Recombinant Human IGF-I/IGF-1 Protein, CF

Recombinant Human IGF-I/IGF-1 (Catalog # 291-G1) stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.3‑1.5 ng/mL.

1 μg/lane of Recombinant Human IGF-I/IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.

MALDI-TOF analysis of Recombinant Human IGF-I/IGF-1.The major peak corresponds to the calculated molecular mass, 7650 Da. The minor peak at 7873 is a matrix-associated artifact of the MALDI-TOF.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human IGF-I/IGF-1 Protein, CF Summary

• Details of Functionality: Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED₅₀ for this effect is 0.3-1.5 ng/mL.
• Source: E. coli-derived human IGF-I/IGF-1 protein
  Gly49-Ala118
• Accession #: P05019
• N-terminal Sequence: Gly49
• Protein/Peptide Type: Recombinant Proteins
• Gene: IGF1
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 7.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 7 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 200 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IGF-I/IGF-1 Protein, CF

• IBP1
• IGF1
• IGF-1
• IGF1A
• IGFI
• IGF-I
• IGF-IA
• IGF-IB
• insulin-like growth factor 1 (somatomedin C)
• insulin-like growth factor 1
• insulin-like growth factor I
• insulin-like growth factor IA
• insulin-like growth factor IB
• Mechano growth factor
• MGF
• Somatomedin A
• Somatomedin C
• somatomedin-C

Background

Insulin-like growth factor I (IGF-I or IGF-1), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C‑terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-1 protein is identical between isoforms and is generated by proteolytic removal of the N- and C‑terminal regions. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II/IGF-2. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4‑7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half‑life and modulating its interactions with receptors (10).

1. Philippou, A. et al. (2007) In Vivo 21:45.
2. Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275.
3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.

Publications for IGF-I/IGF-1 (291-G1)(229)

Publications using 291-G1

• Campbell, CA;Calderon, R;Pavani, G;Cheng, X;Barakat, R;Snella, E;Liu, F;Peng, X;Essner, JJ;Dorman, KS;McGrail, M;Gadue, P;French, DL;Espin-Palazon, R; p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation Nature communications 2024-09-06 [PMID: 39242546] (Bioassay, Human)
• Giacomoni, J;Åkerblom, M;Habekost, M;Fiorenzano, A;Kajtez, J;Davidsson, M;Parmar, M;Björklund, T; Identification and validation of novel engineered AAV capsid variants targeting human glia Frontiers in neuroscience 2024-08-13 [PMID: 39193523] (Bioassay, Human)
• Kent, GM;Atkins, MH;Lung, B;Nikitina, A;Fernandes, IM;Kwan, JJ;Andrews, TS;MacParland, SA;Keller, GM;Gage, BK; Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells Cell reports 2024-08-14 [PMID: 39146183] (Bioassay, Human)
• Majlessipour, F;Zhu, G;Baca, N;Kumbaji, M;Hwa, V;Danielpour, M; Skeletal overgrowth in a pre-pubescent child treated with pan-FGFR inhibitor Heliyon 2024-06-15 [PMID: 38841436] (Bioassay, Human)
• Lorenzo-Martín, LF;Hübscher, T;Bowler, AD;Broguiere, N;Langer, J;Tillard, L;Nikolaev, M;Radtke, F;Lutolf, MP; Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo Nature 2024-04-24 [PMID: 38658753] (Bioassay, Transgenic Mouse)
• Gaal, OI;Liu, R;Marginean, D;Badii, M;Cab?u, G;Hotea, I;Nica, V;Colcear, D;HINT Consortium, ;Pamfil, C;Merriman, TR;Rednic, S;Popp, RA;Cri?an, TO;Joosten, LAB; GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells Scientific reports 2024-02-12 [PMID: 38347000] (Bioassay, Human)
• Mozin, E;Massouridès, E;Mournetas, V;Lièvre, C;Bourdon, A;Jackson, DL;Packer, JS;Trapnell, C;Guiner, CL;Adjali, O;Pinset, C;Mack, DL;Dupont, JB; Dystrophin deficiency impairs cell junction formation during embryonic myogenesis bioRxiv : the preprint server for biology 2023-12-07 [PMID: 38106055] (Bioassay, Human)
• Davis-Anderson, K;Micheva-Viteva, S;Solomon, E;Hovde, B;Cirigliano, E;Harris, J;Twary, S;Iyer, R; CRISPR/Cas9 Directed Reprogramming of iPSC for Accelerated Motor Neuron Differentiation Leads to Dysregulation of Neuronal Fate Patterning and Function International journal of molecular sciences 2023-11-10 [PMID: 38003351] (Bioassay, Human)
• Chang, S;Xiao, W;Xie, Y;Xu, Z;Li, B;Wang, G;Hu, K;Zhang, Y;Zhou, J;Song, D;Zhu, H;Wu, X;Lu, Y;Shi, J;Zhu, W; TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage Cancer medicine 2023-11-09 [PMID: 37942576] (Bioassay, Human)
• Byeon, HJ;Chae, MK;Ko, J;Lee, EJ;Kikkawa, DO;Jang, SY;Yoon, JS; The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves' Orbitopathy Investigative ophthalmology & visual science 2023-08-01 [PMID: 37555734] (Bioassay, Human)
• Oiwa, K;Watanabe, S;Onodera, K;Iguchi, Y;Kinoshita, Y;Komine, O;Sobue, A;Okada, Y;Katsuno, M;Yamanaka, K; Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis Science advances 2023-08-04 [PMID: 37540751] (Bioassay, Human)
• Archilia, EC;Bello, CAP;Batalha, IM;Wulstein, K;Enriquez, C;Schütz, LF; Effects of follicle-stimulating hormone, insulin-like growth factor 1, fibroblast growth factor 2, and fibroblast growth factor 9 on sirtuins expression and histone deacetylase activity in bovine granulosa cells Theriogenology 2023-07-12 [PMID: 37454576] (Bioassay, Bovine)
• Meng, F;Zhang, S;Xie, J;Zhou, Y;Wu, Q;Lu, B;Zhou, S;Zhao, X;Li, Y; Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells Journal of hematology & oncology 2023-06-14 [PMID: 37316891] (Bioassay, Human)
• Nguyen, VTT;Taheri, N;Choi, EL;Kellogg, TA;Linden, DR;Hayashi, Y; Insulin-like growth factor1 preserves gastric pacemaker cells and motor function in aging via ERK1/2 activation Cellular and molecular gastroenterology and hepatology 2023-06-08 [PMID: 37301443] (Bioassay, Mouse)
• Rashid, MI;Ito, T;Miya, F;Shimojo, D;Arimoto, K;Onodera, K;Okada, R;Nagashima, T;Yamamoto, K;Khatun, Z;Shimul, RI;Niwa, JI;Katsuno, M;Sobue, G;Okano, H;Sakurai, H;Shimizu, K;Doyu, M;Okada, Y; Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling Scientific reports 2023-05-25 [PMID: 37231024] (Bioassay, Human)
• Maylem, ERS;Spicer, LJ;Batalha, IM;Sch�tz, LF; Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells Domestic animal endocrinology 2023-04-25 [PMID: 37167929] (Bioassay, Bovine)
• CA Hayes, NI Morgan, KC Thomas, MJ Pushie, A Vijayasank, BG Ashmore, K Wontor, MA De Leon, NM Ashpole Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage bioRxiv : the preprint server for biology, 2023-04-02;0(0):. 2023-04-02 [PMID: 37034764] (Bioassay, Mouse)
• AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G&gt;A (p.D249N) autosomal dominant mutation in TUBB4A Stem Cell Research, 2023-03-26;69(0):103083. 2023-03-26 [PMID: 37003180] (Bioassay, Human)
• NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome International Journal of Molecular Sciences, 2023-02-09;24(4):. 2023-02-09 [PMID: 36834891] (Bioassay, Human)
• EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (Bioassay, Human, Mouse)
• HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective bioRxiv : the preprint server for biology, 2023-02-10;0(0):. 2023-02-10 [PMID: 36798313] (Bioassay, Human)
• PY Su, W Lee, J Zernant, SH Tsang, T Nagasaki, B Corneo, R Allikmets Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture Oncogene, 2022-11-14;65(0):102973. 2022-11-14 [PMID: 36455383] (Bioassay, Human)
• Jung-Won Shin, Sungwon An, Dongin Kim, Hyunjoo Kim, Jinhyung Ahn, Jaehyun Eom et al. Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier Cell Reports Methods 2022-11-21 [PMID: 36452865] (Bioassay, Human)
• C Bueno, M Blanquer, D García-Ber, S Martínez, JM Moraleda Binucleated human bone marrow-derived mesenchymal cells can be formed during neural-like differentiation with independence of any cell fusion events Scientific Reports, 2022-11-30;12(1):20615. 2022-11-30 [PMID: 36450873] (Bioassay, Human)
• ESY Ng, N Kady, J Hu, A Dave, Z Jiang, J Pei, MB Gorin, A Matynia, RA Radu Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration Cells, 2022-11-02;11(21):. 2022-11-02 [PMID: 36359858] (Bioassay, Human)
• M Ridenour, LJ Spicer, JL Grindstaff Insulin-like growth factor 1 and the hormonal mediation of sibling rivalry General and comparative endocrinology, 2022-11-07;330(0):114163. 2022-11-07 [PMID: 36356644] (Bioassay, Eastern Bluebirds)
• F Fang, L Xu, L Liang, M Qu, H Yao, W Yue, L Chen, D Chen, Z Fan, L He, X Nan, H Zhang, X Xie, X Pei The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation Cell Death & Disease, 2022-10-21;13(10):886. 2022-10-21 [PMID: 36270980] (Bioassay, Human)
• T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro Nature Communications, 2022-09-15;13(1):5427. 2022-09-15 [PMID: 36109497] (Cell Culture, Mouse)
• Z Liu, D Meng, J Wang, H Cao, P Feng, S Wu, N Wang, C Dang, P Hou, P Xia GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway Cell Death & Disease, 2022-08-30;13(8):751. 2022-08-30 [PMID: 36042202] (Bioassay, Human)
• Y Tang, DJ Kwiatkowsk, EP Henske Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment Nature Communications, 2022-08-26;13(1):5018. 2022-08-26 [PMID: 36028490] (Bioassay, Mouse)
• S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay Nature Communications, 2022-08-25;13(1):5003. 2022-08-25 [PMID: 36008413] (Bioassay, Mouse)
• LJ Spicer, JR Evans, NB Schreiber Hormone regulation of thrombospondin-1 mRNA in porcine granulosa cells in vitro Oncogene, 2022-07-26;244(0):107048. 2022-07-26 [PMID: 35914333] (Bioassay, Porcine)
• C Nunes, L Depestel, L Mus, KM Keller, L Delhaye, A Louwagie, M Rishfi, A Whale, N Kara, SR Andrews, F Dela Cruz, D You, A Siddiquee, CT Cologna, S De Craemer, E Dolman, C Bartenhage, F De Vloed, E Sanders, A Eggermont, SL Bekaert, W Van Loocke, JW Bek, G Dewyn, S Loontiens, G Van Isterd, B Decaesteke, L Tilleman, F Van Nieuwe, V Vermeirsse, C Van Neste, B Ghesquiere, S Goossens, S Eyckerman, K De Preter, M Fischer, J Houseley, J Molenaar, B De Wilde, SS Roberts, K Durinck, F Speleman RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition Science Advances, 2022-07-13;8(28):eabn1382. 2022-07-13 [PMID: 35857500] (Bioassay, Human)
• IB Kim, T Lee, J Lee, J Kim, S Lee, IG Koh, JH Kim, JY An, H Lee, WK Kim, YS Ju, Y Cho, SJ Yu, SA Kim, M Oh, DW Han, E Kim, JK Choi, HJ Yoo, JH Lee Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder Oncogene, 2022-07-15;0(0):. 2022-07-15 [PMID: 35840799] (Bioassay, Human)
• MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-02-21;31(0):100852. 2022-02-21 [PMID: 35782608] (Bioassay, Human)
• V Kheirollah, A Khadim, G Kiliaris, M Korfei, MM Barroso, I Alexopoulo, AI Vazquez-Ar, M Wygrecka, C Ruppert, A Guenther, W Seeger, S Herold, E El Agha Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis Cells, 2022-06-20;11(12):. 2022-06-20 [PMID: 35741102] (Bioassay, Human)
• MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor Biomolecules, 2022-06-18;12(6):. 2022-06-18 [PMID: 35740973] (Bioassay, Human)
• M Berlak, E Tucker, M Dorel, A Winkler, A McGearey, E Rodriguez-, BM da Costa, K Barker, E Fyle, E Calton, S Eising, K Ober, D Hughes, E Koutrouman, P Carter, R Stankunait, P Proszek, N Jain, C Rosswog, H Dorado-Gar, JJ Molenaar, M Hubank, G Barone, J Anderson, P Lang, HE Deubzer, A Künkele, M Fischer, A Eggert, C Kloft, AG Henssen, M Boettcher, F Hertwig, N Blüthgen, L Chesler, JH Schulte Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells Molecular Cancer, 2022-06-10;21(1):126. 2022-06-10 [PMID: 35689207] (Bioassay, Human)
• E Metzler, H Escobar, DY Sunaga-Fra, S Sauer, S Diecke, S Spuler Generation of hiPSC-Derived Skeletal Muscle Cells: Exploiting the Potential of Skeletal Muscle-Derived hiPSCs Biomedicines, 2022-05-23;10(5):. 2022-05-23 [PMID: 35625941] (Bioassay, Human)
• KMA De Kleijn, KR Straasheij, WA Zuure, GJM Martens Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids Biomedicines, 2022-04-29;10(5):. 2022-04-29 [PMID: 35625761] (Bioassay, Human)
• FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus Cell Transplantation, 2022-01-01;31(0):9636897221101. 2022-01-01 [PMID: 35596532] (Bioassay, Human)
• SA Luff, JP Creamer, S Valsoni, C Dege, R Scarfò, A Dacunto, S Cascione, LN Randolph, E Cavalca, I Merelli, SA Morris, A Ditadi, CM Sturgeon Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells Nature Cell Biology, 2022-04-28;0(0):. 2022-04-28 [PMID: 35484246] (Bioassay, Human)
• Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)
• SL Pereira, ME Shoemaker, S Gawel, GJ Davis, M Luo, VA Mustad, JT Cramer Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia Nutrients, 2022-03-11;14(6):. 2022-03-11 [PMID: 35334853] (Bioassay, Human)
• L Zhu, D Retana, P García-Góm, L Álvaro-Esp, N Priego, M Masmudi-Ma, N Yebra, L Miarka, E Hernández-, C Blanco-Apa, S Martínez, C Sobrino, N Ajenjo, MJ Artiga, E Ortega-Pai, R Torres-Rui, S Rodríguez-, RENACER, R Soffietti, L Bertero, P Cassoni, T Weiss, J Muñoz, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, O Toldos, Y Ruano, L Alcázar, G Blasco, J Fernández-, E Caleiras, M Lafarga, D Megías, O Graña-Cast, C Nör, MD Taylor, LS Young, D Varešlija, N Cosgrove, FJ Couch, L Cussó, M Desco, S Mouron, M Quintela-F, M Weller, J Pastor, M Valiente A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis Embo Molecular Medicine, 2022-02-17;0(0):e14552. 2022-02-17 [PMID: 35174975] (Bioassay, Human)
• KN Lin, K Zhang, W Zhao, SY Huang, H Li Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells International Journal of Molecular Sciences, 2022-01-28;23(3):. 2022-01-28 [PMID: 35163437] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021-12-23;59(0):102635. 2021-12-23 [PMID: 35074682] (Bioassay, Human)
• Louise Thiry, Jean-Pierre Clément, Rainer Haag, Timothy E Kennedy, Stefano Stifani Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate ASN Neuro 2022-01-13 [PMID: 35023784] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)
• KD Abu-Bonsra, DF Newgreen, M Dottori Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds Cells, 2021-10-26;10(11):. 2021-10-26 [PMID: 34831120] (Bioassay, Human)
• AN Holowatyj, B Gigic, CA Warby, J Ose, T Lin, P Schrotz-Ki, CM Ulrich, JJ Bernard The Use of Human Serum Samples to Study Malignant Transformation: A Pilot Study Cells, 2021-10-06;10(10):. 2021-10-06 [PMID: 34685650] (Bioassay, Human)
• W M Kholosy, M Derieppe, F van den Ha, K Ober, Y Su, L Custers, L Schild, L M J van Zo, L M Wellens, H R Ariese, CL Szanto, J Wienke, MP Dierselhui, D van Vuurde, EM Dolman, JJ Molenaar Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies Journal of personalized medicine, 2021-08-30;11(9):. 2021-08-30 [PMID: 34575646] (Bioassay, Human)
• PR Gajjala, RK Kasam, D Soundarara, D Sinner, SK Huang, AG Jegga, SK Madala Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis JCI Insight, 2021-10-22;0(0):. 2021-10-22 [PMID: 34520400] (Bioassay, Human, Mouse)
• AM Thiebaut, I Buendia, V Ginet, E Lemarchand, MB Boudjadja, Y Hommet, L Lebouvier, C Lechevalli, M Maillasson, E Hedou, N Déglon, F Oury, M Rubio, J Montaner, J Puyal, D Vivien, BD Roussel Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia Autophagy, 2021-09-14;0(0):1-21. 2021-09-14 [PMID: 34520334] (Bioassay, Human)
• Masahiro Otsu, Zubair Ahmed, Daniel Fulton Generation of Multipotential NG2 Progenitors From Mouse Embryonic Stem Cell-Derived Neural Stem Cells Frontiers in Cell and Developmental Biology 2021-08-24 [PMID: 34504841] (Bioassay, Mouse)
• G Iannello, A Patel, D Sirabella, B Corneo, V Thaker Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity Stem Cell Research, 2021-06-21;54(0):102432. 2021-06-21 [PMID: 34214899] (Bioassay, Human)
• KMA Abdel-Raou, R Rezgui, C Stefanini, JCM Teo, N Christofor Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands Biology, 2021-06-16;10(6):. 2021-06-16 [PMID: 34208436] (Cell Culture, Human)
• L Wang, M Yang, H Jin PI3K/AKT phosphorylation activates ERRalpha by upregulating PGC?1alpha and PGC?1beta in gallbladder cancer Molecular Medicine Reports, 2021-06-29;24(2):. 2021-06-29 [PMID: 34184087] (Bioassay, Human)
• C Qiao, W Huang, J Chen, W Feng, T Zhang, Y Wang, D Liu, X Ji, M Xie, M Sun, D Fan, K Wu, L Xia IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R Cell Death & Disease, 2021-06-01;12(6):564. 2021-06-01 [PMID: 34075028] (Bioassay, Human)
• J Borsoi, M Morato-Mar, F de Araújo, L Assis Pere, LE Farinha-Ar, R Delgado Sa, AB Alvarez Pe, L Veiga Pere Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients Stem Cell Research, 2021-05-25;54(0):102407. 2021-05-25 [PMID: 34062330] (Bioassay, Human)
• C de O Mende, C Lopes-Siqu, F Pettito-As, M Pereira-Ol, MP de Oliveir, C Pirmez, AM Da-Cruz, H Goto Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis Journal of Immunology Research, 2021-03-29;2021(0):6657785. 2021-03-29 [PMID: 33860062] (Bioassay, L. braziliensis)
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• Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E Insulin growth factor-1 protects against excitotoxicity in the rat striatum. Neuroreport, 2004-10-05;15(14):2251-4. 2004-10-05 [PMID: 15371744] (In Vivo, Rat)
• Gahr SA, Kocamis H, Richter JJ, Killefer J The effects of in ovo rhIGF-I administration on expression of the growth hormone secretagogue receptor (GHSR) during chicken embryonic development. Growth Dev Aging, 2004-01-01;68(1):3-10. 2004-01-01 [PMID: 15307660] (In Vivo, Chicken)
• Brenner N, Huning M, Stange R Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif. Tissue Int., 2004-04-01;74(4):388-97. 2004-04-01 [PMID: 15255077] (In Vivo, Rat)
• Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats. Bone, 2004-05-01;34(5):862-8. 2004-05-01 [PMID: 15121018] (In Vivo, Rat)
• Studer RK, Bergman R, Stubbs T, Decker K Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther., 2003-11-07;6(1):R56-R64. 2003-11-07 [PMID: 14979938] (Bioassay, Rabbit)
• Oropeza A, Wrenzycki C, Herrmann D, Hadeler KG, Niemann H Improvement of the developmental capacity of oocytes from prepubertal cattle by intraovarian insulin-like growth factor-I application. Biol. Reprod., 2004-02-06;70(6):1634-43. 2004-02-06 [PMID: 14766727] (In Vivo, Bovine)
• Loeser RF, Carlson CS, Del Carlo M, Cole A Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum., 2002-09-01;46(9):2349-57. 2002-09-01 [PMID: 12355482] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene, 2002-08-22;21(37):5673-83. 2002-08-22 [PMID: 12173037] (Bioassay, Human)
• Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest. Ophthalmol. Vis. Sci., 2002-07-01;43(7):2462-7. 2002-07-01 [PMID: 12091451] (In Vivo, Mouse)
• Loeser RF, 2018, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. e0194453, 2000-09-01;43(9):2110-20. 2000-09-01 [PMID: 11014363] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Deleu S, Pirson I, Clermont F, Nakamura T, Dumont JE, Maenhaut C Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli. J. Cell. Physiol., 1999-11-01;181(2):342-54. 1999-11-01 [PMID: 10497313] (Bioassay, Canine)

Bioinformatics

• Gene Symbol: IGF1
• Uniprot:
  • P05019()