24. Show All 24 Publications.
Publications using AF-241-NA Applications Species
ER Trzeciak, N Zimmer, PW Kämmerer, D Thiem, B Al-Nawas, A Tuettenber, S Blatt GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate Biomedicines, 2022;10(12):. 2022 [PMID: 36551892] (Functional Assay, Human) Functional Assay Human
SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs Nature Immunology, 2022;0(0):. 2022 [PMID: 36456734] (Neutralization, Human) Neutralization Human
X Zhou, X Li, R Wang, D Hua, C Sun, L Yu, C Shi, W Luo, Z Jiang, W An, Q Wang, S Yu Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFbeta/SMAD signalling during gliomagenesis Cell Death & Disease, 2022;13(9):818. 2022 [PMID: 36153326] (Western Blot, Human) Western Blot Human
I Hanson, KE Pitman, U Altanerova, ? Altaner, E Malinen, NFJ Edin Low-Dose-Rate Radiation-Induced Secretion of TGF-beta3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding International Journal of Molecular Sciences, 2022;23(15):. 2022 [PMID: 35897723] (Neutralization, Human) Neutralization Human
N Ju, H Hayashi, M Shimamura, S Baba, S Yoshida, R Morishita, H Rakugi, H Nakagami Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice Scientific Reports, 2022;12(1):12474. 2022 [PMID: 35864207] (ICC, Human) ICC Human
N Zimmer, FK Krebs, S Zimmer, H Mitzel-Rin, EJ Kumm, K Jurk, S Grabbe, C Loquai, A Tuettenber Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis Cancers, 2020;12(12):. 2020 [PMID: 33291452] (Cell Culture, Human) Cell Culture Human
LL Lin, ER Kost, CL Lin, P Valente, CM Wang, MG Kolonin, AC Daquinag, X Tan, N Lucio, CN Hung, CP Wang, NB Kirma, TH Huang PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer Cell Rep, 2020;33(2):108253. 2020 [PMID: 33053339] (CyTof, Human) CyTof Human
C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells Hum Vaccin Immunother, 2018;0(0):0. 2018 [PMID: 29420117] (Western Blot, Human) Western Blot Human
OE Olsen, A Skjærvik, BF Størdal, A Sundan, T Holien TGF-? contamination of purified recombinant GDF15 PLoS ONE, 2017;12(11):e0187349. 2017 [PMID: 29161287] (Neutralization, Human) Neutralization Human
24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats PLoS ONE, 2016;11(8):e0161782. 2016 [PMID: 27575371] (Blocking, Rat) Blocking Rat
Show All 24 Publications.

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Gene Symbol TGFBR2