VEGFR1/Flt-1 Products

Description

Receptors for VEGF, VEGFB and PGF have tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors--the tyrosine kinases FLK1 and FLT1--are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.

Bioinformatics

Entrez	14254 Mouse 2321 Human 54251 Rat
Uniprot	AAH39007 Human AAH39007.1 Human NM_002019 Human P17948 Human P35969 Mouse
Product By Gene ID	2321
Alternate Names	EC 2.7.10 EC 2.7.10.1 FLT FLT-1 Fms-like tyrosine kinase 1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor) FRT Tyrosine-protein kinase FRT Tyrosine-protein kinase receptor FLT vascular endothelial growth factor receptor 1 Vascular permeability factor receptor VEGFR1 VEGFR-1

Research Areas for VEGFR1/Flt-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Endothelial Cell Markers
HIF Target Genes
Hypoxia
Phospho-Specific
Signal Transduction
Stem Cell Markers
Tumor Suppressors
Tyrosine Kinases