Human TNF RI/TNFRSF1A Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human TNF RI/TNFRSF1A Quantikine ELISA Kit Summary

• Background: The Quantikine Human sTNF RI Immunoassay is a 4.5 hour solid phase ELISA designed to measure sTNF RI in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human sTNF RI, as well as antibodies raised against this polypeptide. The recombinant protein represents the non-glycosylated, N-terminal methionyl form of the naturally occurring human so...luble Type I receptor for TNF with an apparent molecular weight of approximately 18.6 kDa. This immunoassay has been shown to accurately quantitate the recombinant sTNF RI. Results obtained on samples containing natural sTNF RI showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values of natural sTNF RI. Since the measurement of human sTNF RI by this immunoassay is relatively insensitive to added TNF-alpha or TNF-beta, it is probable that this measurement corresponds to the total amount of the soluble receptor present in samples (i.e. the total amount of free receptor plus the total amount of receptor bound to TNF).
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• Specificity: Natural and recombinant human sTNF RI
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TNFRSF1A

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TNF RI/TNFRSF1A Quantikine ELISA Kit

• CD120a antigen
• CD120a
• FPF
• p55
• p55-R
• p60
• TNF RI
• TNFARMGC19588
• TNF-R
• TNF-R1
• TNFR1TBP1
• TNFR55
• TNF-R55
• TNFR60
• TNFRI
• TNF-RI
• TNF-R-I
• TNFR-I
• TNFRSF1A
• tumor necrosis factor binding protein 1
• Tumor necrosis factor receptor 1
• tumor necrosis factor receptor 1A isoform beta
• tumor necrosis factor receptor superfamily member 1A
• tumor necrosis factor receptor superfamily, member 1A
• tumor necrosis factor receptor type 1
• Tumor necrosis factor receptor type I
• tumor necrosis factor-alpha receptor

Background

Tumor necrosis factors (TNFs) are pleiotropic cytokines that are considered primary modifiers of the inflammatory and immune reactions of animals produced in response to injury or infection. Two forms of TNF, designated TNF-alpha (or cachectin) and TNF-beta (or lymphotoxin), have been described that share 30% sequence similarity and compete for binding to the same receptors. TNFs play a necessary and beneficial role as mediators of host resistance to infections and tumor formation. However, over-production or inappropriate expression of these factors can lead to a variety of pathological conditions, including wasting, systemic toxicity, and septic shock. For reviews of the literature relating to these factors, see references 1 and 2. 

The actions of TNFs are produced subsequent to binding of the factors to cell surface receptors. Two distinct TNF receptors have been identified and cloned. Virtually all cell types studied show the presence of one or both of these receptor types. One receptor type, termed TNF RII (Type A, Type a, 75 kDa or utr antigen), shows an apparent molecular weight of 75 kDa. The gene for this receptor encodes a presumptive transmembrane protein of 439 amino acid (aa) residues (3, 19). The other receptor type, termed TNF RI (Type B, Type b, 55 kDa or htr antigen), shows an apparent molecular weight of 55 kDa. The gene for this protein encodes a transmembrane protein of 426 aa residues (4, 5, 19). Both receptor types show high affinity binding of either TNF-alpha or TNF-beta . The two receptor types are immunologically distinct but their extracellular domains show similarities in the pattern of cysteine residue locations in four domains (3). The intracellular domains of the two receptor types are apparently unrelated, suggesting the possibility that the two receptor types employ different signal transduction pathways. 

Several groups have identified soluble TNF binding proteins in human serum and urine (6-8) that can neutralize the biological activities of TNF-alpha and TNF-beta . Two types have been identified and designated sTNF RI (or TNF BPI) and sTNF RII (or TNF BPII). These soluble forms have now been shown to represent truncated forms of the two types of TNF receptors discussed above. The soluble receptor forms apparently arise as a result of shedding of the extracellular domains of the receptors, and concentrations of about 1-2 ng/mL are found in the serum and urine of healthy subjects (9, 10). The levels of the soluble receptors vary from individual to individual but are stable over time for given individuals (9). 

Elevated levels of TNF receptors have been found in the amniotic fluid and urine of pregnant women (11), in serum or plasma in association with pathological conditions such as endotoxinemia (12, 13), meningiococcemia (14), and HIV infection (15), and in plasma and ascites of patients in association with infections and malignancies (16). The mechanisms involved in the induction of shedding of the TNF receptors are not well understood. There are reports of correlations between increased TNF levels and soluble receptor levels, suggesting generally that stimuli that cause TNF levels to rise also induce shedding of TNF receptors (12-14, 17). There is also evidence, however, that suggests the shedding of the two types of soluble receptors is independently regulated (13). 2 For research use only. Not for use in diagnostic procedures. 

The physiological role of the soluble TNF receptors is not known. It is known that both types of soluble receptors can bind to TNF in vitro and inhibit its biological activity by competing with cell surface receptors for TNF binding. Consequently it has been suggested that shedding of soluble receptors in response to TNF release could serve as a mechanism for binding and inhibiting the TNF not immediately bound to surface receptors, thus protecting other cells from the effects of TNF and localizing the inflammatory response (12, 17). It is also possible that shedding of receptors represents a mechanism for desensitizing the cells that shed the receptors from the effects of TNF (17). On the other hand, it has been reported that at low concentrations of TNF, binding to soluble receptors can stabilize TNF and augment some of its activities (18). Thus it is possible that under some conditions the pool of TNF bound to soluble receptors could represent a reservoir for the stabilization and controlled release of TNF

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TNF RI/TNFRSF1A (DRT100)(82)

Publications using DRT100

• KHT Salai, LY Wu, JR Chong, YL Chai, B Gyanwali, C Robert, S Hilal, N Venketasub, GS Dawe, CP Chen, MKP Lai Elevated Soluble TNF-Receptor 1 in the Serum of Predementia Subjects with Cerebral Small Vessel Disease Biomolecules, 2023-03-13;13(3):. 2023-03-13 [PMID: 36979460] (Human)
• T Gohda, M Murakoshi, Y Suzuki, M Hiki, T Naito, K Takahashi, Y Tabe Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patients PLoS ONE, 2022-10-11;17(10):e0275745. 2022-10-11 [PMID: 36219652] (Human)
• T Hinton, D Karnak, M Tang, R Jiang, Y Luo, P Boonstra, Y Sun, DJ Nancarrow, E Sandford, P Ray, C Maurino, M Matuszak, MJ Schipper, MD Green, GA Yanik, M Tewari, IE Naqa, CA Schonewolf, RT Haken, S Jolly, TS Lawrence, D Ray Improved prediction of radiation pneumonitis by combining biological and radiobiological parameters using a data-driven Bayesian network analysis Translational Oncology, 2022-04-20;21(0):101428. 2022-04-20 [PMID: 35460942] (Human)
• Z Albar, M Albakri, J Hajjari, M Karnib, SE Janus, SG Al-Kindi Inflammatory Markers and Risk of Heart Failure With Reduced to Preserved Ejection Fraction The American journal of cardiology, 2022-01-03;0(0):. 2022-01-03 [PMID: 34986991] (Human)
• T Takao, H Yanagisawa, M Suka, Y Yoshida, Y Onishi, T Tahara, T Kikuchi, A Kushiyama, M Anai, K Takahashi, S Wakabayash, H Yamazaki, S Kawazu, Y Iwamoto, M Noda, M Kasuga Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study Journal of diabetes investigation, 2021-10-07;0(0):. 2021-10-07 [PMID: 34533892] (Human)
• A Wardzy?ska, M Pawe?czyk, J Rywaniak, J Makowska, J Jamroz-Brz, ML Kowalski Circulating miRNA expression in asthmatics is age-related and associated with clinical asthma parameters, respiratory function and systemic inflammation Respiratory Research, 2021-06-10;22(1):177. 2021-06-10 [PMID: 34112152] (Human)
• M Oshima, A Hara, T Toyama, M Jun, C Pollock, M Jardine, S Harrap, N Poulter, ME Cooper, M Woodward, J Chalmers, V Perkovic, MG Wong, T Wada Comparison of Circulating Biomarkers in Predicting Diabetic Kidney Disease Progression With Autoantibodies to Erythropoietin Receptor Kidney international reports, 2020-11-10;6(2):284-295. 2020-11-10 [PMID: 33615053] (Human)
• MM Cousins, E Morris, C Maurino, TP Devasia, D Karnak, D Ray, ND Parikh, D Owen, RK Ten Haken, MJ Schipper, TS Lawrence, KC Cuneo TNFR1 and the TNF&alpha axis as a targetable mediator of liver injury from stereotactic body radiation therapy Translational Oncology, 2020-12-13;14(1):100950. 2020-12-13 [PMID: 33395747] (Human)
• R Cezar, A Winter, D Desigaud, M Pastore, L Kundura, AM Dupuy, C Cognot, T Vincent, C Reynes, C Dunyach-Re, JP Lavigne, R Sabatier, P Le Merre, E Maggia, P Corbeau Identification of distinct immune activation profiles in adult humans Scientific Reports, 2020-11-30;10(1):20824. 2020-11-30 [PMID: 33257766] (Human)
• L Hassan, D Medenwald, D Tiller, A Kluttig, B Ludwig-Kra, FB Kraus, KH Greiser, R Mikolajczy The association between change of soluble tumor necrosis factor receptor R1 (sTNF-R1) measurements and cardiovascular and all-cause mortality-Results from the population-based (Cardiovascular Disease, Living and Ageing in Halle) CARLA study 2002-2016 PLoS ONE, 2020-10-26;15(10):e0241213. 2020-10-26 [PMID: 33104754] (Human)
• DL Roth, WE Haley, OC Sheehan, J Huang, JD Rhodes, P Durda, VJ Howard, JD Walston, M Cushman The transition to family caregiving and its effect on biomarkers of inflammation Proc. Natl. Acad. Sci. U.S.A., 2020-06-24;0(0):. 2020-06-24 [PMID: 32581123] (Human)
• M Murakoshi, T Gohda, Y Suzuki Circulating Tumor Necrosis Factor Receptors: A Potential Biomarker for the Progression of Diabetic Kidney Disease Int J Mol Sci, 2020-03-13;21(6):. 2020-03-13 [PMID: 32183005] (Human)
• JV Baker, J Wolfson, T Peterson, M Mooberry, M Gissel, H Mystakelis, MW Henderson, K Garcia-Mye, FS Rhame, TW Schacker, KE Brummel-Zi, I Sereti, NS Key, RP Tracy Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial Open Forum Infect Dis, 2020-02-01;7(2):ofaa026. 2020-02-01 [PMID: 32055640] (Human)
• JF Camargo, S Pallikkuth, I Moroz, Y Natori, ML Alcaide, A Rodriguez, G Guerra, GW Burke, S Pahwa Pretransplant Levels of C-Reactive Protein,�Soluble TNF Receptor-1, and�CD38+HLADR+ CD8 T Cells Predict Risk of Allograft Rejection in HIV+ Kidney Transplant Recipients Kidney Int Rep, 2019-08-19;4(12):1705-1716. 2019-08-19 [PMID: 31844807] (Human)
• FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019-06-21;4(10):1373-1386. 2019-06-21 [PMID: 31701047] (Human)
• J Uwada, T Yazawa, H Nakazawa, D Mikami, SM Krug, M Fromm, K Sada, I Muramatsu, T Taniguchi Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells Cell. Signal., 2019-07-08;63(0):109358. 2019-07-08 [PMID: 31295519] (Human)
• N Ohta, H Yasudo, M Mizutani, T Matsushige, R Fukano, S Kittaka, K Maehara, K Ichihara, S Ohga, S Hasegawa Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection Cytokine, 2019-05-29;120(0):258-263. 2019-05-29 [PMID: 31153005] (Human)
• KP Loh, JA Tooze, BJ Nicklas, SB Kritchevsk, JD Williamson, LR Ellis, BL Powell, TS Pardee, NG Goyal, HD Klepin Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia J Geriatr Oncol, 2019-04-05;0(0):. 2019-04-05 [PMID: 30962090] (Human)
• R Grzanka, A Damasiewic, A Kasperska- Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria Allergy Asthma Clin Immunol, 2019-03-14;15(0):15. 2019-03-14 [PMID: 30911316] (Human)
• H Yogasundar, A Nikhanj, BN Putko, M Boutin, S Jain-Ghai, A Khan, C Auray-Blai, ML West, GY Oudit Elevated Inflammatory Plasma Biomarkers in Patients With Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction J Am Heart Assoc, 2018-11-06;7(21):e009098. 2018-11-06 [PMID: 30571380] (Human)
• SS Foo, W Chen, Y Chan, WS Lee, SA Lee, G Cheng, K Nielsen-Sa, P Brasil, JU Jung Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies JCI Insight, 2018-11-02;3(21):. 2018-11-02 [PMID: 30385728] (Human)
• Y Matsukiyo, H Nagai, T Matsui, Y Igarashi Host Immunological Effects of Partial Splenic Embolization in Patients with Liver Cirrhosis J Immunol Res, 2018-07-15;2018(0):1746391. 2018-07-15 [PMID: 30116748] (Human)
• R Sharaf, GQ Lee, X Sun, B Etemad, LM Aboukhater, Z Hu, ZL Brumme, E Aga, RJ Bosch, Y Wen, G Namazi, C Gao, EP Acosta, RT Gandhi, JM Jacobson, D Skiest, DM Margolis, R Mitsuyasu, P Volberding, E Connick, DR Kuritzkes, MM Lederman, XG Yu, M Lichterfel, JZ Li HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers J. Clin. Invest., 2018-08-20;0(0):. 2018-08-20 [PMID: 30024859] (Human)
• N Vande Cast, J Oyamada, C Shimizu, BM Best, EV Capparelli, AH Tremoulet, JC Burns Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease Clin Pharmacokinet, 2018-12-01;0(0):. 2018-12-01 [PMID: 29623653] (Human)
• AT Holdbrooks, CM Britain, SL Bellis ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor J. Biol. Chem., 2017-12-12;0(0):. 2017-12-12 [PMID: 29233887] (Human)
• MA Belury, E Bowman, J Gabriel, B Snyder, M Kulkarni, M Palettas, X Mo, JE Lake, D Zidar, SF Sieg, B Rodriguez, MP Playford, A Andrade, DR Kuritzkes, NN Mehta, MM Lederman, NT Funderburg Prospective Analysis of Lipid Composition Changes with Antiretroviral Therapy and Immune Activation in Persons Living with HIV Pathog Immun, 2017-10-06;2(3):376-403. 2017-10-06 [PMID: 29098203] (Human)
• LR de Armas, S Pallikkuth, V George, S Rinaldi, R Pahwa, KL Arheart, S Pahwa Reevaluation of immune activation in the era of cART and an aging HIV-infected population JCI Insight, 2017-10-19;2(20):. 2017-10-19 [PMID: 29046481] (Human)
• M Mizutani, S Hasegawa, T Matsushige, N Ohta, S Kittaka, M Hoshide, T Kusuda, K Takahashi, K Ichihara, S Ohga Distinctive inflammatory profile between acute focal bacterial nephritis and acute pyelonephritis in children Cytokine, 2017-07-03;99(0):24-29. 2017-07-03 [PMID: 28683358] (Human)
• J Uwada, T Yazawa, MT Islam, MRI Khan, SM Krug, M Fromm, SI Karaki, Y Suzuki, A Kuwahara, H Yoshiki, K Sada, Muramatsu, T Taniguchi Activation of muscarinic receptors prevents TNF-?-mediated intestinal epithelial barrier disruption through p38 MAPK Cell. Signal., 2017-04-12;0(0):. 2017-04-12 [PMID: 28412413] (Human)
• T Gohda, S Maruyama, N Kamei, S Yamaguchi, T Shibata, M Murakoshi, S Horikoshi, Y Tomino, I Ohsawa, H Gotoh, S Nojiri, Y Suzuki Circulating TNF Receptors 1 and 2 Predict Mortality in Patients with End-stage Renal Disease Undergoing Dialysis Sci Rep, 2017-03-03;7(0):43520. 2017-03-03 [PMID: 28256549] (Human)
• EJ Williams, KJ Baines, BS Berthon, LG Wood Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial Nutrients, 2017-02-08;9(2):. 2017-02-08 [PMID: 28208713] (Human)
• M Kulkarni, E Bowman, J Gabriel, T Amburgy, E Mayne, DA Zidar, C Maierhofer, AN Turner, JA Bazan, SL Koletar, MM Lederman, SF Sieg, NT Funderburg Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection Open Forum Infect Dis, 2016-10-15;3(4):ofw224. 2016-10-15 [PMID: 28066794] (Human)
• Prevalent peripheral arterial disease and inflammatory burden BMC Geriatr, 2016-12-09;16(1):213. 2016-12-09 [PMID: 27938334] (Human)
• Anti-TNF-? Drugs Differently Affect the TNF?-sTNFR System and Monocyte Subsets in Patients with Psoriasis PLoS ONE, 2016-12-09;11(12):e0167757. 2016-12-09 [PMID: 27936119] (Human)
• Hack-Lyoung Kim Soluble Tumor Necrosis Factor Receptors and Arterial Stiffness in Patients With Coronary Atherosclerosis Am. J. Hypertens, 2017-03-01;0(0):. 2017-03-01 [PMID: 27927628] (Human)
• Anti-Drug Antibodies, Drug Levels, Interleukin-6 and Soluble TNF Receptors in Rheumatoid Arthritis Patients during the First 6 Months of Treatment with Adalimumab or Infliximab: A Descriptive Cohort Study PLoS ONE, 2016-09-08;11(9):e0162316. 2016-09-08 [PMID: 27606615] (Human)
• Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury J Clin Invest, 2016-08-02;0(0):. 2016-08-02 [PMID: 27482889] (Human)
• Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS) J Bone Miner Res, 2016-07-25;0(0):. 2016-07-25 [PMID: 27371811] (Human)
• S Ouyang, W Li, Z Liu, Y Li, S Li, J Wu Association between serum soluble tumor necrosis factor-? receptors and early childhood obesity Endocr J, 2016-03-31;0(0):. 2016-03-31 [PMID: 27040725] (Human)
• Ghislain M, Bastard J, Meyer L, Capeau J, Fellahi S, Gerard L, May T, Simon A, Vigouroux C, Goujard C Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities. PLoS ONE, 2015-12-04;10(12):e0144317. 2015-12-04 [PMID: 26636578] (Human)
• Jarrett O, Brady K, Modur S, Plants J, Landay A, Ghassemi M, Golub E, Spear G, Novak R T. vaginalis Infection Is Associated with Increased IL-8 and TNFr1 Levels but with the Absence of CD38 and HLADR Activation in the Cervix of ESN. PLoS ONE, 2015-06-17;10(6):e0130146. 2015-06-17 [PMID: 26083468] (Human)
• Hayslip J, Dressler E, Weiss H, Taylor T, Chambers M, Noel T, Miriyala S, Keeney J, Ren X, Sultana R, Vore M, Butterfield D, St Clair D, Moscow J Plasma TNF-alpha and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study. PLoS ONE, 2015-04-24;10(4):e0124988. 2015-04-24 [PMID: 25909710] (Human)
• Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J, Tomino Y Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy. PLoS ONE, 2015-04-10;10(4):e0122212. 2015-04-10 [PMID: 25860248] (Human)
• Duvillard L, Ortega-Deballon P, Bourredjem A, Scherrer M, Mantion G, Delhorme J, Deguelte-Lardiere S, Petit J, Bonithon-Kopp C A case-control study of pre-operative levels of serum neutrophil gelatinase-associated lipocalin and other potential inflammatory markers in colorectal cancer. BMC Cancer, 2014-12-03;14(0):912. 2014-12-03 [PMID: 25472811] (Human)
• Pisetsky D, Trace S, Brownley K, Hamer R, Zucker N, Roux-Lombard P, Dayer J, Bulik C The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study. Cytokine, 2014-06-14;69(1):110-5. 2014-06-14 [PMID: 25022969] (Human)
• Putko B, Wang Z, Lo J, Anderson T, Becher H, Dyck J, Kassiri Z, Oudit G Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology. PLoS ONE, 2014-06-12;9(6):e99495. 2014-06-12 [PMID: 24923671] (Human)
• Broch K, Askevold E, Gjertsen E, Ueland T, Yndestad A, Godang K, Stueflotten W, Andreassen J, Svendsmark R, Smith H, Aakhus S, Aukrust P, Gullestad L The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial. PLoS ONE, 2014-02-25;9(2):e89732. 2014-02-25 [PMID: 24586994] (Human)
• Funderburg N, Andrade A, Chan E, Rosenkranz S, Lu D, Clagett B, Pilch-Cooper H, Rodriguez B, Feinberg J, Daar E, Mellors J, Kuritzkes D, Jacobson J, Lederman M Dynamics of immune reconstitution and activation markers in HIV+ treatment-naive patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine. PLoS ONE, 2013-12-18;8(12):e83514. 2013-12-18 [PMID: 24367599] (Human)
• Wong J, Muthuswamy R, Bartlett D, Kalinski P IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology, 2013-09-12;2(9):e26245. 2013-09-12 [PMID: 24228233] (Human)
• Lee J, Gohda T, Walker W, Skupien J, Smiles A, Holak R, Jeong J, McDonnell K, Krolewski A, Niewczas M Risk of ESRD and all cause mortality in type 2 diabetes according to circulating levels of FGF-23 and TNFR1. PLoS ONE, 2013-03-20;8(3):e58007. 2013-03-20 [PMID: 23526964] (Human)
• Shimizu M, Yachie A Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages. Cytokine, 2012-06-08;60(1):226-32. 2012-06-08 [PMID: 22682876] (Human)
• Grote VA, Kaaks R, Nieters A, Tjonneland A, Halkjaer J, Overvad K, Skjelbo Nielsen MR, Boutron-Ruault MC, Clavel-Chapelon F, Racine A, Teucher B, Becker S, Pischon T, Boeing H, Trichopoulou A, Cassapa C, Stratigakou V, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Rodriguez L, Duell EJ, Sanchez MJ, Dorronsoro M, Navarro C, Gurrea AB, Siersema PD, Peeters PH, Ye W, Sund M, Lindkvist B, Johansen D, Khaw KT, Wareham N, Allen NE, Travis RC, Fedirko V, Jenab M, Michaud DS, Chuang SC, Romaguera D, Bueno-de-Mesquita HB, Rohrmann S Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. Br. J. Cancer, 2012-04-26;106(11):1866-74. 2012-04-26 [PMID: 22617158] (Human)
• Barbour KE, Boudreau R, Danielson ME, Youk AO, Wactawski-Wende J, Greep NC, LaCroix AZ, Jackson RD, Wallace RB, Bauer DC, Allison MA, Cauley JA Inflammatory markers and the risk of hip fracture: the Women's Health Initiative. J. Bone Miner. Res., 2012-05-01;27(5):1167-76. 2012-05-01 [PMID: 22392817] (Human)
• Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults. PLoS ONE, 2011-10-13;6(10):e26050. 2011-10-13 [PMID: 22022504] (Human)
• Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, Shen Y Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol Neurodegener, 2011-10-06;6(0):69. 2011-10-06 [PMID: 21978728] (Human)
• Kawut SM, Barr RG, Johnson WC Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study. Biomarkers, 2010-10-05;15(8):731-8. 2010-10-05 [PMID: 20923324] (Human)
• Johansson AC, Nandakumar KS, Persson AM, Olsson I, Hansson M Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy. Exp. Hematol., 2009-05-30;37(8):969-78. 2009-05-30 [PMID: 19486922] (Mouse)
• Gombos T, Forhecz Z, Pozsonyi Z, Wallentin S, Papassotiriou J, Kunde J, Morgenthaler NG, Janoskuti L, Prohaszka Z Adrenomedullin and endothelin-1 are related to inflammation in chronic heart failure. Inflamm. Res., 2009-06-01;58(6):298-305. 2009-06-01 [PMID: 19212702] (Human)
• Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Collins B, Basta M, Pejovic S, Chrousos GP Selective effects of CPAP on sleep apnoea-associated manifestations. Eur. J. Clin. Invest., 2008-08-01;38(8):585-95. 2008-08-01 [PMID: 18627419] (Human)
• Choi SW, Kitko CL, Braun T, Paczesny S, Yanik G, Mineishi S, Krijanovski O, Jones D, Whitfield J, Cooke K, Hutchinson RJ, Ferrara JL, Levine JE Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival. Blood, 2008-05-23;112(4):1539-42. 2008-05-23 [PMID: 18502834] (Human)
• Denollet J, Vrints CJ, Conraads VM Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure. Brain Behav. Immun., 2008-02-20;22(5):736-43. 2008-02-20 [PMID: 18068948] (Human)
• Canault M, Leroyer AS, Peiretti F, Leseche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am. J. Pathol., 2007-09-14;171(5):1713-23. 2007-09-14 [PMID: 17872973] (Human)
• Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J. Am. Coll. Cardiol., 2007-06-04;49(24):2341-9. 2007-06-04 [PMID: 17572250] (Human)
• Doucet M, Russell AP, Leger B, Debigare R, Joanisse DR, Caron MA, LeBlanc P, Maltais F Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 2007-05-03;176(3):261-9. 2007-05-03 [PMID: 17478621] (Human)
• Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J. Bone Miner. Res., 2007-07-01;22(7):1088-95. 2007-07-01 [PMID: 17419681] (Human)
• Corvino CL, Mamoni RL, Fagundes GZ, Blotta MH Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. Clin. Exp. Immunol., 2007-03-01;147(3):483-90. 2007-03-01 [PMID: 17302897] (Human)
• Tellier E, Rebsomen L The shedding activity of ADAM17 is sequestered in lipid rafts. Exp. Cell Res., 2006-09-05;312(20):3969-80. 2006-09-05 [PMID: 17010968] (Primate - Cholrocebus pygerythrus (Vervet Monkey))
• Lecube A, Hernandez C, Genesca J, Simo R Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study. Diabetes Care, 2006-05-01;29(5):1096-101. 2006-05-01 [PMID: 16644643] (Human)
• D'Osualdo A Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications. Arthritis Rheum., 2006-03-01;54(3):998-1008. 2006-03-01 [PMID: 16508982] (Human)
• Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, Saussereau E, El-Sayed R, Chollet-Martin S Experimental heatstroke in baboon: analysis of the systemic inflammatory response. Shock, 2005-10-01;24(4):332-5. 2005-10-01 [PMID: 16205317] (Primate - Papio hamadryas (Hamadyras Baboon))
• Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005-09-07;31(5):335-48. 2005-09-07 [PMID: 16099671] (Human)
• Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA, Chollet-Martin S Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. Crit. Care Med., 2005-06-01;33(6):1359-64. 2005-06-01 [PMID: 15942356] (Human)
• Parissis JT, Adamopoulos S, Karatzas D, Paraskevaidis J, Livanis E, Kremastinos D Growth hormone-induced reduction of soluble apoptosis mediators is associated with reverse cardiac remodelling and improvement of exercise capacity in patients with idiopathic dilated cardiomyopathy. Eur J Cardiovasc Prev Rehabil, 2005-04-01;12(2):164-8. 2005-04-01 [PMID: 15785303] (Human)
• Kaneyama K, Segami N, Sun W, Sato J, Fujimura K Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005-04-01;99(4):411-8. 2005-04-01 [PMID: 15772591] (Human)
• Kaneyama K, Segami N, Sun W, Sato J, Fujimura K Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005-03-01;99(3):276-84. 2005-03-01 [PMID: 15716832] (Human)
• Tagawa T, Kozower BD, Kanaan SA, Daddi N, Muraoka M, Oka T, Ritter JH, Patterson GA Gene transfer of tumor necrosis factor inhibitor improves the function of lung allografts. J. Thorac. Cardiovasc. Surg., 2004-06-01;127(6):1558-63. 2004-06-01 [PMID: 15173707] (Human)
• McNamara PS, Flanagan BF, Selby AM, Hart CA, Smyth RL Pro- and anti-inflammatory responses in respiratory syncytial virus bronchiolitis. Eur. Respir. J., 2004-01-01;23(1):106-12. 2004-01-01 [PMID: 14738241] (Human)
• Lukashevich IS, Tikhonov I, Rodas JD, Zapata JC, Yang Y, Djavani M, Salvato MS Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation. J. Virol., 2003-02-01;77(3):1727-37. 2003-02-01 [PMID: 12525606] (Primate - Macaca mulatta (Rhesus Macaque))
• Attanasio R, Brasky KM, Robbins SH, Jayashankar L, Nash RJ, Butler TM Age-related autoantibody production in a nonhuman primate model. Clin. Exp. Immunol., 2001-03-01;123(3):361-5. 2001-03-01 [PMID: 11298120] (Primate - Papio cynocephalus (Yellow Baboon))
• Rooney M, Varsani H, Martin K, Lombard PR, Dayer JM, Woo P Tumour necrosis factor alpha and its soluble receptors in juvenile chronic arthritis. Rheumatology (Oxford), 2000-04-01;39(4):432-8. 2000-04-01 [PMID: 10817778] (Human)
• Welty-Wolf KE, 2016, Carraway MS, Ghio A, Kantrow SP, Huang YC, Piantadosi CA Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. 1-23, 2000-05-01;13(5):404-9. 2000-05-01 [PMID: 10807017] (Primate - Papio cynocephalus (Yellow Baboon))
• Otterness IG, Swindell AC, Zimmerer RO, Poole AR, Ionescu M, Weiner E An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline. Osteoarthr. Cartil., 2000-05-01;8(3):180-5. 2000-05-01 [PMID: 10806045] (Human)

Bioinformatics

• Gene Symbol: TNFRSF1A