The antibody MEM-263 reacts with extracellular (N-terminal) domain of standard CD44 (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. HLDA III; WS Code T 155
Protein A purified
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Alternate Names for CD44 Antibody (MEM-263) [FITC]
CD44 molecule (Indian blood group)
cell surface glycoprotein CD44
chondroitin sulfate proteoglycan 8
Extracellular matrix receptor III
GP90 lymphocyte homing/adhesion receptor
hematopoietic cell E- and L-selectin ligand
Heparan sulfate proteoglycan
homing function and Indian blood group system
MDU2CD44 antigen (homing function and Indian blood group system)
Phagocytic glycoprotein 1
Phagocytic glycoprotein I
CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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