Western Blot: XPF Antibody [NB100-60679] - Detection of Human XPF/ERCC4 on HeLa whole cell lysate using NB100-60679.
Immunohistochemistry: XPF Antibody [NB100-60679] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- XPF/ERCC4 used at a dilution of 1:200 (1ug/ml). Detection: DAB
Immunohistochemistry-Paraffin: XPF Antibody [NB100-60679] - FFPE section of human prostate carcinoma. Affinity purified rabbit anti-XPF/ERCC4 used at a dilution of 1:500. Detection: DAB staining using ...read more
The immunogen recognized by this antibody maps to a region between residue 855 and 905 of human xeroderma pigmentosum, complementation group F using the numbering given in entry AAB07689.1 (GeneID 2072).
Immunogen affinity purified
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The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. ELISA reactivity reported in scientific literature (PMID:20812782). Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
104 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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