TWEAK R/TNFRSF12 Antibody (ITEM-4) Summary
The immunogen for this antibody is TWEAKR.
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Aqueous buffer, may contain carrier protein/stabilizer (proprietary).
0.09% Sodium Azide
Protein A or G purified
This has been tested by flow cytometric analysis on human or mouse Fn14 transfected cells. This can be used at less than or equal to 1 ug per test. A test is defined as the amount (ug)/test of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Use in WB and IHC-F was reported in the scientific literature (PMID: 19473660).
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Alternate Names for TWEAK R/TNFRSF12 Antibody (ITEM-4)
- CD266 antigen
- FGF-inducible 14
- Fibroblast growth factor-inducible immediate-early response protein 14
- FN14tumor necrosis factor receptor superfamily member 12A
- tumor necrosis factor receptor superfamily, member 12A
- type I transmembrane protein Fn14
The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Species: Hu, Mu, Rt, Bv, Ca, Ch, Xp
Applications: WB, Simple Western
Applications: WB, IHC, IHC-P
Applications: Flow, Neut
Species: Hu, Mu
Applications: WB, Simple Western, IP
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC, ICFlow
Applications: WB, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
Applications: WB, Flow, Neut
Publications for TWEAK R/TNFRSF12 Antibody (NBP2-00409) (0)
There are no publications for TWEAK R/TNFRSF12 Antibody (NBP2-00409).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for TWEAK R/TNFRSF12 Antibody (NBP2-00409) (0)
There are no reviews for TWEAK R/TNFRSF12 Antibody (NBP2-00409).
By submitting a review earn points towards our Rewards Program.
- 250 points for product review
- 500 additional points for an image with your product review
- Double points (500) if you are the first to review this product
- Double points (1000) if you are the first to review this product with an image
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for TWEAK R/TNFRSF12 Antibody (NBP2-00409) (0)
Other Available Formats
Additional TWEAK R/TNFRSF12 Antibody (ITEM-4) Products
Related Products by Gene
, MATRIX METALLOPROTEINASE 9
Bioinformatics Tool for TWEAK R/TNFRSF12 Antibody (NBP2-00409)
Discover related pathways, diseases and genes to TWEAK R/TNFRSF12 Antibody (NBP2-00409). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
PTMs for TWEAK R/TNFRSF12 Antibody (NBP2-00409)
Learn more about PTMs related to TWEAK R/TNFRSF12 Antibody (NBP2-00409).
Blogs on TWEAK R/TNFRSF12