PDGF R beta Antibody [Unconjugated]


PDGF R beta was detected in immersion fixed frozen sections of mouse embryo spinal cord using 5 µg/mL Goat Anti-Mouse PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1042) ...read more
Western blot shows lysates of rat spinal cord tissue, rat brain tissue, and mouse brain tissue. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse PDGF R beta Antigen Affinity-purified Polyclonal ...read more

Product Details

Reactivity MuSpecies Glossary
Applications WB, IHC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
View Available Formulations
Catalog# & Formulation Size Price

PDGF R beta Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse PDGF R beta
Accession # P05622
Detects mouse PDGF R beta in direct ELISAs and Western blots. In direct ELISAs, this antibody shows approximately 35% cross-reactivity with recombinant human PDGF R beta.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.25 ug/mL
  • Immunohistochemistry 5-15 ug/mL
Read Publications using
AF1042 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PDGF R beta Antibody [Unconjugated]

  • beta-type platelet-derived growth factor receptor
  • CD140 antigen-like family member B
  • CD140b antigen
  • CD140b
  • EC 2.7.10
  • EC
  • JTK12
  • PDGF R beta
  • PDGFR1
  • PDGF-R-beta
  • platelet-derived growth factor receptor, beta polypeptide


The platelet-derived growth factor (PDGF) family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and a heterodimer (PDGF-AB) (1, 2). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptors (PDGF R alpha and R beta ). Whereas alpha / alpha homo-dimerization is induced by PDGF-AA, -BB, -CC, and -AB, alpha / beta hetero-dimerization is induced by PDGF-AB, -BB, -CC, and -DD, and beta / beta homo-dimerization is induced only by PDGF-BB, and -DD (1 - 4). Both PDGF R alpha and R beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3-ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. Ligand-induced receptor dimerization results in autophosphorylation in trans resulting in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, and cell migration. Many cell types, including fibroblasts and smooth muscle cells, express both the alpha and beta  receptors. Others have only the alpha receptors (oligodendrocyte progenitor cells, mesothelial cells, liver sinusoidal endothelial cells, astrocytes, platelets and megakaryocytes) or only the beta  receptors (myoblasts, capillary endothelial cells, pericytes, T cells, myeloid hematopoietic cells and macrophages). A soluble PDGF R alpha has been detected in normal human plasma and serum as well as in the conditioned medium of the human osteosarcoma cell line MG-63 (5). Both the recombinant mouse and human soluble PDGF R alpha bind PDGF with high affinity and are potent PDGF antagonists.

  1. Betshotz, C. et al. (2001) BioEssays 23:494.
  2. Ostman, A. and A.H. Heldin (2001) Advances in Cancer Research 80:1.
  3. Gilbertson, D. et al. (2001) J. Biol. Chem. 276:27406.
  4. LaRochells, W.J. et al. (2001) Nature Cell Biol. 3:517.
  5. Tiesman, J. and C.E. Hart (1993) J. Biol. Chem. 5:9621.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready
Species: Hu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ELISA(Sta)
Species: Mu
Applications: WB, IHC, Neut
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
Species: Hu
Applications: WB, Simple Western
Species: Hu, Mu, Rt, Mk
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Species: Hu
Applications: WB, Simple Western, IHC
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IP, CyTOF-ready
Species: Hu, Mu, Rt, Bv, Ca, GP, Sh
Applications: WB, IHC, IHC-P
Species: Hu
Applications: WB, Flow, IHC, IHC-P
Species: Hu
Applications: WB, IHC, IHC-P, PEP-ELISA
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, IHC
Species: Mu
Applications: WB, IHC

Publications for PDGF R beta Antibody (AF1042)(22)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: Flow Cytometry, IHC, IHC-Fr, IHC-P, Neutralization, Western Blot.

Filter By Application
Flow Cytometry
Western Blot
All Applications
Filter By Species
All Species
Showing Publications 1 - 10 of 22. Show All 22 Publications.
Publications using AF1042 Applications Species
J Rose Dayto, MC Franke, Y Yuan, L Cruz-Oreng Straightforward method for singularized and region-specific CNS microvessels isolation J. Neurosci. Methods, 2019;0(0):. 2019 [PMID: 30797797] (IHC, Mouse) IHC Mouse
JK Lighthouse, RM Burke, LS Velasquez, RA Dirkx, A Aiezza, CS Moravec, JD Alexis, A Rosenberg, EM Small Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts JCI Insight, 2019;4(1):. 2019 [PMID: 30626739] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Q Ma, Z Zhao, AP Sagare, Y Wu, M Wang, NC Owens, PB Verghese, J Herz, DM Holtzman, BV Zlokovic Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-?42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener, 2018;13(1):57. 2018 [PMID: 30340601] (IHC, Mouse) IHC Mouse
T Liu, W Ma, H Xu, M Huang, D Zhang, Z He, L Zhang, S Brem, DM O'Rourke, Y Gong, Y Mou, Z Zhang, Y Fan PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma Nat Commun, 2018;9(1):3439. 2018 [PMID: 30150753] (Western Blot, Human) Western Blot Human
A Dubrac, SE Künzel, SH Künzel, J Li, RR Chandran, K Martin, DM Greif, RH Adams, A Eichmann NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy Nat Commun, 2018;9(1):3463. 2018 [PMID: 30150707] (IHC, Mouse) IHC Mouse
R Nakazato, K Kawabe, D Yamada, S Ikeno, M Mieda, S Shimba, E Hinoi, Y Yoneda, T Takarada Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction J. Neurosci., 2017;0(0):. 2017 [PMID: 28912161] (IHC, Mouse) IHC Mouse
R Tsutsumi, J Harizanova, R Stockert, K Schröder, PIH Bastiaens, BG Neel Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2 Nat Commun, 2017;8(1):466. 2017 [PMID: 28878211] (Western Blot, Mouse) Western Blot Mouse
WC Chen, Z Wang, MA Missinato, DW Park, DW Long, HJ Liu, X Zeng, NA Yates, K Kim, Y Wang Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration Sci Adv, 2016;2(11):e1600844. 2016 [PMID: 28138518] (IHC-Fr, Mouse) IHC-Fr Mouse
Jessica Duncombe Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis Neuropathol. Appl. Neurobiol, 2016;0(0):. 2016 [PMID: 28039950] (IHC, Mouse) IHC Mouse
Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice Proc. Natl. Acad. Sci. U.S.A, 2016;0(0):. 2016 [PMID: 27956620] (IHC-Fr, Mouse) IHC-Fr Mouse
Show All 22 Publications.

Reviews for PDGF R beta Antibody (AF1042) (0)

There are no reviews for PDGF R beta Antibody (AF1042). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for PDGF R beta Antibody (AF1042) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin BAF1042

Additional PDGF R beta Products

Bioinformatics Tool for PDGF R beta Antibody (AF1042)

Discover related pathways, diseases and genes to PDGF R beta Antibody (AF1042). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for PDGF R beta Antibody (AF1042)

Discover more about diseases related to PDGF R beta Antibody (AF1042).

Pathways for PDGF R beta Antibody (AF1042)

View related products by pathway.

PTMs for PDGF R beta Antibody (AF1042)

Learn more about PTMs related to PDGF R beta Antibody (AF1042).

Blogs on PDGF R beta

There are no specific blogs for PDGF R beta, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our PDGF R beta Antibody [Unconjugated] and receive a gift card or discount.


Gene Symbol PDGFRB