Human PlGF Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

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Catalog# & Conjugate Size Price

Human PlGF Quantikine ELISA Kit Summary

Background
The Quantikine Human PlGF Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure human PlGF in cell culture supernates, serum, plasma, and urine. The immunoassay kit contains E. coli-expressed recombinant human PlGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human PlGF accurately. Results obtained u...sing natural human PlGF showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human PlGF.
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Specificity
Natural and recombinant human PlGF
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
PGF

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using
DPG00 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human PlGF Quantikine ELISA Kit

  • D12S1900
  • PGF
  • PGFL
  • placenta growth factor
  • placental growth factor
  • placental growth factor, vascular endothelial growth factor-related protein
  • PlGF
  • PlGF-2
  • PLGFplacental growth factor-like
  • SHGC-10760

Background

PlGF (placenta growth factor) is a homodimeric growth factor that competes with VEGF for binding to VEGF R1/Flt-1. It therefore increases the availability of VEGF to bind to VEGF R2/KDR/Flk-1 and trigger angiogenesis. It can form heterodimers with some forms of VEGF and decrease the angiogenic effect of VEGF on VEGF R2. Circulating PlGF levels increase during pregnancy, reaching a peak in mid-gestation; this increase is attenuated in preeclampsia. PlGF induces monocyte activation and migration as well as production of inflammatory cytokines and VEGF. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. PlGF can also inhibit TIMP3 expression in the spleen, leading to immune triggering of hypertension.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for PLGF (DPG00)(68)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: ELISA Capture.


Filter By Application
ELISA Capture
(1)
All Applications
Filter By Species
Human
(65)
Mouse
(2)
All Species
Showing Publications 1 - 10 of 68. Show All 68 Publications.
Publications using DPG00 Applications Species
EO Anto, DA Coall, EA Asiamah, OO Afriyie, O Addai-Mens, YA Wiafe, W Owiredu, C Obirikoran, ME Annani-Ako, NA Titiloye, E Adua, E Acheampong, EA Adu, S Opoku, AO Anto, A Tawiah, Y Wang, W Wang Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia PLoS ONE, 2022;17(3):e0265717. 2022 [PMID: 35312727] (Human) Human
H Wada, T Shinozaki, M Suzuki, S Sakagami, Y Ajiro, J Funada, M Matsuda, M Shimizu, T Takenaka, Y Morita, K Yonezawa, H Matsubara, Y Ono, T Nakamura, K Fujimoto, A Ninomiya, T Kato, T Unoki, D Takagi, K Wada, M Wada, M Iguchi, H Yamakage, T Kusakabe, A Yasoda, A Shimatsu, K Kotani, N Satoh-Asah, M Abe, M Akao, K Hasegawa, EXCEED?J S Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED-J Study Journal of the American Heart Association, 2022;11(3):e023464. 2022 [PMID: 35048713] (Human) Human
K Yagi, K Mimura, T Tomimatsu, T Matsuyama, Y Kawanishi, A Kakigano, H Nakamura, M Endo, T Kimura Potency of Tokishakuyakusan in treating preeclampsia: Drug repositioning method by in vitro screening of the Kampo library PLoS ONE, 2020;15(12):e0244684. 2020 [PMID: 33378412] (Human) Human
JG Parchem, K Kanasaki, SB Lee, M Kanasaki, JL Yang, Y Xu, KM Earl, RA Keuls, VH Gattone, R Kalluri STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects JCI Insight, 2020;0(0):. 2020 [PMID: 33301424] (Mouse) Mouse
S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia Cells, 2020;9(9):. 2020 [PMID: 32878300] (Human) Human
DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy PLoS ONE, 2020;15(4):e0232287. 2020 [PMID: 32339208] (Human) Human
P Nikuei, M Rajaei, N Roozbeh, F Mohseni, F Poordarvis, M Azad, S Haidari Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia BMC Pregnancy Childbirth, 2020;20(1):80. 2020 [PMID: 32033594] (Human) Human
W Jiao, JF Ji, W Xu, W Bu, Y Zheng, A Ma, B Zhao, Q Fan Distinct downstream signaling and the roles of VEGF and PlGF in high glucose-mediated injuries of human retinal endothelial cells in culture Sci Rep, 2019;9(1):15339. 2019 [PMID: 31653890] (Human) Human
HW Unger, AP Hansa, C Buffet, W Hasang, A Teo, L Randall, M Ome-Kaius, S Karl, AA Anuan, JG Beeson, I Mueller, SJ Stock, SJ Rogerson Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection Sci Rep, 2019;9(1):2260. 2019 [PMID: 30783215] (Human) Human
Y Nakada, R Kawakami, M Matsui, T Ueda, T Nakano, H Nakagawa, T Nishida, K Onoue, T Soeda, S Okayama, M Watanabe, H Okura, Y Saito Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure Circ. J., 2018;0(0):. 2018 [PMID: 30587700] (Human) Human
Show All 68 Publications.

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Bioinformatics

Gene Symbol PGF