IL-4 Antibody (101) - Azide and BSA Free

• Reactivity: Hu
• Applications: ELISA
• Clone: 101
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: Azide and BSA Free

IL-4 Antibody (101) - Azide and BSA Free Summary

• Description: This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-4 (Uniprot#: P05112-1; His25-Ser153).
• Specificity: No cross-reactivity in ELISA with:
  
  Mouse IL4
  Canine IL4
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: IL4
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:5000-1:10000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 um filtered solution in PBS
• Preservative: No Preservative
• Purity: Protein A purified

Alternate Names for IL-4 Antibody (101) - Azide and BSA Free

• B cell growth factor 1
• BCDF
• B-cell stimulatory factor 1
• BCGF1
• BCGF-1
• binetrakin
• BSF1
• BSF-1
• IL4
• IL-4
• IL-4B_cell stimulatory factor 1
• IL4E12
• interleukin 4
• interleukin-4
• Lymphocyte stimulatory factor 1
• MGC79402
• pitrakinra

Background

IL-4 (Interleukin 4, B cell stimulatory factor) is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. IL-4 has many different functions including promoting proliferation and differentiation of immunologically competent cells. One of its main functions is regulating differentiation of naive CD4+ T cells into helper Th2 cells, the other main function is regulating B cells IgE and IgG1 production. Human IL-4 shows 50% homology with mouse IL-4, but its activities are species-specific and human IL-4 shows no activity on murine and rat cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IL-4 Antibody (NBP2-90001)(3)

Publications using NBP2-90001

• Chen R, Wang J, Dai X et al. Augmented PFKFB3-mediated glycolysis by interferon- gamma promotes inflammatory M1 polarization through the JAK2/STAT1 pathway in local vascular inflammation in Takayasu arteritis Arthritis research & therapy 2022-12-12 [PMID: 36510278]
• Chen B, Guan X, Gunning W et al. Negative modulation of B cell activation by MC1R signaling protects against membranous nephropathy Journal of the American Society of Nephrology : JASN 2022 Nov 29 [PMID: 36446431]
• Zeng J, Sun Y, Sun S et al. Leveraging Nanodrug Delivery System for Simultaneously Targeting Tumor Cells and M2 Tumor-Associated Macrophages for Efficient Colon Cancer Therapy ACS applied materials & interfaces 2022 Nov 16 [PMID: 36327132]

Bioinformatics

• Gene Symbol: IL4