TGF-alpha Antibody (tAb2) [DyLight 650]

• Reactivity: Hu
• Applications: DB, ELISA, Flow
• Clone: tAb2
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: DyLight 650

TGF-alpha Antibody (tAb2) [DyLight 650] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Biologically active hemocyanin-coupled human TGF-alpha.
• Specificity: tAb2 binds the N-terminal sequence of TGF-alpha, VVSHFND (with residues 4 to 7 being the minimal binding epitope).
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TGFA
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Dot Blot
  • ELISA
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TGF-alpha Antibody (tAb2) [DyLight 650]

• protransforming growth factor alpha
• TFGA
• TGFA
• TGFalpha
• TGF-alpha
• transforming growth factor, alpha
• transforming growth factor-alpha

Background

Transforming growth factor alpha (TGFalpha) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFalpha is 33% homologous at the amino acid level to epidermal growth factor (EGF). TGFalpha binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor beta. TGFalpha is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFalpha bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TGFA