Human BAFF/BLyS/TNFSF13B Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human BAFF/BLyS/TNFSF13B Quantikine ELISA Kit Summary

Background
The Quantikine Human BAFF/BLyS Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BAFF/BLyS in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human BAFF/BLyS and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human BAFF/BLyS showed linear curves that were parallel to the standard curves obta...ined using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human BAFF.
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Specificity
Natural and recombinant human BAFF/BLyS
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
TNFSF13B

Applications/Dilutions

Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using DBLYS0B.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human BAFF/BLyS/TNFSF13B Quantikine ELISA Kit

  • ApoL related ligand TALL-1
  • B lymphocyte stimulator
  • BAFF
  • BAFFB-cell activating factor
  • B-cell-activating factor
  • BLyS
  • BLYSB-lymphocyte stimulator
  • CD257 antigen
  • CD257
  • Dendritic cell-derived TNF-like molecule
  • DTL
  • TALL1
  • TALL-1delta BAFF
  • TALL1Delta4 BAFF
  • THANK
  • TNF- and APOL-related leukocyte expressed ligand 1
  • TNF and ApoL-related leukocyte expressed ligand 1
  • TNF homolog that activates apoptosis
  • TNFSF13B
  • TNFSF20
  • tumor necrosis factor (ligand) superfamily, member 13b
  • tumor necrosis factor (ligand) superfamily, member 20
  • tumor necrosis factor ligand superfamily member 13B
  • tumor necrosis factor superfamily, member 13b
  • tumor necrosis factor-like protein ZTNF4
  • ZTNF4

Background

BAFF (B-cell activating factor), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a TNF superfamily ligand that plays a critical role in the development and survival of B lineage cells. It can be expressed as a homotrimer or as a heteromer in association with the related protein APRIL. It is produced by many hematopoietic cell types, and a soluble form can be released by activated neutrophils. Both BAFF and APRIL signal through the receptors BCMA and TACI, and BAFF additionally signals through BAFF R. Mice that overexpress BAFF exhibit elevated B cell numbers, increased formation and size of germinal centers, and symptoms of autoimmunity. In addition, BAFF costimulates T cell activation, promotes a Th1 biased immune response, and promotes the expansion of Treg cells.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for BAFF/BLyS/TNFSF13B (DBLYS0B)(53)

We have publications tested in 2 confirmed species: Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).


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Human
(51)
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
(1)
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Showing Publications 1 - 10 of 53. Show All 53 Publications.
Publications using DBLYS0B Applications Species
J Irure-Vent, D San Segund, E Rodrigo, D Merino, L Belmar-Veg, JC Ruiz San M, R Valero, A Benito, M López-Hoyo High Pretransplant BAFF Levels and B-cell Subset Polarized towards a Memory Phenotype as Predictive Biomarkers for Antibody-Mediated Rejection Int J Mol Sci, 2020;21(3):. 2020 [PMID: 31991734] (Human) Human
A Brinkhoff, Y Zeng, A Sieberichs, S Dolff, X Shilei, M Sun, H Engler, S Benson, J Korth, M Schedlowsk, A Kribben, O Witzke, B Wilde B cell dynamics during experimental endotoxemia in humans Biosci. Rep., 2019;0(0):. 2019 [PMID: 30962268] (Human) Human
V Lagou, JE Garcia-Per, I Smets, L Van Horebe, M Vandebergh, L Chen, K Mallants, T Prezzemolo, K Hilven, S Humblet-Ba, M Moisse, P Van Damme, G Boeckxstae, P Bowness, B Dubois, J Dooley, A Liston, A Goris Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators Cell Rep, 2018;25(3):798-810.e6. 2018 [PMID: 30332657] (Human) Human
AS Wilhelmson, M Lantero Ro, A Stubelius, P Fogelstran, I Johansson, MB Buechler, S Lianoglou, VN Kapoor, ME Johansson, JB Fagman, A Duhlin, P Tripathi, A Camponesch, BT Porse, AG Rolink, H Nissbrandt, SJ Turley, H Carlsten, IL Mårtensson, MCI Karlsson, Å Tivesten Testosterone is an endogenous regulator of BAFF and splenic B cell number Nat Commun, 2018;9(1):2067. 2018 [PMID: 29802242] (Human) Human
K James, C Chipeta, A Parker, S Harding, SJ Cockell, CS Gillespie, J Hallinan, F Barone, SJ Bowman, WF Ng, BA Fisher, B-cell activity markers are associated with different disease activity domains in primary Sj�gren's syndrome Rheumatology (Oxford), 2018;0(0):. 2018 [PMID: 29608774] (Human) Human
L Alvarez, L Riancho, J Calvo-Alén, M Lopez Hoyo, V Martinez-T Peripheral B-Cell Subset Distribution in Primary Antiphospholipid Syndrome Int J Mol Sci, 2018;19(2):. 2018 [PMID: 29462939] (Human) Human
J Heremans, JE Garcia-Per, E Turro, SM Schlenner, I Casteels, R Collin, F de Zegher, D Greene, S Humblet-Ba, S Lesage, P Matthys, CJ Penkett, K Put, K Stirrups, C Thys, C Van Geet, E Van Nieuwe, C Wouters, I Meyts, K Freson, A Liston, Abnormal differentiation of B cells and megakaryocytes in Roifman syndrome J. Allergy Clin. Immunol., 2018;0(0):. 2018 [PMID: 29391254] (Human) Human
I Smets, B Fiddes, JE Garcia-Per, D He, K Mallants, W Liao, J Dooley, G Wang, S Humblet-Ba, B Dubois, A Compston, J Jones, A Coles, A Liston, M Ban, A Goris, S Sawcer Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells Brain, 2018;0(0):. 2018 [PMID: 29361022] (Human) Human
Y Fu, L Wang, C Xie, K Zou, L Tu, W Yan, X Hou Comparison of non-invasive biomarkers faecal BAFF, calprotectin and FOBT in discriminating IBS from IBD and evaluation of intestinal inflammation Sci Rep, 2017;7(1):2669. 2017 [PMID: 28572616] (Human) Human
S Wang, T Yang, J Wan, Y Zhang, Y Fan Elevated C-X-C motif ligand 13 and B-cell-activating factor levels in neuromyelitis optica during remission Brain Behav, 2017;7(4):e00648. 2017 [PMID: 28413701] (Human) Human
Show All 53 Publications.

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Product General Protocols

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FAQs for BAFF/BLyS/TNFSF13B (DBLYS0B). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DBLYS0B
HRP DBLYS0B
HRP DBLYS0B

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Bioinformatics

Gene Symbol TNFSF13B