GLI-1 Products

Antibodies
GLI-1 Antibody
GLI-1 Antibody
NB600-600
Species: Hu, Mu
Applications: WB, ChIP, ELISA, Flow-IC, IHC, IHC-P
Host: Rabbit Polyclonal
GLI-1 Antibody
GLI-1 Antibody
NBP2-24662
Species: Hu, Mu, Pm, Equine
Applications: WB, ICC/IF, IHC-P
Host: Rabbit Polyclonal
Lysates
GLI-1 Overexpression Lysate ( ...
GLI-1 Overexpression Lysate (Native)
NBL1-11109
Applications: WB
Proteins
GLI-1 Partial Recombinant Pro ...
GLI-1 Partial Recombinant Protein
H00002735-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
GLI-1 RNAi
GLI-1 RNAi
H00002735-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Gli1 was produced against a peptide corresponding to the carboxy-terminal region of the mouse Gli-1 protein. This region is not conserved among other gli family members, namely Gli-2 and Gli-3. Gli was termed by Kinzler et al. (1987) as 'glioma-associated oncogene' amplified in malignant gliomas. Analysis of the cloned gene demonstrates that the gene contains 5 repeats of zinc-finger sequences, which places gli in the family of Kruppel (Kr) zinc finger proteins. Northern analysis reveals that GLI is expressed in embryonal carcinoma cells but not in most adult tissue. GLI has been localized to 12q13-q14.3 by Southern blot analysis. On mouse the gene is located on chromosome 10. In mice, 3 zinc finger transcription factors, Gli-1, Gl-i2 and Gli-3, have been implicated in the transduction of Sonic hedgehog (Shh) signal. In papillary epithelium, shh, gli1 and ptc all follow similar expression patterns. Gli1 expression is central and probably sufficient for tumor development in humans.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 2735
Alternate Names
  • glioma-associated oncogene homolog 1 (zinc finger protein)
  • Glioma-associated oncogene
  • glioma-associated oncogene family zinc finger 1
  • GLIzinc finger protein GLI1
  • Oncogene GLI
  • GLI family zinc finger 1

Research Areas for GLI-1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction
Stem Cell Signaling Pathway
Transcription Factors and Regulators

Bioinformatics Tool for GLI-1

Discover related pathways, diseases and genes to GLI-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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