TRAF3IP2 Antibody


Western Blot: TRAF3IP2 Antibody [NB100-56740] - Analysis of CIKS using NB100-56740 on 15 ugs of mouse kidney cell lysate.
Immunohistochemistry-Paraffin: TRAF3IP2 Antibody [NB100-56740] - Analysis of ACT1 in human kidney tissue using ACT1 antibody at 5 ug/ml.
Western Blot: TRAF3IP2 Antibody [NB100-56740] - Analysis of ACT1 in human kidney lysate in the A) absence and B) presence of immunizing peptide using ACT1 antibody at 2 ug/ml.
Simple Western: TRAF3IP2 Antibody [NB100-56740] - Simple Western lane view shows a specific band for TRAF3IP2 in 0.5 mg/ml of Hek293 lysate. This experiment was performed under reducing conditions using the 12-230 kDa more

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, Simple Western, IHC-P
0.5 mg/ml

Order Details

TRAF3IP2 Antibody Summary

This antibody was developed against a synthetic peptide (QDLPRPLRSREFPQFEP) corresponding to amino acids 225-241 of human TRAF3IP2.
An approx. 60 kDa band is observed.
Protein G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
0.5 mg/ml
Protein G purified


  • Western Blot 1-2 ug/ml
  • Simple Western 1:10
  • Immunohistochemistry-Paraffin
Application Notes
In Simple Western only 10-15 uL of the recommended dilution is used per data point.
Read Publications using
NB100-56740 in the following applications:

  • IP
    1 publication
  • WB
    3 publications

Reactivity Notes

Predicted to react with Rat. The amino acid sequence used as immunogen for this antibody is 100% homologous in human, 88% in rat, and 82% in mouse.

Alternate Names for TRAF3IP2 Antibody

  • ACT1DKFZP586G0522
  • adapter protein CIKS
  • C6orf2
  • C6orf4chromosome 6 open reading frame 5
  • C6orf5DKFZp586G0522
  • C6orf6MGC3581
  • CIKSchromosome 6 open reading frame 2
  • Connection to IKK and SAPK/JNK
  • NFkB-activating protein ACT1
  • Nuclear factor NF-kappa-B activator 1
  • TRAF3 interacting protein 2
  • TRAF3-interacting protein 2


NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines, such as IL-1 results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes (2). Recently, Li et al. (3) have isolated a cDNA coding for a protein named Act1 (NF- B activator 1). Act1/CIKS cDNA codes for a protein containing 574 aa with a predicated molecular mass of 60 kDa. Act1/CIKS protein contains a helix-loop-helix domain in its N-terminal portion and a coiled-coil structure at the C terminus. Act1 lacks any catalytic domain, however, it activates IKK through the helix-loop-helix domain. The activation of NF- B by Act1 appears to be through the NIK-IKK complex, because a NIK dominant-negative mutant protein inhibited Act1-induced NF- B activation. IL-1 responsive pathway is also necessary for Act1 function. Act1 mRNA is expressed in a variety of tissues, with high level in thymus, kidney and placenta; moderate level in heart, skeletal muscle, colon, liver, lung and small intestine; and at a very low level in brain, spleen, and peripheral blood leukocytes.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRAF3IP2 Antibody (NB100-56740)(5)

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

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Contact Information

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Gene Symbol TRAF3IP2

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