Mouse Lipocalin-2/NGAL DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Lipocalin-2/NGAL DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Lcn2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Lipocalin-2/NGAL DuoSet ELISA, 15 Plate

• 24p3
• 25 kDa alpha-2-microglobulin-related subunit of MMP-9
• HNL
• LCN2
• lipocalin 2 (oncogene 24p3)
• lipocalin 2
• Lipocalin2
• Lipocalin-2
• migration-stimulating factor inhibitor
• MSFI
• neutrophil gelatinase-associated lipocalin
• NGAL
• NGALlipocalin-2
• Oncogene 24p3
• p25
• Siderocalin
• Uterocalin

Background

The Lipocalin family comprises a diverse group of mostly secreted soluble proteins that bind hydrophobic ligands and act as transporters, carrying small molecules to specific cells. Lipocalins are related by possessing an 8-stranded beta-barrel structure. Lipocalin-1, also named tear lipocalin (TL), von Ebners gland protein (VEG) and tear pre-albumin, binds a large number of hydrophobic molecules and exhibits cysteine proteinase inhibitor and endonuclear activities. Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is a component of granules in neutrophils from tissues that are normally exposed to microorganisms and is upregulated during inflammation. Lipocalin-2 can form homodimers and can heterodimerize with the neutrophil gelatinase MMP-9.

Publications for Lipocalin-2/NGAL (DY1857)(102)

Publications using DY1857

• E Torres-Mar, S Holowacz, J Delannoy, L Lenoir, E Jacouton, S Gervason, M Meynier, AS Boucard, FA Carvalho, F Barbut, LG Bermúdez-H, P Langella, AJ Waligora-D Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome Scientific Reports, 2022;12(1):19776. 2022 [PMID: 36396717] (Mouse)
• M Andrews, T Yoshida, CM Henderson, H Pflaum, A McGregor, JA Lieberman, IH de Boer, T Vaisar, J Himmelfarb, B Kestenbaum, JY Chung, SM Hewitt, BA Santo, B Ginley, P Sarder, AZ Rosenberg, T Murakami, JB Kopp, Z Kuklenyik, AN Hoofnagle Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury PLoS ONE, 2022;17(10):e0276649. 2022 [PMID: 36279295] (Transgenic Mouse)
• D Papoutsis, SDC Rocha, AM Herfindal, S Kjølsrud B, H Carlsen Intestinal effect of faba bean fractions in WD-fed mice treated with low dose of DSS PLoS ONE, 2022;17(8):e0272288. 2022 [PMID: 35939489] (Mouse)
• JR Ippolito, BD Piccolo, MS Robeson, DE Barney, J Ali, P Singh, SR Hennigar Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis The Journal of nutritional biochemistry, 2022;0(0):109065. 2022 [PMID: 35609848] (Mouse)
• Y Yoshimatsu, T Sujino, K Miyamoto, Y Harada, S Tanemoto, K Ono, S Umeda, K Yoshida, T Teratani, T Suzuki, Y Mikami, N Nakamoto, N Sasaki, K Takabayash, N Hosoe, H Ogata, K Sawada, T Imamura, A Yoshimura, T Kanai Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut Cell Reports, 2022;39(6):110773. 2022 [PMID: 35545035] (Mouse)
• M Sobota, PN Rodilla Ra, A Cambré, A Rocker, J Mortier, T Gervais, T Haas, D Cornillet, D Chauvin, I Hug, T Julou, A Aertsen, M Diard The expression of virulence genes increases membrane permeability and sensitivity to envelope stress in Salmonella Typhimurium PloS Biology, 2022;20(4):e3001608. 2022 [PMID: 35389980] (Mouse)
• R Sun, X Gu, C Lei, L Chen, S Chu, G Xu, MA Doll, Y Tan, W Feng, L Siskind, CJ McClain, Z Deng Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection Cell Reports, 2022;38(13):110560. 2022 [PMID: 35354041] (Mouse)
• BW Jester, H Zhao, M Gewe, T Adame, L Perruzza, DT Bolick, J Agosti, N Khuong, R Kuestner, C Gamble, K Cruickshan, J Ferrara, R Lim, T Paddock, C Brady, S Ertel, M Zhang, A Pollock, J Lee, J Xiong, M Tasch, T Saveria, D Doughty, J Marshall, D Carrieri, L Goetsch, J Dang, N Sanjaya, D Fletcher, A Martinez, B Kaldis, K Sigmar, E Afreen, T Nguyen, A Randolph, A Taber, A Krzeszowsk, B Robinett, DB Volkin, F Grassi, R Guerrant, R Takeuchi, B Finrow, C Behnke, J Roberts Development of spirulina for the manufacture and oral delivery of protein therapeutics Nature Biotechnology, 2022;0(0):. 2022 [PMID: 35314813] (Mouse)
• FA Vicentini, JC Szamosi, L Rossi, L Griffin, K Nieves, D Bihan, IA Lewis, QJ Pittman, MG Swain, MG Surette, SA Hirota, KA Sharkey Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation Brain, Behavior, and Immunity, 2022;102(0):266-278. 2022 [PMID: 35259427] (Mouse)
• S Olivier, H Diounou, C Pochard, L Frechin, E Durieu, M Foretz, M Neunlist, M Rolli-Derk, B Viollet Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis Cells, 2022;11(4):. 2022 [PMID: 35203241] (Mouse)
• RH Mills, PS Dulai, Y Vázquez-Ba, C Sauceda, N Daniel, RR Gerner, LE Batachari, M Malfavon, Q Zhu, K Weldon, G Humphrey, M Carrillo-T, LD Goldasich, M Bryant, M Raffatellu, RA Quinn, AT Gewirtz, B Chassaing, H Chu, WJ Sandborn, PC Dorrestein, R Knight, DJ Gonzalez Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity Nature Microbiology, 2022;7(2):262-276. 2022 [PMID: 35087228] (Mouse)
• X Yuan, H Xue, X Xu, X Jiao, Z Pan, Y Zhang Closely related Salmonella Derby strains triggered distinct gut microbiota alteration Gut pathogens, 2022;14(1):6. 2022 [PMID: 35078518] (Mouse)
• RPL van Swelm, S Beurskens, H Dijkman, ETG Wiegerinck, R Roelofs, F Thévenod, J van der Vl, JFM Wetzels, DW Swinkels, B Smeets Kidney tubule iron loading in experimental focal segmental glomerulosclerosis Scientific Reports, 2022;12(1):1199. 2022 [PMID: 35075227] (Mouse)
• JI Wurster, RL Peterson, CE Brown, S Penumutchu, DV Guzior, K Neugebauer, WH Sano, MM Sebastian, RA Quinn, P Belenky Streptozotocin-induced hyperglycemia alters the cecal metabolome and exacerbates antibiotic-induced dysbiosis Cell Reports, 2021;37(11):110113. 2021 [PMID: 34910917] (Mouse)
• CR Shaler, AA Parco, W Elhenawy, J Dourka, J Jury, EF Verdu, BK Coombes Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts Nature Communications, 2021;12(1):6664. 2021 [PMID: 34795263] (Mouse)
• B Texler, A Zollner, V Reinstadle, SJ Reider, S Macheiner, B Jelusic, A Pfister, C Watschinge, N Przysiecki, H Tilg, H Oberacher, AR Moschen Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics Cellular and Molecular Gastroenterology and Hepatology, 2021;0(0):. 2021 [PMID: 34624526] (Mouse)
• C Mullineaux, D Carson, EGD Hopkins, I Glegola-Ma, A Escobar-Ze, HP Browne, TD Lawley, G Frankel Citrobacter amalonaticus Inhibits the Growth of Citrobacter rodentium in the Gut Lumen MBio, 2021;12(5):e0241021. 2021 [PMID: 34609899] (Mouse)
• A Sivignon, SY Yu, N Ballet, P Vandekerck, N Barnich, Y Guerardel Heteropolysaccharides from S. cerevisiae show anti-adhesive properties against E. coli associated with Crohn's disease Carbohydrate polymers, 2021;271(0):118415. 2021 [PMID: 34364556] (Mouse)
• H Ahn, G Lee, J Kim, J Park, SG Kang, SI Yoon, E Lee, GS Lee NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation Cells, 2021;10(7):. 2021 [PMID: 34359830] (Mouse)
• C Teufel, E Horvath, A Peter, C Ercan, S Piscuoglio, MN Hall, D Finke, FM Lehmann mTOR signaling mediates ILC3-driven immunopathology Mucosal Immunology, 2021;0(0):. 2021 [PMID: 34341503] (Mouse)
• AM Porras, Q Shi, H Zhou, R Callahan, G Montenegro, N Solomons, IL Brito Geographic differences in gut microbiota composition impact susceptibility to enteric infection Cell Reports, 2021;36(4):109457. 2021 [PMID: 34320343] (Mouse)
• B Olson, X Zhu, MA Norgard, P Diba, PR Levasseur, AC Buenafe, C Huisman, KG Burfeind, KA Michaelis, G Kong, T Braun, DL Marks Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment Brain, Behavior, and Immunity, 2021;0(0):. 2021 [PMID: 34245812] (Mouse)
• MC Andrews, CPM Duong, V Gopalakris, V Iebba, WS Chen, L Derosa, MAW Khan, AP Cogdill, MG White, MC Wong, G Ferrere, A Fluckiger, MP Roberti, P Opolon, MT Alou, S Yonekura, W Roh, CN Spencer, IF Curbelo, L Vence, A Reuben, S Johnson, R Arora, G Morad, M Lastrapes, EN Baruch, L Little, C Gumbs, ZA Cooper, PA Prieto, K Wani, AJ Lazar, MT Tetzlaff, CW Hudgens, MK Callahan, M Adamow, MA Postow, CE Ariyan, PO Gaudreau, L Nezi, D Raoult, C Mihalcioiu, A Elkrief, RC Pezo, LE Haydu, JM Simon, HA Tawbi, J McQuade, P Hwu, WJ Hwu, RN Amaria, EM Burton, SE Woodman, S Watowich, A Diab, SP Patel, IC Glitza, MK Wong, L Zhao, J Zhang, NJ Ajami, J Petrosino, RR Jenq, MA Davies, JE Gershenwal, PA Futreal, P Sharma, JP Allison, B Routy, L Zitvogel, JA Wargo Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade Nature Medicine, 2021;0(0):. 2021 [PMID: 34239137] (Mouse)
• L Abernathy-, MR Barron, JM George, MG Dieterle, KC Vendrov, IL Bergin, VB Young Intestinal Inflammation and Altered Gut Microbiota Associated with Inflammatory Bowel Disease Render Mice Susceptible to Clostridioides difficile Colonization and Infection MBio, 2021;0(0):e0273320. 2021 [PMID: 34126769] (Mouse)
• T Kimizuka, N Seki, G Yamaguchi, M Akiyama, S Higashi, K Hase, YG Kim Amino Acid-Based Diet Prevents Lethal Infectious Diarrhea by Maintaining Body Water Balance in a Murine Citrobacter rodentium Infection Model Nutrients, 2021;13(6):. 2021 [PMID: 34072947] (Mouse)
• B Olson, X Zhu, MA Norgard, PR Levasseur, JT Butler, A Buenafe, KG Burfeind, KA Michaelis, KR Pelz, H Mendez, J Edwards, SM Krasnow, AJ Grossberg, DL Marks Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia Nature Communications, 2021;12(1):2057. 2021 [PMID: 33824339] (Mouse)
• J An, X Zhao, Y Wang, J Noriega, AT Gewirtz, J Zou Western-style diet impedes colonization and clearance of Citrobacter rodentium PloS Pathogens, 2021;17(4):e1009497. 2021 [PMID: 33819308] (Mouse)
• E Viennois, B Chassaing Consumption of Select Dietary Emulsifiers Exacerbates the Development of Spontaneous Intestinal Adenoma International Journal of Molecular Sciences, 2021;22(5):. 2021 [PMID: 33807577] (Mouse)
• S Olivier, C Pochard, H Diounou, V Castillo, J Divoux, J Alcantara, J Leclerc, S Guilmeau, C Huet, W Charifi, TV Varin, N Daniel, M Foretz, M Neunlist, BL Salomon, P Ghosh, A Marette, M Rolli-Derk, B Viollet Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis Molecular Metabolism, 2021;47(0):101183. 2021 [PMID: 33548500] (Mouse)
• Z Dwyer, M Chaiquin, J Landrigan, K Ayoub, P Shail, J Rocha, CL Childers, KB Storey, DJ Philpott, H Sun, S Hayley The impact of dextran sodium sulphate and probiotic pre-treatment in a murine model of Parkinson's disease Journal of Neuroinflammation, 2021;18(1):20. 2021 [PMID: 33422110] (Mouse)
• CY Liu, SS Tam, Y Huang, PE Dubé, R Alhosh, N Girish, S Punit, S Nataneli, F Li, JM Bender, MK Washington, DB Polk TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice Cell Rep, 2020;33(3):108275. 2020 [PMID: 33086075] (Mouse)
• E Viennois, A Bretin, PE Dubé, AC Maue, CJG Dauriat, N Barnich, AT Gewirtz, B Chassaing Dietary Emulsifiers Directly Impact Adherent-Invasive E.�coli Gene Expression to Drive Chronic Intestinal Inflammation Cell Rep, 2020;33(1):108229. 2020 [PMID: 33027647] (Mouse)
• M Ohno, M Hasegawa, A Hayashi, G Caballero-, CJ Alteri, TD Lawley, N Kamada, G Núñez, N Inohara Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3 PLoS Pathog, 2020;16(10):e1008928. 2020 [PMID: 33027280] (Mouse)
• F Adiliaghda, P Cavallaro, V Mohad, M Almpani, F Kühn, MH Gharedaghi, M Najibi, LG Rahme, RA Hodin Targeting the gut to prevent sepsis from a cutaneous burn JCI Insight, 2020;5(19):. 2020 [PMID: 33004693] (Mouse)
• DC Montrose, R Nishiguchi, S Basu, HA Staab, XK Zhou, H Wang, L Meng, M Johncilla, JR Cubillos-R, DK Morales, MT Wells, KW Simpson, S Zhang, B Dogan, C Jiao, Z Fei, A Oka, JW Herzog, RB Sartor, AJ Dannenberg Dietary Fructose Alters the Composition, Localization and Metabolism of Gut Microbiota in Association with Worsening Colitis Cell Mol Gastroenterol Hepatol, 2020;0(0):. 2020 [PMID: 32961355] (Mouse)
• B Cuffaro, ALW Assohoun, D Boutillier, L Súkeníková, J Desramaut, S Boudebbouz, S Salomé-Des, J Hrdý, AJ Waligora-D, E Maguin, C Grangette In Vitro Characterization of Gut Microbiota-Derived Commensal Strains: Selection of Parabacteroides distasonis Strains Alleviating TNBS-Induced Colitis in Mice Cells, 2020;9(9):. 2020 [PMID: 32947881] (Mouse)
• J Wu, Z Wei, P Cheng, C Qian, F Xu, Y Yang, A Wang, W Chen, Z Sun, Y Lu Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis Theranostics, 2020;10(23):10665-10679. 2020 [PMID: 32929373] (Mouse)
• K Meyers, M López, J Ho, S Wills, S Rayalam, S Taval Lipocalin-2 deficiency may predispose to the progression of spontaneous age-related adiposity in mice Sci Rep, 2020;10(1):14589. 2020 [PMID: 32883997] (Mouse)
• KG Lahue, MK Lara, AA Linton, B Lavoie, Q Fang, MM McGill, JW Crothers, C Teuscher, GM Mawe, AL Tyler, JM Mahoney, DN Krementsov Identification of novel loci controlling inflammatory bowel disease susceptibility utilizing the genetic diversity of wild-derived mice Genes Immun., 2020;0(0):. 2020 [PMID: 32848229] (Mouse)
• EY Lin, HJ Lai, YK Cheng, KQ Leong, LC Cheng, YC Chou, YC Peng, YH Hsu, HS Chiang Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis Biomedicines, 2020;8(8):. 2020 [PMID: 32764411] (Mouse)
• EY Lin, HJ Lai, YK Cheng, KQ Leong, LC Cheng, YC Chou, YC Peng, YH Hsu, HS Chiang Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis Biomedicines, 2020;8(8):. 2020 [PMID: 32764411] (Mouse)
• E Gimier, M Chervy, A Agus, A Sivignon, E Billard, M Privat, S Viala, R Minet-Quin, A Buisson, E Vazeille, N Barnich, J Denizot Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn's disease Sci Rep, 2020;10(1):12922. 2020 [PMID: 32737335] (Mouse)
• E Gimier, M Chervy, A Agus, A Sivignon, E Billard, M Privat, S Viala, R Minet-Quin, A Buisson, E Vazeille, N Barnich, J Denizot Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn's disease Sci Rep, 2020;10(1):12922. 2020 [PMID: 32737335] (Mouse)
• R Yang, H Huang, S Cui, Y Zhou, T Zhang, Y Zhou IFN-&gamma promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b Cell Death Dis, 2020;11(7):603. 2020 [PMID: 32733020] (Mouse)
• R Yang, H Huang, S Cui, Y Zhou, T Zhang, Y Zhou IFN-gamma promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b Cell Death Dis, 2020;11(7):603. 2020 [PMID: 32733020] (Mouse)
• M Biagioli, A Carino, C Di Giorgio, S Marchianò, M Bordoni, R Roselli, E Distrutti, S Fiorucci Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation Nutrients, 2020;12(7):. 2020 [PMID: 32629887] (Mouse)
• YG Zhang, R Lu, S Wu, I Chatterjee, D Zhou, Y Xia, J Sun Vitamin D Receptor Protects Against Dysbiosis and Tumorigenesis via the JAK/STAT Pathway in Intestine Cell Mol Gastroenterol Hepatol, 2020;0(0):. 2020 [PMID: 32497792] (Mouse)
• P Tod, EN Bukosza, B Róka, T Kaucsár, A Fintha, T Krenács, G Szénási, P Hamar Post-Ischemic Renal Fibrosis Progression Is Halted by Delayed Contralateral Nephrectomy: The Involvement of Macrophage Activation Int J Mol Sci, 2020;21(11):. 2020 [PMID: 32481551] (Mouse)
• E van Tilbur, VK Pettersen, MW Gutierrez, I Laforest-L, NG Jendzjowsk, JB Cavin, FA Vicentini, CM Keenan, HR Ramay, J Samara, WK MacNaughto, RJA Wilson, MM Kelly, KD McCoy, KA Sharkey, MC Arrieta Intestinal fungi are causally implicated in microbiome assembly and immune development in mice Nat Commun, 2020;11(1):2577. 2020 [PMID: 32444671] (Mouse)
• P Saha, X Xiao, Y Li, RM Golonka, AA Abokor, BS Yeoh, M Vijay-Kuma Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains Physiol Rep, 2020;8(9):e14441. 2020 [PMID: 32385968] (Mouse)
• AI Yu, L Zhao, KA Eaton, S Ho, J Chen, S Poe, J Becker, A Gonzalez, D McKinstry, M Hasso, J Mendoza-Ca, J Whitfield, C Koumpouras, PD Schloss, EC Martens, GY Chen Gut Microbiota Modulate CD8�T Cell Responses to Influence Colitis-Associated Tumorigenesis Cell Rep, 2020;31(1):107471. 2020 [PMID: 32268087] (Mouse)
• AK Warda, PH de Almeida, CM Hueston, G Di Benedet, AG Clooney, C Hill Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis Front Microbiol, 2020;11(0):69. 2020 [PMID: 32082288] (Mouse)
• M Kumar, A Leon Coria, S Cornick, B Petri, S Mayengbam, HB Jijon, F Moreau, J Shearer, K Chadee Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling Nat Commun, 2020;11(1):483. 2020 [PMID: 31980623] (Mouse)
• BJ Bivona, S Takai, DM Seth, R Satou, LM Harrison-B Chymase inhibition retards albuminuria in type 2 diabetes Physiol Rep, 2019;7(24):e14302. 2019 [PMID: 31872559] (Mouse)
• HQ Tran, RE Ley, AT Gewirtz, B Chassaing Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases Nat Commun, 2019;10(1):5650. 2019 [PMID: 31827095] (Mouse)
• DT Riglar, DL Richmond, L Potvin-Tro, AA Verdegaal, AD Naydich, S Bakshi, E Leoncini, LG Lyon, J Paulsson, PA Silver Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator Nat Commun, 2019;10(1):4665. 2019 [PMID: 31604953] (Mouse)
• A Suwandi, A Galeev, R Riedel, S Sharma, K Seeger, T Sterzenbac, L García Pas, EC Boyle, O Gal-Mor, M Hensel, J Casadesús, JF Baines, GA Grassl Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization PLoS Pathog., 2019;15(7):e1007915. 2019 [PMID: 31329635] (Mouse)
• KJ Meade, F Sanchez, A Aguayo, N Nadales, SG Hamalian, TL Uhlendorf, LR Banner, JA Kelber Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung Oncotarget, 2019;10(32):3027-3039. 2019 [PMID: 31105883] (Mouse)
• H Dubois, F Sorgeloos, ST Sarvestani, L Martens, Y Saeys, JM Mackenzie, M Lamkanfi, G van Loo, I Goodfellow, A Wullaert Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection PLoS Pathog., 2019;15(4):e1007709. 2019 [PMID: 31017981] (Mouse)
• L Zhou, C Chu, F Teng, NJ Bessman, J Goc, EK Santosa, GG Putzel, H Kabata, JR Kelsen, RN Baldassano, MA Shah, RE Sockolow, E Vivier, G Eberl, KA Smith, GF Sonnenberg Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2 Nature, 2019;0(0):. 2019 [PMID: 30944470] (Mouse)
• EGD Hopkins, TI Roumelioti, C Mullineaux, JS Choudhary, G Frankel Intestinal Epithelial Cells and the Microbiome Undergo Swift Reprogramming at the Inception of Colonic Citrobacter rodentium Infection MBio, 2019;10(2):. 2019 [PMID: 30940698] (Mouse)
• JL Pope, Y Yang, RC Newsome, W Sun, X Sun, M Ukhanova, J Neu, JP Issa, V Mai, C Jobin Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate Sci Rep, 2019;9(1):3380. 2019 [PMID: 30833613] (Mouse)
• F Laudisi, D Di Fusco, V Dinallo, C Stolfi, A Di Grazia, I Marafini, A Colantoni, A Ortenzi, C Alteri, F Guerrieri, M Mavilio, F Ceccherini, M Federici, TT MacDonald, I Monteleone, G Monteleone The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation Cell Mol Gastroenterol Hepatol, 2019;7(2):457-473. 2019 [PMID: 30765332] (Mouse)
• P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kuma PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium Mucosal Immunol, 2019;0(0):. 2019 [PMID: 30710097] (Mouse)
• C Janowitz, YK Nakamura, C Metea, A Gligor, W Yu, L Karstens, JT Rosenbaum, M Asquith, P Lin Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis Invest. Ophthalmol. Vis. Sci., 2019;60(1):420-429. 2019 [PMID: 30695094] (Mouse)
• CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses PLoS Pathog., 2018;14(10):e1007406. 2018 [PMID: 30365535] (Mouse)
• X Xiao, P Saha, BS Yeoh, JA Hipp, V Singh, M Vijay-Kuma Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects J. Nutr. Biochem., 2018;62(0):28-34. 2018 [PMID: 30218980] (Mouse)
• JA Smith, A Braga, J Verheyen, S Basilico, S Bandiera, C Alfaro-Cer, L Peruzzotti, D Shu, F Haque, P Guo, S Pluchino RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity Mol Ther Nucleic Acids, 2018;10(0):103-121. 2018 [PMID: 29499926] (Mouse)
• HT Groves, L Cuthbertso, P James, MF Moffatt, MJ Cox, JS Tregoning Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota Front Immunol, 2018;9(0):182. 2018 [PMID: 29483910] (Mouse)
• DN Bronner, F Faber, EE Olsan, MX Byndloss, NA Sayed, G Xu, W Yoo, D Kim, S Ryu, CB Lebrilla, AJ Bäumler Genetic Ablation of Butyrate Utilization Attenuates Gastrointestinal Salmonella Disease Cell Host Microbe, 2018;23(2):266-273.e4. 2018 [PMID: 29447698] (Mouse)
• AF Schulfer, T Battaglia, Y Alvarez, L Bijnens, VE Ruiz, M Ho, S Robinson, T Ward, LM Cox, AB Rogers, D Knights, RB Sartor, MJ Blaser Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice Nat Microbiol, 2017;0(0):. 2017 [PMID: 29180726] (Mouse)
• LF Mager, VH Koelzer, R Stuber, L Thoo, I Keller, I Koeck, M Langenegge, C Simillion, SP Pfister, M Faderl, V Genitsch, I Tcymbarevi, P Juillerat, X Li, Y Xia, E Karamitopo, R Lyck, I Zlobec, S Hapfelmeie, R Bruggmann, KD McCoy, AJ Macpherson, C Müller, B Beutler, P Krebs The ESRP1-GPR137 axis contributes to intestinal pathogenesis Elife, 2017;6(0):. 2017 [PMID: 28975893] (Mouse)
• Y Kim, AG Wu, A Jaja-Chime, BL Graf, C Waterman, MP Verzi, I Raskin Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice PLoS ONE, 2017;12(9):e0184709. 2017 [PMID: 28922365] (Mouse)
• K Watanabe, CA Gilchrist, MJ Uddin, SL Burgess, MM Abhyankar, SN Moonah, Z Noor, JR Donowitz, BN Schneider, T Arju, E Ahmed, M Kabir, M Alam, R Haque, P Pramoonjag, B Mehrad, WA Petri Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis PLoS Pathog., 2017;13(8):e1006513. 2017 [PMID: 28817707] (Mouse)
• M Quiros, H Nishio, PA Neumann, D Siuda, JC Brazil, V Azcutia, R Hilgarth, MN O'Leary, V Garcia-Her, G Leoni, M Feng, G Bernal, H Williams, PH Dedhia, C Gerner-Smi, J Spence, CA Parkos, TL Denning, A Nusrat Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling J. Clin. Invest., 2017;0(0):. 2017 [PMID: 28783045] (Mouse)
• AL Tubbs, B Liu, TD Rogers, RB Sartor, EA Miao Dietary Salt Exacerbates Experimental Colitis J. Immunol., 2017;0(0):. 2017 [PMID: 28637899] (Mouse)
• DT Riglar, TW Giessen, M Baym, SJ Kerns, MJ Niederhube, RT Bronson, JW Kotula, GK Gerber, JC Way, PA Silver Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation Nat. Biotechnol., 2017;0(0):. 2017 [PMID: 28553941] (Mouse)
• MA Borton, A Sabag-Daig, J Wu, LM Solden, BS O'Banion, RA Daly, RA Wolfe, JF Gonzalez, VH Wysocki, BMM Ahmer, KC Wrighton Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome Microbiome, 2017;5(1):47. 2017 [PMID: 28449706] (Mouse)
• P Saha, BS Yeoh, RA Olvera, X Xiao, V Singh, D Awasthi, BC Subramania, Q Chen, M Dikshit, Y Wang, CA Parent, M Vijay-Kuma Bacterial Siderophores Hijack Neutrophil Functions J. Immunol., 2017;0(0):. 2017 [PMID: 28432145] (Mouse)
• C Li, I Maillet, C Mackowiak, C Viala, F Di Padova, M Li, D Togbe, V Quesniaux, Y Lai, B Ryffel Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells Cell Death Dis, 2017;8(4):e2735. 2017 [PMID: 28383552] (Mouse)
• François Reichardt Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and LPS-induced TLR4 signaling J. Physiol. (Lond.), 2016;0(0):. 2016 [PMID: 28000223] (Mouse)
• Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation Theranostics, 2016;6(12):2250-2266. 2016 [PMID: 27924161] (Mouse)
• Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis Cell Mol Gastroenterol Hepatol, 2016;2(4):482-498.e6. 2016 [PMID: 27458605] (Mouse)
• Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System J Neurosci, 2016;36(20):5608-22. 2016 [PMID: 27194339] (Mouse)
• Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase Sci Rep, 2016;6(0):26164. 2016 [PMID: 27192942] (Mouse)
• Kaucsar T, Godo M, Revesz C, Kovacs M, Mocsai A, Kiss N, Albert M, Krenacs T, Szenasi G, Hamar P Urine/Plasma Neutrophil Gelatinase Associated Lipocalin Ratio Is a Sensitive and Specific Marker of Subclinical Acute Kidney Injury in Mice. PLoS ONE, 2016;11(1):e0148043. 2016 [PMID: 26824608] (Mouse)
• Allais L, Kumar S, Debusschere K, Verschuere S, Maes T, De Smet R, Conickx G, De Vos M, Laukens D, Joos G, Brusselle G, Elewaut D, Cuvelier C, Bracke K The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFDeltaARE Mice. PLoS ONE, 2015;10(11):e0141570. 2015 [PMID: 26523550] (Mouse)
• Kortman G, Mulder M, Richters T, Shanmugam N, Trebicka E, Boekhorst J, Timmerman H, Roelofs R, Wiegerinck E, Laarakkers C, Swinkels D, Bolhuis A, Cherayil B, Tjalsma H Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens. Eur J Immunol, 2015;45(9):2553-67. 2015 [PMID: 26046550] (Mouse)
• Chassaing , Benoit, Koren , Omry, Goodrich , Julia K, Poole , Angela C, Srinivasan , Shanthi, Ley , Ruth E, Gewirtz , Andrew T Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature, 2015;519(7541):92-6. 2015 [PMID: 25731162] (Mouse)
• Leoni , Giovanna, Neumann , Philipp-, Kamaly , Nazila, Quiros , Miguel, Nishio , Hikaru, Jones , Hefin R, Sumagin , Ronen, Hilgarth , Roland S, Alam , Ashfaqul, Fredman , Gabriell, Argyris , Ioannis, Rijcken , Emile, Kusters , Dennis, Reutelingsperger , Chris, Perretti , Mauro, Parkos , Charles, Farokhzad , Omid C, Neish , Andrew S, Nusrat , Asma Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest, 2015;125(3):1215-27. 2015 [PMID: 25664854] (Mouse)
• Floderer M, Prchal-Murphy M, Vizzardelli C Dendritic cell-secreted lipocalin2 induces CD8+ T-cell apoptosis, contributes to T-cell priming and leads to a TH1 phenotype. PLoS ONE, 2014;9(7):e101881. 2014 [PMID: 25010215] (Mouse)
• Dulek D, Newcomb D, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill T, Blackwell T, Moore M, Boyd K, Kolls J, Peebles R Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun, 2014;82(9):3723-39. 2014 [PMID: 24958709] (Mouse)
• Zager R, Johnson A, Frostad K Rapid renal alpha-1 antitrypsin gene induction in experimental and clinical acute kidney injury. PLoS ONE, 2014;9(5):e98380. 2014 [PMID: 24848503] (Mouse)
• Shashidharamurthy R, Machiah D, Aitken J, Putty K, Srinivasan G, Chassaing B, Parkos C, Selvaraj P, Vijay-Kumar M Differential role of lipocalin 2 during immune complex-mediated acute and chronic inflammation in mice. Arthritis Rheum, 2013;65(4):1064-73. 2013 [PMID: 23280250] (Mouse)
• Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS ONE, 2012;7(9):e44328. 2012 [PMID: 22957064] (Mouse)
• Chassaing B, Srinivasan G, Delgado M, Young A, Gewirtz A, Vijay-Kumar M Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS ONE, 2012;7(9):e44328. 2012 [PMID: 22957064] (Mouse)
• Louten J, Mattson JD, Malinao MC, Li Y, Emson C, Vega F, Wardle RL, Van Scott MR, Fick RB, McClanahan TK, de Waal Malefyt R, Beaumont M Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma. Biomark Insights, 2012;7(0):87-104. 2012 [PMID: 22837640] (Mouse)
• Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, de Angelis MH, Hamelmann E, Stoeger T, Schulz H Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation. Respir. Res., 2011;12(0):94. 2011 [PMID: 21756372] (Mouse)
• Pitteri SJ, Kelly-Spratt KS, Gurley KE Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression. Cancer Res., 2011;71(15):5090-100. 2011 [PMID: 21653680] (Mouse)
• Kelly-Spratt KS, Pitteri SJ, Gurley KE, Liggitt D, Chin A, Kennedy J, Wong CH, Zhang Q, Buson TB, Wang H, Hanash SM, Kemp CJ Plasma proteome profiles associated with inflammation, angiogenesis, and cancer. PLoS ONE, 2011;6(5):e19721. 2011 [PMID: 21589862] (Mouse)
• Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, Sitaraman SV, Knight R, Ley RE, Gewirtz AT Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science, 2010;328(5975):228-31. 2010 [PMID: 20203013] (Mouse)
• Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009;4(11):e7916. 2009 [PMID: 19936259] (Mouse)

Bioinformatics

• Gene Symbol: Lcn2