AGTR-1 Antibody

Images

 
Western Blot: AGTR-1 Antibody [NBP1-77078] - Effects of Ang(1-7) and/or A-779 treatments to the sham and OVX animals for 6 weeks on the expressions of RAS different proteins and osteoclastogenesis modulating factors in ...read more
Immunocytochemistry/ Immunofluorescence: AGTR-1 Antibody [NBP1-77078] - Mouse Kidney cells at 20 ug/ml.
Immunohistochemistry-Paraffin: AGTR-1 Antibody [NBP1-77078] - Mouse kidney tissue at 2.5 ug/mL.
Western Blot: AGTR-1 Antibody [NBP1-77078] - Mouse kidney tissue lysate with Angiotensin II Type 1 Receptor antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: AGTR-1 Antibody [NBP1-77078] - Staining of mouse kidney tissue with antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Gp, Rb, ShSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

AGTR-1 Antibody Summary

Immunogen
Antibody was raised against a 16 amino acid synthetic peptide from near the center of human AGTR1. The immunogen is located within amino acids 210 - 260 of AGTR1. Amino Acid Squence: KKAYEIQKNKPRNDDI
Predicted Species
Porcine (100%), Bovine (94%), Guinea Pig (100%), Rabbit (100%), Sheep (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AGTR1
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA
  • Immunocytochemistry/Immunofluorescence 20 ug/mL
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
Theoretical MW
41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
AGTR-1 Protein (NBP1-77078PEP)
Publications
Read Publications using
NBP1-77078 in the following applications:

  • 1 publication
  • WB
    1 publication

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Chicken (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for AGTR-1 Antibody

  • AG2S
  • AGTR1
  • AGTR-1
  • AGTR1AAngiotensin II type-1 receptor
  • Angiostensin Receptor
  • angiotensin II receptor, type 1
  • angiotensin receptor 1
  • angiotensin receptor 1B
  • AT1
  • AT1AR
  • AT1AT1AR
  • AT1B
  • AT1BR
  • AT1R
  • AT2R1
  • AT2R1A
  • AT2R1AGTR1B
  • AT2R1BAT1BR
  • HAT1R
  • type-1 angiotensin II receptor
  • type-1B angiotensin II receptor

Background

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. AGTR1, the type 1 receptor, is thought to mediate the major cardiovascular effects of angiotensin II and may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. AGTR1 has recently been found to regulate the differentiation of bone marrow-derived monocyte lineage progenitors from hematopoietic stem cells, indicating the diversity of the roles of AGTR1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for AGTR-1 Antibody (NBP1-77078)(8)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC-P, WB.


Filter By Application
IHC-P
(1)
WB
(1)
All Applications
Filter By Species
Mouse
(2)
All Species
Showing Publications 1 - 8 of 8.
Publications using NBP1-77078 Applications Species
Saez T, Spaans F, Kirschenman R et al. High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation Clin. Sci. Sep 18 2020 [PMID: 32856035]
Jang IA, Kim EN, Lim JH et al. Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney. Biochem. Pharmacol. Nov 16 2018 [PMID: 30424556]
Zhang XB, Cai JH, Yang YY et al. Telmisartan attenuates kidney apoptosis and autophagy-related protein expression levels in an intermittent hypoxia mouse model. Sleep Breath Sep 15 2018 [PMID: 30219962] (WB, Mouse) WB Mouse
Abuohashish HM, Ahmed MM, Sabry D et al. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats. Biomed. Pharmacother. May 19 2017 [PMID: 28531801]
Baker DJ, Childs BG, Durik M et al. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan Nature Feb 11 2016 [PMID: 26840489] (IHC-P, Mouse) IHC-P Mouse
Tsubakimoto Y, Yamada H, Yokoi H et al. Bone marrow angiotensin AT1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells. Arterioscler. Thromb. Vasc. Biol. 29:1529-36. 2009 [PMID: 19628784]
Mottl AK, Shoham DA, North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med. 10:560-574. 2008 [PMID: 18641512]
Miyazaki Y Ichikawa I. Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 128:89-97. 2001 [PMID: 11137441]

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for AGTR-1 Antibody (NBP1-77078) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-77078AF350
Alexa Fluor 405 NBP1-77078AF405
Alexa Fluor 488 NBP1-77078AF488
Alexa Fluor 532 NBP1-77078AF532
Alexa Fluor 594 NBP1-77078AF594
Alexa Fluor 647 NBP1-77078AF647
Alexa Fluor 700 NBP1-77078AF700
Alexa Fluor 750 NBP1-77078AF750
Biotin NBP1-77078B
DyLight 350 NBP1-77078UV
DyLight 405 NBP1-77078V
DyLight 488 NBP1-77078G
DyLight 550 NBP1-77078R
DyLight 594 NBP1-77078DL594
DyLight 650 NBP1-77078C
DyLight 680 NBP1-77078FR
DyLight 755 NBP1-77078IR
FITC NBP1-77078F
HRP NBP1-77078H
Janelia Fluor 549 NBP1-77078JF549
Janelia Fluor 646 NBP1-77078JF646

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Bioinformatics

Gene Symbol AGTR1
Entrez
Uniprot