CXCR3 Antibody (49801)

Images

 
CXCR3 was detected in immersion fixed paraffin-embedded sections of human tonsil using Human CXCR3 Monoclonal Antibody (Catalog # MAB160) at 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB ...read more
Recombinant Human CXCL11/I‑TAC (Catalog # 672-IT) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR3 in a dose-dependent manner (orange line). The amount of cells that migrated through to the ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready, Neut
Clone
49801
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

CXCR3 Antibody (49801) Summary

Immunogen
NS0 mouse myeloma cell line transfected with human CXCR3
Met1-Leu368
Accession # P49682
Specificity
Detects human CXCR3.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CXCR3
Purity
Protein A or G purified from ascites
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
  • CyTOF-ready
  • Neutralization 0.3-1.5 ug/mL
Publications
Read Publications using
MAB160 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from ascites
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR3 Antibody (49801)

  • CD183 antigen
  • CD183
  • chemokine (C-X-C motif) receptor 3
  • chemokine (C-X-C) receptor 3
  • CKR-L2IP-10 receptor
  • CMKAR3
  • C-X-C chemokine receptor type 3
  • CXCR3
  • CXC-R3
  • CXCR-3
  • G protein-coupled receptor 9CD182
  • GPR9
  • GPR9Mig-R
  • Interferon-inducible protein 10 receptor
  • IP10 receptor
  • IP10-R
  • Mig receptor
  • MigR

Background

CXCR3 is a G protein-coupled chemokine receptor that binds the alpha chemokines MIG (CXCL9), IP-10 (CXCL10), and I-TAC (CXCL11). CXCR3 is expressed on activated T cells, B cells, and NK cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: Flow, IHC, CyTOF-ready, Neut

Publications for CXCR3 Antibody (MAB160-100)(40)

We have publications tested in 3 confirmed species: Human, Rat, Feline.

We have publications tested in 12 applications: Flow, Functional Assay, ICC, ICC Fresh, IF, IHC, IHC Fresh/Frozen, IHC Frozen, IHC Paraffin-embedded, Internalization Assay, Neut, WB.


Filter By Application
Flow
(14)
Functional Assay
(2)
ICC
(5)
ICC Fresh
(1)
IF
(1)
IHC
(3)
IHC Fresh/Frozen
(1)
IHC Frozen
(2)
IHC Paraffin-embedded
(2)
Internalization Assay
(1)
Neut
(1)
WB
(6)
All Applications
Filter By Species
Human
(37)
Rat
(1)
Feline
(1)
All Species
Showing Publications 1 - 10 of 40. Show All 40 Publications.
Publications using MAB160 Applications Species
F Bellora, A Dondero, MV Corrias, B Casu, S Regis, F Caliendo, A Moretta, M Cazzola, C Elena, L Vinti, F Locatelli, C Bottino, R Castriconi Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages J. Immunol., 2017;0(0):. 2017 [PMID: 28701512] (Flow,, Human) Flow Human
H Bronger, A Karge, T Dreyer, D Zech, S Kraeft, S Avril, M Kiechle, M Schmitt Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells Oncol Lett, 2017;13(6):4224-4230. 2017 [PMID: 28599423] (WB,, Human) WB Human
N Rahman, PM Brauer, L Ho, T Usenko, M Tewary, JC Zúñiga-Pfl, PW Zandstra Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence Nat Commun, 2017;8(0):15380. 2017 [PMID: 28541275] (Functional Assay,, Human) Functional Assay Human
C Windmüller, D Zech, S Avril, M Boxberg, T Dawidek, B Schmalfeld, M Schmitt, M Kiechle, H Bronger CXCR3 mediates ascites-directed tumor cell migration and predicts poor outcome in ovarian cancer patients Oncogenesis, 2017;6(5):e331. 2017 [PMID: 28504691] (WB,, Human) WB Human
JH Han, CH Suh, JY Jung, MH Ahn, MH Han, JE Kwon, H Yim, HA Kim Elevated circulating levels of the interferon-?-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still&#039;s disease Sci Rep, 2017;7(0):46652. 2017 [PMID: 28436448] (IHC,, Human) IHC Human
W Szczeklik, B Jakie?a, K Wawrzycka-, M Sanak, M Hubalewska, A Padjas, M Surmiak, K Szczeklik, J Sznajd, J Musia? Skewing towards Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis Eur. J. Immunol, 2017;0(0):. 2017 [PMID: 28155222] (Flow,, Human) Flow Human
Kuang-Hui Sun TNF-? augments CXCR2 and CXCR3 to promote progression of renal cell carcinoma J Cell Mol Med, 2016;0(0):. 2016 [PMID: 27297979] (WB,, Human) WB Human
Karjalainen M, Ojaniemi M, Haapalainen A, Mahlman M, Salminen A, Huusko J, Maatta T, Kaukola T, Anttonen J, Ulvila J, Haataja R, Teramo K, Kingsmore S, Palotie A, Muglia L, Ramet M, Hallman M CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth. J Immunol, 2015;195(5):2187-98. 2015 [PMID: 26209629] (WB,, Human) WB Human
McCully M, Collins P, Hughes T, Thomas C, Billen J, O'Donnell V, Moser B Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol, 2015;195(1):96-104. 2015 [PMID: 26002980] (Flow,, Human) Flow Human
Zsiros E, Duttagupta P, Dangaj D, Li H, Frank R, Garrabrant T, Hagemann I, Levine B, June C, Zhang L, Wang E, Marincola F, Bedognetti D, Powell D, Tanyi J, Feldman M, Kandalaft L, Coukos G The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clin Cancer Res, 2015;21(12):2840-50. 2015 [PMID: 25712684]
Show All 40 Publications.

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Bioinformatics

Gene Symbol CXCR3
Entrez
Uniprot