Mouse IL-18/IL-1F4 ELISA

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse IL-18/IL-1F4 ELISA Summary

• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il18

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-18/IL-1F4 ELISA

• Iboctadekin
• IFN-gamma-inducing factor
• IGIF
• IGIFIL-1 gamma
• IL18
• IL-18
• IL-18MGC12320
• IL-1F4
• IL1F4iboctadekin
• IL-1g
• Interferon gamma-inducing factor
• interleukin 18 (interferon-gamma-inducing factor)
• Interleukin-1 gamma
• interleukin-18

Background

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1 gamma , is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-gamma and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-gamma that inhibits IgE production.

Publications for IL-18/IL-1F4 (7625)(53)

Publications using 7625

• Y Wang, C Chen, J Chen, T Sang, H Peng, X Lin, Q Zhao, S Chen, T Eling, X Wang Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation Redox Biology, 2022-04-27;52(0):102322. 2022-04-27 [PMID: 35504134] (Western Blot, Mouse)
• Y Bai, Q Han, B Dong, H Lin, Y Jiang, X Zhang, H Chen, Y Yu PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression Brain research bulletin, 2022-03-30;184(0):56-67. 2022-03-30 [PMID: 35367313] (Mouse)
• D Lian, L Zhu, Y Yu, X Zhang, Y Lin, J Liu, R Han, Y Guo, D Cai, W Xiao, Y Chen, H He, D Xu, C Zheng, X Wang, Y Huang, Y Chen Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation Journal of leukocyte biology, 2022-02-27;0(0):. 2022-02-27 [PMID: 35224772] (Mouse)
• P Xu, C Tao, Y Zhu, G Wang, L Kong, W Li, R Li, J Li, C Zhang, L Wang, X Liu, W Sun, W Hu TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage Journal of Neuroinflammation, 2021-08-30;18(1):188. 2021-08-30 [PMID: 34461942] (Mouse)
• E Igel, A Haller, PR Wolfkiel, M Orr-Asman, A Jaeschke, DY Hui Distinct pro-inflammatory properties of myeloid cell-derived apolipoprotein E2 and E4 in atherosclerosis promotion The Journal of Biological Chemistry, 2021-08-21;0(0):101106. 2021-08-21 [PMID: 34425108] (Mouse)
• H Zhang, X Li, J Wang, Q Cheng, Y Shang, G Wang Baicalin relieves Mycoplasma�pneumoniae infection?induced lung injury through regulating microRNA?221 to inhibit the TLR4/NF?&kappaB signaling pathway Molecular Medicine Reports, 2021-06-10;24(2):. 2021-06-10 [PMID: 34109422] (Mouse)
• SY Cheon, BN Koo, SY Kim, EH Kam, J Nam, EJ Kim Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice Scientific Reports, 2021-04-16;11(1):8376. 2021-04-16 [PMID: 33863952] (Mouse)
• L Ye, H Guo, Y Wang, Y Peng, Y Zhang, S Li, M Yang, L Wang Exosomal circEhmt1 Released from Hypoxia-Pretreated Pericytes Regulates High Glucose-Induced Microvascular Dysfunction via the NFIA/NLRP3 Pathway Oxidative Medicine and Cellular Longevity, 2021-03-18;2021(0):8833098. 2021-03-18 [PMID: 33815662] (Mouse)
• N Eissa, O Elgazzar, H Hussein, GN Hendy, CN Bernstein, JE Ghia Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis Biomedicines, 2021-02-01;9(2):. 2021-02-01 [PMID: 33535452] (Mouse)
• X Wu, S Pan, W Luo, Z Shen, X Meng, M Xiao, B Tan, K Nie, T Tong, X Wang Roseburia�intestinalis?derived flagellin ameliorates colitis by targeting miR?223?3p?mediated activation of NLRP3 inflammasome and pyroptosis Mol Med Rep, 2020-07-23;0(0):. 2020-07-23 [PMID: 32700754] (Mouse)
• G de la Rosa, AI Gómez, MC Baños, P Pelegrín Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1&beta Production Int J Mol Sci, 2020-06-30;21(13):. 2020-06-30 [PMID: 32630144] (Mouse)
• S Xiong, Z Hong, LS Huang, Y Tsukasaki, S Nepal, A Di, M Zhong, W Wu, Z Ye, X Gao, GN Rao, D Mehta, J Rehman, AB Malik IL-1beta suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury J. Clin. Invest., 2020-07-01;130(7):3684-3698. 2020-07-01 [PMID: 32298238] (Mouse)
• LR Ling, DH Zheng, ZY Zhang, WH Xie, YH Huang, ZX Chen, XZ Wang, D Li Effect of HBx on inflammation and mitochondrial oxidative stress in mouse hepatocytes Oncol Lett, 2020-02-17;19(4):2861-2869. 2020-02-17 [PMID: 32218840] (Mouse)
• H Lecoeur, E Prina, T Rosazza, K Kokou, P N'Diaye, N Aulner, H Varet, G Bussotti, Y Xing, G Milon, R Weil, G Meng, GF Späth Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-&kappaB/NLRP3-Mediated Inflammatory Response Cell Rep, 2020-02-11;30(6):1870-1882.e4. 2020-02-11 [PMID: 32049017] (Mouse)
• C Rumfield, I Hyseni, JW McBride, DH Walker, R Fang Activation of ASC Inflammasome Driven by TLR4 Contributes to Host Immunity against Rickettsial Infection Infect. Immun., 2020-03-23;0(0):. 2020-03-23 [PMID: 32014896] (Mouse)
• SL Wang, BZ Shao, SB Zhao, X Chang, P Wang, CY Miao, ZS Li, Y Bai Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease Cell Death Dis, 2019-09-30;10(6):391. 2019-09-30 [PMID: 31564717] (Mouse)
• RP Semper, M Vieth, M Gerhard, R Mejías-Luq Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses J. Immunol., 2019-09-11;0(0):. 2019-09-11 [PMID: 31511355] (Mouse)
• R Chen, L Zeng, S Zhu, J Liu, HJ Zeh, G Kroemer, H Wang, TR Billiar, J Jiang, D Tang, R Kang cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis Sci Adv, 2019-05-22;5(5):eaav5562. 2019-05-22 [PMID: 31131320] (Mouse)
• JH Bae, SI Jo, SJ Kim, JM Lee, JH Jeong, JS Kang, NJ Cho, SS Kim, EY Lee, JS Moon Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes Cells, 2019-04-08;8(4):. 2019-04-08 [PMID: 30965677] (Mouse)
• D Kurundkar, AR Kurundkar, NB Bone, EJ Becker, W Liu, B Chacko, V Darley-Usm, JW Zmijewski, VJ Thannickal SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury JCI Insight, 2019-01-10;4(1):. 2019-01-10 [PMID: 30626741] (Mouse)
• AP Perera, R Fernando, T Shinde, R Gundamaraj, B Southam, SS Sohal, AAB Robertson, K Schroder, D Kunde, R Eri MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice Sci Rep, 2018-06-05;8(1):8618. 2018-06-05 [PMID: 29872077] (Mouse)
• J Zhu, L Chen, Y Qi, J Feng, L Zhu, Y Bai, H Wu Protective effects of Erigeron breviscapus Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models Mol. Vis., 2018-04-25;24(0):315-325. 2018-04-25 [PMID: 29769797] (Rat)
• YH Kong, SP Xu Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis Oncol. Rep., 2018-04-18;0(0):. 2018-04-18 [PMID: 29693192] (Mouse)
• HM Song, X Li, YY Liu, WP Lu, ZH Cui, L Zhou, D Yao, HM Zhang Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS Int. J. Mol. Med., 2018-03-27;0(0):. 2018-03-27 [PMID: 29620148] (Mouse)
• ZW Dong, YF Yuan Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury Int. J. Mol. Med., 2018-03-09;41(6):3353-3365. 2018-03-09 [PMID: 29532887] (Mouse)
• CM Su, IC Wang, SC Liu, Y Sun, L Jin, SW Wang, HP Lee, WP Tseng, CH Tang Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts Sci Rep, 2017-08-07;7(1):7393. 2017-08-07 [PMID: 28785068] (Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)
• AR Aroor, J Habibi, HK Kandikattu, M Garro-Kach, B Barron, D Chen, MR Hayden, A Whaley-Con, SB Bender, T Klein, J Padilla, JR Sowers, B Chandrasek, VG DeMarco Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice Cardiovasc Diabetol, 2017-05-05;16(1):61. 2017-05-05 [PMID: 28476142] (Mouse)
• Michel van Gelder Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer Breast Cancer Res. Treat, 2016-12-03;0(0):. 2016-12-03 [PMID: 27915436] (Mouse)
• Arne Yndestad Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts Biochim. Biophys. Acta, 2016-11-12;0(0):. 2016-11-12 [PMID: 27845246] (Mouse)
• Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation J Immunol, 2016-08-12;0(0):. 2016-08-12 [PMID: 27521339] (Mouse)
• NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence Sci Rep, 2016-08-01;6(0):30943. 2016-08-01 [PMID: 27476670] (Mouse)
• Pellegrin M, Aubert J, Bouzourene K, Amstutz C, Mazzolai L Voluntary Exercise Stabilizes Established Angiotensin II-Dependent Atherosclerosis in Mice through Systemic Anti-Inflammatory Effects. PLoS ONE, 2015-11-24;10(11):e0143536. 2015-11-24 [PMID: 26600018] (Mouse)
• Li S, Sun R, Chen Y, Wei H, Tian Z TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression. Cancer Res, 2015-01-19;75(6):986-95. 2015-01-19 [PMID: 25600646] (Mouse)
• Moriwaki K, Bertin J, Gough P, Chan F A RIPK3-caspase 8 complex mediates atypical pro-IL-1beta processing. J Immunol, 2015-01-07;194(4):1938-44. 2015-01-07 [PMID: 25567679] (Mouse)
• He W, Yang C, Xia L, Zhao M, Ge R, Huang H, Ji Q, Yang P, Liu Z CD4(+) T cells from food allergy model are resistant to TCR-dependent apoptotic induction. Cytokine, 2014-04-16;68(1):32-9. 2014-04-16 [PMID: 24787054] (Mouse)
• Chow M, Duret H, Andrews D, Faveeuw C, Moller A, Smyth M, Paget C Type I NKT-cell-mediated TNF-alpha is a positive regulator of NLRP3 inflammasome priming. Eur J Immunol, 2014-04-29;44(7):2111-20. 2014-04-29 [PMID: 24687687] (Mouse)
• Park Y, Yoon S, Suh H, Kim D, Park J, Jung H, Kim T, Yoon S, Min J, Na H, Lee S, Lee H, Lee Y, Lee H, Choi I TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis. PLoS Pathog, 2013-10-03;9(10):e1003646. 2013-10-03 [PMID: 24098117] (Mouse)
• Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res, 2013-10-01;28(10):2070-80. 2013-10-01 [PMID: 23553711] (Mouse)
• Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J. Immunol., 2012-07-11;189(4):1911-9. 2012-07-11 [PMID: 22786765] (Mouse)
• Gottfries J, Melgar S, Michaelsson E Modelling of mouse experimental colitis by global property screens: a holistic approach to assess drug effects in inflammatory bowel disease. PLoS ONE, 2012-01-18;7(1):e30005. 2012-01-18 [PMID: 22279558] (Mouse)
• Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J. Immunol., 2011-06-29;187(3):1333-46. 2011-06-29 [PMID: 21715688] (Mouse)
• Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K Galectin-3 contributes to neonatal hypoxic-ischemic brain injury. Neurobiol. Dis., 2010-01-04;38(1):36-46. 2010-01-04 [PMID: 20053377] (Mouse)
• Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature, 2009-06-03;460(7252):269-73. 2009-06-03 [PMID: 19494813] (Mouse)
• Venkatachalam K, Prabhu SD, Reddy VS, Boylston WH, Valente AJ, Chandrasekar B Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury. J. Biol. Chem., 2009-01-21;284(12):7853-65. 2009-01-21 [PMID: 19164288] (Mouse)
• Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, Enelow R, Elias JA Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J. Clin. Invest., 2008-08-01;118(8):2771-84. 2008-08-01 [PMID: 18654661] (Mouse)
• Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Eur. J. Pharmacol., 2008-06-16;590(1):400-8. 2008-06-16 [PMID: 18598692] (Mouse)
• Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J. Leukoc. Biol., 2008-05-21;84(2):529-36. 2008-05-21 [PMID: 18495787] (Mouse)
• Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT Deletion of TLR5 results in spontaneous colitis in mice. J. Clin. Invest., 2007-12-01;117(12):3909-21. 2007-12-01 [PMID: 18008007] (Mouse)
• Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J. Immunol., 2007-02-01;178(3):1948-59. 2007-02-01 [PMID: 17237446] (Mouse)
• Thakur A, Barrett RP, McClellan S, Hazlett LD Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice. Curr. Eye Res., 2004-10-01;29(4):225-33. 2004-10-01 [PMID: 15590467] (Mouse)
• Verdrengh M, Thomas JA, Hultgren OH IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection. Microbes Infect., 2004-11-01;6(14):1268-72. 2004-11-01 [PMID: 15555532] (Mouse)
• Harandi AM, Eriksson K, Holmgren J A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J. Virol., 2003-01-01;77(2):953-62. 2003-01-01 [PMID: 12502811] (Mouse)

Bioinformatics

• Gene Symbol: Il18