GLI-1 Antibody [DyLight 550]


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Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P
DyLight 550

GLI-1 Antibody [DyLight 550] Summary

A synthetic peptide made to an internal portion of the human Gli1 protein (between residues 150-200) [UniProt P08151]
Cytoplasm. Nucleus. Note: Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization.
Immunogen affinity purified
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  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This Gli1 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, and Western Blot. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for GLI-1 Antibody [DyLight 550]

  • GLI family zinc finger 1
  • GLI1
  • GLI-1
  • glioma-associated oncogene family zinc finger 1
  • glioma-associated oncogene homolog 1 (zinc finger protein)
  • Glioma-associated oncogene
  • GLIzinc finger protein GLI1
  • Oncogene GLI


Gli1 is a transcription factor involved in development, patterning and the regulation of cell fate-determination. A down-stream effector of the Hedgehog (HH) signaling pathway, Gli proteins work with other transcriptional activators to up-regulate the expression of Gli-response genes. In addition to its role in embryogenesis, the aberrant activation of the HH/Gli pathway has been identified in numerous forms of cancer, implicating the Gli family of proteins as potential therapeutic targets. In the absence of a stimulus, Gli1 is anchored to the cytoplasm via Cos-2, which is then released and translocates to the nucleus upon activation of the HH pathway. In the nucleus, Gli1 binds DNA via a highly conserved C2-H2 zinc finger domain and acts exclusively as an activator increasing transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-78259AF350
Alexa Fluor 405 NBP1-78259AF405
Alexa Fluor 488 NBP1-78259AF488
Alexa Fluor 532 NBP1-78259AF532
Alexa Fluor 594 NBP1-78259AF594
Alexa Fluor 647 NBP1-78259AF647
Alexa Fluor 700 NBP1-78259AF700
Alexa Fluor 750 NBP1-78259AF750
Biotin NBP1-78259B
DyLight 350 NBP1-78259UV
DyLight 405 NBP1-78259V
DyLight 488 NBP1-78259G
DyLight 550 NBP1-78259R
DyLight 650 NBP1-78259C
DyLight 680 NBP1-78259FR
DyLight 755 NBP1-78259IR
FITC NBP1-78259F
HRP NBP1-78259H
Janelia Fluor 549 NBP1-78259JF549
Janelia Fluor 646 NBP1-78259JF646

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Gene Symbol GLI1