Innate Immunity

Toll-like receptor 2 activation contributes to oral squamous cell carcinoma development and miRNA-mediated drug resistance

How to identify B cell subsets using flow cytometry

Lipopolysaccharide from gut microbiome localizes in human atherosclerotic plaques and promotes TLR4-mediated oxidative stress

Toll-like receptors in the intestinal epithelial cells

NOX2 oxidase is a potential target for broad-spectrum antiviral therapies

The inflammasome: an inflammation-initiating machine, Novus Biologicals

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers

MAPK Signaling Links Autophagy and Inflammation

TRIF/TICAM1 and mitochondrial dynamics in the innate immune response

TRIF, also known as toll like receptor adaptor molecule 1 or TICAM1, is known for its role in invading foreign pathogens as part of our innate immune response. TRIF/TICAM1 is a TIR-domain adaptor protein (toll/interleukin-1 receptor) that interacts with the Toll-like receptors (TLRs) through intracellular signaling and recognition of its TIR site.

The role of TLR4 in breast cancer

Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cytokine production depending on the behavior patterns of the pathogen itself.  Specifically, TLR4 acts through bacterial lipopolysaccharide (LPS), which composes the outer wall of Gram-negative bacteria.  Bacterial LPS is also a potent activator of the immune system.

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