CCR7 Antibody

Images

 
Immunohistochemistry-Paraffin: CCR7 Antibody [NLS848] - Analysis of anti-CCR7 antibody with transfected cells expressing CCR7 at 14 ug/ ml.
Immunohistochemistry-Paraffin: CCR7 Antibody [NLS848] - Analysis of anti-CCR7 antibody with transfection control at 14 ug/ml.
Immunohistochemistry-Paraffin: CCR7 Antibody [NLS848] - Analysis of anti-CCR7 antibody with human tonsil at dilution: 14 ug/ml
Immunohistochemistry-Paraffin: CCR7 Antibody [NLS848] - Analysis of anti-CCR7 antibody with human spleen at dilution 14 ug/ml.

Product Details

Summary
Reactivity Hu, Bt, Bv, Eq, Mk, Pm, Mu, Rt, Po, Ca, Ha, RbSpecies Glossary
Applications IHC-P, ICC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CCR7 Antibody Summary

Immunogen
Synthetic 17 amino acid peptide from C-terminus of human CCR7.
Specificity
Human CCR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CXCR5 (65%).
Predicted Species
Mouse (94%), Rat (94%), Porcine (94%), Rabbit (94%), Canine (94%), Hamster (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CCR7
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunocytochemistry 14 ug/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (94%), Panda (94%), Turkey (88%), Chicken (88%), Zebrafish (88%), Opossum (82%), Xenopus (82%), Pufferfish (82%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCR7 Antibody

  • BLR2C-C chemokine receptor type 7
  • C-C CKR-7
  • CC-CKR-7
  • CCR7
  • CCR-7
  • CD197 antigen
  • CD197
  • CDw197CC chemokine receptor 7
  • chemokine (C-C motif) receptor 7
  • CMKBR7chemokine (C-C) receptor 7
  • EBI1EBV-induced G protein-coupled receptor 1
  • EBV-induced G-protein coupled receptor 1
  • Epstein-Barr virus induced gene 1
  • Epstein-Barr virus induced G-protein coupled receptor
  • Epstein-Barr virus-induced G-protein coupled receptor 1
  • EVI1
  • lymphocyte-specific G protein-coupled peptide receptor
  • MIP-3 beta receptor

Background

CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. This receptor is particularly expressed in lymphoid tissues and in activated B and T lymphocytes. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CCR7
Entrez
Uniprot