Human CD40 Ligand/TNFSF5 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human CD40 Ligand/TNFSF5 Quantikine ELISA Kit Summary

Background
The Quantikine Human CD40 Ligand Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CD40 Ligand in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human CD40 Ligand and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CD40 Ligand showed linear curves that were parallel to the... standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CD40 Ligand.
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Specificity
Natural and recombinant human CD40 Ligand
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CD40LG

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DCDL40.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CD40 Ligand/TNFSF5 Quantikine ELISA Kit

  • CD154 antigen
  • CD154
  • CD40 antigen ligand
  • CD40 Ligand
  • CD40L
  • CD40-L
  • CD40LG
  • CD40LIGM
  • gp39
  • hCD40L
  • HIGM1
  • T-B cell-activating molecule
  • T-BAM
  • T-cell antigen Gp39
  • TNF-related activation protein
  • TNFSF5
  • TNFSF5IMD3
  • TRAP
  • TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
  • tumor necrosis factor (ligand) superfamily member 5
  • Tumor necrosis factor ligand superfamily member 5

Background

CD40 Ligand, also known as TNFSF5, CD154, TRAP, and gp39, is a trimeric protein that is expressed in transmembrane and soluble forms. It is expressed by many immune cell types as well as by endothelial and smooth muscle cells of the vasculature. It binds to CD40 on antigen presenting cells, platelets, and endothelial and epithelial cells, leading to enhanced B cell activation and T cell dependent humoral immune responses. CD40 Ligand dysregulation contributes to immune pathology in AIDS, atherosclerosis, atherothrombosis, and restenosis.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CD40 Ligand/TNFSF5 (DCDL40)(39)

We have publications tested in 1 confirmed species: Human.


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Human
(39)
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Showing Publications 1 - 10 of 39. Show All 39 Publications.
Publications using DCDL40 Applications Species
N Aziz, R Detels, JJ Quint, D Gjertson, T Ryner, AW Butch Biological variation of immunological blood biomarkers in healthy individuals and quality goals for biomarker tests BMC Immunol., 2019;20(1):33. 2019 [PMID: 31521107] (Human) Human
T Sun, M Ju, X Dai, H Dong, W Gu, Y Gao, R Fu, X Liu, Y Huang, W Liu, Y Chi, W Wang, H Li, Y Zhou, L Shi, R Yang, L Zhang Multilevel defects in the hematopoietic niche in essential thrombocythemia Haematologica, 2019;0(0):. 2019 [PMID: 31289202] (Human) Human
ZL Liu, J Hu, XF Xiao, Y Peng, SP Zhao, XZ Xiao, MS Yang The CD40 rs1883832 Polymorphism Affects Sepsis Susceptibility and sCD40L Levels Biomed Res Int, 2018;2018(0):7497314. 2018 [PMID: 29780830] (Human) Human
CD Ruediger, B John, S Kumar, HS Lim, G Rangnekar, KC Roberts-Th, GD Young, D Chase, P Sanders, SR Willoughby Influence of ethnic background on left atrial markers of inflammation, endothelial function and tissue remodelling Indian Pacing Electrophysiol J, 2018;18(1):1-5. 2018 [PMID: 29477215] (Human) Human
A Szentpéter, N Zsíros, VE Varga, H L?rincz, M Katkó, I Seres, P Fülöp, G Paragh, M Harangi Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia VASA, 2017;0(0):1-7. 2017 [PMID: 28602123] (Human) Human
L Lorente, MM Martín, A Pérez-Ceja, J Ferreres, J Solé-Violá, L Labarta, C Díaz, A Jiménez Non-survivor septic patients have persistently higher serum sCD40L levels than survivors J Crit Care, 2017;41(0):177-182. 2017 [PMID: 28570959] (Human) Human
V Bláha, M Bláha, M Lánská, D Solichová, L Kujovská K, E Havel, P Vyroubal, Z Zadák, P Žák, L Sobotka Lipoprotein apheresis in the treatment of dyslipidaemia - the Czech Republic experience Physiol Res, 2017;66(0):S91-S100. 2017 [PMID: 28379034] (Human) Human
Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis Sci Rep, 2016;6(0):36862. 2016 [PMID: 27857173] (Human) Human
Potential predictive role of chemotherapy-induced changes of soluble CD40 ligand in untreated advanced pancreatic ductal adenocarcinoma Onco Targets Ther, 2016;9(0):4681-6. 2016 [PMID: 27555786] (Human) Human
Fuentes E, Pereira J, Mezzano D, Alarcon M, Caballero J, Palomo I Inhibition of platelet activation and thrombus formation by adenosine and inosine: studies on their relative contribution and molecular modeling. PLoS ONE, 2014;9(11):e112741. 2014 [PMID: 25393959] (Human) Human
Show All 39 Publications.

Reviews for CD40 Ligand/TNFSF5 (DCDL40) (0)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for CD40 Ligand/TNFSF5 (DCDL40). (Showing 1 - 2 of 2 FAQs).

  1. I am looking for paired ABs for use in detecting CD40L (rat) by ELISA. Do you have such a reagent(s) available?
    • Unfortunately we currently do not have any CD40 Ligand antibody pairs that have been validated in Rat. The only antibody pairs we offer for CD40L are validated in Human. I apologize for this inconvenience. If you would be interested in testing one of our products in Rat I'd like to invite you to participate in our Innovators Reward Program. Please contact us at innovators@novusbio.com with any questions regarding this program.
  2. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DCDL40
HRP DCDL40
HRP DCDL40

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Bioinformatics Tool for CD40 Ligand/TNFSF5 (DCDL40)

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Bioinformatics

Gene Symbol CD40LG