FoxP3 Antibody (16J4G6) - Delta 2 (exon 2 deleted) specific - Azide and BSA Free

Western Blot: FOXP3 Antibody (16J4G6) [Azide Free] [NBP2-24954] - analysis of FOXP32 and full-length (wild-type) transfected 293 cell lysate using this antibody. At 1 ug/ml, this antibody. In contrast, this antibody.

• Reactivity: Hu
• Applications: WB
• Clone: 16J4G6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

FoxP3 Antibody (16J4G6) - Delta 2 (exon 2 deleted) specific - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse FoxP3 Antibody (16J4G6) - Delta 2 (exon 2 deleted) specific - Azide and BSA Free (NBP2-24953) is a monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A synthetic peptide corrsponding to the exon 2 deletion site was used to immunize mice.
• Isotype: IgM Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: FOXP3
• Purity: Ammonium sulfate precipitation

Applications/Dilutions

• Dilutions:
  • Western Blot 1-3 ug/ml

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Sterile - filtered PBS
• Preservative: No Preservative
• Purity: Ammonium sulfate precipitation

Alternate Names for FoxP3 Antibody (16J4G6) - Delta 2 (exon 2 deleted) specific - Azide and BSA Free

• AIID
• AIIDMGC141961
• DIETER
• forkhead box P3
• Forkhead Box Protein P3
• FoxP3
• FOXP3delta7
• immune dysregulation, polyendocrinopathy, enteropathy, X-linked
• Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked
• IPEX
• JM2
• MGC141961
• MGC141963
• PIDX
• PIDXMGC141963
• SCURFIN
• XPID
• XPIDpolyendocrinopathy, enteropathy, X-linked

Background

Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for FoxP3 Antibody (NBP2-24954). (Showing 1 - 3 of 3 FAQ).

1. Does FoxP3 antibodies comes in lyophilized form?
   • FoxP3 antibodies, aka JM2 IPEX, and Scurfin antibodies, have the following products in lyophilized form: NBP1-18319, AF3240.
2. What the theoretical molecular weight for FoxP3 antibodies?
   • The TMW of FoxP3 antibodies is approximately 47 - 52 kDa.
3. What is the immunogen sequence of this FoxP3 antibody?
   • A synthetic sequence corresponding to the exon 2 deletion site of FoxP3. The exact sequence is proprietary.

Bioinformatics

• Gene Symbol: FOXP3