Western Blot: CCR1 Antibody [NB100-56334] - A375 lysate probed with CCR1 antibody at 2 ug/ml dilution.
Immunohistochemistry-Paraffin: CCR1 Antibody [NB100-56334] - Formalin-fixed, paraffin-embedded normal human spleen tissue stained with CCR1 antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen. Note granulocyte ...read more
Flow Cytometry: CCR1 Antibody [NB100-56334] - Image 1: Surface staining of mouse primary epidermal cells (B-6 mice, 30wks) with CL 11-PE, CD11c PE-Cy5, and CCR1 (Langerans), stained with rabbit isotype control (shaded ...read more
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors (1). The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines (2-4). Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation (5,6).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
CCR1 (C-C chemokine receptor type 1) Chemokines play a central role in inflammation and are crucial for recruitment of immune cells to sites of infection. The chemokine-dependent activation of leukocytes occurs through binding to G-protein coupled receptors. These chemokine receptor s... Read full blog post.