Human PlGF Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human PlGF Quantikine ELISA Kit Summary

• Background: The Quantikine Human PlGF Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure human PlGF in cell culture supernates, serum, plasma, and urine. The immunoassay kit contains E. coli-expressed recombinant human PlGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human PlGF accurately. Results obtained u...sing natural human PlGF showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human PlGF.
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• Specificity: Natural and recombinant human PlGF
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: PGF

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human PlGF Quantikine ELISA Kit

• D12S1900
• PGF
• PGFL
• placenta growth factor
• placental growth factor
• placental growth factor, vascular endothelial growth factor-related protein
• PlGF
• PlGF-2
• PLGFplacental growth factor-like
• SHGC-10760

Background

PlGF (placenta growth factor) is a homodimeric growth factor that competes with VEGF for binding to VEGF R1/Flt-1. It therefore increases the availability of VEGF to bind to VEGF R2/KDR/Flk-1 and trigger angiogenesis. It can form heterodimers with some forms of VEGF and decrease the angiogenic effect of VEGF on VEGF R2. Circulating PlGF levels increase during pregnancy, reaching a peak in mid-gestation; this increase is attenuated in preeclampsia. PlGF induces monocyte activation and migration as well as production of inflammatory cytokines and VEGF. These activities facilitate wound, bone fracture, and cardiac repair, but also contribute to inflammation in active sickle cell disease and atherosclerosis. PlGF can also inhibit TIMP3 expression in the spleen, leading to immune triggering of hypertension.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for PLGF (DPG00)(81)

Publications using DPG00

• Granitzer, S;Widhalm, R;Ellinger, I;Zeisler, H;Forsthuber, M;Foessleitner, P;Geschrey, E;Saleh, L;Knöfler, M;Desoye, G;Ettel, P;Weichhart, T;Musiejovsky, L;Schabbauer, G;Salzer, H;Rosner, M;Hengstschläger, M;Gundacker, C; LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia Nature communications 2025-10-14 [PMID: 41087351] (Human)
• Yang, Z;Jia, X;Deng, Q;Luo, M;Hou, Y;Yue, J;Mei, J;Shan, N;Wu, Z; Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/?-catenin signaling to alleviate preeclampsia International immunopharmacology 2023-02-01 [PMID: 37724958] (Human)
• Schönborn, M;Gregorczyk-Maga, I;Batko, K;Maga, M;Bogucka, K;Gawlik, K;Pawlica-Gosiewska, D;Maga, P; Angiogenic and Microvascular Status Alterations after Endovascular Revascularization of Lower Limb Arteries among Patients with Diabetic Foot Syndrome: A Prospective 12-Month Follow-Up Study Journal of clinical medicine 2023-08-27 [PMID: 37685648] (Human)
• Komaki, R;Miyagaki, T;Tanaka, M;Nakajima, K;Okano, T;Takeuchi, S;Kadono, T; Increased Interleukin-36 beta Expression Promotes Angiogenesis in Japanese Atopic Dermatitis International journal of molecular sciences 2023-07-05 [PMID: 37446281] ( Human)
• Schönborn, M;Gregorczyk-Maga, I;Batko, K;Bogucka, K;Maga, M;P?otek, A;Pasieka, P;S?owi?ska-Solnica, K;Maga, P; Circulating Angiogenic Factors and Ischemic Diabetic Foot Syndrome Advancement-A Pilot Study Biomedicines 2023-05-27 [PMID: 37371653] (Human)
• X Huang, L Jia, Y Jia, X Xu, R Wang, M Wei, H Li, H Peng, Y Wei, Q He, K Wang sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice Cytokine, 2023-04-14;166(0):156190. 2023-04-14 [PMID: 37062152] (Human, Mouse)
• LO Kurlak, PJ Scaife, LV Briggs, F Broughton, DS Gardner, HD Mistry Alterations in Antioxidant Micronutrient Concentrations in Placental Tissue, Maternal Blood and Urine and the Fetal Circulation in Pre-eclampsia International Journal of Molecular Sciences, 2023-02-10;24(4):. 2023-02-10 [PMID: 36834991] (Human)
• W Dymara-Kon, M Laskowska, E Grywalska, A Hymos, A B?a?ewicz, B Leszczy?sk Similar Pro- and Antiangiogenic Profiles Close to Delivery in Different Clinical Presentations of Two Pregnancy Syndromes: Preeclampsia and Fetal Growth Restriction International Journal of Molecular Sciences, 2023-01-04;24(2):. 2023-01-04 [PMID: 36674486] (Human)
• T Tsai, M Alwees, MA Asaad, J Theile, V Kakkassery, HB Dick, T Schultz, SC Joachim Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy PLoS ONE, 2023-01-20;18(1):e0280488. 2023-01-20 [PMID: 36662891] (Human)
• D Darmochwal, A Chara The Association of IL-17 and PlGF/sENG Ratio in Pre-Eclampsia and Adverse Pregnancy Outcomes International Journal of Environmental Research and Public Health, 2022-12-31;20(1):. 2022-12-31 [PMID: 36613090] (Human)
• I Klaassen, P Avery, RO Schlingema, DHW Steel Vitreous protein networks around ANG2 and VEGF in proliferative diabetic retinopathy and the differential effects of aflibercept versus bevacizumab pre-treatment Scientific Reports, 2022-12-06;12(1):21062. 2022-12-06 [PMID: 36473885] (Human)
• S Kuriyama, T Yamada, A Matsuda, G Takahashi, T Iwai, K Takeda, K Ueda, T Miyasaka, Y Yokoyama, S Shinji, H Sonoda, R Ohta, K Yonaga, S Kanaka, H Yoshida Biomarkers for anti-vascular endothelial growth factor drugs Oncology Letters, 2022-11-07;24(6):463. 2022-11-07 [PMID: 36406183] (Human)
• EO Anto, DA Coall, EA Asiamah, OO Afriyie, O Addai-Mens, YA Wiafe, W Owiredu, C Obirikoran, ME Annani-Ako, NA Titiloye, E Adua, E Acheampong, EA Adu, S Opoku, AO Anto, A Tawiah, Y Wang, W Wang Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia PLoS ONE, 2022-03-21;17(3):e0265717. 2022-03-21 [PMID: 35312727] (Human)
• H Wada, T Shinozaki, M Suzuki, S Sakagami, Y Ajiro, J Funada, M Matsuda, M Shimizu, T Takenaka, Y Morita, K Yonezawa, H Matsubara, Y Ono, T Nakamura, K Fujimoto, A Ninomiya, T Kato, T Unoki, D Takagi, K Wada, M Wada, M Iguchi, H Yamakage, T Kusakabe, A Yasoda, A Shimatsu, K Kotani, N Satoh-Asah, M Abe, M Akao, K Hasegawa, EXCEED?J S Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED-J Study Journal of the American Heart Association, 2022-01-20;11(3):e023464. 2022-01-20 [PMID: 35048713] (Human)
• K Yagi, K Mimura, T Tomimatsu, T Matsuyama, Y Kawanishi, A Kakigano, H Nakamura, M Endo, T Kimura Potency of Tokishakuyakusan in treating preeclampsia: Drug repositioning method by in vitro screening of the Kampo library PLoS ONE, 2020-12-30;15(12):e0244684. 2020-12-30 [PMID: 33378412] (Human)
• JG Parchem, K Kanasaki, SB Lee, M Kanasaki, JL Yang, Y Xu, KM Earl, RA Keuls, VH Gattone, R Kalluri STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects JCI Insight, 2021-01-25;0(0):. 2021-01-25 [PMID: 33301424] (Mouse)
• S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia Cells, 2020-08-31;9(9):. 2020-08-31 [PMID: 32878300] (Human)
• DL Wilson, ME Howard, AM Fung, FJ O'Donoghue, M Barnes, M Lappas, SP Walker Sleep-disordered breathing does not impact maternal outcomes in women with hypertensive disorders of pregnancy PLoS ONE, 2020-04-27;15(4):e0232287. 2020-04-27 [PMID: 32339208] (Human)
• P Nikuei, M Rajaei, N Roozbeh, F Mohseni, F Poordarvis, M Azad, S Haidari Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia BMC Pregnancy Childbirth, 2020-02-07;20(1):80. 2020-02-07 [PMID: 32033594] (Human)
• W Jiao, JF Ji, W Xu, W Bu, Y Zheng, A Ma, B Zhao, Q Fan Distinct downstream signaling and the roles of VEGF and PlGF in high glucose-mediated injuries of human retinal endothelial cells in culture Sci Rep, 2019-10-25;9(1):15339. 2019-10-25 [PMID: 31653890] (Human)
• HW Unger, AP Hansa, C Buffet, W Hasang, A Teo, L Randall, M Ome-Kaius, S Karl, AA Anuan, JG Beeson, I Mueller, SJ Stock, SJ Rogerson Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection Sci Rep, 2019-02-19;9(1):2260. 2019-02-19 [PMID: 30783215] (Human)
• Y Nakada, R Kawakami, M Matsui, T Ueda, T Nakano, H Nakagawa, T Nishida, K Onoue, T Soeda, S Okayama, M Watanabe, H Okura, Y Saito Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure Circ. J., 2018-12-26;0(0):. 2018-12-26 [PMID: 30587700] (Human)
• T Tsai, S Kuehn, N Tsiampalis, MK Vu, V Kakkassery, G Stute, HB Dick, SC Joachim Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients PLoS ONE, 2018-03-27;13(3):e0194603. 2018-03-27 [PMID: 29584759] (Human)
• M Perrotta, A Lori, L Carnevale, S Fardella, G Cifelli, R Iacobucci, F Mastroiaco, D Iodice, F Pallante, M Storto, G Lembo, D Carnevale Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation Cardiovasc. Res., 2018-03-01;114(3):456-467. 2018-03-01 [PMID: 29324984] (ELISA Capture, Mouse)
• KYB Lamm, ML Johnson, J Baker Phil, MB Muntiferin, JM James, HN Jones, RW Redline, A Rokas, LJ Muglia Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome Elife, 2018-01-08;7(0):. 2018-01-08 [PMID: 29309034] (Human)
• M O'Brien, D Baczyk, JC Kingdom Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles Sci Rep, 2017-07-19;7(1):5887. 2017-07-19 [PMID: 28725005] (Human)
• A Dutta, K Brito, G Khramstova, A Mueller, S Chinthala, D Alexander, D Adu, T Ibigbami, J Olamijulo, A Odetunde, K Adigun, L Pruitt, O Olopade, O Ojengbede, S Rana, CO Olopade Household air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention Sci. Total Environ., 2017-05-29;599(0):2175-2181. 2017-05-29 [PMID: 28575932] (Human)
• X Li, QY Yao, HC Liu, QW Jin, BL Xu, SC Zhang, CT Tu Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease J. Cell. Mol. Med., 2017-04-05;0(0):. 2017-04-05 [PMID: 28378526] (Human)
• S Senapati, MD Sammel, SF Butts, P Takacs, K Chung, KT Barnhart Predicting first trimester pregnancy outcome: derivation of a multiple marker test Fertil. Steril., 2016-10-26;106(7):1725-1732.e3. 2016-10-26 [PMID: 28340932] (Human)
• D Wu, T Lai, Y Yuan, M Chen, J Xia, W Li, G Pan, B Yuan, Q Lv, Y Li, D Li, B Wu Elevated expression of placental growth factor is associated with airway-wall vascular remodelling and thickening in smokers with asthma Sci Rep, 2017-02-21;7(0):43017. 2017-02-21 [PMID: 28220848] (Human)
• VS Jammalamad, P Abraham Spectrum of Factors Triggering Endothelial Dysfunction in PIH J Clin Diagn Res, 2016-12-01;10(12):BC14-BC17. 2016-12-01 [PMID: 28208844] (Human)
• Ingrid C Weel Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia PLoS ONE, 2016-06-17;11(6):e0157584. 2016-06-17 [PMID: 27315098] (Human)
• D Dauwe, B Pelacho, A Wibowo, AS Walravens, K Verdonck, H Gillijns, E Caluwe, P Pokreisz, N van Gastel, G Carmeliet, M Depypere, F Maes, N Vanden Dri, W Droogne, J Van Cleemp, J Vanhaecke, F Prosper, C Verfaillie, A Luttun, S Janssens Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved J Am Heart Assoc, 2016-04-18;5(4):. 2016-04-18 [PMID: 27091182] (Human)
• Bessho H, Wong B, Huang D, Siew E, Huang D, Tan J, Ong C, Tan S, Matsumoto K, Iwamura M, Teh B Inhibition of placental growth factor in renal cell carcinoma. Anticancer Res, 2015-01-01;35(1):531-41. 2015-01-01 [PMID: 25550599] (Human)
• Hou H, Cheng S, Chung K, Kuo M, Yeh C, Chang B, Lu H, Wang H, Yu C Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis. Autophagy, 2014-06-25;10(9):1509-21. 2014-06-25 [PMID: 24988221] (Human)
• Calcaterra F, Taddeo A, Colombo E, Cappelletti M, Martinelli A, Calabrese S, Mavilio D, Cetin I, Della Bella S Reduction of maternal circulating endothelial progenitor cells in human pregnancies with intrauterine growth restriction. Placenta, 2014-04-26;35(7):431-6. 2014-04-26 [PMID: 24819155] (Human)
• White W, Garrett A, Craici I, Wagner S, Fitz-Gibbon P, Butters K, Brost B, Rose C, Grande J, Garovic V Persistent urinary podocyte loss following preeclampsia may reflect subclinical renal injury. PLoS ONE, 2014-03-24;9(3):e92693. 2014-03-24 [PMID: 24664365] (Human)
• Liu , Linda Y, Yang , Ting, Ji , Jun, Wen , Qiaojun, Morgan , Alexande, Jin , Bo, Chen , Gongxing, Lyell , Deirdre, Stevenson , David K, Ling , Xuefeng, Butte , Atul J Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia. BMC Med, 2013-11-06;11(0):236. 2013-11-06 [PMID: 24195779] (Human)
• El-Tarhouny S, Almasry S, Elfayomy A, Baghdadi H, Habib F Placental growth factor and soluble Fms-like tyrosine kinase 1 in diabetic pregnancy: A possible relation to distal villous immaturity. Histol Histopathol, 2013-08-13;29(2):259-72. 2013-08-13 [PMID: 23939615] (Human)
• Huang Q, Wang S, Zhang M, Huang L, Tian J, Yu Y, Wang Z, Zhong M Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia. Placenta, 2013-07-27;34(10):949-52. 2013-07-27 [PMID: 23899470] (Human)
• Chaturvedi , Pallavi, Gilkes , Daniele, Wong , Carmen C, Luo , Weibo, Zhang , Huafeng, Wei , Hong, Takano , Naoharu, Schito , Luana, Levchenko , Andre, Semenza , Gregg L Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest, 2012-12-17;123(1):189-205. 2012-12-17 [PMID: 23318994] (Human)
• Cytokine and angiogenic factors associated with efficacy and toxicity of pazopanib in advanced soft-tissue sarcoma: an EORTC-STBSG study. Br. J. Cancer, 2012-07-17;107(4):639-45. 2012-07-17 [PMID: 22805326] (Human)
• Yamashita-Kashima Y, Fujimoto-Ouchi K, Yorozu K, Kurasawa M, Yanagisawa M, Yasuno H, Mori K Biomarkers for antitumor activity of bevacizumab in gastric cancer models. BMC Cancer, 2012-01-25;12(0):37. 2012-01-25 [PMID: 22273502] (Human)
• Rahbari NN, Schmidt T, Falk CS, Hinz U, Herber M, Bork U, Buchler MW, Weitz J, Koch M Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer. BMC Cancer, 2011-07-05;11(0):286. 2011-07-05 [PMID: 21729304] (Human)
• Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study. Clin. Cancer Res., 2011-06-20;17(15):5113-22. 2011-06-20 [PMID: 21690570] (Human)
• de Groot JF, Piao Y, Tran H, Gilbert M, Wu HK, Liu J, Bekele BN, Cloughesy T, Mehta M, Robins HI, Lassman A, Deangelis L, Camphausen K, Chen A, Yung W, Prados M, Wen PY, Heymach JV Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept. Clin. Cancer Res., 2011-06-01;17(14):4872-4881. 2011-06-01 [PMID: 21632852] (Human)
• Loupakis F, Cremolini C, Fioravanti A Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer. Br. J. Cancer, 2011-03-15;104(8):1262-9. 2011-03-15 [PMID: 21407216] (Human)
• Horne AW, Shaw JL Placental Growth Factor: A Promising Diagnostic Biomarker for Tubal Ectopic Pregnancy. J. Clin. Endocrinol. Metab., 2010-11-03;0(0):. 2010-11-03 [PMID: 21047920] (Human)
• Jeyabalan A, Powers RW, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, Lindheimer MD, Sibai B, Landon M, Miodovnik M, Caritis S, Roberts JM, Kuller J, Cotroneo M, Kamon T, Mercer B, Ramsey R, Paul R, Rabello Y, McCart D, Mueller E, Goldenberg R, Copper R, Sorokin Y, Norman G, Millinder A, Christmas JT, McCoy S, Elder S, Elder N, Carter B, Pemberton V, Thurnau G, Meier A, Minton V, Meis P, Swain M, Moawad AH, Jones P, Iams JD, Meadows S, Brenner S, Collins B, Newman RB, Carter SG, Romero R, Sabo V, Thom E, Bain RP, MacPherson C, Johnson D, Fischer ML, McNellis D, Spong C, Catz C, Yaffe S Effect of smoking on circulating angiogenic factors in high risk pregnancies. PLoS ONE, 2010-10-12;5(10):e13270. 2010-10-12 [PMID: 20967275] (Human)
• Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. Angiogenesis, 2010-10-16;13(4):337-47. 2010-10-16 [PMID: 20953695] (Human)
• Powers RW, Jeyabalan A, Clifton RG Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS ONE, 2010-10-11;5(10):e13263. 2010-10-11 [PMID: 20948996] (Human)
• Jaffe IZ, Newfell BG, Aronovitz M Placental growth factor mediates aldosterone-dependent vascular injury in mice. J. Clin. Invest., 2010-11-01;120(11):3891-900. 2010-11-01 [PMID: 20921624] (Human)
• Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis. Biol. Reprod., 2010-03-24;83(1):27-35. 2010-03-24 [PMID: 20335639] (Human)
• Brittain JE, Hulkower B, Jones SK, Strayhorn D, De Castro L, Telen MJ, Orringer EP, Hinderliter A, Ataga KI Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood, 2009-12-29;115(10):2014-20. 2009-12-29 [PMID: 20040765] (Human)
• Verlohren S, Galindo A, Schlembach D, Zeisler H, Herraiz I, Moertl MG, Pape J, Dudenhausen JW, Denk B, Stepan H An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia. Am. J. Obstet. Gynecol., 2009-10-21;202(2):161.e1-161.e1. 2009-10-21 [PMID: 19850276] (Human)
• Nibal Zaghloul, Sonia L. Hernandez, Jae-O Bae, Jianzhong Huang, Jason C Fisher, Alice Lee et al. Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma Int J Oncol 2011-03-24 [PMID: 19148474] (Mouse)
• Cassidy A, Chiuve SE, Manson JE, Rexrode KM, Girman CJ, Rimm EB Potential role for plasma placental growth factor in predicting coronary heart disease risk in women. Arterioscler. Thromb. Vasc. Biol., 2008-10-16;29(1):134-9. 2008-10-16 [PMID: 18927470] (Human)
• Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Hutson TE, Margolin K, Harmon CS, DePrimo SE, Kim ST, Chen I, George DJ Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J. Clin. Oncol., 2008-08-01;26(22):3743-8. 2008-08-01 [PMID: 18669461] (Human)
• Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease. J. Am. Coll. Cardiol., 2008-07-29;52(5):387-93. 2008-07-29 [PMID: 18652948] (Human)
• Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R, Yagel S, Mandelboim O Endometrial NK cells are special immature cells that await pregnancy. J. Immunol., 2008-08-01;181(3):1869-76. 2008-08-01 [PMID: 18641324] (Human)
• Jeyabalan A, Powers RW, Durica AR, Harger GF, Roberts JM, Ness RB Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia. Am. J. Hypertens., 2008-06-19;21(8):943-7. 2008-06-19 [PMID: 18566591] (Human)
• Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Human)
• Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis. Fertil. Steril., 2008-03-17;89(4):922-6. 2008-03-17 [PMID: 18343373] (Human)
• Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J. Am. Coll. Cardiol., 2007-06-04;49(24):2341-9. 2007-06-04 [PMID: 17572250] (Human)
• Apple FS, Pearce LA, Chung A, Ler R, Murakami MM Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome. Clin. Chem., 2007-03-23;53(5):874-81. 2007-03-23 [PMID: 17384009] (Human)
• Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am. J. Pathol., 2006-10-01;169(4):1167-82. 2006-10-01 [PMID: 17003476] (Human)
• Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N. Engl. J. Med., 2006-09-07;355(10):992-1005. 2006-09-07 [PMID: 16957146] (Human)
• Wallner W, Sengenberger R, Strick R, Strissel PL, Meurer B, Beckmann MW, Schlembach D Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction. Clin. Sci., 2007-01-01;112(1):51-7. 2007-01-01 [PMID: 16928195] (Human)
• Iwama H, Uemura S, Naya N, Imagawa K, Takemoto Y, Asai O, Onoue K, Okayama S, Somekawa S, Kida Y, Takeda Y, Nakatani K, Takaoka M, Kawata H, Horii M, Nakajima T, Doi N, Saito Y Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction. J. Am. Coll. Cardiol., 2006-03-27;47(8):1559-67. 2006-03-27 [PMID: 16630991] (Human)
• Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006-06-01;53(8):845-57. 2006-06-01 [PMID: 16586492] (Human)
• Briguori C, Testa U, Colombo A, Petrucci E, Condorelli G, Airoldi F, Peschle C, Condorelli G Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals. Am. J. Cardiol., 2005-12-20;97(4):472-6. 2005-12-20 [PMID: 16461039] (Human)
• Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis. Am. J. Obstet. Gynecol., 2006-02-01;194(2):551-6. 2006-02-01 [PMID: 16458660] (Human)
• Buhimschi CS, Norwitz ER, Funai E, Richman S, Guller S, Lockwood CJ, Buhimschi IA Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am. J. Obstet. Gynecol., 2005-03-01;192(3):734-41. 2005-03-01 [PMID: 15746665] (Human)
• Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA Urinary placental growth factor and risk of preeclampsia. JAMA, 2005-01-05;293(1):77-85. 2005-01-05 [PMID: 15632339] (Human)
• Nishishita T, Ouchi K, Zhang X, Inoue M, Inazawa T, Yoshiura K, Kuwabara K, Nakaoka T, Watanabe N, Igura K, Takahashi TA, Yamashita N A potential pro-angiogenic cell therapy with human placenta-derived mesenchymal cells. Biochem. Biophys. Res. Commun., 2004-12-03;325(1):24-31. 2004-12-03 [PMID: 15522196] (Human)
• Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med., 2004-02-05;350(7):672-83. 2004-02-05 [PMID: 14764923] (Human)
• Tsao PN, Su YN, Li H, Huang PH, Chien CT, Lai YL, Lee CN, Chen CA, Cheng WF, Wei SC, Yu CJ, Hsieh FJ, Hsu SM Overexpression of placenta growth factor contributes to the pathogenesis of pulmonary emphysema. Am. J. Respir. Crit. Care Med., 2003-11-25;169(4):505-11. 2003-11-25 [PMID: 14644931] (Human)
• Maynard SE, Min JY, Merchan J, Lim KH, Mondal S, Stillman IE, Epstein FH, Karumanchi SA Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest., 2003-03-01;111(5):649-58. 2003-03-01 [PMID: 12618519] (Human)
• Oura H, Bertoncini J, Velasco P, Brown LF, Carmeliet P, Detmar M A critical role of placental growth factor in the induction of inflammation and edema formation. Blood, 2002-09-05;101(2):560-7. 2002-09-05 [PMID: 12393422] (Human)
• Chappell LC, 107299, Seed PT, Briley A, Kelly FJ, Hunt BJ, Charnock-Jones DS, Mallet AI, Poston L A longitudinal study of biochemical variables in women at risk of preeclampsia. Optimization of differentiation protocols of dental tissues stem cells to pancreatic beta-cells, 2002-07-01;187(1):127-36. 2002-07-01 [PMID: 12114900]
• Zhou Y, 2019, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. 2002-04-01;160(4):1405-23. 2002-04-01 [PMID: 11943725] (Human)

FAQs for PLGF (DPG00). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: PGF