Mouse IL-18/IL-1F4 ELISA

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Mouse IL-18/IL-1F4 ELISA Summary

Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Il18

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using 7625.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-18/IL-1F4 ELISA

  • Iboctadekin
  • IFN-gamma-inducing factor
  • IGIF
  • IGIFIL-1 gamma
  • IL18
  • IL-18
  • IL-18MGC12320
  • IL-1F4
  • IL1F4iboctadekin
  • IL-1g
  • Interferon gamma-inducing factor
  • interleukin 18 (interferon-gamma-inducing factor)
  • Interleukin-1 gamma
  • interleukin-18

Background

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production.

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Publications for IL-18/IL-1F4 (7625)(49)

We have publications tested in 2 confirmed species: Mouse, Rat.


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Mouse
(47)
Rat
(1)
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Showing Publications 1 - 10 of 49. Show All 49 Publications.
Publications using 7625 Applications Species
D Lian, L Zhu, Y Yu, X Zhang, Y Lin, J Liu, R Han, Y Guo, D Cai, W Xiao, Y Chen, H He, D Xu, C Zheng, X Wang, Y Huang, Y Chen Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation Journal of leukocyte biology, 2022;0(0):. 2022 [PMID: 35224772] (Mouse) Mouse
P Xu, C Tao, Y Zhu, G Wang, L Kong, W Li, R Li, J Li, C Zhang, L Wang, X Liu, W Sun, W Hu TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage Journal of Neuroinflammation, 2021;18(1):188. 2021 [PMID: 34461942] (Mouse) Mouse
E Igel, A Haller, PR Wolfkiel, M Orr-Asman, A Jaeschke, DY Hui Distinct pro-inflammatory properties of myeloid cell-derived apolipoprotein E2 and E4 in atherosclerosis promotion The Journal of Biological Chemistry, 2021;0(0):101106. 2021 [PMID: 34425108] (Mouse) Mouse
H Zhang, X Li, J Wang, Q Cheng, Y Shang, G Wang Baicalin relieves Mycoplasma�pneumoniae infection?induced lung injury through regulating microRNA?221 to inhibit the TLR4/NF?&kappaB signaling pathway Molecular Medicine Reports, 2021;24(2):. 2021 [PMID: 34109422] (Mouse) Mouse
SY Cheon, BN Koo, SY Kim, EH Kam, J Nam, EJ Kim Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice Scientific Reports, 2021;11(1):8376. 2021 [PMID: 33863952] (Mouse) Mouse
L Ye, H Guo, Y Wang, Y Peng, Y Zhang, S Li, M Yang, L Wang Exosomal circEhmt1 Released from Hypoxia-Pretreated Pericytes Regulates High Glucose-Induced Microvascular Dysfunction via the NFIA/NLRP3 Pathway Oxidative Medicine and Cellular Longevity, 2021;2021(0):8833098. 2021 [PMID: 33815662] (Mouse) Mouse
N Eissa, O Elgazzar, H Hussein, GN Hendy, CN Bernstein, JE Ghia Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis Biomedicines, 2021;9(2):. 2021 [PMID: 33535452] (Mouse) Mouse
X Wu, S Pan, W Luo, Z Shen, X Meng, M Xiao, B Tan, K Nie, T Tong, X Wang Roseburia�intestinalis?derived flagellin ameliorates colitis by targeting miR?223?3p?mediated activation of NLRP3 inflammasome and pyroptosis Mol Med Rep, 2020;0(0):. 2020 [PMID: 32700754] (Mouse) Mouse
G de la Rosa, AI Gómez, MC Baños, P Pelegrín Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1&beta Production Int J Mol Sci, 2020;21(13):. 2020 [PMID: 32630144] (Mouse) Mouse
LR Ling, DH Zheng, ZY Zhang, WH Xie, YH Huang, ZX Chen, XZ Wang, D Li Effect of HBx on inflammation and mitochondrial oxidative stress in mouse hepatocytes Oncol Lett, 2020;19(4):2861-2869. 2020 [PMID: 32218840] (Mouse) Mouse
Show All 49 Publications.

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Blogs on IL-18/IL-1F4.

Immune Cell Metabolic Flux Influences Type I Diabetes
By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...  Read full blog post.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release
By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...  Read full blog post.

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Bioinformatics

Gene Symbol Il18