ACE-2 Products

Antibodies
ACE-2 Antibody (SN0754)
ACE-2 Antibody (SN0754)
Species: Hu, Mu, Rt, Ha
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Antibody Pairs
ACE-2 Antibody Pair [HRP]
ACE-2 Antibody Pair [HRP]
NBP2-79626
Species: Rt
Applications: S-ELISA
Host: Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Human ACE-2 ELISA Kit (Colori ...
Human ACE-2 ELISA Kit (Colorimetric)
NBP2-78734
Species: Hu
Applications: ELISA
Human ACE-2 ELISA Kit (Chemil ...
Human ACE-2 ELISA Kit (Chemilumine...
NBP2-66387
Species: Hu
Applications: ELISA
Human ACE-2 DuoSet ELISA, 5 P ...
Human ACE-2 DuoSet ELISA, 5 Plate
DY933-05
Species: Hu
Applications: ELISA
Proteins
Recombinant Human ACE-2 Prote ...
Recombinant Human ACE-2 Protein, CF
933-ZN
Species: Hu
Applications: Bioactivity, Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Mouse ACE-2 Prote ...
Recombinant Mouse ACE-2 Protein, CF
3437-ZN
Species: Mu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Rat ACE-2 Protein ...
Recombinant Rat ACE-2 Protein, CF
4516-ZN
Species: Rt
Applications: Enzyme Activity
Formulation Catalog # Availability Price  

Description

Angiotensin I Converting Enzyme 2 (ACE2), also known as ACEH (ACE homologue), is an integral membrane protein and a zinc metalloprotease of the ACE family (theoretical molecular weight 92 kDa). The predicted mouse ACE2 protein sequence consists of 798 amino acids, including an N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. Mouse ACE2 is 40% homologous in amino acid identity to the N- and C-terminal domains of mouse somatic ACE. Enzymatically, ACE2 converts the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts Ang I to Ang II.

Genetic data from Drosophila, mice and rats show that the ACE2 protein is an essential regulator of heart function in vivo. ACE2 mRNA is found at high levels in testis, kidney and heart with moderate levels in colon, small intestine, and ovary. The ACE2 protein contributes to organ function through the renin-angiotensin system, playing a central role in vascular, renal, and myocardial physiology.

Virology research has demonstrated that the severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein binds to its functional receptor, ACE2 (1). Vimentin is a type III intermediate filament protein expressed in mesenchymal cells that helps comprise the cytoskeleton in all animal cells. Studies have demonstrated that vimentin allows cell binding that allows the uptake of SARS-CoV spike protein into a host (2). This direct interaction of SARS-CoV with vimentin has been identified as an entry mechanism for the virus into a host, mediated by the SARS-CoV receptor ACE2 (1,2). It has been shown that ACE2 is the SARS-CoV-2 receptor required for cell entry and plays a physiological role in the replication of SARS-CoV in an infected host (1). Studies using human ACE2 antibody demonstrated a blockade of SARS-CoV-2 and ACE2 interaction, indicating an important physiological component of viral transmission and potential anti-viral therapeutic strategies (3).

References

1. Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A.,... Farzan, M. (2003). Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 426(6965), 450-454. doi:10.1038/nature02145

2. Yu YT, Chien SC, Chen IY, Lai CT, Tsay YG, Chang SC, Chang MF. (2016) Surface vimentin is critical for the cell entry of SARS-CoV. J Biomed Sci. doi: 10.1186/s12929-016-0234-7

3. Hoffmann, M., Kleine-Weber, H., Schroeder, S., Kruger, N., Herrler, T., Erichsen, S.,... Pohlmann, S. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. doi:10.1016/j.cell.2020.02.052

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 59272
Alternate Names
  • EC 3.4.17
  • ACE-related carboxypeptidase
  • EC 3.4.17.23
  • Metalloprotease MPROT15
  • angiotensin-converting enzyme 2
  • Angiotensin-converting enzyme homolog
  • ACEHangiotensin I converting enzyme 2
  • DKFZp434A014
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Research Areas for ACE-2

Find related products by research area and learn more about each of the different research areas below.

Immunology
Virology, Bacteria and Parasites

Bioinformatics Tool for ACE-2

Discover related pathways, diseases and genes to ACE-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ACE-2 Blog Posts

Check out the latest blog posts on ACE-2.
Blocking SARS-CoV-2 Cell Entry: A potential Strategy Against COVID-19 Pandemic
By Jamshed Arslan, Pharm. D., PhD. Coronaviruses are a family of enveloped RNA viruses. Some family members circulate in human populations, but others like severe acute respiratory syndrome coronavirus (SARS-CoV) ar...    Read more.
Read more ACE-2 related blogs.