IL-17RA/IL-17R Antibody (133617) [Unconjugated]


K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human IL-17 R Monoclonal Antibody (Catalog # MAB177, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram) more
Recombinant Human IL‑17/IL‑17A induces CXCL1/GRO alpha secretion in the HT‑29 human colon adenocarcinoma cell line in a dose-dependent manner (orange line), as measured by the Human CXCL1/GRO alpha DuoSet more
Genetic Strategies: IL-17 RA/IL-17 R knockout K562 human myelogenous leukemia cell line was stained with Mouse Anti-Human IL-17 RA/IL-17 R Monoclonal Antibody (Catalog # MAB177, filled histogram) or isotype more

Product Details

Reactivity HuSpecies Glossary
Applications WB, Flow, B/N, CyTOF-ready, KO
Validated by:

Genetic Strategies


Order Details

IL-17RA/IL-17R Antibody (133617) [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant human IL‑17 RA/IL‑17 R
Accession # Q96F46
Detects human IL‑17 RA/IL‑17 R in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) IL‑17 R, rmIL‑17B R, or recombinant human IL‑17B R is observed. In Western blots, no cross-reactivity with rmIL-17 R is observed
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Knockout Validated 0.25 ug/10^6 cells
  • Neutralization
  • Western Blot 1 ug/mL
Read Publications using
MAB177 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-17RA/IL-17R Antibody (133617) [Unconjugated]

  • CD217 antigen
  • CD217
  • Cdw217
  • CDw217interleukin 17 receptor
  • hIL-17R
  • IL-17 R
  • IL-17 RA
  • IL-17 receptor A
  • IL17RA
  • IL-17RA
  • IL-17RAMGC10262
  • IL17Rinterleukin-17 receptor A
  • interleukin 17 receptor A


Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R) which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL-17 R is a 120 kDa, 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. Within the ECD, human IL-17 R shares 72% aa sequence identity with mouse and rat IL‑17 R. The signaling events of IL-17 includes activation of NF-kappa B and JNK, and require TNF receptor-associated factors 6 (TRAF6) in the signaling pathway.

  1. Yao, Z. et al. (1997) Cytokine 9:794.
  2. Schwander, R. et al. (2000) J. Exp. Med. 191:1233.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-17RA/IL-17R Antibody (MAB177)(17)

We have publications tested in 2 confirmed species: Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).

We have publications tested in 5 applications: Flow Cytometry, IHC, IHC-P, Neutralization, Western Blot.

Filter By Application
Flow Cytometry
Western Blot
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Filter By Species
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
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Showing Publications 1 - 10 of 17. Show All 17 Publications.
Publications using MAB177 Applications Species
G Margetts, S Kleidonas, NS Zaibi, MS Zaibi, KD Edwards Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L BMC complementary medicine and therapies, 2022-05-12;22(1):131. 2022-05-12 [PMID: 35550086] (Neutralization, Human) Neutralization Human
JW Bolt, AW van Kuijk, MBM Teunissen, D van der Co, S Aarrass, DM Gerlag, PP Tak, MG van de San, MC Lebre, LGM van Baarse Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis Biomedicines, 2022-01-29;10(2):. 2022-01-29 [PMID: 35203534] (IHC, Human) IHC Human
A Gatsiou, K Sopova, A Tselepis, K Stellos Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State Cells, 2021-07-22;10(8):. 2021-07-22 [PMID: 34440624] (Western Blot, Human) Western Blot Human
J Wu, J Guo, Q Cao, Y Wang, J Chen, Z Wang, Z Yuan Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway Oncol Lett, 2016-12-08;13(2):770-776. 2016-12-08 [PMID: 28356957] (Neutralization, Human) Neutralization Human
PA Szabo, A Goswami, DM Mazzuca, K Kim, DB O'Gorman, DA Hess, ID Welch, HA Young, B Singh, JK McCormick, SM Haeryfar Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology J. Immunol, 2017-02-20;0(0):. 2017-02-20 [PMID: 28219889] (Neutralization, Human) Neutralization Human
Schminke B, Trautmann S, Mai B, Miosge N, Blaschke S Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage. Eur J Immunol, 2015-12-14;46(2):440-5. 2015-12-14 [PMID: 26558442] (Western Blot, Human) Western Blot Human
Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, Ryan-Payseur B, Chen Z Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vgamma2Vdelta2 T cells after Mycobacterium tuberculosis infection or vaccination. Eur J Immunol, 2015-02-01;45(2):442-51. 2015-02-01 [PMID: 25141829] (Neutralization, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)) Neutralization Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol, 2011-12-21;5(2):140-9. 2011-12-21 [PMID: 22189956] (Flow Cytometry, Human) Flow Cytometry Human
Ramirez-Carrozzi V, Sambandam A, Luis E IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol., 2011-10-12;12(12):1159-66. 2011-10-12 [PMID: 21993848] (Neutralization, Human) Neutralization Human
Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH TH17 cytokines induce human airway smooth muscle cell migration. J. Allergy Clin. Immunol., 2011-02-22;127(4):1046-53.e1-2. 2011-02-22 [PMID: 21345484] (Neutralization, Human) Neutralization Human
Show All 17 Publications.

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Gene Symbol IL17RA