Recombinant Human HGF Protein

Recombinant Human HGF (294-HG) induces IL-11 secretion in Saos-2 human osteosarcoma cells. The ED50 for this effect is equal to less than 4.00 ng/mL.

Adult stem cell-derived liver organoids were cultured using Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and liver organoid initiation medium, which includes Recombinant Human HGF (Catalog # 294-HG), Recombinant Human BMP-7 (354-BP), Recombinant Human EGF (236-EG), Recombinant Human FGF-10 (345-FG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), and Recombinant Human Wnt-3a (5036-WN), along with the other reagents listed in the liver organoid initiation medium recipe in the human liver organoid culture protocol. After 3 days, liver organoid expansion medium was added for 7-10 days, followed by liver organoid differentiation medium, which includes Recombinant Human HGF (Catalog # 294-HG), Recombinant Human BMP-7 (354-BP), Recombinant Human EGF (236-EG), and Recombinant Human FGF-19 (969-FG), along with the other reagents listed in the liver organoid differentiation medium recipe in the human liver organoid culture protocol. Differentiated human liver organoids were stained using a (A) Mouse Anti-Human Serum Albumin Monoclonal Antibody (MAB1455; red) and a (B) Goat Anti-Human HNF-3beta Antigen Affinity-purified Polyclonal Antibody (AF2400; red) and counterstained with DAPI (5748; blue).

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human HGF Protein Summary

• Details of Functionality: Measured by its ability to induce IL-11 secretion by Saos‑2 human osteosarcoma cells. Hjertner, O. et al. (1999) Blood 94:3883. The ED₅₀ for this effect is equal to or less than 4.00 ng/mL.
• Source: Spodoptera frugiperda, Sf 21 (baculovirus)-derived human HGF protein
  Gln32-Ser728 (Asp384Asn, Asp416Asn, Leu622Ser, His645Arg, Val678Ile)
• Accession #: P14210.2
• N-terminal Sequence: alpha chain: No results obtained; Gln32 predicted
  beta chain: Val495
• Structure / Form: Disulfide-linked heterodimer
• Protein/Peptide Type: Recombinant Proteins
• Gene: HGF
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 53.7 kDa ( alpha chain), 26 kDa ( beta chain).
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 60-70 kDa, non-reducing conditions
  60 kDa, and 33-34 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in NaH₂PO₄ and NaCl with BSA as a carrier protein.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human HGF Protein

• deafness, autosomal recessive 39
• DFNB39
• EC 3.4.21
• EC 3.4.21.7
• fibroblast-derived tumor cytotoxic factor
• F-TCF
• hepatocyte growth factor (hepapoietin A; scatter factor)
• Hepatopoeitin-A
• Hepatopoietin A
• HGF
• HGFB
• HPTA
• HPTAhepatocyte growth factor
• lung fibroblast-derived mitogen
• Scatter factor
• SF
• SFhepatopoeitin-A

Background

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE‑like domain, four Kringle domains, and a serine proteinase-like domain that has no detectable protease activity (1‑5). Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive
disulfide‑linked HGF with a 60 kDa alpha  and 30 kDa beta  chain. Alternate splicing generates human HGF isoforms that lack the proteinase‑like domain and different numbers of the Kringle domains. Human HGF shares 91%‑94% aa sequence identity with bovine, canine, feline, mouse, and rat HGF. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET (6, 7). HGF-dependent c-MET activation is implicated in the development of many human cancers (8). HGF regulates epithelial morphogenesis by inducing cell scattering and branching tubulogenesis (9, 10). HGF induces the up‑regulation of integrin alpha 2 beta 1 in epithelial cells by a selective increase in alpha 2 gene transcription (11). This integrin serves as a collagen I receptor, and its blockade disrupts epithelial cell branching tubulogenesis (11, 12). HGF can also alter epithelium morphology by the induction of nectin‑1 alpha  ectodomain shedding, an adhesion protein component of adherens junctions (13). In the thyroid, HGF induces the proliferation, motility, and loss of differentiation markers of thyrocytes and inhibits TSH‑stimulated iodine uptake (14). HGF promotes the motility of cardiac stem cells in damaged myocardium (15).

1. Karihaloo, A. et al. (2005) Nephron Exp. Nephrol. 100:e40.
2. Hammond, D.E. et al. (2004) Curr. Top. Microbiol. Immunol. 286:21.
3. Rosario, M. and W. Birchmeier (2004) Dev. Cell 7:3.
4. Lesk, A.M. and W.D. Fordham (1996) J. Mol. Biol. 258:501.
5. Nakamura, T. et al. (1989) Nature 342:440.
6. Mizuno, K., et al. (1994) J. Biol. Chem. 269:1131.
7. Gheradi, E. et al. (2003) Proc. Natl. Acad. Sci. 100:12039.
8. Corso, S. et al. (2005) Trends Mol. Med. 11:284.
9. Maeshima, A. et al. (2000) Kid. Int. 58:1511.
10. Montesano, R. et al. (1991) Cell 67:901.
11. Chiu, S-J. et al. (2002) J. Biomed. Sci. 9:261.
12. Saelman, E.U.M. et al. (1995) J. Cell Sci. 108:3531.
13. Tanaka, Y. et al. (2002) Biochem. Biophys. Res. Commun. 299:472.
14. Mineo, R. et al. (1994) Endocrinology 145:4355.
15. Urbanek, K. et al. (2005) Circ. Res. 97:663.

Publications for HGF (294-HG)(118)

Publications using 294-HG

• Barzegar, M;Dhukhwa, A;Patel, VN;Velasquez, FC;Das, S;Patil, AH;Halushka, MK;Zack, DJ;Chamling, X; Profiling miRNAs involved in Human Oligodendrocyte Precursor Cell Differentiation and Maturation bioRxiv : the preprint server for biology 2025-12-26 [PMID: 41497631] (Bioassay, Human)
• Devlin, KL;Smith, R;Bucher, E;Dane, M;Bowman, CL;Carlson, EJ;Kilburn, D;Sudar, D;Feiler, HS;Heiser, LM;Langer, EM;Korkola, JE; Growth factors maintain intratumoral heterogeneity and drive therapeutic resistance in triple-negative breast cancer Cell reports 2025-12-31 [PMID: 41477765] (Bioassay, Human)
• Ruffilli, C;Röth, S;Zelcer, N;Moreau, K; Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET Scientific reports 2025-01-02 [PMID: 39748066] (Bioassay, Human)
• Gao, H;Huang, X;Cai, Z;Cai, B;Wang, K;Li, J;Kuang, J;Wang, B;Zhai, Z;Ming, J;Cao, S;Qin, Y;Pei, D; Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells Cell & bioscience 2024-07-15 [PMID: 39010176] (Bioassay, Human)
• Mozin, E;Massouridès, E;Mournetas, V;Lièvre, C;Bourdon, A;Jackson, DL;Packer, JS;Trapnell, C;Guiner, CL;Adjali, O;Pinset, C;Mack, DL;Dupont, JB; Dystrophin deficiency impairs cell junction formation during embryonic myogenesis bioRxiv : the preprint server for biology 2023-12-07 [PMID: 38106055] (Bioassay, Human)
• Gesualdi, L;Berardini, M;Scicchitano, B;Castaldo, C;Bizzarri, M;Filippini, A;Riccioli, A;Schiraldi, C;Ferranti, F;Liguoro, D;Mancini, R;Ricci, G;Catizone, A; ERK Signaling Pathway Is Constitutively Active in NT2D1 Non-Seminoma Cells and Its Inhibition Impairs Basal and HGF-Activated Cell Proliferation Biomedicines 2023-01-01 [PMID: 37509533] (Bioassay, Human)
• M Carbonaro, K Wang, H Huang, D Frleta, A Patel, A Pennington, M Desclaux, S Moller-Tan, J Grindley, J Altarejos, J Zhong, G Polites, W Poueymirou, S Jaspers, C Kyratsous, B Zambrowicz, A Murphy, JC Lin, LE Macdonald, C Daly, M Sleeman, G Thurston, Z Li IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models Science Advances, 2023-04-14;9(15):eadf4490. 2023-04-14 [PMID: 37058568] (Bioassay, Human)
• G Rizzo, SE Pineda Cha, E Vandenkoor, CL Cárdenas R, V Cento, V Garlatti, M Wozny, G Sammarco, A Di Claudio, L Meanti, S Elangovan, A Romano, G Roda, L Loy, A Dal Buono, R Gabbiadini, S Lovisa, R Rusconi, A Repici, A Armuzzi, S Vetrano Pomegranate Extract Affects Gut Biofilm Forming Bacteria and Promotes Intestinal Mucosal Healing Regulating the Crosstalk between Epithelial Cells and Intestinal Fibroblasts Nutrients, 2023-04-05;15(7):. 2023-04-05 [PMID: 37049615] (Bioassay, Human)
• S Wenhua, T Tsunematsu, M Umeda, H Tawara, N Fujiwara, Y Mouri, R Arakaki, N Ishimaru, Y Kudo Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma Cancer Medicine, 2023-01-23;0(0):. 2023-01-23 [PMID: 36691359] (Bioassay, Human)
• JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity Cell Reports, 2022-12-06;41(10):111775. 2022-12-06 [PMID: 36476855] (Bioassay, Human)
• Rodrigo M. Florentino, Kazutoyo Morita, Nils Haep, Takashi Motomura, Ricardo Diaz-Aragon, Lanuza A.P. Faccioli et al. Biofabrication of synthetic human liver tissue with advanced programmable functions iScience 2022-12-22 [PMID: 36404924] (Bioassay, Human)
• R Yoshida, M Saigi, T Tani, BF Springer, H Shibata, S Kitajima, NR Mahadevan, M Campisi, W Kim, Y Kobayashi, TC Thai, K Haratani, Y Yamamoto, SK Sundararam, EH Knelson, A Vajdi, I Canadas, R Uppaluri, CP Paweletz, JJ Miret, PH Lizotte, PC Gokhale, PA Janne, DA Barbie MET-induced CD73 restrains STING-mediated immunogenicity of EGFR-mutant lung cancer Cancer Research, 2022-11-02;0(0):. 2022-11-02 [PMID: 36066413] (Bioassay, Human)
• Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)
• J Krumm, K Sekine, P Samaras, A Brazovskaj, M Breunig, R Yasui, A Kleger, H Taniguchi, M Wilhelm, B Treutlein, JG Camp, B Kuster High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development Cell Reports, 2022-03-29;38(13):110604. 2022-03-29 [PMID: 35354033] (Bioassay, Human)
• P Banerjee, GY Xiao, X Tan, VJ Zheng, L Shi, MNB Rabassedas, HF Guo, X Liu, J Yu, L Diao, J Wang, WK Russell, J Roszik, CJ Creighton, JM Kurie The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells Nature Communications, 2021-11-03;12(1):6354. 2021-11-03 [PMID: 34732702] (Bioassay, Human)
• E Zahmatkesh, MH Ghanian, I Zarkesh, Z Farzaneh, M Halvaei, Z Heydari, F Moeinvazir, A Othman, M Ruo beta , A Piryaei, R Gramignoli, S Yakhkeshi, A Nüssler, M Najimi, H Baharvand, M Vosough Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes Cells, 2021-05-21;10(6):. 2021-05-21 [PMID: 34063948] (Bioassay, Human)
• Wuchang Zhang, Wei Liu, Lingfei Jia, Demeng Chen, Insoon Chang, Michael Lake et al. Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress Molecular Cell 2021-05-01 [PMID: 33743195] (Bioassay, Human)
• X Chamling, A Kallman, W Fang, CA Berlinicke, JL Mertz, P Devkota, IEM Pantoja, MD Smith, Z Ji, C Chang, A Kaushik, L Chen, KA Whartenby, PA Calabresi, HQ Mao, H Ji, TH Wang, DJ Zack Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells Nature Communications, 2021-01-28;12(1):652. 2021-01-28 [PMID: 33510160] (Bioassay, Human)
• C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response Cell Stem Cell, 2021-01-04;28(2):331-342.e5. 2021-01-04 [PMID: 33450186] (Bioassay, Human)
• L Gesualdi, E Leonetti, A Cucina, BM Scicchitan, S Sorrentino, MG Tarsitano, A Isidori, M Bizzarri, A Filippini, A Riccioli, M Cammarota, V Gigantino, G Ricci, A Catizone The PI3K/AKT Pathway Is Activated by HGF in NT2D1 Non-Seminoma Cells and Has a Role in the Modulation of Their Malignant Behavior Int J Mol Sci, 2020-11-17;21(22):. 2020-11-17 [PMID: 33212946] (Cell Culture, Human)
• AC Hedman, DE McNulty, Z Li, L Gorisse, RS Annan, DB Sacks Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function J Biol Chem, 2020-10-21;0(0):. 2020-10-21 [PMID: 33087447] (Bioassay, Mouse)
• A Walens, J Lin, JS Damrauer, B McKinney, R Lupo, R Newcomb, DB Fox, NW Mabe, J Gresham, Z Sheng, AB Sibley, T De Buyssch, H Kelkar, PA Mieczkowsk, K Owzar, JV Alvarez Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence Nat Commun, 2020-10-06;11(1):5017. 2020-10-06 [PMID: 33024122] (Cell Culture, Human)
• S Sato, N Matsumoto, K Hisaie, S Uematsu Alcohol abrogates human norovirus infectivity in a pH-dependent manner Sci Rep, 2020-09-28;10(1):15878. 2020-09-28 [PMID: 32985508] (Cell Culture, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)
• C Volz, S Breid, C Selenz, A Zaplatina, K Golfmann, L Meder, F Dietlein, S Borchmann, S Chatterjee, M Siobal, J Schöttle, A Florin, M Koker, M Nill, L Ozreti?, N Uhlenbrock, S Smith, R Büttner, H Miao, B Wang, HC Reinhardt, D Rauh, M Hallek, A Acker-Palm, LC Heukamp, RT Ullrich Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC Cell Rep, 2020-04-28;31(4):107568. 2020-04-28 [PMID: 32348765] (Bioassay, Human)
• M Grosch, S Ittermann, E Rusha, T Greisle, C Ori, DJ Truong, AC O'Neill, A Pertek, GG Westmeyer, M Drukker Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation BMC Biol., 2020-04-22;18(1):42. 2020-04-22 [PMID: 32321486] (Cell Culture, Human)
• K Han, SE Pierce, A Li, K Spees, GR Anderson, JA Seoane, YH Lo, M Dubreuil, M Olivas, RA Kamber, M Wainberg, K Kostyrko, MR Kelly, M Yousefi, SW Simpkins, D Yao, K Lee, CJ Kuo, PK Jackson, A Sweet-Cord, A Kundaje, AJ Gentles, C Curtis, MM Winslow, MC Bassik CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities Nature, 2020-03-11;580(7801):136-141. 2020-03-11 [PMID: 32238925] (Bioassay, Human)
• A Fumagalli, KC Oost, L Kester, J Morgner, L Bornes, L Bruens, L Spaargaren, M Azkanaz, T Schelfhors, E Beerling, MC Heinz, D Postrach, D Seinstra, AM Sieuwerts, JWM Martens, S van der El, M van Baalen, D Bhowmick, N Vrisekoop, SIJ Ellenbroek, SJE Suijkerbui, HJ Snippert, J van Rheene Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer Cell Stem Cell, 2020-03-12;0(0):. 2020-03-12 [PMID: 32169167] (Bioassay, Human)
• NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells Nat. Biotechnol., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094658] (Bioassay, Human)
• JS Kim, SI Hwang, JL Ryu, HS Hong, JM Lee, SM Lee, X Jin, C Han, JH Kim, J Han, MR Lee, DH Woo ER stress reliever enhances functionalities of in vitro cultured hepatocytes Stem Cell Res, 2020-02-12;43(0):101732. 2020-02-12 [PMID: 32087526] (Human)
• Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Nat. Immunol., 2020-02-17;21(3):274-286. 2020-02-17 [PMID: 32066947] (Cell Culture, Human)
• H Chen, C Lin, T Peng, C Hu, C Lu, L Li, Y Wang, R Han, M Feng, F Sun, Y He Metformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1 Cell Death Dis, 2020-02-10;11(2):111. 2020-02-10 [PMID: 32041944] (Cell Culture, Human)
• F Tonon, GG Giobbe, A Zambon, C Luni, O Gagliano, A Floreani, G Grassi, N Elvassore In vitro metabolic zonation through oxygen gradient on a chip Sci Rep, 2019-09-19;9(1):13557. 2019-09-19 [PMID: 31537830] (Bioassay, Human)
• YC Kim, J Lee, JN An, JH Kim, YW Choi, L Li, SH Kwon, MY Lee, B Lee, JG Jeong, SS Yu, CS Lim, YS Kim, S Kim, SH Yang, JP Lee Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis Sci Rep, 2019-09-17;9(1):13495. 2019-09-17 [PMID: 31530851] (Bioassay, Proliferation, Human)
• L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human)
• G Yu, Z Wang, S Zeng, S Liu, C Zhu, R Xu, RE Liu Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma Biomed Res Int, 2019-02-11;2019(0):9053295. 2019-02-11 [PMID: 30886866] (Bioassay, Human)
• R Graves-Dea, G Bogatcheva, S Rehman, Y Lu, JN Higginboth, B Singh Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer Oncotarget, 2019-02-12;10(13):1320-1333. 2019-02-12 [PMID: 30863492] (Bioassay, Human)
• GA Khan, S Bhagat, MI Alam PGE2 -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors J. Leukoc. Biol., 2019-03-05;0(0):. 2019-03-05 [PMID: 30835912] (Bioassay, Human)
• H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors Mol Ther Methods Clin Dev, 2019-01-29;13(0):243-252. 2019-01-29 [PMID: 30828587] (Bioassay, Human)
• S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation JCI Insight, 2019-03-21;0(0):. 2019-03-21 [PMID: 30721154] (Bioassay, Human)
• VS Hughes, DW Siemann Failures in preclinical and clinical trials of c-Met inhibitors: evaluation of pathway activity as a promising selection criterion Oncotarget, 2019-01-04;10(2):184-197. 2019-01-04 [PMID: 30719213] (Bioassay, Human)
• L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos Nat Commun, 2019-01-21;10(1):364. 2019-01-21 [PMID: 30664750] (Bioassay, Human)
• E Leonetti, L Gesualdi, KC Scheri, S Dinicola, L Fattore, MG Masiello, A Cucina, R Mancini, M Bizzarri, G Ricci, A Catizone c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells Int J Mol Sci, 2019-01-14;20(2):. 2019-01-14 [PMID: 30646583] (Bioassay, Human)
• T Navas, TD Pfister, S Colantonio, A Aziz, L Dieckman, RG Saul, J Kaczmarczy, S Borgel, SY Alcoser, MG Hollingshe, YH Lee, DP Bottaro, T Hiltke, G Whiteley, N Takebe, RJ Kinders, RE Parchment, JE Tomaszewsk, JH Doroshow Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells PLoS ONE, 2018-06-21;13(6):e0199361. 2018-06-21 [PMID: 29928062] (ELISA (Standard))
• J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 2018-06-13;0(0):9636897187803. 2018-06-13 [PMID: 29895168] (Bioassay, Human)
• I Olmez, Y Zhang, L Manigat, M Benamar, B Brenneman, I Nakano, J Godlewski, A Bronisz, J Lee, T Abbas, R Abounader, B Purow Combined c-Met/Trk inhibition overcomes resistance to CDK4/6 inhibitors in Glioblastoma Cancer Res., 2018-05-29;0(0):. 2018-05-29 [PMID: 29844123] (Bioassay, Human)
• R Okamoto, K Takayama, N Akita, Y Nagamoto, D Hosokawa, S Iizuka, F Sakurai, H Suemizu, K Ohashi, H Mizuguchi Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B Cell Transplant, 2018-02-01;27(2):299-309. 2018-02-01 [PMID: 29637813] (Bioassay, Human)
• J Ou, JM Ball, Y Luan, T Zhao, KJ Miyagishim, Y Xu, H Zhou, J Chen, DK Merriman, Z Xie, BS Mallon, W Li iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications Cell, 2018-03-22;0(0):. 2018-03-22 [PMID: 29576452] (Bioassay, Squirrel)
• WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver Cell Transplant, 2017-12-01;26(12):1868-1877. 2017-12-01 [PMID: 29390880] (Bioassay, Mouse)
• K Yamane, T Mazaki, Y Shiozaki, A Yoshida, K Shinohara, M Nakamura, Y Yoshida, D Zhou, T Kitajima, M Tanaka, Y Ito, T Ozaki, A Matsukawa Collagen-Binding Hepatocyte Growth Factor (HGF) alone or with a Gelatin- furfurylamine Hydrogel Enhances Functional Recovery in Mice after Spinal Cord Injury Sci Rep, 2018-01-17;8(1):917. 2018-01-17 [PMID: 29343699] (In Vivo, Mouse)
• R Kanteti, T Mirzapoiaz, JJ Riehm, I Dhanasingh, B Mambetsari, J Wang, P Kulkarni, G Kaushik, P Seshachary, MP Ponnusamy, HL Kindler, MW Nasser, SK Batra, R Salgia Focal Adhesion Kinase a Potential Therapeutic Target for Pancreatic Cancer and Malignant Pleural Mesothelioma Cancer Biol. Ther., 2018-02-22;0(0):0. 2018-02-22 [PMID: 29303405] (Bioassay, Human)
• YJ Han, YH Kang, SB Shivakumar, D Bharti, YB Son, YH Choi, WU Park, JH Byun, GJ Rho, BW Park Stem Cells from Cryopreserved Human Dental Pulp Tissues Sequentially Differentiate into Definitive Endoderm and Hepatocyte-Like Cells in vitro Int J Med Sci, 2017-11-02;14(13):1418-1429. 2017-11-02 [PMID: 29200956] (Bioassay, Human)
• Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation. Oncotarget, 2017-05-29;0(0):1949-2553. 2017-05-29 [PMID: 28968967] (Bioassay, Human)
• H Park, D Kim, E Kim, JK Sa, HW Lee, S Yu, J Oh, SH Kim, Y Yoon, DH Nam Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain Int J Mol Sci, 2017-09-13;18(9):. 2017-09-13 [PMID: 28902178] (Bioassay, Human)
• C Clémenson, C Chargari, W Liu, M Mondini, C Ferté, MF Burbridge, V Cattan, A Jacquet-Be, E Deutsch The MET/AXL/FGFR inhibitor S49076 impairs Aurora B activity and improves the antitumor efficacy of radiotherapy Mol. Cancer Ther., 2017-06-15;0(0):. 2017-06-15 [PMID: 28619752] (Bioassay, Human)
• JG Camp, K Sekine, T Gerber, H Loeffler-W, H Binder, M Gac, S Kanton, J Kageyama, G Damm, D Seehofer, L Belicova, M Bickle, R Barsacchi, R Okuda, E Yoshizawa, M Kimura, H Ayabe, H Taniguchi, T Takebe, B Treutlein Multilineage communication regulates human liver bud development from pluripotency Nature, 2017-06-14;0(0):. 2017-06-14 [PMID: 28614297] (Bioassay, Human)
• C Zou, Y Lu, X Teng, S Wang, X Sun, F Huang, G Shu, X Huang, H Guo, Z Chen, J Zhang, YA Zhang MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys Sci Rep, 2017-05-31;7(1):2505. 2017-05-31 [PMID: 28566744] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura Establishment of a refined culture method for rat colon organoids Biochem. Biophys. Res. Commun., 2017-05-27;0(0):. 2017-05-27 [PMID: 28559141] (Bioassay, Rat)
• S Mitani, K Takayama, Y Nagamoto, K Imagawa, F Sakurai, M Tachibana, R Sumazaki, H Mizuguchi Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling Mol. Ther., 2017-04-24;25(6):1420-1433. 2017-04-24 [PMID: 28462819] (Bioassay, Human)
• F Sakurai, S Mitani, T Yamamoto, K Takayama, M Tachibana, K Watashi, T Wakita, S Iijima, Y Tanaka, H Mizuguchi Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection Sci Rep, 2017-04-04;7(0):45698. 2017-04-04 [PMID: 28374759] (Bioassay, Human)
• ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes Am. J. Hum. Genet., 2017-03-30;100(4):617-634. 2017-03-30 [PMID: 28366443] (Bioassay, Human)
• DA Elberry, SN Amin, RS Esmail, LA Rashed, MM Gamal Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis EXCLI J, 2016-11-07;15(0):652-670. 2016-11-07 [PMID: 28337098] (Bioassay, Rat)
• Y Song, J Jang, TH Shin, SM Bae, JS Kim, KM Kim, SJ Myung, EK Choi, HR Seo Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells J. Exp. Clin. Cancer Res, 2017-03-03;36(1):38. 2017-03-03 [PMID: 28253902] (Bioassay, Human)
• CE Weeden, Y Chen, SB Ma, Y Hu, G Ramm, KD Sutherland, GK Smyth, ML Asselin-La Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway PLoS Biol, 2017-01-26;15(1):e2000731. 2017-01-26 [PMID: 28125611] (Bioassay, Human)
• Hugh S O'Neill A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation J Tissue Eng Regen Med, 2017-06-19;0(0):. 2017-06-19 [PMID: 27943590] (Bioassay, N/A)
• SW Lee, JU Chong, SO Min, SY Bak, KS Kim Are Adipose-Derived Stem Cells From Liver Falciform Ligaments Another Possible Source of Mesenchymal Stem Cells? Cell Transplant, 2016-11-24;26(5):855-866. 2016-11-24 [PMID: 27938473] (Bioassay, Human)
• Jong Seok Lee EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells Yonsei Med. J., 2017-01-01;58(1):9-18. 2017-01-01 [PMID: 27873490] (Bioassay, Human)
• ABBV-399, a c-Met Antibody Drug Conjugate that Targets Both MET Amplified and c-Met Overexpressing Tumors, Irrespective of MET Pathway Dependence Clin Cancer Res, 2016-08-29;0(0):. 2016-08-29 [PMID: 27573171] (Bioassay, Human)
• Yasuhiro Ikeda Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration Stem Cells Transl Med, 2016-03-17;5(5):694-702. 2016-03-17 [PMID: 26987352] (Bioassay, Human)
• Rudisch A, Dewhurst M, Horga L, Kramer N, Harrer N, Dong M, van der Kuip H, Wernitznig A, Bernthaler A, Dolznig H, Sommergruber W High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFkappaB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts. PLoS ONE, 2015-04-28;10(4):e0124283. 2015-04-28 [PMID: 25919140] (Bioassay, Human)
• Czysz , Katherin, Minger , Stephen, Thomas , Nick DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS ONE, 2015-02-06;10(2):e0117689. 2015-02-06 [PMID: 25659159] (Bioassay, Human)
• Klijn C, Durinck S, Stawiski E, Haverty P, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, Pau G, Reeder J, Cao Y, Mukhyala K, Selvaraj S, Yu M, Zynda G, Brauer M, Wu T, Gentleman R, Manning G, Yauch R, Bourgon R, Stokoe D, Modrusan Z, Neve R, de Sauvage F, Settleman J, Seshagiri S, Zhang Z A comprehensive transcriptional portrait of human cancer cell lines. Nat Biotechnol, 2014-12-08;33(3):306-12. 2014-12-08 [PMID: 25485619] (Bioassay, Human)
• Falcon B, Swearingen M, Gough W, Lee L, Foreman R, Uhlik M, Hanson J, Lee J, McClure D, Chintharlapalli S An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors. PLoS ONE, 2014-09-11;9(9):e106901. 2014-09-11 [PMID: 25210890] (Bioassay, Human)
• Korhan P, Erdal E, Kandemis E, Cokakli M, Nart D, Yilmaz F, Can A, Atabey N Reciprocal activating crosstalk between c-Met and caveolin 1 promotes invasive phenotype in hepatocellular carcinoma. PLoS ONE, 2014-08-22;9(8):e105278. 2014-08-22 [PMID: 25148256] (Bioassay, Human)
• Rizvi S, Mertens J, Bronk S, Hirsova P, Dai H, Roberts L, Kaufmann S, Gores G Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis. J Biol Chem, 2014-06-27;289(33):22835-49. 2014-06-27 [PMID: 24973208] (Bioassay, Human)
• Ao , Ying, Mich-Basso , Jocelyn, Lin , Bo, Yang , Lei High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS ONE, 2014-06-20;9(6):e100417. 2014-06-20 [PMID: 24949734] (Bioassay, Porcine)
• Menard L, Parker P, Kermorgant S Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways. Nat Commun, 2014-05-19;5(0):3907. 2014-05-19 [PMID: 24835487] (Bioassay, Human)
• Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors. Stem Cells, 2014-08-01;32(8):2178-87. 2014-08-01 [PMID: 24740884] (Bioassay, Human)
• Ekert , Jason E, Johnson , Kjell, Strake , Brandy, Pardinas , Jose, Jarantow , Stephen, Perkinson , Robert, Colter , David C Three-dimensional lung tumor microenvironment modulates therapeutic compound responsiveness in vitro--implication for drug development. PLoS ONE, 2014-03-17;9(3):e92248. 2014-03-17 [PMID: 24638075] (Bioassay, Human)
• Kanteti R, El-Hashani E, Dhanasingh I, Tretiakova M, Husain A, Sharma S, Sharma J, Vokes E, Salgia R Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer. BMC Cancer, 2014-03-14;14(0):185. 2014-03-14 [PMID: 24628993] (Bioassay, Human)
• Vogel S, Chatterjee M, Metzger K, Borst O, Geisler T, Seizer P, Muller I, Mack A, Schumann S, Buhring H, Lang F, Sorg R, Langer H, Gawaz M Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET. J Biol Chem, 2014-02-24;289(16):11068-82. 2014-02-24 [PMID: 24567328] (Bioassay, Human)
• Chattopadhyay , Chandran, Grimm , Elizabet, Woodman , Scott E Simultaneous inhibition of the HGF/MET and Erk1/2 pathways affect uveal melanoma cell growth and migration. PLoS ONE, 2014-02-13;9(2):e83957. 2014-02-13 [PMID: 24551032] (Bioassay, Human)
• Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports, 2013-10-03;1(4):322-35. 2013-10-03 [PMID: 24319667] (Bioassay, Human)
• Huang , Sarah X, Islam , Mohammad, O'Neill , John, Hu , Zheng, Yang , Yong-Gua, Chen , Ya-Wen, Mumau , Melanie, Green , Michael, Vunjak-Novakovic , Gordana, Bhattacharya , Jahar, Snoeck , Hans-Wil Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 2013-12-01;32(1):84-91. 2013-12-01 [PMID: 24291815] (Bioassay, Human)
• Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision. Development, 2013-11-27;141(1):91-100. 2013-11-27 [PMID: 24284203] (Bioassay, Human)
• Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2013-11-19;2(0):e00940. 2013-11-19 [PMID: 24252877]
• Ramani V, Sanderson R Chemotherapy stimulates syndecan-1 shedding: a potentially negative effect of treatment that may promote tumor relapse. Matrix Biol, 2013-10-18;35(0):215-22. 2013-10-18 [PMID: 24145151] (Bioassay, Human)
• Yen B, Yen M, Hsu P, Liu K, Wang C, Bai C, Sytwu H Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-met and STAT3. Stem Cell Reports, 2013-07-25;1(2):139-51. 2013-07-25 [PMID: 24052949] (Bioassay, Human)
• Chang , William, Andrejecsk , Jillian, Kluger , Martin S, Saltzman , W Mark, Pober , Jordan S Pericytes modulate endothelial sprouting. Cardiovasc Res, 2013-09-16;100(3):492-500. 2013-09-16 [PMID: 24042014] (Bioassay, Human)
• Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiainen M, Gstaiger M, Lehti K EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion. J Cell Biol, 2013-04-29;201(3):467-84. 2013-04-29 [PMID: 23629968] (Bioassay, Human)
• Hasenauer S, Malinger D, Koschut D, Pace G, Matzke A, von Au A, Orian-Rousseau V Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins. PLoS ONE, 2013-04-23;8(4):e62357. 2013-04-23 [PMID: 23626807] (Bioassay, Human)
• Gourlaouen , Morgane, Welti , Jonathan, Vasudev , Naveen S, Reynolds , Andrew R Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells. J Biol Chem, 2013-01-22;288(11):7467-80. 2013-01-22 [PMID: 23341459] (Bioassay, Human)
• Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, Majolino I, Novarese L, Rocci A, Gambella M, Ciciarello M, Scambia G, Palumbo A, Locatelli F, De Cristofaro R, Rutella S Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. J Transl Med, 2012-12-11;10(0):247. 2012-12-11 [PMID: 23232072] (Bioassay, Human)
• Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 2012-11-27;21(1):228-39. 2012-11-27 [PMID: 23183535] (Bioassay, Human)
• Furcht C, Munoz Rojas A, Nihalani D, Lazzara M Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations. Oncogene, 2012-07-09;32(18):2346-55, 2355. 2012-07-09 [PMID: 22777356] (Bioassay, Human)
• Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells, 2011-06-01;29(6):964-71. 2011-06-01 [PMID: 21563278] (Bioassay, Mouse)
• Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol., 2011-01-18;31(6):1174-85. 2011-01-18 [PMID: 21245381] (Bioassay, Human)
• Ramani VC, Yang Y, Ren Y Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity. J. Biol. Chem., 2010-12-03;286(8):6490-9. 2010-12-03 [PMID: 21131364] (Bioassay, Human)
• Casazza A, Finisguerra V, Capparuccia L Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J. Clin. Invest., 2010-07-26;120(8):2684-98. 2010-07-26 [PMID: 20664171] (Bioassay, Human)
• Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, Mizunoya W, Ikeuchi Y, Furuse M, Allen RE High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. Am. J. Physiol., Cell Physiol., 2009-12-09;298(3):C465-76. 2009-12-09 [PMID: 20007454] (Bioassay, Rat)
• Phin S, Marchand-Adam S, Fabre A, Marchal-Somme J, Bantsimba-Malanda C, Kataoka H, Soler P, Crestani B Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice. Am. J. Respir. Cell Mol. Biol., 2009-05-15;42(3):286-93. 2009-05-15 [PMID: 19448157] (Activation, Mouse)
• Buchstein N, Hoffmann D, Smola H, Lang S, Paulsson M, Niemann C, Krieg T, Eming SA Alternative proteolytic processing of hepatocyte growth factor during wound repair. Am. J. Pathol., 2009-04-23;174(6):2116-28. 2009-04-23 [PMID: 19389925] (Bioassay, Human)
• Tatsumi R, Wuollet AL, Tabata K, Nishimura S, Tabata S, Mizunoya W, Ikeuchi Y, Allen RE A role for calcium-calmodulin in regulating nitric oxide production during skeletal muscle satellite cell activation. Am. J. Physiol., Cell Physiol., 2009-01-21;296(4):C922-9. 2009-01-21 [PMID: 19158401] (Control, Rat)
• Ueda Y, Karasawa Y, Satoh Y, Nishikawa S, Imaki J, Ito M Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture. Invest. Ophthalmol. Vis. Sci., 2008-12-20;50(5):1978-87. 2008-12-20 [PMID: 19098316] (Bioassay, Mouse)
• Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor. J. Invest. Dermatol., 2008-11-20;129(5):1140-8. 2008-11-20 [PMID: 19020551] (Bioassay, Human)
• Nicoleau C, Benzakour O, Agasse F, Thiriet N, Petit J, Prestoz L, Roger M, Jaber M, Coronas V Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal. Stem Cells, 2009-02-01;0(0):. 2009-02-01 [PMID: 18988709] (Bioassay, Rat)
• Reed SA, Johnson SE Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types. J. Cell. Physiol., 2008-05-01;215(2):329-36. 2008-05-01 [PMID: 17929245] (Bioassay, Equine)
• Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J. Biol. Chem., 2007-08-24;282(43):31643-55. 2007-08-24 [PMID: 17720976] (Bioassay, Human)
• Skibinski G, Elborn JS, Ennis M Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-03-23;293(1):L69-76. 2007-03-23 [PMID: 17384084] (Bioassay, Human)
• Kitajima T, Terai H, Ito Y A fusion protein of hepatocyte growth factor for immobilization to collagen. Biomaterials, 2007-01-19;28(11):1989-97. 2007-01-19 [PMID: 17239947] (Bioassay, Human)
• Li F, Shetty AK, Sugahara K Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways. J. Biol. Chem., 2006-12-04;282(5):2956-66. 2006-12-04 [PMID: 17145750] (Bioassay, Fish - Prionace glauca (Blue Shark))
• Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression. J. Endocrinol., 2006-10-01;191(1):65-81. 2006-10-01 [PMID: 17065390] (Bioassay, Hamster)
• Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)
• Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int. J. Dev. Biol., 2006-01-01;50(7):645-52. 2006-01-01 [PMID: 16892178] (Bioassay, Human)
• Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am. J. Pathol., 2006-07-01;169(1):200-8. 2006-07-01 [PMID: 16816373] (Bioassay, Human)
• Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics. Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2701-8. 2006-06-01 [PMID: 16723489] (In Vivo, Rat)
• Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-09-01;58(17):4008-14. 1998-09-01 [PMID: 9731515] (Bioassay, Human)

Bioinformatics

• Gene Symbol: HGF
• Uniprot:
  • P14210.2()