Amphiregulin Antibody - BSA Free

Immunohistochemistry-Paraffin: Amphiregulin Antibody [NBP1-87071] - Staining of human testis shows weak membranous /cytoplasmic positivity in cells in seminiferous ducts.

Immunohistochemistry-Paraffin: Amphiregulin Antibody [NBP1-87071] - Staining of human placenta shows strong membranous positivity in cytotrophoblastic cells.

Immunohistochemistry-Paraffin: Amphiregulin Antibody [NBP1-87071] - Staining of human Fallopian tube shows moderate membranous/cytoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: Amphiregulin Antibody [NBP1-87071] - Staining of human liver shows no positivity in hepatocytes, as expected.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Amphiregulin Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Amphiregulin Antibody - BSA Free (NBP1-87071) is a polyclonal antibody validated for use in IHC. Anti-Amphiregulin Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: FSGDHSADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERC
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AREG
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  Amphiregulin Protein (NBP1-87071PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Amphiregulin Antibody - BSA Free

• Amphiregulin
• AR
• AREG
• AREGB
• Colorectum cell-derived growth factor
• CRDGF
• MGC13647
• schwannoma-derived growth factor
• SDGF

Background

The protein encoded by the Amphiregulin gene is a member of the epidermal growth factor family. It is an autocrine growth factor aswell as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) andtransforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote thegrowth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encodedprotein is associated with a psoriasis-like skin phenotype. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Amphiregulin Antibody (NBP1-87071)(1)

Publication using NBP1-87071

• Barton VN, D'Amato NC, Gordon MA et al. Multiple Molecular Subtypes of Triple-Negative Breast Cancer Critically Rely on Androgen Receptor and Respond to Enzalutamide In Vivo. Mol Cancer Ther 2015-03-01 [PMID: 25713333] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: AREG
• Entrez:
  • 374(Human)
• Uniprot:
  • P15514()