ACE-2 Products

Description

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Bioinformatics

Entrez	59272 Human
Uniprot	Q9BYF1 Human NP_068576 Human
Product By Gene ID	59272
Alternate Names	EC 3.4.17 ACE-related carboxypeptidase EC 3.4.17.23 Metalloprotease MPROT15 angiotensin-converting enzyme 2 Angiotensin-converting enzyme homolog ACEHangiotensin I converting enzyme 2 DKFZp434A014 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Diseases related to ACE-2

Discover more about diseases related to ACE-2.

Hypertensive Disease
Severe Acute Respiratory Syndrome
Kidney Diseases
Cardiovascular Diseases
Hypertrophy
Fibrosis
Diabetes Mellitus
Heart Failure
Diabetic Nephropathy
Inflammation
Injury To Kidney
Myocardial Infarction
Cardiac Hypertrophy
Infarction
Diabetes Mellitus, Experimental
Atherosclerosis
Pathologic Vasoconstriction
Infective Disorder
Proteinuria Of Undiagnosed Cause

Pathways for ACE-2

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Pathogenesis
Localization
Cell Cycle
Vasoconstriction
Mitosis
Cell Proliferation
Transport
Regulation Of Blood Pressure
Excretion
Membrane Fusion
Cell Division
Cytokinesis
Virulence
Cell Growth
Immune Response
Secretion
Mating
Glycosylation
Angiogenesis
Tropism

Research Areas for ACE-2

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Immunology
Virology, Bacteria and Parasites

PTMs for ACE-2

Learn more about PTMs related to ACE-2.

Cleavage
Phosphorylation
Glycosylation
Deglycosylation
Biotinylation
Oxidation
Carboxylation
Nitration
Reduction

Bioinformatics Tool for ACE-2

Discover related pathways, diseases and genes to ACE-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.