CXCR1/IL-8RA Antibody (42705) [Unconjugated]

Images

 
CXCR1/IL‑8 RA was detected in immersion fixed frozen sections of human lymph nodes using Mouse Anti-Human CXCR1/IL‑8 RA Monoclonal Antibody (Catalog # MAB330) at 15 µg/mL overnight at 4 °C. Tissue was stained ...read more
CXCR1/IL‑8 RA was detected in immersion fixed paraffin-embedded sections of human endometrial cancer tissue using Mouse Anti-Human CXCR1/IL‑8 RA Monoclonal Antibody (Catalog # MAB330) at 5 µg/mL overnight at 4 °C. ...read more
Recombinant Human CXCL8/IL‑8 (Catalog # 208-IL) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR1 in a dose-dependent manner (orange line). The amount of cells that migrated through to the ...read more
Human peripheral blood granulocytes were stained with Mouse Anti-HumanCXCR1/IL‑8 RA Monoclonal Antibody (Catalog # MAB330, filled histogram) or isotype control antibody (Catalog # MAB003, open histogram), ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, B/N, CyTOF-reported
Clone
42705
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

CXCR1/IL-8RA Antibody (42705) [Unconjugated] Summary

Additional Information
Clone 42705 was used by HLDA to establish CD designation
Immunogen
NS0 mouse myeloma cell line transfected with human CXCR1/IL-8 RA
Met1-Leu350
Accession # AAA59159
Specificity
Detects human CXCR1/IL-8 RA transfectants but not the parental cell line. It does not cross-react with human CXCR2.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CXCR1
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
  • CyTOF-reported
  • Neutralization 0.4-2.0 ug/mL
Publications
Read Publications using
MAB330 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR1/IL-8RA Antibody (42705) [Unconjugated]

  • CD128
  • CD181 antigen
  • CD181
  • CDw128aC-C
  • chemokine (C-X-C motif) receptor 1
  • CKR-1
  • CMKAR1
  • C-X-C chemokine receptor type 1
  • CXCR1
  • CXC-R1
  • CXCR-1
  • High affinity interleukin-8 receptor A
  • IL-8 RA
  • IL-8 receptor type 1
  • IL-8R A
  • IL8R1
  • IL8RA
  • IL8RAC-C-CKR-1
  • IL8RBA
  • interleukin 8 receptor, alpha
  • interleukin-8 receptor type 1
  • interleukin-8 receptor type A

Background

The human C-X-C chemokine IL-8 is a potent neutrophil chemotactic and activating factor. Two distinct G protein-linked cell surface receptors, known as IL-8 RA (type I or CXCR1) and IL-8 RB (type II or CXCR2), can interact with the IL-8 molecule. These two receptors share 77% amino acid homology. CXCR1 expression has been documented on neutrophils, monocytes, and a small population of T cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCR1/IL-8RA Antibody (MAB330)(35)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Guinea Pig.

We have publications tested in 10 applications: Bioassay, Flow Cytometry, Functional Assay, ICC, IHC, IHC-Fr, IHC-P, In Vivo, Neutralization, Western Blot.


Filter By Application
Bioassay
(1)
Flow Cytometry
(8)
Functional Assay
(1)
ICC
(2)
IHC
(1)
IHC-Fr
(2)
IHC-P
(1)
In Vivo
(1)
Neutralization
(16)
Western Blot
(2)
All Applications
Filter By Species
Human
(31)
Mouse
(2)
Rat
(1)
Guinea Pig
(1)
All Species
Showing Publications 1 - 10 of 35. Show All 35 Publications.
Publications using MAB330 Applications Species
I Sharma, A Singh, F Siraj, S Saxena IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma J. Biomed. Sci., 2018;25(1):62. 2018 [PMID: 30086759] (Bioassay, Human) Bioassay Human
CH Hung, FM Chen, YC Lin, ML Tsai, SL Wang, YC Chen, YT Chen, MF Hou Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer BMC Cancer, 2018;18(1):366. 2018 [PMID: 29614988] (Flow Cytometry, Human) Flow Cytometry Human
P Mazzuca, S Marsico, K Schulze, S Mitola, MC Pils, C Giagulli, CA Guzman, A Caruso, F Caccuri Role of autophagy in the HIV-1 matrix protein p17-driven lymphangiogenesis J. Virol., 2017;0(0):. 2017 [PMID: 28592537] (Neutralization, Human) Neutralization Human
ALT Loi, S Hoonhorst, C van Aalst, J Langereis, V Kamp, S Sluis-Eisi, N Ten Hacken, JW Lammers, L Koenderman Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients Respir. Res., 2017;18(1):100. 2017 [PMID: 28532454] (Flow Cytometry, Human) Flow Cytometry Human
Nader Alaridah Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs J Innate Immun, 2016;0(0):. 2016 [PMID: 28013312] (Neutralization, Mouse) Neutralization Mouse
Chen, Lianyu, Fan, Jie, Chen, Hao, Meng, Zhiqiang, Chen, Zhen, Wang, Peng, Liu, Luming The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases. Sci Rep, 2014;4(0):5911. 2014 [PMID: 25081383] (Neutralization, Human) Neutralization Human
Al-Alwan L, Chang Y, Rousseau S, Martin J, Eidelman D, Hamid Q CXCL1 inhibits airway smooth muscle cell migration through the decoy receptor Duffy antigen receptor for chemokines. J Immunol, 2015;193(3):1416-26. 2015 [PMID: 24981451] (Western Blot, Human) Western Blot Human
Chen, Lianyu, Qu, Chao, Chen, Hao, Xu, Litao, Qi, Qi, Luo, Jianmin, Wang, Kun, Meng, Zhiqiang, Chen, Zhen, Wang, Peng, Liu, Luming Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer. PLoS ONE, 2014;9(4):e96177. 2014 [PMID: 24781445] (Neutralization, Human) Neutralization Human
Cartwright A, Schmutz C, Askari A, Kuiper J, Middleton J Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis. Cytokine, 2014;67(2):53-9. 2014 [PMID: 24725539] (Flow Cytometry, Human) Flow Cytometry Human
Caccuri, Francesc, Giagulli, Cinzia, Reichelt, Joachim, Martorelli, Debora, Marsico, Stefania, Bugatti, Antonell, Barone, Ines, Rusnati, Marco, Guzman, Carlos A, Dolcetti, Riccardo, Caruso, Arnaldo Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth. J Virol, 2014;88(10):5706-17. 2014 [PMID: 24623414] (Neutralization, Human) Neutralization Human
Show All 35 Publications.

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Bioinformatics

Gene Symbol CXCR1
Uniprot