TGF-alpha Products

Description

Transforming growth factor alpha (TGFalpha) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFalpha is 33% homologous at the amino acid level to epidermal growth factor (EGF). TGFalpha binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor beta. TGFalpha is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFalpha bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.

Bioinformatics

Entrez	21802 Mouse 24827 Rat 7039 Human
Uniprot	AAH05308 Human NM_003236 Human NP_003227 Human NP_003227.1 Human P01135 Human
Product By Gene ID	7039
Alternate Names	protransforming growth factor alpha TFGA transforming growth factor, alpha transforming growth factor-alpha

Research Areas for TGF-alpha

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cell Cycle and Replication
Signal Transduction