Phosphospecific Survivin Antibody [Ser20] now available from Novus Biologicals

Survivin is a structurally unique inhibitor of apoptosis (IAP) that has been linked to protection from apoptosis, control of cell division, and cellular adaptation to stress. In order for survivin to provide this cytoprotection an interaction with at least one other IAP, such as XIAP, is necessary. It has recently been shown that Survivin is phosphorylated at Ser20 by protein kinase A (PKA) in the cytosol but not in the mitochondria. This phosphorylation on Ser20 disrupts the binding of cytosolic survivin to XIAP and therefore diminishes survivin's cytoprotective properties.

Release Date: 
Wednesday, October 8, 2008 - 06:00