Human CCL4/MIP-1 beta Quantikine ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

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Catalog# & Conjugate Size Price

Human CCL4/MIP-1 beta Quantikine ELISA Kit Summary

Background
The Quantikine Human MIP-1 beta Immunoassay is a 3.0 or 4.5 hour solid phase ELISA designed to measure MIP-1 beta in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human MIP-1 beta (Act-2 variant) and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant human MIP-1 beta. Resu...lts obtained using natural human MIP-1 beta showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human MIP-1 beta.
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Specificity
Natural and recombinant human MIP-1 beta
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CCL4

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DMB00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL4/MIP-1 beta Quantikine ELISA Kit

  • ACT2
  • ACT-2
  • AT744.1
  • C-C motif chemokine 4
  • CCL4
  • chemokine (C-C motif) ligand 4
  • Exodus-3
  • G-26 T-lymphocyte-secreted protein
  • G-26
  • HC21
  • LAG1
  • LAG-1
  • Lymphocyte activation gene 1 protein
  • Macrophage inflammatory protein 1-beta
  • MIP1 beta
  • MIP-1 beta
  • MIP1B
  • MIP1B1
  • MIP-1-beta
  • MIP-1-beta(1-69)
  • PAT 744
  • Protein H400
  • SCYA2
  • SCYA4
  • secreted protein G-26
  • SIS-gamma
  • small inducible cytokine A4 (homologous to mouse Mip-1b)
  • Small-inducible cytokine A4
  • T-cell activation protein 2

Background

CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL4/MIP-1 beta (DMB00)(43)

We have publications tested in 4 confirmed species: Human, Primate, Primate - Macaca mulatta (Rhesus Macaque), Primate - Pan troglodytes (Chimpanzee).


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Human
(39)
Primate
(1)
Primate - Macaca mulatta (Rhesus Macaque)
(2)
Primate - Pan troglodytes (Chimpanzee)
(1)
All Species
Showing Publications 1 - 10 of 43. Show All 43 Publications.
Publications using DMB00 Applications Species
A Hackel, A Aksamit, K Bruderek, S Lang, S Brandau TNF-alpha and IL-1beta sensitize human MSC for IFN-gamma signalling and enhance neutrophil recruitment Eur. J. Immunol., 2020;0(0):. 2020 [PMID: 32845509] (Human) Human
L Sadeghi, G Arvidsson, M Merrien, A M Wasik, A Görgens, CIE Smith, B Sander, AP Wright Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells Cancers (Basel), 2020;12(5):. 2020 [PMID: 32370190] (Human) Human
Y Lu, BK Yoo, AHC Ng, J Kim, S Yeom, J Tang, MM Lin, AH Zewail, JR Heath 4D electron microscopy of T cell activation Proc. Natl. Acad. Sci. U.S.A., 2019;116(44):22014-22019. 2019 [PMID: 31611413] (Human) Human
N Aziz, R Detels, JJ Quint, D Gjertson, T Ryner, AW Butch Biological variation of immunological blood biomarkers in healthy individuals and quality goals for biomarker tests BMC Immunol., 2019;20(1):33. 2019 [PMID: 31521107] (Human) Human
N Zhang, G Zhang, N Liu, W Lin, S Ji, M Zheng, K Chen, X Liang, G Li, Y Ma, J Zhu, T Niu, LL Li, J Li, YQ Wei, SY Yang A novel orally available Syk/Src/Jak2 inhibitor, SKLB-850, showed potent anti-tumor activities in B cell lymphoma (BCL) models Oncotarget, 2017;8(67):111495-111507. 2017 [PMID: 29340070] (Human) Human
NA Johdi, L Mazlan, I Sagap, R Jamal Profiling of cytokines, chemokines and other soluble proteins as a potential biomarker in colorectal cancer and polyps Cytokine, 2017;99(0):35-42. 2017 [PMID: 28689023] (Human) Human
Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia J Immunol, 2016;0(0):. 2016 [PMID: 27534555] (Human) Human
Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions Cytokine, 2016;84(0):17-24. 2016 [PMID: 27208752] (Human) Human
Sadeghi M, Lahdou I, Oweira H, Daniel V, Terness P, Schmidt J, Weiss K, Longerich T, Schemmer P, Opelz G, Mehrabi A Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma. Br J Cancer, 2015;113(5):756-62. 2015 [PMID: 26270232] (Human) Human
Balakrishnan K, Peluso M, Fu M, Rosin N, Burger J, Wierda W, Keating M, Faia K, O'Brien S, Kutok J, Gandhi V The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL. Leukemia, 2015;29(9):1811-22. 2015 [PMID: 25917267] (Human) Human
Show All 43 Publications.

Reviews for CCL4/MIP-1 beta (DMB00) (0)

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Product General Protocols

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FAQs for CCL4/MIP-1 beta (DMB00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DMB00
HRP DMB00
HRP DMB00

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Bioinformatics

Gene Symbol CCL4