Histone Deacetylase 4/HDAC4 Antibody

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Western Blot: Histone Deacetylase 4/HDAC4 Antibody [NB100-56341] - Analysis of HDAC-4 in Jurkat cell lysate with this antibody.

Product Details

Summary
Reactivity Hu, Rt, Ch, PmSpecies Glossary
Applications WB, ChIP, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Histone Deacetylase 4/HDAC4 Antibody Summary

Immunogen
This antibody was generated by immunizing rabbits with a synthetic peptide corresponding to amino acids 194-209 of human HDAC4.
Specificity
A 140 kDa band is observed.
Predicted Species
Rat (100%), Primate (100%), Chicken (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HDAC4
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • Chromatin Immunoprecipitation 1:20-1:1000
  • Immunoprecipitation assay dependent
Application Notes
Chromatin Immunoprecipitation: Refer to Caretti et al (2003) and Imbriano (2005) for details.
Positive Control
Jurkat Lysate (NB800-PC2)
Histone Deacetylase 4/HDAC4 Lysate (NBL1-11482)
Publications
Read Publications using NB100-56341.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Histone Deacetylase 4/HDAC4 Antibody

  • HA6116
  • HD4EC 3.5.1.98
  • HDAC4
  • HDAC-A
  • HDACABDMR
  • Histone Deacetylase 4
  • histone deacetylase A
  • KIAA0288AHO3

Background

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ChIP Video Protocol
ChIP Webinar

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol HDAC4
Entrez
Uniprot