IL-7R alpha/CD127 Antibody (R34-34)

Images

 
Flow Cytometry: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - Facs staining of PBL with R34-34
Flow Cytometry: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - Facs staining of R34-34-transfected Cos7 cells
Immunoprecipitation: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - R34-34 antigen from 125I-surface labelled Pre-Alp cells

Product Details

Summary
Reactivity Hu, CaSpecies Glossary
Applications Flow, IP, B/N
Clone
R34-34
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

View Available Conjugates

IL-7R alpha/CD127 Antibody (R34-34) Summary

Immunogen
IL7R Alpha/CD127 was used as immunogen.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL7R
Purity
Ion exchange chromatography
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Block/Neutralize
  • Flow Cytometry 1:10-1:1000
  • Immunoprecipitation 1:10-1:500
Publications
Read Publications using DDX0700P-100.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris-NaCl (pH 8.0)
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Ion exchange chromatography

Notes

This product is manufactured by Dendritics and distributed by Novus Biologicals in North America and other select countries. To order in the following countries: Germany, Finland, United Kingdom, Norway, Denmark, Switzerland, Austria, Japan, and South Korea, please contact Dendritics for additional ordering information.

Alternate Names for IL-7R alpha/CD127 Antibody (R34-34)

  • CD127 antigen
  • CD127
  • CD127ILRA
  • CDW127
  • IL-7 R alpha
  • IL-7 receptor subunit alpha
  • IL7R alpha
  • IL-7R alpha
  • IL-7R subunit alpha
  • IL7R
  • IL7RA
  • IL-7Ra
  • IL-7R-alpha
  • interleukin 7 receptor alpha chain
  • interleukin 7 receptor isoform H5-6
  • interleukin 7 receptor
  • interleukin-7 receptor subunit alpha

Background

Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-7R alpha/CD127 Antibody (DDX0700P-100)(40)


Showing Publications 1 - 10 of 40. Show All 40 Publications.
Publications using DDX0700P-100 Applications Species
Faller EM et al. IL-7 receptor recovery on CD8 T-cells isolated from HIV+ patients is inhibited by the HIV Tat protein. PLoS One 2014 Jul 17 [PMID: 25033393]
Larbi et al. Generation of multipotent early lymphoid progenitors from human embryonic stem cells. Stem Cells Dev 2014 Dec 15 [PMID: 24955741]
Munneke JM et al. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. Blood 2014 Jul 31 [PMID: 24855210]
Forsberg A et al. GATA binding protein 3+ group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates. J Allergy Clin Immunol 2014 Jul [PMID: 24636083]
Peguillet I et al. High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer. Cancer Res 2014 Apr 15 [PMID: 24535711]
Sereti I et al. Decreases in Colonic and Systemic Inflammation inChronic HIV Infection after IL-7 Administration. PLoS Pathog 2014 Jan 30 [PMID: 24497828]
Compeer EB et al. Tubulation of endosomal structures in human dendritic cells by Toll-like receptor ligation and lymphocyte contact accompanies antigen cross-presentation. J Biol Chem 2014 Jan 3 [PMID: 24235148]
Yu X et al. TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal Immunol 2014 May [PMID: 24220298]
Lozza L et al. Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guerin. Eur J Immunol 2014 Jan [PMID: 24114554]
Ponchel F et al. An immunological biomarker to predict MTX response in early RA. Ann Rheum Dis 2014 Nov [PMID: 23989988]
Show All 40 Publications.

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Bioinformatics

Gene Symbol IL7R