The immunogen recognized by this antibody maps to a region between residue 732 and 782 of human excision repair cross-complementing rodent repair deficiency, complementation group 3 using the numbering given in entry NP_000113.1 (GeneID 2071).
Rat (100%), Porcine (100%), Xenopus (100%), Rabbit (100%), Primate (100%), Bovine (100%), Equine (100%), Guinea Pig (100%), Fish (100%), Canine (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Based on 100% sequence identity, this antibody is predicted to react with X. laevis, X. tropicalis, Panda, Orangutan, Rhesus Monkey, Gorilla, West Indian ocean coelacanth, Tasmanian devil, White-tufted-ear marmoset and Northern white-cheeked gibbon.
Alternate Names for XPB Antibody
Basic transcription factor 2 89 kDa subunit
DNA excision repair protein ERCC-3
DNA repair protein complementing XP-B cells
excision repair cross-complementing rodent repair deficiency, complementationgroup 3 (xeroderma pigmentosum group B complementing)
Xeroderma pigmentosum group B-complementing protein
xeroderma pigmentosum, complementation group B
XPBTFIIH 89 kDa subunit
ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3'-5' DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.