Human Angiopoietin-2 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human Angiopoietin-2 Quantikine ELISA Kit Summary

• Background: The Quantikine Human Angiopoietin-2 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Angiopoietin-2 in cell culture supernates, serum, plasma, and saliva. It contains NS0-expressed recombinant human Angiopoietin-2 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Angiopoietin-2 showed linear curves that were parallel... to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Angiopoietin-2.
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• Specificity: Natural and recombinant human Angiopoietin-2
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: ANGPT2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Angiopoietin-2 Quantikine ELISA Kit

• AGPT2
• ANG2
• ANG-2
• angiopoietin 2
• Angiopoietin-2
• angiopoietin-2a
• angiopoietin-2B
• angiopoitin 2
• ANGPT2
• Tie2-ligand

Background

Angiopoietins, Ang-1, Ang-2, and Ang-3 (mouse)/Ang-4 (human), are natural agonists or antagonists of the Tie-2 receptor tyrosine kinase and are important modulators of angiogenesis. Two domains characterize the angiopoietin family of proteins: an N-terminal coiled-coil domain that mediates homo-oligomerization, and a C-terminal fibrinogen-like domain that binds Tie-2.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Angiopoietin-2 (DANG20)(99)

Publications using DANG20

• Szymczak, A;Kusztal, M;Go??biowski, T;Letachowicz, K;Go?dzik, A;Ko?cielska-Kasprzak, K;Tukiendorf, A;Krajewska, M; High Plasma Angiopoietin-2 Levels Predict the Need to Initiate Dialysis within Two Years in Patients with Chronic Kidney Disease International journal of molecular sciences 2023-06-12 [PMID: 37373181] (Human)
• N Subramania, K Hofwimmer, B Tavira, L Massier, DP Andersson, P Arner, J Laurenciki Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4+ T cells Cardiovascular Diabetology, 2023-04-12;22(1):84. 2023-04-12 [PMID: 37046242] (Human)
• T Tsai, M Alwees, MA Asaad, J Theile, V Kakkassery, HB Dick, T Schultz, SC Joachim Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy PLoS ONE, 2023-01-20;18(1):e0280488. 2023-01-20 [PMID: 36662891] (Human)
• P Dumnicka, M Mazur-Lask, P Ceranowicz, M Sporek, W Kolber, J Tiso?czyk, M Ku?niewski, B Maziarz, B Ku?nierz-C Acute Changes in Serum Creatinine and Kinetic Glomerular Filtration Rate Estimation in Early Phase of Acute Pancreatitis Journal of Clinical Medicine, 2022-10-19;11(20):. 2022-10-19 [PMID: 36294481] (Human)
• RM Critelli, F Milosa, A Romanzi, S Lasagni, G Marcelli, L Di Marco, A Pivetti, F Schepis, D Romagnoli, S Mancarella, F Dituri, ML Martinez-C, G Giannelli, E Villa Upregulation of the oestrogen target gene SIX1 is associated with higher growth speed and decreased survival in HCV-positive women with hepatocellular carcinoma Oncology Letters, 2022-09-21;24(5):395. 2022-09-21 [PMID: 36276500] (Human)
• B Ni, S Chen, KA Ryan, ML Maitland, JS Farrar, M Witzenrath, B Gubier, C Serdjebi, K Bertotti, R Wang, FN Salloum, L Marino, BD Mitchell, FS Celi Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome Molecular Metabolism, 2022-08-30;0(0):101588. 2022-08-30 [PMID: 36055577] (Human)
• M Hultström, K Fromell, A Larsson, B Persson, B Nilsson, SE Quaggin, C Betsholtz, R Frithiof, M Lipcsey, M Jeansson Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients Biomedicines, 2022-06-06;10(6):. 2022-06-06 [PMID: 35740360] (Human, Mouse)
• J Kaur, K Kamboj, AK Yadav, P Kaur, V Kumar, V Jha Cholecalciferol supplementation and angiogenic markers in chronic kidney disease PLoS ONE, 2022-06-03;17(6):e0268946. 2022-06-03 [PMID: 35657784] (Human)
• Y Qin, A Dinabandhu, X Cao, JC Sanchez, K Jee, M Rodrigues, C Guo, J Zhang, J Vancel, D Menon, NS Khan, T Ma, SY Tzeng, YJ Daoud, JJ Green, GL Semenza, S Montaner, A Sodhi ANGPTL4 influences the therapeutic response of neovascular age-related macular degeneration patients by promoting choroidal neovascularization JCI Insight, 2022-07-08;0(0):. 2022-07-08 [PMID: 35653189] (Human)
• Y Yamada, Y Zhong, S Miki, A Taura, TH Rabbitts The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis Scientific Reports, 2022-05-04;12(1):7226. 2022-05-04 [PMID: 35508511] (Human)
• M Haffke, H Freitag, G Rudolf, M Seifert, W Doehner, N Scherbakov, L Hanitsch, K Wittke, S Bauer, F Konietschk, F Paul, J Bellmann-S, C Kedor, C Scheibenbo, F Sotzny Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) Journal of Translational Medicine, 2022-03-22;20(1):138. 2022-03-22 [PMID: 35317812] (Human)
• NM Karabid, T Wiedemann, S Gulde, H Mohr, RC Segaran, J Geppert, M Rohm, G Vitale, G Gaudenzi, A Dicitore, DP Ankerst, Y Chen, R Braren, G Kaissis, F Schilling, M Schillmaie, G Eisenhofer, S Herzig, F Roncaroli, JB Honegger, NS Pellegata Angpt2/Tie2 autostimulatory loop controls tumorigenesis Embo Molecular Medicine, 2022-03-10;0(0):e14364. 2022-03-10 [PMID: 35266635] (Human)
• O Sibila, L Perea, N Albacar, J Moisés, T Cruz, N Mendoza, B Solarat, G Lledó, G Espinosa, JA Barberà, JR Badia, A Agustí, J Sellarés, R Faner Elevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge Respiratory Research, 2022-02-21;23(1):37. 2022-02-21 [PMID: 35189887] (Human)
• J Wo?, S Chocholska, W Kowalska, W Tomczak, A Szyma?ska, A Karczmarcz, A Szuster-Ci, A Wojciechow, A Bojarska-J Prognostic Value of Tie2-Expressing Monocytes in Chronic Lymphocytic Leukemia Patients Cancers, 2021-06-05;13(11):. 2021-06-05 [PMID: 34198760] (Human)
• S Fujiwara-S, Y Ueda, M Fujikawa, M Osaki, N Yamanaka, T Matsumoto Mucopolysaccharide polysulfate promotes microvascular stabilization and barrier integrity of dermal microvascular endothelial cells via activation of the angiopoietin-1/Tie2 pathway Journal of dermatological science, 2021-06-02;0(0):. 2021-06-02 [PMID: 34148739] (Human)
• BE Barber, MJ Grigg, KA Piera, Y Chen, T William, JB Weinberg, TW Yeo, NM Anstey Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria Scientific Reports, 2021-05-07;11(1):9741. 2021-05-07 [PMID: 33963210] (Human)
• T Seki, N Yanaihara, JS Shapiro, M Saito, J Tabata, R Yokomizo, D Noguchi, T Kuroda, A Kawabata, J Suzuki, K Takahashi, H Matsuzawa, M Miyake, M Takenaka, Y Iida, S Yanagida, A Okamoto Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma Scientific Reports, 2021-04-08;11(1):7689. 2021-04-08 [PMID: 33833265] (Human)
• RLI Crake, MR Strother, E Phillips, MP Doogue, M Zhang, CMA Frampton, BA Robinson, MJ Currie Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study Scientific Reports, 2021-03-11;11(1):5648. 2021-03-11 [PMID: 33707475] (Human)
• Y Osawa, S Yoshio, Y Aoki, M Korenaga, M Imamura, T Oide, M Okawara, H Kawai, Y Tsutsui, Y Yoshida, S Yoshikawa, T Mori, T Yamazoe, T Kanto Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients BMC gastroenterology, 2021-02-08;21(1):55. 2021-02-08 [PMID: 33557759] (Human)
• MA Hannappe, L Arnould, A Méloux, B Mouhat, F Bichat, M Zeller, Y Cottin, C Binquet, C Vergely, C Creuzot-Ga, C Guenancia Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients Sci Rep, 2020-10-07;10(1):16718. 2020-10-07 [PMID: 33028913] (Human)
• SA Kennedy, ME Morrissey, MR Dunne, F O'Connell, CT Butler, MC Cathcart, AM Buckley, BJ Mehigan, JO Larkin, P McCormick, BN Kennedy, J O'Sullivan Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors BMC Cancer, 2020-10-02;20(1):952. 2020-10-02 [PMID: 33008336] (Human)
• KM Terlikowsk, B Dobrzycka, R Terlikowsk, A Sienkiewic, M Kinalski, SJ Terlikowsk Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer BMC Cancer, 2020-09-25;20(1):921. 2020-09-25 [PMID: 32977765] (Human)
• J Wajda, P Dumnicka, M Sporek, B Maziarz, W Kolber, A Z?bek-Adam, P Ceranowicz, M Ku?niewski, B Ku?nierz-C Does Beta-Trace Protein (BTP) Outperform Cystatin C as a Diagnostic Marker of Acute Kidney Injury Complicating the Early Phase of Acute Pancreatitis? J Clin Med, 2020-01-11;9(1):. 2020-01-11 [PMID: 31940861] (Human)
• C Gao, Z Gong, D Wang, J Huang, Y Qian, M Nie, W Jiang, X Liu, H Luo, J Yuan, T Xiang, S An, W Quan, H Wei, J Zhang, R Jiang Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p Aging (Albany NY), 2019-12-16;11(24):12147-12164. 2019-12-16 [PMID: 31841443] (Human)
• FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019-06-21;4(10):1373-1386. 2019-06-21 [PMID: 31701047] (Human)
• M Klinger, G Zugmaier, V Nägele, ME Goebeler, C Brandl, M Stelljes, H Lassmann, A von Stacke, RC Bargou, P Kufer Adhesion of T cells to endothelial cells facilitates blinatumomab-associated neurologic adverse events Cancer Res., 2019-10-29;0(0):. 2019-10-29 [PMID: 31662326] (Human)
• S Kazune, A Caica, K Volceka, O Suba, U Rubins, A Grabovskis Relationship of mottling score, skin microcirculatory perfusion indices and biomarkers of endothelial dysfunction in patients with septic shock: an observational study Crit Care, 2019-09-11;23(1):311. 2019-09-11 [PMID: 31511042] (Human)
• NAM Dekker, ALI van Leeuwe, WWJ van Strien, J Majolée, R Szulcek, ABA Vonk, PL Hordijk, C Boer, CE van den Br Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels Crit Care, 2019-04-11;23(1):117. 2019-04-11 [PMID: 30975180] (Human)
• FM de Oliveir, CB Araújo, DF de Freitas, BFT Arruda, LJM de Macêdo, VB Salles, GC Meneses, AMC Martins, AB Libório Fibroblast growth factor 23, endothelium biomarkers and acute kidney injury in critically-ill patients J Transl Med, 2019-04-11;17(1):121. 2019-04-11 [PMID: 30971270] (Human)
• R Wang, T Yamada, S Arai, K Fukuda, H Taniguchi, A Tanimoto, A Nishiyama, S Takeuchi, K Yamashita, K Ohtsubo, J Matsui, N Onoda, E Hirata, S Taira, S Yano Distribution and Activity of Lenvatinib in Brain Tumor Models of Human Anaplastic Thyroid Cancer Cells in Severe Combined Immune Deficient Mice Mol. Cancer Ther., 2019-03-29;18(5):947-956. 2019-03-29 [PMID: 30926637] (Human)
• M Varas-Godo, S Acuña-Gall, S Venegas-Du, C Hill, A Caceres-Ve, O Realini, LJ Monteiro, G Zavala, M Khoury, R Romero, G Rice, SE Illanes Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia Stem Cells Int, 2019-01-27;2019(0):1916542. 2019-01-27 [PMID: 30809262] (Human)
• W Kolber, P Dumnicka, M Maraj, B Ku?nierz-C, P Ceranowicz, M P?dziwiatr, B Maziarz, M Mazur-Lask, M Ku?niewski, M Sporek, J Walocha Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis? Int J Mol Sci, 2018-06-20;19(6):. 2018-06-20 [PMID: 29925813] (Human)
• Y Shi, H Yan, J Yuan, H Zhang, J Huang, Z Ni, J Qian, W Fang Different patterns of inflammatory and angiogenic factors are associated with peritoneal small solute transport and peritoneal protein clearance in peritoneal dialysis patients BMC Nephrol, 2018-05-23;19(1):119. 2018-05-23 [PMID: 29792163] (Human)
• C Robinson, L Tsang, A Solomon, AJ Woodiwiss, S Gunter, M Mer, HC Hsu, M Gomes, GR Norton, AME Millen, PH Dessein Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis Peptides, 2018-02-21;102(0):31-37. 2018-02-21 [PMID: 29475075] (Human)
• NJ Meyer, JP Reilly, R Feng, JD Christie, SL Hazen, CJ Albert, JD Franke, CL Hartman, J McHowat, DA Ford Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome JCI Insight, 2017-12-07;2(23):. 2017-12-07 [PMID: 29212955] (Human)
• F Moritz, J Schniering, JHW Distler, RE Gay, S Gay, O Distler, B Maurer Tie2 as a novel key factor of microangiopathy in systemic sclerosis Arthritis Res. Ther., 2017-05-25;19(1):105. 2017-05-25 [PMID: 28545512] (Human)
• D Gozal, A Khalyfa, Z Qiao, DL Smith, MF Philby, D Koren, L Kheirandis Angiopoietin-2 and soluble Tie-2 receptor plasma levels in children with obstructive sleep apnea and obesity Obesity (Silver Spring), 2017-05-05;0(0):. 2017-05-05 [PMID: 28474375] (Human)
• S Demolli, A Doddaballa, K Devraj, K Stark, Y Manavski, A Eckart, CM Zehendner, T Lucas, T Korff, M Hecker, S Massberg, S Liebner, D Kaluza, RA Boon, S Dimmeler Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D Cardiovasc. Res., 2017-05-01;113(6):681-691. 2017-05-01 [PMID: 28453731] (Human)
• K Wang, W Liu, Y Song, X Wu, Y Zhang, S Li, Y Gao, J Tu, Y Liu, C Yang The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration Lab. Invest., 2017-04-10;0(0):. 2017-04-10 [PMID: 28394321] (Human)
• P Dumnicka, B Ku?nierz-C, M Sporek, M Mazur-Lask, K Gil, M Ku?niewski, P Ceranowicz, Z Warzecha, A Dembi?ski, J Bonior, R Dro?d? Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis Int J Mol Sci, 2017-04-02;18(4):. 2017-04-02 [PMID: 28368336] (Human)
• P Ku?, R Charkiewic, D Klasa-Mazu, T Milczek, B Mroczko, J Nikli?ski, P Lauda?ski Profiling of selected angiogenesis-related genes in serous ovarian cancer patients Adv Med Sci, 2017-02-21;62(1):116-120. 2017-02-21 [PMID: 28235714] (Human)
• Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease Sci Rep, 2016-12-19;6(0):39400. 2016-12-19 [PMID: 27991547] (Human)
• Shenyi Jiang IL-35 Inhibits Angiogenesis through VEGF/Ang2/Tie2 Pathway in Rheumatoid Arthritis Cell. Physiol. Biochem, 2016-12-14;40(5):1105-1116. 2016-12-14 [PMID: 27960151] (Human)
• TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1 Sci Adv, 2016-04-01;2(4):e1501290. 2016-04-01 [PMID: 27757426] (Human)
• Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling Sci Rep, 2016-07-04;6(0):29029. 2016-07-04 [PMID: 27374240] (Human)
• D Dauwe, B Pelacho, A Wibowo, AS Walravens, K Verdonck, H Gillijns, E Caluwe, P Pokreisz, N van Gastel, G Carmeliet, M Depypere, F Maes, N Vanden Dri, W Droogne, J Van Cleemp, J Vanhaecke, F Prosper, C Verfaillie, A Luttun, S Janssens Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved J Am Heart Assoc, 2016-04-18;5(4):. 2016-04-18 [PMID: 27091182] (Human)
• Jongman R, van Klarenbosch J, Molema G, Zijlstra J, de Vries A, van Meurs M Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass. PLoS ONE, 2015-08-26;10(8):e0136205. 2015-08-26 [PMID: 26309217] (Human)
• Salazar R, Capdevila J, Laquente B, Manzano J, Pericay C, Villacampa M, Lopez C, Losa F, Safont M, Gomez A, Alonso V, Escudero P, Gallego J, Sastre J, Gravalos C, Biondo S, Palacios A, Aranda E A randomized phase II study of capecitabine-based chemoradiation with or without bevacizumab in resectable locally advanced rectal cancer: clinical and biological features. BMC Cancer, 2015-02-26;15(0):60. 2015-02-26 [PMID: 25886378] (Human)
• Verstraete M, Debucquoy A, Dekervel J, Van Pelt J, Verslype C, Devos E, Chiritescu G, Dumon K, D'Hoore A, Gevaert O, Sagaert X, Van Cutsem E, Haustermans K Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial. Br J Cancer, 2015-03-17;112(8):1314-25. 2015-03-17 [PMID: 25867261] (Human)
• Dessein , Patrick, Hsu , Hon-Chun, Tsang , Linda, Millen , Aletta M, Woodiwiss , Angela J, Norton , Gavin R, Solomon , Ahmed, Gonzalez-Gay , Miguel A Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis. PLoS ONE, 2015-03-25;10(3):e0121693. 2015-03-25 [PMID: 25806966] (Human)
• Zheng X, Ohsaki E, Ueda K Mechanism of angiopoietin-1 upregulation in Kaposi's sarcoma-associated herpesvirus-infected PEL cell lines. J Virol, 2015-01-28;89(9):4786-97. 2015-01-28 [PMID: 25631079] (Human)
• Tsai , Yi-Chun, Chiu , Yi-Wen, Tsai , Jer-Chia, Kuo , Hung-Tie, Lee , Su-Chu, Hung , Chi-Chih, Lin , Ming-Yen, Hwang , Shang-Jy, Kuo , Mei-Chua, Chen , Hung-Chu Association of angiopoietin-2 with renal outcome in chronic kidney disease. PLoS ONE, 2014-10-03;9(10):e108862. 2014-10-03 [PMID: 25279852] (Human)
• Gomes L, Alves-Junior E, Rodrigues-Jesus C, Nery A, Gasquez-Martin T, Fontes C Angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratio as indicators of potential severity of Plasmodium vivax malaria in patients with thrombocytopenia. PLoS ONE, 2014-10-02;9(10):e109246. 2014-10-02 [PMID: 25275496] (Human)
• Sallinen H, Heikura T, Koponen J, Kosma V, Heinonen S, Yla-Herttuala S, Anttila M Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer. BMC Cancer, 2014-09-23;14(0):696. 2014-09-23 [PMID: 25245329] (Human)
• Voigtlander T, David S, Thamm K, Schlue J, Metzger J, Manns M, Lankisch T Angiopoietin-2 and biliary diseases: elevated serum, but not bile levels are associated with cholangiocarcinoma. PLoS ONE, 2014-05-13;9(5):e97046. 2014-05-13 [PMID: 24823366] (Human)
• Krautkramer E, Grouls S, Hettwer D, Rafat N, Tonshoff B, Zeier M Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease. J Virol, 2013-10-23;88(1):483-9. 2013-10-23 [PMID: 24155401] (Human)
• Wertenbroek , Marieke, Schepers , Marianne, Kamminga-Rasker , Hannetta, Bottema , Jan T, Muller Kobold , Anneke C, Roelofsen , Han, de Jong , Koert P Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases. BMC Cancer, 2013-05-30;13(1):266. 2013-05-30 [PMID: 23721455] (Human)
• Schauer D, Starlinger P, Reiter C, Jahn N, Zajc P, Buchberger E, Bachleitner-Hofmann T, Bergmann M, Stift A, Gruenberger T, Brostjan C Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer. PLoS ONE, 2012-09-04;7(9):e44450. 2012-09-04 [PMID: 22973451] (Human)
• Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A, 2012-06-04;109(25):10024-9. 2012-06-04 [PMID: 22665799] (Primate - Papio cynocephalus (Yellow Baboon))
• Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J, Pallota MG, Zarba JJ, Boyer M, Riordan S, Strickland A, Tebbutt N, Thomson B, Borbath I, De Greve J, Van Laethem J-, Van Steenbergen W, Van Vlierberghe H, Barrios C, Cosme de Oliveira A, Kotzev I, Takov D, Tchernev K, Burak K, Ma M, Metrakos P, Olweny C, Sherman M, Gamargo Garate C, Martinez-Castillo J, Beaugrand M, Bennouna J, Blanc J-, Bronowicki J-, Degos F, Dominguez S, Grange J-, Hillon P, Raoul J-, Seitz J-, Blum H, Buggisch P, Caspary W, Dollinger M, Gerken G, Goke B, Gregor M, Greten T, Haussinger D, Hilgard P, Scherübl J, Scheulen M, Schmid R, Spengler U, Wiest R, Zeuzem S, Arvanitakis C, Germanidis G, Katsos I, Figer A, Stemmer S, Amadori D, Bolondi L, Cognetti F, Craxi A, Farinati F, Gridelli C, Martoni A, Mazzaferro V, Porta C, Ricci S, Sangiovanni A, Santoro A, Trevisani F, Cisnero Garza LE, Gane E, O'Donnell A, Leon J, Lozano A, Jassem J, Rydzewska G, Szawlowski A, Tomczak P, Badulescu F, Miron L, Kubyshkin V, Bruix J, Forner A, Bustamante Schneider J, Diago M, Montero Alvarez JL, Pascual S, Ruíz del Arbol L, Sangro B, Solá R, Tabernero J, Muellhaupt B, Roth A, Jeffry Evans TR, Falk S, Meyer T, Reeves H, Ross P, Befeler A, Boyer T, Britten C, Byrne T, Garcia-Tsao G, Gold P, Goldenberg A, Heuman D, Kennedy P, Koch A, Llovet JM, Marrero J, Schilsky M, Schwartz J, Schwartz M Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clin. Cancer Res., 2012-02-28;18(8):2290-300. 2012-02-28 [PMID: 22374331] (Human)
• Rasul S, Reiter MH, Ilhan A, Lampichler K, Wagner L, Kautzky-Willer A Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study. Cardiovasc Diabetol, 2011-06-23;10(0):55. 2011-06-23 [PMID: 21699724] (Human)
• Ricciuto DR, Dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, Lafferty EI, Cook DJ, Fox-Robichaud A, Kahnamoui K, Kain KC, Liaw PC, Liles WC Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis* Crit. Care Med., 2011-04-01;0(0):. 2011-04-01 [PMID: 21242795] (Human)
• Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. Br. J. Cancer, 2010-11-16;104(1):51-9. 2010-11-16 [PMID: 21081932] (Human)
• Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc. Res., 2010-07-29;89(1):157-65. 2010-07-29 [PMID: 20675298] (Human)
• Maffei R, Martinelli S, Santachiara R Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia. Blood, 2010-04-09;116(4):584-92. 2010-04-09 [PMID: 20382847] (Human)
• Boucherat O, Franco-Montoya ML, Delacourt C, Martinovic J, Masse V, Elie C, Thebaud B, Benachi A, Bourbon JR Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF. Am. J. Physiol. Lung Cell Mol. Physiol., 2010-03-26;298(6):L849-56. 2010-03-26 [PMID: 20348277] (Human)
• Berisha B, Meyer HH, Schams D Effect of prostaglandin F2 alpha on local luteotropic and angiogenic factors during induced functional luteolysis in the bovine corpus luteum. Biol. Reprod., 2010-01-07;82(5):940-7. 2010-01-07 [PMID: 20056670] (Bovine)
• Hurliman AK, Speroff L, Stouffer RL, Patton PE, Lee A, Molskness TA Changes in circulating levels and ratios of angiopoietins during pregnancy but not during the menstrual cycle and controlled ovarian stimulation. Fertil. Steril., 2009-05-23;93(5):1493-9. 2009-05-23 [PMID: 19476937] (Human, Primate - Macaca mulatta (Rhesus Macaque))
• Shantha Kumara HM, Feingold D, Kalady M, Dujovny N, Senagore A, Hyman N, Cekic V, Whelan RL Colorectal resection is associated with persistent proangiogenic plasma protein changes: postoperative plasma stimulates in vitro endothelial cell growth, migration, and invasion. Ann. Surg., 2009-06-01;249(6):973-7. 2009-06-01 [PMID: 19474682] (Human)
• Labonte L, Li Y, Yang L, Gillingham A, Halpenny M, Giulivi A, Sills T, Evans K, Zanke B, Allan DS Increased plasma EPO and MIP-1 alpha are associated with recruitment of vascular progenitors but not CD34(+) cells in autologous peripheral blood stem cell grafts. Exp. Hematol., 2009-06-01;37(6):673-8. 2009-06-01 [PMID: 19463769] (Human)
• Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis. Fertil. Steril., 2009-03-25;94(1):52-7. 2009-03-25 [PMID: 19324337] (Human)
• Helfrich I, Edler L, Sucker A, Thomas M, Christian S, Schadendorf D, Augustin HG Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin. Cancer Res., 2009-02-15;15(4):1384-92. 2009-02-15 [PMID: 19228739] (Human)
• Serefhanoglu S, Goker H, Buyukasik Y, Turgut M, Sayinalp N, Haznedaroglu IC, Aksu S, Akman U, Ozcebe OI Changes in vascular endothelial growth factor, angiopoietins, and Tie-2 levels with G-CSF stimulation in healthy donors. Ann. Hematol., 2008-12-11;88(7):667-71. 2008-12-11 [PMID: 19082594] (Human)
• Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, Piera K, Price RN, Duffull SB, Celermajer DS, Anstey NM Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc. Natl. Acad. Sci. U.S.A., 2008-10-28;105(44):17097-102. 2008-10-28 [PMID: 18957536] (Human)
• Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease. J. Am. Coll. Cardiol., 2008-07-29;52(5):387-93. 2008-07-29 [PMID: 18652948] (Human)
• Shim WS, Lim SY, Li SQ, Gu Y, Ong HC, Song IC, Chuah SC, Wong P Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium. J. Mol. Cell. Cardiol., 2008-04-27;45(1):70-80. 2008-04-27 [PMID: 18514708] (Porcine)
• Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Human)
• Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma? Ann. Surg., 2008-02-01;247(2):320-6. 2008-02-01 [PMID: 18216540] (Human)
• Choudhury A, Freestone B, Patel J, Lip GY Relationship of soluble CD40 ligand to vascular endothelial growth factor, angiopoietins, and tissue factor in atrial fibrillation: a link among platelet activation, angiogenesis, and thrombosis? Chest, 2007-12-01;132(6):1913-9. 2007-12-01 [PMID: 18079224] (Human)
• Kanazawa H, Tochino Y, Asai K Angiopoietin-2 as a contributing factor of exercise-induced bronchoconstriction in asthmatic patients receiving inhaled corticosteroid therapy. J. Allergy Clin. Immunol., 2007-11-26;121(2):390-5. 2007-11-26 [PMID: 18037159] (Human)
• Lee CY, Tien HF, Hu CY, Chou WC, Lin LI Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia. Br. J. Cancer, 2007-09-11;97(7):877-82. 2007-09-11 [PMID: 17848952] (Human)
• Park JH, Park KJ, Kim YS, Sheen SS, Lee KS, Lee HN, Oh YJ, Hwang SC Serum angiopoietin-2 as a clinical marker for lung cancer. Chest, 2007-05-15;132(1):200-6. 2007-05-15 [PMID: 17505039] (Human)
• Vart RJ, Nikitenko LL, Lagos D, Trotter MW, Cannon M, Bourboulia D, Gratrix F, Takeuchi Y, Boshoff C Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Res., 2007-05-01;67(9):4042-51. 2007-05-01 [PMID: 17483315] (Human)
• Anagnostopoulos A, Eleftherakis-Papaiakovou V, Kastritis E, Tsionos K, Bamias A, Meletis J, Dimopoulos MA, Terpos E Serum concentrations of angiogenic cytokines in Waldenstrom macroglobulinaemia: the ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity. Br. J. Haematol., 2007-06-01;137(6):560-8. 2007-06-01 [PMID: 17451406] (Human)
• Kanazawa H, Nomura S, Asai K Roles of angiopoietin-1 and angiopoietin-2 on airway microvascular permeability in asthmatic patients. Chest, 2007-04-01;131(4):1035-41. 2007-04-01 [PMID: 17426207] (Human)
• Niedzwiecki S, Stepien T, Kopec K, Kuzdak K, Komorowski J, Krupinski R, Stepien H Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers. Cytokine, 2007-03-19;36(5):291-5. 2007-03-19 [PMID: 17374490] (Human)
• Caine GJ, Ryan P, Lip GY, Blann AD Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients. Cancer Lett., 2007-01-19;251(2):296-301. 2007-01-19 [PMID: 17240049] (Human)
• Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat. Med., 2006-11-05;12(11):1286-93. 2006-11-05 [PMID: 17086189] (Human)
• Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum., 2006-10-01;54(10):3152-62. 2006-10-01 [PMID: 17009243] (Human)
• Molskness TA, Stouffer RL, Burry KA, Gorrill MJ, Lee DM, Patton PE Circulating levels of total angiopoietin-2 and the soluble Tie-2 receptor in women during ovarian stimulation and early gestation. Fertil. Steril., 2006-09-14;86(5):1531-3. 2006-09-14 [PMID: 16978614] (Human)
• Quartarone E, Alonci A, Allegra A, Bellomo G, Calabro L, D'Angelo A, Del Fabro V, Grasso A, Cincotta M, Musolino C Differential levels of soluble angiopoietin-2 and Tie-2 in patients with haematological malignancies. Eur. J. Haematol., 2006-09-15;77(6):480-5. 2006-09-15 [PMID: 16978237] (Human)
• Caine GJ, Stonelake PS, Lip GY, Blann AD Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer. Cancer Lett., 2006-08-07;248(1):131-6. 2006-08-07 [PMID: 16891056] (Human)
• Tseng JJ, Hsu SL, Ho ES, Hsieh YT, Wen MC, Chou MM Differential expression of angiopoietin-1, angiopoietin-2, and Tie receptors in placentas from pregnancies complicated by placenta accreta. Am. J. Obstet. Gynecol., 2006-02-01;194(2):564-71. 2006-02-01 [PMID: 16458662] (Human)
• Furstenberger G, von Moos R, Lucas R, Thurlimann B, Senn HJ, Hamacher J, Boneberg EM Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer. Br. J. Cancer, 2006-02-27;94(4):524-31. 2006-02-27 [PMID: 16450002] (Human)
• Koutroubakis IE, Xidakis C, Karmiris K, Sfiridaki A, Kandidaki E, Kouroumalis EA Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease. Eur. J. Clin. Invest., 2006-02-01;36(2):127-32. 2006-02-01 [PMID: 16436095] (Human)
• Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol., 2005-11-01;175(9):6177-89. 2005-11-01 [PMID: 16237115] (Human)
• Watanabe D, Suzuma K, Suzuma I, Ohashi H, Ojima T, Takagi H Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Am. J. Ophthalmol., 2005-03-01;139(3):476-81. 2005-03-01 [PMID: 15767056] (Human)
• Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model. Biochem. Biophys. Res. Commun., 2004-09-17;322(2):684-92. 2004-09-17 [PMID: 15325284] (Human)

Bioinformatics

• Gene Symbol: ANGPT2