Kummarapurugu, AB;Hawkridge, AM;Ma, J;Osei, S;Martin, RK;Zheng, S;Voynow, JA; Neutrophil Elastase decreases SARS-CoV-2 Spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomian from the epithelial surface The Journal of biological chemistry 2023-05-13 [PMID: 37187291] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
Barreto, EA;Cruz, AS;Veras, FP;Martins, R;Bernardelli, RS;Paiva, IM;Lima, TM;Singh, Y;Guimar�es, RC;Damasceno, S;Pereira, N;Alves, JM;Gon�alves, TT;Forato, J;Muraro, SP;Souza, GF;Batah, SS;Proenca-Modena, JL;Mori, MA;Cunha, FQ;Louzada-Junior, P;Cunha, TM;Nakaya, HI;Fabro, A;de Oliveira, RDR;Arruda, E;R�a, R;R�a Neto, �;Fernandes da Silva, MM;Leiria, LO; COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis Proceedings of the National Academy of Sciences of the United States of America 2023-05-23 [PMID: 37186819] (Neutralization, Human) |
Neutralization |
Human |
M Ulinici, A Sulji?, M Poggianell, R Milan Bono, K Resman Rus, A Paraschiv, AM Bonetti, M Todiras, A Corlateanu, S Groppa, E Ceban, M Petrovec, A Marcello Characterisation of the Antibody Response in Sinopharm (BBIBP-CorV) Recipients and COVID-19 Convalescent Sera from the Republic of Moldova Vaccines, 2023-03-13;11(3):. 2023-03-13 [PMID: 36992221] (FLOW, Human) |
FLOW |
Human |
AT Tang, DW Buchholz, KM Szigety, B Imbiakha, S Gao, M Frankfurte, M Wang, J Yang, P Hewins, P Mericko-Is, NA Leu, S Sterling, IA Monreal, J Sahler, A August, X Zhu, KA Jurado, M Xu, EE Morrisey, SE Millar, HC Aguilar, ML Kahn Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection PloS Biology, 2023-02-06;21(2):e3001989. 2023-02-06 [PMID: 36745682] (IHC, Western Blot, Mouse) |
IHC, Western Blot |
Mouse |
N Tailor, BM Warner, BD Griffin, K Tierney, E Moffat, K Frost, R Vendramell, A Leung, M Willman, SP Thomas, Y Pei, SA Booth, C Embury-Hya, SK Wootton, D Kobasa Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene Viruses, 2022-12-28;15(1):. 2022-12-28 [PMID: 36680125] (Western Blot, Human) |
Western Blot |
Human |
Y Kato, K Nishiyama, J Man Lee, Y Ibuki, Y Imai, T Noda, N Kamiya, T Kusakabe, Y Kanda, M Nishida TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation International Journal of Molecular Sciences, 2022-12-21;24(1):. 2022-12-21 [PMID: 36613540] (Western Blot, Mouse) |
Western Blot |
Mouse |
A Miluzio, A Cuomo, C Cordiglier, L Donnici, E Pesce, M Bombaci, M Conti, A Fasciani, L Terraccian, L Manganaro, M Toccafondi, A Scagliola, S Oliveto, S Ricciardi, R Grifantini, R De Frances, S Abrignani, N Manfrini, S Biffo Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2 EBioMedicine, 2022-12-28;87(0):104390. 2022-12-28 [PMID: 36584595] (Co-Immunoprecipitation, Flow Cytometry, IHC, Western Blot, Human) |
Co-Immunoprecipitation, Flow Cytometry, IHC, Western Blot |
Human |
X Guo, J Cao, JP Cai, J Wu, J Huang, P Asthana, SKK Wong, ZW Ye, S Gurung, Y Zhang, S Wang, Z Wang, X Ge, HY Kwan, A Lyu, KM Chan, N Wong, J Huang, Z Zhou, ZX Bian, S Yuan, HLX Wong Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2 Nature Communications, 2022-12-23;13(1):7907. 2022-12-23 [PMID: 36564389] (ICC, Human) |
ICC |
Human |
DR Adney, J Lovaglio, JE Schulz, CK Yinda, VA Avanzato, E Haddock, JR Port, MG Holbrook, PW Hanley, G Saturday, D Scott, C Shaia, AM Nelson, JR Spengler, C Tansey, CM Cossaboom, NM Wendling, C Martens, J Easley, SW Yap, SN Seifert, VJ Munster Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2 JCI Insight, 2022-11-22;7(22):. 2022-11-22 [PMID: 36509288] (IHC, Mink) |
IHC |
Mink |
SB Biering, FT Gomes de S, LV Tjang, F Pahmeier, C Zhu, R Ruan, SF Blanc, TS Patel, CM Worthingto, DR Glasner, B Castillo-R, V Servellita, NTN Lo, MP Wong, CM Warnes, DR Sandoval, TM Clausen, YA Santos, DM Fox, V Ortega, AM Näär, RS Baric, SA Stanley, HC Aguilar, JD Esko, CY Chiu, JE Pak, PR Beatty, E Harris SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling Nature Communications, 2022-12-09;13(1):7630. 2022-12-09 [PMID: 36494335] (Western Blot, Human) |
Western Blot |
Human |
H Guo, A Li, TY Dong, J Su, YL Yao, Y Zhu, ZL Shi, M Letko ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells MBio, 2022-11-21;0(0):e0256622. 2022-11-21 [PMID: 36409074] (Neutralization, Bat, Human) |
Neutralization |
Bat, Human |
JV Harte, SL Wakerlin, AJ Lindsay, JV McCarthy, C Coleman-Va Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2 Viruses, 2022-09-21;14(10):. 2022-09-21 [PMID: 36298651] |
|
|
J Song, RD Chow, M Pena-Herna, L Zhang, SA Loeb, EY So, OD Liang, P Ren, S Chen, CB Wilen, S Lee LRRC15 inhibits SARS-CoV-2 cellular entry in trans PloS Biology, 2022-10-13;20(10):e3001805. 2022-10-13 [PMID: 36228039] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
K Shilagardi, ED Spear, R Abraham, DE Griffin, S Michaelis The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation MBio, 2022-10-05;0(0):e0254322. 2022-10-05 [PMID: 36197088] (Western Blot, Human) |
Western Blot |
Human |
TD Saccon, F Mousovich-, RG Ludwig, VC Carregari, AB Dos Anjos, ASC Dos Passos, MC Martini, PP Barbosa, GF de Souza, SP Muraro, J Forato, MR Amorim, RE Marques, FP Veras, E Barreto, TT Gonçalves, IM Paiva, NPB Fazolini, CMK Onodera, RB Martins Ju, PHC de Araújo, SS Batah, RMM Viana, DM de Melo, AT Fabro, E Arruda, F Queiroz Cu, TM Cunha, MAM Pretti, BJ Smith, H Marques-So, TL Knittel, GP Ruiz, GS Profeta, TCM Fontes-Cal, M Boroni, MAR Vinolo, AS Farias, PMM Moraes-Vie, JMA Bizzacchi, T Teesalu, FDM Chaim, E Cazzo, EA Chaim, JL Proença-Mó, D Martins-de, MK Osako, LO Leiria, MA Mori SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner Nature Communications, 2022-09-29;13(1):5722. 2022-09-29 [PMID: 36175400] (ICC, African Green Monkey) |
ICC |
African Green Monkey |
N Brasu, I Elia, V Russo, G Montacchie, SA Stabile, C De Intinis, F Fesi, K Gizzi, M Macagno, M Montone, B Mussolin, A Grifoni, S Faravelli, S Marchese, F Forneris, R De Frances, A Sette, V Barnaba, A Sottile, A Sapino, L Pace Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination Nature Immunology, 2022-09-22;0(0):. 2022-09-22 [PMID: 36138186] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
M Montano, AR Victor, DK Griffin, T Duong, N Bolduc, A Farmer, V Garg, AK Hadjantona, A Coates, FL Barnes, CG Zouves, WC Greene, M Viotti SARS-CoV-2 can infect human embryos Scientific Reports, 2022-09-14;12(1):15451. 2022-09-14 [PMID: 36104397] (Control, ICC, Human) |
Control, ICC |
Human |
Y Yao, K Subedi, T Liu, N Khalasawi, CD Pretto-Ker, JW Wotring, J Wang, C Yin, A Jiang, C Fu, P Dimitrion, J Li, J Veenstra, Q Yi, K McKinnon, JE McKinnon, JZ Sexton, L Zhou, QS Mi Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes Cell Discovery, 2022-09-09;8(1):89. 2022-09-09 [PMID: 36085197] (Western Blot, Human) |
Western Blot |
Human |
J Hou, Y Wei, J Zou, R Jaffery, S Liang, C Zheng, K Chen, PY Shi, Y Chen, X Xie, W Peng Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection Research square, 2022-08-15;0(0):. 2022-08-15 [PMID: 36032971] (Western Blot, Human) |
Western Blot |
Human |
B Meng, R Datir, J Choi, CITIID-NIH, JR Bradley, KGC Smith, JH Lee, RK Gupta SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity Cell Reports, 2022-08-03;40(7):111220. 2022-08-03 [PMID: 35963244] (Neutralization, Human) |
Neutralization |
Human |
P Su, D Zhai, AHC Wong, F Liu Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice Molecular Brain, 2022-08-09;15(1):71. 2022-08-09 [PMID: 35945596] (Co-Immunoprecipitation, IHC, Western Blot, Human, Mouse) |
Co-Immunoprecipitation, IHC, Western Blot |
Human, Mouse |
Y Zhu, KY Chew, M Wu, AC Karawita, G McCallum, LE Steele, A Yamamoto, LI Labzin, T Yarlagadda, AA Khromykh, X Wang, JDJ Sng, CJ Stocks, Y Xia, TR Kollmann, D Martino, M Joensuu, FA Meunier, G Balistreri, H Bielefeldt, AC Bowen, A Kicic, PD Sly, KM Spann, KR Short Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells PloS Biology, 2022-08-01;20(8):e3001728. 2022-08-01 [PMID: 35913989] (ICC, Western Blot, Human) |
ICC, Western Blot |
Human |
CW Chang, KM Parsi, M Somasundar, E Vanderleed, P Liu, J Cruz, A Cousineau, RW Finberg, EA Kurt-Jones A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants Viruses, 2022-06-23;14(7):. 2022-06-23 [PMID: 35891350] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
H Stölting, L Baillon, R Frise, K Bonner, RJ Hewitt, PL Molyneaux, ML Gore, Breathing, WS Barclay, S Saglani, CM Lloyd Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1 Mucosal Immunology, 2022-07-15;0(0):. 2022-07-15 [PMID: 35840680] (IHC, Human) |
IHC |
Human |
M Ramal-Sanc, C Castellini, C Cimini, A Taraschi, L Valbonetti, A Barbonetti, N Bernabò, B Barboni ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa International Journal of Molecular Sciences, 2022-03-28;23(7):. 2022-03-28 [PMID: 35409054] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
P Spitalieri, F Centofanti, M Murdocca, MG Scioli, A Latini, S Di Cesare, G Citro, A Rossi, A Orlandi, S Miersch, SS Sidhu, PP Pandolfi, A Botta, F Sangiuolo, G Novelli Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids Cells, 2022-04-05;11(7):. 2022-04-05 [PMID: 35406799] (IHC, Human) |
IHC |
Human |
C Junqueira, Â Crespo, S Ranjbar, LB de Lacerda, M Lewandrows, J Ingber, B Parry, S Ravid, S Clark, MR Schrimpf, F Ho, C Beakes, J Margolin, N Russell, K Kays, J Boucau, U Das Adhika, SM Vora, V Leger, L Gehrke, L Henderson, E Janssen, D Kwon, C Sander, J Abraham, MB Goldberg, H Wu, G Mehta, S Bell, AE Goldfeld, MR Filbin, J Lieberman FcgammaR-mediated SARS-CoV-2 infection of monocytes activates inflammation Nature, 2022-04-06;0(0):. 2022-04-06 [PMID: 35385861] (Flow Cytometry, Neutralization, Human) |
Flow Cytometry, Neutralization |
Human |
L Casciola-R, DR Thiemann, F Andrade, MI Trejo-Zamb, EK Leonard, JB Spangler, NE Skinner, J Bailey, S Yegnasubra, R Wang, AM Vaghasia, A Gupta, AL Cox, SC Ray, RM Linville, Z Guo, PC Searson, CE Machamer, S Desiderio, LM Sauer, O Laeyendeck, BT Garibaldi, L Gao, M Damarla, PM Hassoun, JE Hooper, CA Mecoli, L Christophe, L Gutierrez-, Q Yang, D Hines, WA Clarke, RE Rothman, A Pekosz, KZ Fenstermac, Z Wang, SL Zeger, A Rosen IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function JCI Insight, 2022-05-09;7(9):. 2022-05-09 [PMID: 35349483] (IHC, Human) |
IHC |
Human |
Y Menuchin-L, A Schreiber, A Lecanda, A Mecate-Zam, L Brunotte, OE Psathaki, S Ludwig, T Rauen, HR Schöler SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids Stem Cell Reports, 2022-03-24;0(0):. 2022-03-24 [PMID: 35334213] (Neutralization, Human) |
Neutralization |
Human |
X Wang, J Luo, Z Wen, L Shuai, C Wang, G Zhong, X He, H Cao, R Liu, J Ge, R Hua, Z Sun, X Wang, J Wang, Z Bu Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung PloS Pathogens, 2022-02-17;18(2):e1010343. 2022-02-17 [PMID: 35176124] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
S Krasemann, U Haferkamp, S Pfefferle, MS Woo, F Heinrich, M Schweizer, A Appelt-Men, A Cubukova, J Barenberg, J Leu, K Hartmann, E Thies, JL Littau, D Sepulveda-, L Zhang, K Ton, Y Liang, J Matschke, F Ricklefs, T Sauvigny, J Sperhake, A Fitzek, A Gerhartl, A Brachner, N Geiger, EM König, J Bodem, S Franzenbur, A Franke, S Moese, FJ Müller, G Geisslinge, C Claussen, A Kannt, A Zaliani, P Gribbon, B Ondruschka, W Neuhaus, MA Friese, M Glatzel, O Pless The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 Stem Cell Reports, 2022-01-20;0(0):. 2022-01-20 [PMID: 35063125] (Neutralization, Human) |
Neutralization |
Human |
L El-Shennaw, AD Hoffmann, NK Dashzeveg, KM McAndrews, PJ Mehl, D Cornish, Z Yu, VL Tokars, V Nicolaescu, A Tomatsidou, C Mao, CJ Felicelli, CF Tsai, C Ostiguin, Y Jia, L Li, K Furlong, J Wysocki, X Luo, CF Ruivo, D Batlle, TJ Hope, Y Shen, YK Chae, H Zhang, VS LeBleu, T Shi, S Swaminatha, Y Luo, D Missiakas, GC Randall, AR Demonbreun, MG Ison, R Kalluri, D Fang, H Liu Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Nature Communications, 2022-01-20;13(1):405. 2022-01-20 [PMID: 35058437] (Western Blot, Human) |
Western Blot |
Human |
J Grau-Expós, D Perea, M Suppi, N Massana, A Vergara, MJ Soler, B Trinite, J Blanco, J García-Pér, J Alcamí, A Serrano-Mo, J Rosado, V Falcó, M Genescà, MJ Buzon Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells PloS Pathogens, 2022-01-13;18(1):e1010171. 2022-01-13 [PMID: 35025963] (ICC, IHC, Human) |
ICC, IHC |
Human |
J Shi, X Jin, Y Ding, X Liu, A Shen, Y Wu, M Peng, C Shen Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice Vaccines, 2021-11-24;9(12):. 2021-11-24 [PMID: 34960131] (ELISA Detection, Human) |
ELISA Detection |
Human |
SB Biering, FTG de Sousa, LV Tjang, F Pahmeier, R Ruan, SF Blanc, TS Patel, CM Worthingto, DR Glasner, B Castillo-R, V Servellita, NTN Lo, MP Wong, CM Warnes, DR Sandoval, TM Clausen, YA Santos, V Ortega, HC Aguilar, JD Esko, CY Chui, JE Pak, PR Beatty, E Harris SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling bioRxiv : the preprint server for biology, 2021-12-13;0(0):. 2021-12-13 [PMID: 34931188] (Western Blot, Human) |
Western Blot |
Human |
J Wang, G Yang, X Wang, Z Wen, L Shuai, J Luo, C Wang, Z Sun, R Liu, J Ge, X He, R Hua, X Wang, X Yang, W Chen, G Zhong, Z Bu SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells Cell Discovery, 2021-12-14;7(1):119. 2021-12-14 [PMID: 34903715] (Flow Cytometry, Neutralization, Human, Primate - C. aethiops) |
Flow Cytometry, Neutralization |
Human, Primate - C. aethiops |
L Helms, S Marchiano, IB Stanaway, TY Hsiang, BA Juliar, S Saini, YT Zhao, A Khanna, R Menon, F Alakwaa, C Mikacenic, ED Morrell, MM Wurfel, M Kretzler, JL Harder, CE Murry, J Himmelfarb, H Ruohola-Ba, PK Bhatraju, M Gale, BS Freedman Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations JCI Insight, 2021-12-22;0(0):. 2021-12-22 [PMID: 34767537] (IHC, Human) |
IHC |
Human |
L Nguyen, KA McCord, DT Bui, KM Bouwman, EN Kitova, M Elaish, D Kumawat, GC Daskhan, I Tomris, L Han, P Chopra, TJ Yang, SD Willows, AL Mason, LK Mahal, TL Lowary, LJ West, SD Hsu, T Hobman, SM Tompkins, GJ Boons, RP de Vries, MS Macauley, JS Klassen Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2 Nature Chemical Biology, 2021-11-09;0(0):. 2021-11-09 [PMID: 34754101] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
X Duan, X Tang, MS Nair, T Zhang, Y Qiu, W Zhang, P Wang, Y Huang, J Xiang, H Wang, RE Schwartz, DD Ho, T Evans, S Chen An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection Cell Reports, 2021-10-15;37(6):109920. 2021-10-15 [PMID: 34731648] (IHC, Human) |
IHC |
Human |
MW Ku, P Authié, M Bourgine, F Anna, A Noirat, F Moncoq, B Vesin, F Nevo, J Lopez, P Souque, C Blanc, I Fert, S Chardenoux, L Lafosse, D Cussigh, D Hardy, K Nemirov, F Guinet, F Langa Vive, L Majlessi, P Charneau Brain Cross-Protection against SARS-CoV-2 Variants by a Lentiviral Vaccine in New Transgenic Mice Embo Molecular Medicine, 2021-10-25;0(0):e14459. 2021-10-25 [PMID: 34647691] (Western Blot, Transgenic Mouse) |
Western Blot |
Transgenic Mouse |
S Singh, G Garcia, R Shah, AA Kramerov, RE Wright, TM Spektor, AV Ljubimov, V Arumugaswa, A Kumar SARS-CoV-2 and its variants of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response The ocular surface, 2021-09-25;0(0):. 2021-09-25 [PMID: 34583089] (ICC, IHC, Human) |
ICC, IHC |
Human |
SP Shukla, KB Cho, V Rustagi, X Gao, X Fu, SX Zhang, B Guo, DG Udugamasoo "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry International Journal of Molecular Sciences, 2021-08-20;22(16):. 2021-08-20 [PMID: 34445669] (Flow Cytometry, Western Blot, Human) |
Flow Cytometry, Western Blot |
Human |
EJ Sherman, BT Emmer ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes Scientific Reports, 2021-08-05;11(1):15900. 2021-08-05 [PMID: 34354120] (Western Blot, Flow Cytometry, Human) |
Western Blot, Flow Cytometry |
Human |
M Alenquer, F Ferreira, D Lousa, M Valério, M Medina-Lop, ML Bergman, J Gonçalves, J Demengeot, RB Leite, J Lilue, Z Ning, C Penha-Gonç, H Soares, CM Soares, MJ Amorim Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies PloS Pathogens, 2021-08-05;17(8):e1009772. 2021-08-05 [PMID: 34352039] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
CLC Almeida-da, H Matshik Da, K Liu, DM Ojcius Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells International Journal of Molecular Sciences, 2021-07-18;22(14):. 2021-07-18 [PMID: 34299289] (ICC, Western Blot, Human) |
ICC, Western Blot |
Human |
Y Kondo, JL Larabee, L Gao, H Shi, B Shao, CM Hoover, JM McDaniel, YC Ho, R Silasi-Man, SA Archer-Har, P Azadi, RS Srinivasan, AR Rezaie, A Borczuk, JC Laurence, F Lupu, J Ahamed, RP McEver, JF Papin, Z Yu, L Xia L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus JCI Insight, 2021-07-22;6(14):. 2021-07-22 [PMID: 34291736] (IHC, Human) |
IHC |
Human |
L Wang, D Sievert, AE Clark, S Lee, H Federman, BD Gastfriend, EV Shusta, SP Palecek, AF Carlin, JG Gleeson A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology Nature Medicine, 2021-07-09;0(0):. 2021-07-09 [PMID: 34244682] (IHC, Human) |
IHC |
Human |
M Puray-Chav, KM LaPak, TP Schrank, JL Elliott, DP Bhatt, MJ Agajanian, R Jasuja, DQ Lawson, K Davis, PW Rothlauf, Z Liu, H Jo, N Lee, K Tenneti, JE Eschbach, C Shema Mugi, EM Cousins, EW Cloer, HR Vuong, LA VanBlargan, AL Bailey, P Gilchuk, JE Crowe, MS Diamond, DN Hayes, SPJ Whelan, A Horani, SL Brody, D Goldfarb, MB Major, SB Kutluay Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell Cell Reports, 2021-06-23;0(0):109364. 2021-06-23 [PMID: 34214467] (Western Blot, Human) |
Western Blot |
Human |
M Zhao, PY Su, DA Castro, TN Tripler, Y Hu, M Cook, AI Ko, SF Farhadian, B Israelow, CS Dela Cruz, Y Xiong, RE Sutton, Yale IMPAC Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2 PloS Pathogens, 2021-06-24;17(6):e1009683. 2021-06-24 [PMID: 34166473] (Western Blot, Human) |
Western Blot |
Human |
X Wang, CH Chen, S Badeti, JH Cho, A Naghizadeh, Z Wang, D Liu Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion Cell & bioscience, 2021-06-23;11(1):114. 2021-06-23 [PMID: 34162440] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
M Baratchian, JM McManus, MP Berk, F Nakamura, S Mukhopadhy, W Xu, S Erzurum, J Drazba, J Peterson, EA Klein, B Gaston, N Sharifi Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes Scientific Reports, 2021-05-27;11(1):11130. 2021-05-27 [PMID: 34045511] (IHC, Mouse) |
IHC |
Mouse |
T Ebisudani, S Sugimoto, K Haga, A Mitsuishi, R Takai-Toda, M Fujii, K Toshimitsu, J Hamamoto, K Sugihara, T Hishida, H Asamura, K Fukunaga, H Yasuda, K Katayama, T Sato Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening Cell Reports, 2021-05-19;0(0):109218. 2021-05-19 [PMID: 34038715] (ICC, Human) |
ICC |
Human |
AZ Eriksen, R Møller, B Makovoz, SA Uhl, BR tenOever, TA Blenkinsop SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Cell Stem Cell, 2021-05-17;0(0):. 2021-05-17 [PMID: 34022129] (IHC, Human) |
IHC |
Human |
CH Chen, S Badeti, JH Cho, A Naghizadeh, X Wang, D Liu Deletion of ER-retention Motif on SARS-CoV-2 Spike Protein Reduces Cell Hybrid During Cell-cell Fusion Research square, 2021-04-09;0(0):. 2021-04-09 [PMID: 33851149] (Flow Cytometry, ICC, Human) |
Flow Cytometry, ICC |
Human |
M Dittmar, JS Lee, K Whig, E Segrist, M Li, B Kamalia, L Castellana, K Ayyanathan, FL Cardenas-D, EE Morrisey, R Truitt, W Yang, K Jurado, K Samby, H Ramage, DC Schultz, S Cherry Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 Cell Reports, 2021-03-23;35(1):108959. 2021-03-23 [PMID: 33811811] (Western Blot, Human) |
Western Blot |
Human |
SJ Dicken, MJ Murray, LG Thorne, AK Reuschl, C Forrest, M Ganeshalin, L Muir, MD Kalemera, M Palor, LE McCoy, C Jolly, GJ Towers, MB Reeves, J Grove Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2 bioRxiv : the preprint server for biology, 2021-03-22;0(0):. 2021-03-22 [PMID: 33791702] (Flow Cytometry, Western Blot, Human) |
Flow Cytometry, Western Blot |
Human |
Y Zhang, R Guo, SH Kim, H Shah, S Zhang, JH Liang, Y Fang, M Gentili, CNO Leary, SJ Elledge, DT Hung, VK Mootha, BE Gewurz SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication Nature Communications, 2021-03-15;12(1):1676. 2021-03-15 [PMID: 33723254] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
J Baggen, L Persoons, E Vanstreels, S Jansen, D Van Loover, B Boeckx, V Geudens, J De Man, D Jochmans, J Wauters, E Wauters, BM Vanaudenae, D Lambrechts, J Neyts, K Dallmeier, HJ Thibaut, M Jacquemyn, P Maes, D Daelemans Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 Nature Genetics, 2021-03-08;0(0):. 2021-03-08 [PMID: 33686287] (Flow Cytometry, Western Blot, Human) |
Flow Cytometry, Western Blot |
Human |
K Uemura, M Sasaki, T Sanaki, S Toba, Y Takahashi, Y Orba, WW Hall, K Maenaka, H Sawa, A Sato MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2 Scientific Reports, 2021-03-08;11(1):5376. 2021-03-08 [PMID: 33686154] (Flow Cytometry, ICC, Human, Primate) |
Flow Cytometry, ICC |
Human, Primate |
EE Khoury, Y Knaney, A Fokra, S Kinaneh, Z Azzam, SN Heyman, Z Abassi Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease Journal of Cellular and Molecular Medicine, 2021-03-04;0(0):. 2021-03-04 [PMID: 33660945] (IHC, Rat) |
IHC |
Rat |
S Sugimoto, E Kobayashi, M Fujii, Y Ohta, K Arai, M Matano, K Ishikawa, K Miyamoto, K Toshimitsu, S Takahashi, K Nanki, Y Hakamata, T Kanai, T Sato An organoid-based organ-repurposing approach to treat short bowel syndrome Nature, 2021-02-24;0(0):. 2021-02-24 [PMID: 33627870] (IHC, Rat) |
IHC |
Rat |
H Huerga Enc, W Grey, M Garcia-Alb, H Wood, R Ulferts, IV Aramburu, AG Kulasekara, G Mufti, V Papayannop, R Beale, D Bonnet Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients Stem Cell Reports, 2021-02-05;16(3):428-436. 2021-02-05 [PMID: 33581053] (Flow Cytometry, ICC, Human) |
Flow Cytometry, ICC |
Human |
R Tian, AJ Samelson, VV Rezelj, M Chen, GN Ramadoss, X Guo, AM Kain, QD Tran, SA Lim, I Lui, J Nunez, SJ Rockwood, N Liu, J Carlson-St, J Oki, T Maures, K Holden, JS Weissman, JA Wells, B Conklin, M Vignuzzi, M Kampmann BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2 bioRxiv : the preprint server for biology, 2021-09-20;0(0):. 2021-09-20 [PMID: 33501440] (Western Blot, Human) |
Western Blot |
Human |
F Onodi, L Bonnet-Mad, L Meertens, L Karpf, J Poirot, SY Zhang, C Picard, A Puel, E Jouanguy, Q Zhang, J Le Goff, JM Molina, C Delaugerre, JL Casanova, A Amara, V Soumelis SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4 bioRxiv : the preprint server for biology, 2021-01-08;0(0):. 2021-01-08 [PMID: 33442685] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
X Yin, L Riva, Y Pu, L Martin-San, J Kanamune, Y Yamamoto, K Sakai, S Gotoh, L Miorin, PD De Jesus, CC Yang, KM Herbert, S Yoh, JF Hultquist, A García-Sas, SK Chanda MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells Cell Reports, 2021-01-12;34(2):108628. 2021-01-12 [PMID: 33440148] (ICC, Human) |
ICC |
Human |
C Blume, CL Jackson, CM Spalluto, J Legebeke, L Nazlamova, F Conforti, JM Perotin, M Frank, J Butler, M Crispin, J Coles, J Thompson, RA Ridley, LSN Dean, M Loxham, S Reikine, A Azim, K Tariq, DA Johnston, PJ Skipp, R Djukanovic, D Baralle, CJ McCormick, DE Davies, JS Lucas, G Wheway, V Mennella A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection Nature Genetics, 2021-01-11;0(0):. 2021-01-11 [PMID: 33432184] (ICC, Human) |
ICC |
Human |
H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang, H Shuai, D Yang, Y Hou, X Zhang, TT Yuen, JP Cai, AJ Zhang, J Zhou, S Yuan, KK To, IH Chan, KY Sit, DC Foo, IY Wong, AT Ng, TT Cheung, SY Law, WK Au, MA Brindley, Z Chen, KH Kok, JF Chan, KY Yuen Host and viral determinants for efficient SARS-CoV-2 infection of the human lung Nature Communications, 2021-01-08;12(1):134. 2021-01-08 [PMID: 33420022] (Flow Cytometry, Mesocricetus auratus (Hamster)) |
Flow Cytometry |
Mesocricetus auratus (Hamster) |
AZ Mykytyn, TI Breugem, S Riesebosch, D Schipper, PB van den Do, RJ Rottier, MM Lamers, BL Haagmans SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site Elife, 2021-01-04;10(0):. 2021-01-04 [PMID: 33393462] (ICC, IHC, Human) |
ICC, IHC |
Human |
RM Samuel, H Majd, MN Richter, Z Ghazizadeh, SM Zekavat, A Navickas, JT Ramirez, H Asgharian, CR Simoneau, LR Bonser, KD Koh, M Garcia-Kni, M Tassetto, S Sunshine, S Farahvashi, A Kalantari, W Liu, R Andino, H Zhao, P Natarajan, DJ Erle, M Ott, H Goodarzi, F Fattahi Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell, 2020-11-17;27(6):876-889.e12. 2020-11-17 [PMID: 33232663] (ICC, Human) |
ICC |
Human |
JK Osan, SN Talukdar, F Feldmann, B Ann DeMont, K Jerome, KL Bailey, H Feldmann, M Mehedi Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD bioRxiv, 2020-11-12;0(0):. 2020-11-12 [PMID: 33200131] (Western Blot, Human) |
Western Blot |
Human |
R Tandon, D Mitra, P Sharma, MG McCandless, SJ Stray, JT Bates, GD Marshall Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein Sci Rep, 2020-11-05;10(1):19076. 2020-11-05 [PMID: 33154514] (Western Blot, Human) |
Western Blot |
Human |
IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang, PA Gall, CK Liao, LC Shih, CM Schürch, DR McIlwain, P Chu, NA Borchard, D Zarabanda, SS Dholakia, A Yang, D Kim, H Chen, T Kanie, CD Lin, MH Tsai, KM Phillips, R Kim, JB Overdevest, MA Tyler, CH Yan, CF Lin, YT Lin, DT Bau, GJ Tsay, ZM Patel, YA Tsou, A Tzankov, MS Matter, CJ Tai, TH Yeh, PH Hwang, GP Nolan, JV Nayak, PK Jackson ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs Nat Commun, 2020-10-28;11(1):5453. 2020-10-28 [PMID: 33116139] (IHC, Human) |
IHC |
Human |
L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul, AP Carter, LC James, MA Lancaster SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids Cell Stem Cell, 2020-10-13;0(0):. 2020-10-13 [PMID: 33113348] (Western Blot, Human) |
Western Blot |
Human |
W Rut, K Groborz, L Zhang, X Sun, M Zmudzinski, B Pawlik, X Wang, D Jochmans, J Neyts, W M?ynarski, R Hilgenfeld, M Drag SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging Nat Chem Biol, 2020-10-22;0(0):. 2020-10-22 [PMID: 33093684] (ICC, Human) |
ICC |
Human |
L Casciola-R, DR Thiemann, F Andrade, MI Trejo Zamb, JE Hooper, E Leonard, J Spangler, AL Cox, C Machamer, L Sauer, O Laeyendeck, BT Garibaldi, SC Ray, C Mecoli, L Christophe, L Gutierrez-, Q Yang, D Hines, W Clarke, RE Rothman, A Pekosz, K Fenstermac, Z Wang, SL Zeger, A Rosen IgM autoantibodies recognizing ACE2 are associated with severe COVID-19 medRxiv, 2020-10-15;0(0):. 2020-10-15 [PMID: 33083808] (Western Blot, Human) |
Western Blot |
Human |
M Baratchian, JM McManus, M Berk, F Nakamura, S Mukhopadhy, W Xu, S Erzurum, J Drazba, J Peterson, EA Klein, B Gaston, N Sharifi Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2 bioRxiv, 2020-10-14;0(0):. 2020-10-14 [PMID: 33083800] (IHC, Mouse) |
IHC |
Mouse |
X Xie, AE Muruato, X Zhang, KG Lokugamage, CR Fontes-Gar, J Zou, J Liu, P Ren, M Balakrishn, T Cihlar, CK Tseng, S Makino, VD Menachery, JP Bilello, PY Shi A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19 Nat Commun, 2020-10-15;11(1):5214. 2020-10-15 [PMID: 33060595] (ICC, Neutralization, Primate) |
ICC, Neutralization |
Primate |
SP Sajuthi, P DeFord, Y Li, ND Jackson, MT Montgomery, JL Everman, CL Rios, E Pruesse, JD Nolin, EG Plender, ME Wechsler, ACY Mak, C Eng, S Salazar, V Medina, EM Wohlford, S Huntsman, DA Nickerson, S Germer, MC Zody, G Abecasis, HM Kang, KM Rice, R Kumar, S Oh, J Rodriguez-, EG Burchard, MA Seibold Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium Nat Commun, 2020-10-12;11(1):5139. 2020-10-12 [PMID: 33046696] (IHC, Human) |
IHC |
Human |
R Wang, CR Simoneau, J Kulsuptrak, M Bouhaddou, K Travisano, JM Hayashi, J Carlson-St, J Oki, K Holden, NJ Krogan, M Ott, AS Puschnik Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses bioRxiv : the preprint server for biology, 2020-09-24;0(0):. 2020-09-24 [PMID: 32995787] (Western Blot, Human) |
Western Blot |
Human |
J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell, 2020-09-18;0(0):. 2020-09-18 [PMID: 32979316] (Flow Cytometry, ICC, Human) |
Flow Cytometry, ICC |
Human |
E Song, C Zhang, B Israelow, A Lu-Culliga, AV Prado, S Skriabine, P Lu, OE Weizman, F Liu, Y Dai, K Szigeti-Bu, Y Yasumoto, G Wang, C Castaldi, J Heltke, E Ng, J Wheeler, MM Alfajaro, E Levavasseu, B Fontes, NG Ravindra, D Van Dijk, S Mane, M Gunel, A Ring, SA Jaffar Kaz, K Zhang, CB Wilen, TL Horvath, I Plu, S Haik, JL Thomas, A Louvi, SF Farhadian, A Huttner, D Seilhean, N Renier, K Bilguvar, A Iwasaki Neuroinvasion of SARS-CoV-2 in human and mouse brain bioRxiv : the preprint server for biology, 2020-09-08;0(0):. 2020-09-08 [PMID: 32935108] (Neutralization, Human) |
Neutralization |
Human |
I Busnadiego, S Fernbach, MO Pohl, U Karakus, M Huber, A Trkola, S Stertz, BG Hale Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2 MBio, 2020-09-10;11(5):. 2020-09-10 [PMID: 32913009] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
T Azad, R Singaravel, MJF Crupi, T Jamieson, J Dave, EEF Brown, R Rezaei, Z Taha, S Boulton, NT Martin, A Surendran, J Poutou, M Ghahremani, K Nouri, JT Whelan, J Duong, S Tucker, JS Diallo, JC Bell, CS Ilkow Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization Membranes (Basel), 2020-08-30;10(9):. 2020-08-30 [PMID: 32872641] (Western Blot, Human) |
Western Blot |
Human |
F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (IHC, Neutralization, Human, Mouse) |
IHC, Neutralization |
Human, Mouse |
R Rathnasing, S Strohmeier, F Amanat, VL Gillespie, F Krammer, A García-Sas, L Coughlan, M Schotsaert, M Uccellini Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection bioRxiv, 2020-07-06;0(0):. 2020-07-06 [PMID: 32676603] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response bioRxiv, 2020-08-06;0(0):. 2020-08-06 [PMID: 32637964] (Flow Cytometry, ICC, Human) |
Flow Cytometry, ICC |
Human |
J Prévost, R Gasser, G Beaudoin-B, J Richard, R Duerr, A Laumaea, SP Anand, G Goyette, S Ding, H Medjahed, A Lewin, J Perreault, T Tremblay, G Gendron-Le, N Gauthier, M Carrier, D Marcoux, A Piché, M Lavoie, A Benoit, V Loungnarat, G Brochu, M Desforges, PJ Talbot, GT Gould Maul, M Côté, C Therrien, B Serhir, R Bazin, M Roger, A Finzi Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike bioRxiv : the preprint server for biology, 2020-07-30;0(0):. 2020-07-30 [PMID: 32577637] (ICC, Human) |
ICC |
Human |
IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang, PA Gall, CK Liao, LC Shih, CM Schurch, DR McIlwain, P Chu, NA Borchard, D Zarabanda, SS Dholakia, A Yang, D Kim, T Kanie, CD Lin, MH Tsai, KM Phillips, R Kim, JB Overdevest, MA Tyler, CH Yan, CF Lin, YT Lin, DT Bau, GJ Tsay, ZM Patel, YA Tsou, CJ Tai, TH Yeh, PH Hwang, GP Nolan, JV Nayak, PK Jackson Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers medRxiv, 2020-05-12;0(0):. 2020-05-12 [PMID: 32511516] (IHC, Human) |
IHC |
Human |
Y Han, L Yang, X Duan, F Duan, BE Nilsson-Pa, TM Yaron, P Wang, X Tang, T Zhang, Z Zhao, Y Bram, D Redmond, S Houghton, D Nguyen, D Xu, X Wang, S Uhl, Y Huang, JL Johnson, J Xiang, H Wang, FC Pan, LC Cantley, BR tenOever, DD Ho, T Evans, RE Schwartz, HJ Chen, S Chen Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids bioRxiv, 2020-05-05;0(0):. 2020-05-05 [PMID: 32511403] (ICC, Human) |
ICC |
Human |
J Collin, R Queen, D Zerti, B Dorgau, M Georgiou, I Djidrovski, R Hussain, JM Coxhead, A Joseph, P Rooney, S Lisgo, F Figueiredo, L Armstrong, M Lako Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface Ocul Surf, 2020-06-03;0(0):. 2020-06-03 [PMID: 32502616] (IHC, Western Blot, Human) |
IHC, Western Blot |
Human |
J Zhou, C Li, X Liu, MC Chiu, X Zhao, D Wang, Y Wei, A Lee, AJ Zhang, H Chu, JP Cai, CC Yip, IH Chan, KK Wong, OT Tsang, KH Chan, JF Chan, KK To, H Chen, KY Yuen Infection of bat and human intestinal organoids by SARS-CoV-2 Nat. Med., 2020-05-13;0(0):. 2020-05-13 [PMID: 32405028] (ICC, Bat, Human) |
ICC |
Bat, Human |
KHD Crawford, R Eguia, AS Dingens, AN Loes, KD Malone, CR Wolf, HY Chu, MA Tortorici, D Veesler, M Murphy, D Pettie, NP King, AB Balazs, JD Bloom Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays Viruses, 2020-05-06;12(5):. 2020-05-06 [PMID: 32384820] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
M Yang, X Ma, X Xuan, H Deng, Q Chen, L Yuan Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System Front Pharmacol, 2020-04-08;11(0):432. 2020-04-08 [PMID: 32322207] (Western Blot, Human, Mouse) |
Western Blot |
Human, Mouse |
Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens T, Herrler G, Wu N, Nitsche A, Muller M, Drosten C, Pohlmann S SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 2020-03-05;181(0):1-10. 2020-03-05 [PMID: 32142651] (Neutralization, Primate - Cercopithecus aethiops (African Green Monkey)) |
Neutralization |
Primate - Cercopithecus aethiops (African Green Monkey) |
D Tian, A Uda, Y Ami, A Hotta, ES Park, N Nagata, N Iwata-Yosh, A Yamada, K Hirayama, K Miura, Y Koyama, M Azaki, S Morikawa Protective effects of the Francisella tularensis δpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques Sci Rep, 2019-06-24;9(1):9193. 2019-06-24 [PMID: 31235714] (IHC-P, Rhesus Macaca (Macaque)) |
IHC-P |
Rhesus Macaca (Macaque) |
E Schrom, M Huber, M Aneja, C Dohmen, D Emrich, J Geiger, G Hasenpusch, A Herrmann-J, V Kretzschma, O Mykhailyk, T Pasewald, P Oak, A Hilgendorf, D Wohlleber, HG Hoymann, D Schaudien, C Plank, C Rudolph, R Kubisch-Do Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA Mol Ther Nucleic Acids, 2017-04-13;7(0):350-365. 2017-04-13 [PMID: 28624211] (Flow Cytometry, Western Blot, Human) |
Flow Cytometry, Western Blot |
Human |
Fengxia Xiao, Joseph Zimpelman, Dylan Burger, Christopher Kennedy, Richard L Hébert, Kevin D Burns Protein Kinase C-? Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells. Frontiers in Pharmacology, 2016-06-01;0(0):1663-9812. 2016-06-01 [PMID: 27313531] (Western Blot, Mouse) |
Western Blot |
Mouse |
Aleksandra Milewska HTCC: Broad Range Inhibitor of Coronavirus Entry PLoS ONE, 2016-06-01;11(6):e0156552. 2016-06-01 [PMID: 27249425] (IHC, Primate - Macaca mulatta (Rhesus Macaque)) |
IHC |
Primate - Macaca mulatta (Rhesus Macaque) |
Yu Y, Chien S, Chen I, Lai C, Tsay Y, Chang S, Chang M Surface vimentin is critical for the cell entry of SARS-CoV. J Biomed Sci, 2016-01-22;23(1):14. 2016-01-22 [PMID: 26801988] (Neutralization, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
Neutralization |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
Xiao F, Zimpelmann J, Agaybi S, Gurley S, Puente L, Burns K Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells. PLoS ONE, 2014-01-15;9(1):e85958. 2014-01-15 [PMID: 24454948] (Western Blot, Mouse) |
Western Blot |
Mouse |
Eckerle I, Muller M, Kallies S, Gotthardt D, Drosten C In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J, 2013-12-23;10(0):359. 2013-12-23 [PMID: 24364985] (IHC, Human) |
IHC |
Human |
Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pohlmann S TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J Virol, 2013-11-13;88(2):1293-307. 2013-11-13 [PMID: 24227843] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
Ge , Xing-Yi, Li , Jia-Lu, Yang , Xing-Lou, Chmura , Aleksei, Zhu , Guangjia, Epstein , Jonathan, Mazet , Jonna K, Hu , Ben, Zhang , Wei, Peng , Cheng, Zhang , Yu-Ji, Luo , Chu-Ming, Tan , Bing, Wang , Ning, Zhu , Yan, Crameri , Gary, Zhang , Shu-Yi, Wang , Lin-Fa, Daszak , Peter, Shi , Zheng-Li Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 2013-10-30;503(7477):535-8. 2013-10-30 [PMID: 24172901] (IHC, Bat, Civet, Human) |
IHC |
Bat, Civet, Human |
Bertram S, Heurich A, Lavender H, Gierer S, Danisch S, Perin P, Lucas JM, Nelson PS, Pohlmann S, Soilleux EJ Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS ONE, 2012-04-30;7(4):e35876. 2012-04-30 [PMID: 22558251] (IHC-P, Human) |
IHC-P |
Human |
Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron. J. Biol. Chem., 2010-10-21;285(53):41935-46. 2010-10-21 [PMID: 20966072] (IHC-Fr, Western Blot, Mouse) |
IHC-Fr, Western Blot |
Mouse |
Glende J, Schwegmann-Wessels C, Al-Falah M, Pfefferle S, Qu X, Deng H, Drosten C, Naim HY, Herrler G Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. Virology, 2008-09-23;381(2):215-21. 2008-09-23 [PMID: 18814896] (Western Blot, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
Western Blot |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
Epelman S, Tang WH, Chen SY, Van Lente F, Francis GS, Sen S Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J. Am. Coll. Cardiol., 2008-08-26;52(9):750-4. 2008-08-26 [PMID: 18718423] (Neutralization, Human) |
Neutralization |
Human |
Lu Y, Liu DX, Tam JP Lipid rafts are involved in SARS-CoV entry into Vero E6 cells. Biochem. Biophys. Res. Commun., 2008-02-13;369(2):344-9. 2008-02-13 [PMID: 18279660] (Flow Cytometry, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
Flow Cytometry |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
Ren W, Qu X, Li W, Han Z, Yu M, Zhou P, Zhang SY, Wang LF, Deng H, Shi Z Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J. Virol., 2007-12-12;82(4):1899-907. 2007-12-12 [PMID: 18077725] (ICC, Western Blot, Human) |
ICC, Western Blot |
Human |
Inoue Y, Tanaka N, Tanaka Y, Inoue S, Morita K, Zhuang M, Hattori T, Sugamura K Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. J. Virol., 2007-05-23;81(16):8722-9. 2007-05-23 [PMID: 17522231] (Western Blot, Primate - Macaca mulatta (Rhesus Macaque)) |
Western Blot |
Primate - Macaca mulatta (Rhesus Macaque) |
Rockx B, Sheahan T, Donaldson E, Harkema J, Sims A, Heise M, Pickles R, Cameron M, Kelvin D, Baric R Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. J. Virol., 2007-05-16;81(14):7410-23. 2007-05-16 [PMID: 17507479] (Neutralization, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
Neutralization |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
de Lang A, Osterhaus AD, Haagmans BL Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells. Virology, 2006-07-24;353(2):474-81. 2006-07-24 [PMID: 16860835] (ICC, Primate - Chlorocebus pygerythrus (Vervet Monkey)) |
ICC |
Primate - Chlorocebus pygerythrus (Vervet Monkey) |
Tseng CT, Tseng J, Perrone L, Worthy M, Popov V, Peters CJ Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells. J. Virol., 2005-08-01;79(15):9470-9. 2005-08-01 [PMID: 16014910] (ICC, Neutralization, Human) |
ICC, Neutralization |
Human |
Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey GH, Gramberg T, Pohlmann S Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem. Biophys. Res. Commun., 2004-07-09;319(4):1216-21. 2004-07-09 [PMID: 15194496] (Flow Cytometry, Human) |
Flow Cytometry |
Human |
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