TIM-1/KIM-1/HAVCR Antibody

Images

 
Western Blot: TIM-1/KIM-1/HAVCR Antibody [NBP1-76701] - Analysis of TIM-1 in 3T3 cell lysate with TIM-1 antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: TIM-1/KIM-1/HAVCR Antibody [NBP1-76701] - in Human Uterus cells. Dilution 20 ug/mL.
Immunohistochemistry-Paraffin: TIM-1/KIM-1/HAVCR Antibody [NBP1-76701] - Human uterus tissue with TIM-1 antibody at 10 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TIM-1/KIM-1/HAVCR Antibody Summary

Immunogen
Antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human TIM-1. The immunogen is located within amino acids 50 - 100 of TIM-1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HAVCR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
TIM-1 antibody can be used for the detection of TIM-1 by Western blot at 1 - 2 mg/ml Immunofluorescence/Immunocytochemistry (PMID: 22484054)
Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
TIM-1/KIM-1/HAVCR Peptide (NBP1-76701PEP)
Publications
Read Publications using
NBP1-76701 in the following applications:

  • 2 publications
  • IHC
    3 publications
  • WB
    4 publications

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TIM-1/KIM-1/HAVCR Antibody

  • CD365
  • HAVCR1
  • HAVCR-1
  • HAVCRT cell immunoglobin domain and mucin domain protein 1
  • hepatitis A virus cellular receptor 1
  • Kidney injury molecule 1
  • KIM1
  • KIM-1
  • T-cell immunoglobulin and mucin domain-containing protein 1
  • TIM1
  • TIM-1
  • TIM-1TIM
  • TIM1TIMD-1
  • TIMD1T-cell membrane protein 1

Background

The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TIM-1/KIM-1/HAVCR Antibody (NBP1-76701)(7)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC/IF, IHC, WB.


Filter By Application
ICC/IF
(2)
IHC
(3)
WB
(4)
All Applications
Filter By Species
Human
(1)
Mouse
(6)
All Species
Showing Publications 1 - 7 of 7.
Publications using NBP1-76701 Applications Species
Trudu M, Schaeffer C, Riba M et al. Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations Sci Rep 2017 Aug 07 [PMID: 28785050] (WB, Mouse) WB Mouse
Morrison MC, Yakala GK, Liang W et al. Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21. Sci Rep. 2017 Jun 06 [PMID: 28588299] (IHC, Mouse) IHC Mouse
Weber HM, Tsurkan MV, Magno V et al. Heparin-based hydrogels induce human renal tubulogenesis in vitro. Acta Biomater May 17 2017 [PMID: 28526628]
Pei L, Solis G, Nguyen MT et al. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney J. Clin. Invest Jul 1 2016 [PMID: 27214555] (ICC/IF, Mouse) ICC/IF Mouse
Trudu M, Janas S, Lanzani C et al. Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med. 2013 Dec [PMID: 24185693] (WB, Mouse) WB Mouse
Lim A,Chan L, Lai KN et al. Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells The International Journal of Biochemistry & Cell Biology 2012 Mar 27 [PMID: 22484054] (ICC/IF, WB, IHC, Human, Mouse) ICC/IF, WB, IHC Human, Mouse
Sorensen I, Rong S, Susnik N et al. Bbeta(15-42) attenuates the effect of ischemia-reperfusion injury in renal transplantation J Am Soc Nephrol 2011 Oct [PMID: 21841063] (IHC, WB, Mouse) IHC, WB Mouse

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics Tool for TIM-1/KIM-1/HAVCR Antibody (NBP1-76701)

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Bioinformatics

Gene Symbol HAVCR1
Entrez
Uniprot