AMPK alpha 2 [p Ser491] Antibody (23GB5675)

• Reactivity: Hu, Rt
• Applications: WB, Flow, ICC/IF
• Clone: 23GB5675
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

AMPK alpha 2 [p Ser491] Antibody (23GB5675) Summary

• Immunogen: A synthesized peptide derived from human Phospho-AMPK alpha 2 (S491) (Uniprot: P54646)
• Modification: p Ser491
• Specificity: This antibody detects endogenous levels of PRKAA2 only when phosphorylated at S491
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PRKAA2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for AMPK alpha 2 [p Ser491] Antibody (23GB5675)

• 5'-AMP-activated protein kinase catalytic subunit alpha-2
• AMPK alpha 2
• AMPK subunit alpha-2
• AMPK2
• AMPK5'-AMP-activated protein kinase, catalytic alpha-2 chain
• AMPK-alpha-2 chain
• EC 2.7.11
• EC 2.7.11.1
• PRKAA
• PRKAA2
• protein kinase, AMP-activated, alpha 2 catalytic subunit

Background

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRKAA2