CCR1 Antibody

Images

 
Western Blot: CCR1 Antibody [NB100-56334] - A375 lysate probed with CCR1 antibody at 2 ug/ml dilution.
Immunohistochemistry-Paraffin: CCR1 Antibody [NB100-56334] - Formalin-fixed, paraffin-embedded normal human spleen tissue stained with CCR1 antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen. Note granulocyte ...read more
Flow Cytometry: CCR1 Antibody [NB100-56334] - Image 1: Surface staining of mouse primary epidermal cells (B-6 mice, 30wks) with CL 11-PE, CD11c PE-Cy5, and CCR1 (Langerans), stained with rabbit isotype control (shaded ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

CCR1 Antibody Summary

Immunogen
This antibody was raised against a synthetic peptide of human CCR1 protein.
Specificity
In A375, a 42 kDa band should be observed.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CCR1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml
  • Flow Cytometry 5-10 ul/test
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Paraffin 5 ug/ml
Application Notes
Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 23417922)
Positive Control
CCR1 Lysate (NBL1-08887)
Publications
Read Publications using
NB100-56334 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for CCR1 Antibody

  • C-C chemokine receptor type 1
  • CC-CKR-1
  • CCR1
  • CCR-1
  • CD191 antigen
  • CD191
  • chemokine (C-C motif) receptor 1
  • CKR1
  • CKR-1
  • CMKBR1SCYAR1
  • CMKR1
  • HM145C-C CKR-1
  • LD78 receptor
  • Macrophage inflammatory protein 1-alpha receptor
  • MIP-1alpha-R
  • MIP1aR
  • RANTES receptor
  • RANTES-R

Background

Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors (1). The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines (2-4). Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation (5,6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC-P
Supplier Logo

Publications for CCR1 Antibody (NB100-56334)(5)

We have publications tested in 2 confirmed species: Mouse, Rabbit.

We have publications tested in 6 applications: FLOW, Flow-CS, Flow-Cs, Flow-IC, ICC/IF, IHC-Fr.


Filter By Application
FLOW
(1)
Flow-CS
(1)
Flow-Cs
(1)
Flow-IC
(1)
ICC/IF
(1)
IHC-Fr
(1)
All Applications
Filter By Species
Mouse
(3)
Rabbit
(1)
All Species
Showing Publications 1 - 5 of 5.
Publications using NB100-56334 Applications Species
Parlet CP, Schlueter AJ. Mechanisms by Which Chronic Ethanol Feeding Impairs the Migratory Capacity of Cutaneous Dendritic Cells. Alcohol Clin Exp Res 2013 Dec [PMID: 23895590] (FLOW, Mouse) FLOW Mouse
Soehnlein Oliver, Drechsler Maik, Doring Yvonne et al. Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Mol Med. 2013 Mar [PMID: 23417922] (ICC/IF, Mouse) ICC/IF Mouse
Vesosky B, Rottinghaus EK, Stromberg P et al. CCL5 participates in early protection against Mycobacterium tuberculosis. J Leukoc Biol. 2010 Jun [PMID: 20371596] (Flow-Cs, Flow-IC, Rabbit)

Details:
Products cited: 1. CCR1 (IMG-329): Flow (cell surface and intracellular), lung and lymph node from Mycobacterium tuberculosis infected CCL5 knockout and wild type mice, Fig 9. 2. Anti-Rabbit IgG (H+L) FITC Conjugate (20302): Secondary antibody labeled pol
Flow-Cs, Flow-IC Rabbit
Choi SW, Hildebrandt GC, Olkiewicz KM et al. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood. 2007 Nov 1 [PMID: 17641205] (Flow-CS)

Details:
Flow (Cell Surface): Fig 1C (splenocytes harvested from naive donor mice and transplant recipient mice). Splenic CD4+ and CD8+ T-cell expression of CCR1 was analyzed.
Flow-CS
Demoule A, Divangahi M, Danialou G et al. Expression and regulation of CC class chemokines in the dystrophic (mdx) diaphragm. Am J Respir Cell Mol Biol. 2005 Aug [PMID: 15860797] (IHC-Fr, Mouse) IHC-Fr Mouse

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for CCR1 Antibody (NB100-56334) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Blogs on CCR1.

CCR1 (C-C chemokine receptor type 1)
Chemokines play a central role in inflammation and are crucial for recruitment of immune cells to sites of infection. The chemokine-dependent activation of leukocytes occurs through binding to G-protein coupled receptors. These chemokine receptor s...  Read full blog post.

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Bioinformatics

Gene Symbol CCR1
Entrez
Uniprot