VEGFR1/Flt-1 Antibody [HRP] Summary
A synthetic peptide made to an internal region of the mouse VEGF Receptor 1 protein (between residues 800-900) [UniProt# P35969]. There is 87% identity between the immunogen used for this production and the VEGF Receptor 2 protein.
Type 1 membrane protein (isoform Flt1)
Endothelial Cell Marker
This antibody targets VEGFR-1 but has significant cross-reactivity with the VEGFR-2 protein.
Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
Immunogen affinity purified
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Packaging, Storage & Formulations
Store at 4C in the dark.
Immunogen affinity purified
- Western Blot 1:100-1:2000
This VEGF Receptor 1 antibody is useful for Western blot, where a band is seen at ~180-230 kDa (the theoretical molecular weight of mouse VEGFR1 is ~150 kDa and human VEGFR1 is ~151 kDa). The difference in MWs is likely due to glycosylation or other post translational modifications. With CSF-1R/VEGFR2 chimera transfected lysates a doublet is seen at ~150 kDa representing VEGFR-2. An unknown band is also seen at ~50 kDa. Optimal working dilutions should be determined by the investigator.
Immunogen sequence has 100% homology to mouse and rat.
Alternate Names for VEGFR1/Flt-1 Antibody [HRP]
- EC 2.7.10
- EC 126.96.36.199
- Fms-like tyrosine kinase 1
- fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor)
- Tyrosine-protein kinase FRT
- Tyrosine-protein kinase receptor FLT
- vascular endothelial growth factor receptor 1
- Vascular permeability factor receptor
Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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