Human PlGF Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price

Human PlGF Quantikine ELISA Kit Summary

Background
The Quantikine Human PlGF Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure human PlGF in cell culture supernates, serum, plasma, and urine. The immunoassay kit contains E. coli-expressed recombinant human PlGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human PlGF accurately. Results obtained u...sing natural human PlGF showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human PlGF.
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Specificity
Natural and recombinant human PlGF
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
PGF

Applications/Dilutions

Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using
DPG00 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human PlGF Quantikine ELISA Kit

  • D12S1900
  • PGF
  • PGFL
  • placenta growth factor
  • placental growth factor
  • placental growth factor, vascular endothelial growth factor-related protein
  • PlGF
  • PlGF-2
  • PLGFplacental growth factor-like
  • SHGC-10760

Background

PlGF (placenta growth factor) is a homodimeric growth factor that competes with VEGF for binding to VEGF R1/Flt-1. It therefore increases the availability of VEGF to bind to VEGF R2/KDR/Flk-1 and trigger angiogenesis. It can form heterodimers with some forms of VEGF and decrease the angiogenic effect of VEGF on VEGF R2. Circulating PlGF levels increase during pregnancy, reaching a peak in mid-gestation; this increase is attenuated in preeclampsia. PlGF induces monocyte activation and migration as well as production of inflammatory cytokines and VEGF. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. PlGF can also inhibit TIMP3 expression in the spleen, leading to immune triggering of hypertension.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for PLGF (DPG00)(62)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: ELISA Capture.


Filter By Application
ELISA Capture
(1)
All Applications
Filter By Species
Human
(60)
Mouse
(1)
All Species
Showing Publications 1 - 10 of 62. Show All 62 Publications.
Publications using DPG00 Applications Species
DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy PLoS ONE, 2020;15(4):e0232287. 2020 [PMID: 32339208] (Human) Human
W Jiao, JF Ji, W Xu, W Bu, Y Zheng, A Ma, B Zhao, Q Fan Distinct downstream signaling and the roles of VEGF and PlGF in high glucose-mediated injuries of human retinal endothelial cells in culture Sci Rep, 2019;9(1):15339. 2019 [PMID: 31653890] (Human) Human
HW Unger, AP Hansa, C Buffet, W Hasang, A Teo, L Randall, M Ome-Kaius, S Karl, AA Anuan, JG Beeson, I Mueller, SJ Stock, SJ Rogerson Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection Sci Rep, 2019;9(1):2260. 2019 [PMID: 30783215] (Human) Human
Y Nakada, R Kawakami, M Matsui, T Ueda, T Nakano, H Nakagawa, T Nishida, K Onoue, T Soeda, S Okayama, M Watanabe, H Okura, Y Saito Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure Circ. J., 2018;0(0):. 2018 [PMID: 30587700] (Human) Human
T Tsai, S Kuehn, N Tsiampalis, MK Vu, V Kakkassery, G Stute, HB Dick, SC Joachim Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients PLoS ONE, 2018;13(3):e0194603. 2018 [PMID: 29584759] (Human) Human
M Perrotta, A Lori, L Carnevale, S Fardella, G Cifelli, R Iacobucci, F Mastroiaco, D Iodice, F Pallante, M Storto, G Lembo, D Carnevale Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation Cardiovasc. Res., 2018;114(3):456-467. 2018 [PMID: 29324984] (ELISA Capture, Mouse) ELISA Capture Mouse
KYB Lamm, ML Johnson, J Baker Phil, MB Muntiferin, JM James, HN Jones, RW Redline, A Rokas, LJ Muglia Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome Elife, 2018;7(0):. 2018 [PMID: 29309034] (Human) Human
M O'Brien, D Baczyk, JC Kingdom Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles Sci Rep, 2017;7(1):5887. 2017 [PMID: 28725005] (Human) Human
A Dutta, K Brito, G Khramstova, A Mueller, S Chinthala, D Alexander, D Adu, T Ibigbami, J Olamijulo, A Odetunde, K Adigun, L Pruitt, O Olopade, O Ojengbede, S Rana, CO Olopade Household air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention Sci. Total Environ., 2017;599(0):2175-2181. 2017 [PMID: 28575932] (Human) Human
X Li, QY Yao, HC Liu, QW Jin, BL Xu, SC Zhang, CT Tu Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease J. Cell. Mol. Med., 2017;0(0):. 2017 [PMID: 28378526] (Human) Human
Show All 62 Publications.

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Product General Protocols

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FAQs for PLGF (DPG00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.
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Bioinformatics

Gene Symbol PGF