TWEAK R/TNFRSF12 Antibody (ITEM-4) [Biotin]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow
Clone
ITEM-4
Clonality
Monoclonal
Host
Mouse
Conjugate
Biotin

TWEAK R/TNFRSF12 Antibody (ITEM-4) [Biotin] Summary

Immunogen
The immunogen for this antibody is TWEAKR.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF12A
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
This has been tested by flow cytometric analysis on human or mouse Fn14 transfected cells. This can be used at less than or equal to 1 ug per test. A test is defined as the amount (ug)/test of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
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Reviewed Applications
Read 1 Review rated 4
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NBP1-43483 in the following application:

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Purity
Protein A or G purified

Alternate Names for TWEAK R/TNFRSF12 Antibody (ITEM-4) [Biotin]

  • CD266 antigen
  • CD266
  • FGF-inducible 14
  • Fibroblast growth factor-inducible immediate-early response protein 14
  • Fn14
  • FN14tumor necrosis factor receptor superfamily member 12A
  • TNFRSF12
  • TNFRSF12A
  • tumor necrosis factor receptor superfamily, member 12A
  • TWEAK R
  • TWEAKR
  • tweak-receptor
  • type I transmembrane protein Fn14

Background

The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration. It has been reported that ITEM-4 cross-reacts with mouse Fn14. In the mouse, Fn14 is reported to be constitutively expressed by Colon 26 cell line.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Review for TWEAK R/TNFRSF12 Antibody (NBP1-43483) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.
We have 1 review tested in 1 application: Flow.

Reviews using NBP1-43483:
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Images Ratings Applications Species Date Details
Flow Cytometry TWEAK R/TNFRSF12 NBP1-43483
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reviewed by:
Guanhua Xie
Flow Mouse 04/28/2014
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Summary

ApplicationFlow Cytometry
SpeciesMouse

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Recent Reviews

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Guanhua Xie
04/28/2014
Application: Flow
Species: Mouse

Bioinformatics

Gene Symbol TNFRSF12A
Entrez