TRAF3IP2 Products

Description

TRAF3IP2 encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.

Bioinformatics

Entrez	103213 Mouse 10758 Human
Uniprot	AAG15367 Human AAH02823 Human AF274303 Human NM_147686 Human NP_679211 Human O43734 Human
Product By Gene ID	10758
Alternate Names	ACT1DKFZP586G0522 adapter protein CIKS C6orf2 C6orf4chromosome 6 open reading frame 5 C6orf5DKFZp586G0522 C6orf6MGC3581 CIKSchromosome 6 open reading frame 2 Connection to IKK and SAPK/JNK NFkB-activating protein ACT1 Nuclear factor NF-kappa-B activator 1 TRAF3 interacting protein 2 TRAF3-interacting protein 2

Research Areas for TRAF3IP2

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Signal Transduction