Recombinant Human IGF-I/IGF-1 Protein, CF

1 μg/lane of Recombinant Human IGF-I/IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.

Recombinant Human IGF-I/IGF-1 (Catalog # 291-G1) stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.3‑1.5 ng/mL.

MALDI-TOF analysis of Recombinant Human IGF-I/IGF-1.The major peak corresponds to the calculated molecular mass, 7650 Da. The minor peak at 7873 is a matrix-associated artifact of the MALDI-TOF.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human IGF-I/IGF-1 Protein, CF Summary

• Details of Functionality: Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED₅₀ for this effect is 0.3-1.5 ng/mL.
  The specific activity of recombinant human IGF-I/IGF-1 is approximately 2.5 IU/μg, which is calibrated against recombinant human IGF-I/IGF-1 WHO International Standard (NIBSC code: 91/554). Specific activity is for reference purposes only and is not routinely tested.
• Source: E. coli-derived human IGF-I/IGF-1 protein
  Gly49-Ala118
• Accession #: P05019
• N-terminal Sequence: Gly49
• Protein/Peptide Type: Recombinant Proteins
• Gene: IGF1
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 7.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 7 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 200 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IGF-I/IGF-1 Protein, CF

• IBP1
• IGF1
• IGF-1
• IGF1A
• IGFI
• IGF-I
• IGF-IA
• IGF-IB
• insulin-like growth factor 1 (somatomedin C)
• insulin-like growth factor 1
• insulin-like growth factor I
• insulin-like growth factor IA
• insulin-like growth factor IB
• Mechano growth factor
• MGF
• Somatomedin A
• Somatomedin C
• somatomedin-C

Background

Insulin-like growth factor I (IGF-I or IGF-1), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C‑terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-1 protein is identical between isoforms and is generated by proteolytic removal of the N- and C‑terminal regions. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II/IGF-2. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4‑7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half‑life and modulating its interactions with receptors (10).

1. Philippou, A. et al. (2007) In Vivo 21:45.
2. Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275.
3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.

Publications for IGF-I/IGF-1 (291-G1)(173)

Publications using 291-G1

• SL Pereira, ME Shoemaker, S Gawel, GJ Davis, M Luo, VA Mustad, JT Cramer Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia Nutrients, 2022;14(6):. 2022 [PMID: 35334853] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021;59(0):102635. 2021 [PMID: 35074682] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021;10(11):. 2021 [PMID: 34831322] (Bioassay, Human)
• KD Abu-Bonsra, DF Newgreen, M Dottori Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds Cells, 2021;10(11):. 2021 [PMID: 34831120] (Bioassay, Human)
• AN Holowatyj, B Gigic, CA Warby, J Ose, T Lin, P Schrotz-Ki, CM Ulrich, JJ Bernard The Use of Human Serum Samples to Study Malignant Transformation: A Pilot Study Cells, 2021;10(10):. 2021 [PMID: 34685650] (Bioassay, Human)
• W M Kholosy, M Derieppe, F van den Ha, K Ober, Y Su, L Custers, L Schild, L M J van Zo, L M Wellens, H R Ariese, CL Szanto, J Wienke, MP Dierselhui, D van Vuurde, EM Dolman, JJ Molenaar Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies Journal of personalized medicine, 2021;11(9):. 2021 [PMID: 34575646] (Bioassay, Human)
• PR Gajjala, RK Kasam, D Soundarara, D Sinner, SK Huang, AG Jegga, SK Madala Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis JCI Insight, 2021;0(0):. 2021 [PMID: 34520400] (Bioassay, Human)
• AM Thiebaut, I Buendia, V Ginet, E Lemarchand, MB Boudjadja, Y Hommet, L Lebouvier, C Lechevalli, M Maillasson, E Hedou, N Déglon, F Oury, M Rubio, J Montaner, J Puyal, D Vivien, BD Roussel Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia Autophagy, 2021;0(0):1-21. 2021 [PMID: 34520334] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, V Thaker Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity Stem Cell Research, 2021;54(0):102432. 2021 [PMID: 34214899] (Bioassay, Human)
• KMA Abdel-Raou, R Rezgui, C Stefanini, JCM Teo, N Christofor Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands Biology, 2021;10(6):. 2021 [PMID: 34208436] (Cell Culture, Human)
• L Wang, M Yang, H Jin PI3K/AKT phosphorylation activates ERRalpha by upregulating PGC?1alpha and PGC?1beta in gallbladder cancer Molecular Medicine Reports, 2021;24(2):. 2021 [PMID: 34184087] (Bioassay, Human)
• C Qiao, W Huang, J Chen, W Feng, T Zhang, Y Wang, D Liu, X Ji, M Xie, M Sun, D Fan, K Wu, L Xia IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R Cell Death & Disease, 2021;12(6):564. 2021 [PMID: 34075028] (Bioassay, Human)
• J Borsoi, M Morato-Mar, F de Araújo, L Assis Pere, LE Farinha-Ar, R Delgado Sa, AB Alvarez Pe, L Veiga Pere Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients Stem Cell Research, 2021;54(0):102407. 2021 [PMID: 34062330] (Bioassay, Human)
• C de O Mende, C Lopes-Siqu, F Pettito-As, M Pereira-Ol, MP de Oliveir, C Pirmez, AM Da-Cruz, H Goto Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis Journal of Immunology Research, 2021;2021(0):6657785. 2021 [PMID: 33860062] (Bioassay, L. braziliensis)
• M Chiara Per, N Bellitto, ERS Maylem, F Caloni, LJ Spicer Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in�vitro Theriogenology, 2021;168(0):1-12. 2021 [PMID: 33826978] (Bioassay, Feline)
• X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021;34(9):108802. 2021 [PMID: 33657377] (Bioassay, Human)
• J Sheff, P Wang, P Xu, M Arbour, L Masson, H van Faasse, G Hussack, K Kemmerich, E Brunette, D Stanimirov, JJ Hill, J Kelly, F Ni Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor Scientific Reports, 2021;11(1):4284. 2021 [PMID: 33608571] (Surface Plasmon Resonance, Human)
• E Solomon, K Davis-Ande, B Hovde, S Micheva-Vi, JF Harris, S Twary, R Iyer Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation BMC molecular and cell biology, 2021;22(1):13. 2021 [PMID: 33602141] (Bioassay, Human)
• CC Zuliani, II Damas, KC Andrade, CB Westin, ÂM Moraes, IB Coimbra Chondrogenesis of human amniotic fluid stem cells in Chitosan-Xanthan scaffold for cartilage tissue engineering Scientific Reports, 2021;11(1):3063. 2021 [PMID: 33542256] (Bioassay, Human)
• C Phoomak, W Cui, TJ Hayman, SH Yu, P Zhao, L Wells, R Steet, JN Contessa The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress Science Advances, 2021;7(3):. 2021 [PMID: 33523898] (Bioassay, Human)
• C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response Cell Stem Cell, 2021;28(2):331-342.e5. 2021 [PMID: 33450186] (Bioassay, Human)
• S Krueger, A Riess, A Jonitz-Hei, A Weizel, A Seyfarth, H Seitz, R Bader Establishment of a New Device for Electrical Stimulation of Non-Degenerative Cartilage Cells In Vitro International Journal of Molecular Sciences, 2021;22(1):. 2021 [PMID: 33401406] (Bioassay, Human)
• , 0;0(0):. 0 [PMID: 33348564] (Cell Culture, Human)
• L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy Nat Commun, 2020;11(1):5842. 2020 [PMID: 33203880] (Cell Culture, Human)
• KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020;0(0):. 2020 [PMID: 33091368] (Bioassay, Mouse)
• NV Hewawasam, F Lhaf, HA Taylor, K Viloria, A Austin, A King, P Jones, L Jones, MD Turner, NJ Hill Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress Sci Rep, 2020;10(1):15741. 2020 [PMID: 32978479] (Bioassay, Mouse)
• S Riccetti, A Sinigaglia, G Desole, N Nowotny, M Trevisan, L Barzon Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells Viruses, 2020;12(8):. 2020 [PMID: 32806715] (Bioassay, Human)
• DP Ha, AS Lee Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis Cell. Signal., 2020;75(0):109736. 2020 [PMID: 32805346] (Bioassay, Mouse)
• HJ Byeon, JY Kim, J Ko, EJ Lee, K Don, JS Yoon Protein tyrosine phosphatase 1B as a therapeutic target for Graves&#039; orbitopathy in an in vitro model PLoS ONE, 2020;15(8):e0237015. 2020 [PMID: 32760098] (Cell Culture, Human)
• Y Nanki, T Chiyoda, A Hirasawa, A Ookubo, M Itoh, M Ueno, T Akahane, K Kameyama, W Yamagami, F Kataoka, D Aoki Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing Sci Rep, 2020;10(1):12581. 2020 [PMID: 32724113] (Bioassay, Human`)
• ST Chen, WJ Lai, WJ Zhang, QP Chen, LB Zhou, KF So, LL Shi Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons Neural Regen Res, 2020;15(12):2335-2343. 2020 [PMID: 32594058] (Bioassay, Human)
• L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21 Aging (Albany NY), 2020;12(8):6823-6851. 2020 [PMID: 32302288] (Cell Culture, Human)
• T Sato, F Shibata, T Koiwai, N Akimoto Different regulation of lipogenesis in sebocytes and subcutaneous preadipocytes in hamsters in vitro Biochem Biophys Rep, 2020;22(0):100761. 2020 [PMID: 32300663] (Cell Culture, Hamster)
• K Onodera, D Shimojo, Y Ishihara, M Yano, F Miya, H Banno, N Kuzumaki, T Ito, R Okada, B de Araújo, M Ohyama, M Yoshida, T Tsunoda, M Katsuno, M Doyu, G Sobue, H Okano, Y Okada Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs Mol Brain, 2020;13(1):18. 2020 [PMID: 32070397] (Bioassay, Human)
• K Kawai, R Negoro, M Ichikawa, T Yamashita, S Deguchi, K Harada, K Hirata, K Takayama, H Mizuguchi Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies Mol Ther Methods Clin Dev, 2020;17(0):49-57. 2020 [PMID: 31890740] (Cell Culture, Human)
• M Matjusaiti, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, A Williams, SM Pollard Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors Stem Cell Reports, 2019;13(6):1053-1067. 2019 [PMID: 31708478] (Cell Culture, Mouse)
• S Krueger, S Achilles, J Zimmermann, T Tischer, R Bader, A Jonitz-Hei Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields J Clin Med, 2019;8(11):. 2019 [PMID: 31652962] (Bioassay, Human)
• A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination Cell Rep, 2019;29(4):904-919.e9. 2019 [PMID: 31644912] (Bioassay, Mouse)
• JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt V2a interneuron differentiation from mouse and human pluripotent stem cells Nat Protoc, 2019;0(0):. 2019 [PMID: 31628445] (Bioassay, Human)
• T Feng, AA DeVore, MC Perego, BC Morrell, LJ Spicer Effects of N-carbamylglutamate and arginine on steroidogenesis and proliferation of pig granulosa cells in vitro Anim. Reprod. Sci., 2019;209(0):106138. 2019 [PMID: 31514935] (Bioassay, Porcine)
• Z Wang, G Liu, J Mao, M Xie, M Zhao, X Guo, S Liang, H Li, X Li, R Wang IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells Mediators Inflamm., 2019;2019(0):5497467. 2019 [PMID: 31467485] (Bioassay, Human)
• Z Liu, M Osipovitch, A Benraiss, NPT Huynh, R Foti, J Bates, D Chandler-M, RL Findling, PJ Tesar, M Nedergaard, MS Windrem, SA Goldman Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling Cell Rep, 2019;27(13):3832-3843.e6. 2019 [PMID: 31242417] (Bioassay, Human)
• YB Pang, J He, BY Cui, S Xu, XL Li, MY Wu, R Liang, Y Feng, X Guo, XH Zhang, XL Luo A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma Stem Cells Int, 2019;2019(0):5680327. 2019 [PMID: 31065274] (Bioassay, Human)
• S Mayers, PD Moço, T Maqbool, PN Silva, DM Kilkenny, J Audet Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector BMC Biotechnol., 2019;19(1):21. 2019 [PMID: 30987611] (Bioassay, Mouse)
• B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019;27(2):599-615.e12. 2019 [PMID: 30970261] (Differentiation, Human)
• D Zhang, A Wang, J Feng, Q Zhang, L Liu, H Ren Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide?3 kinase/protein kinase B signaling pathway Mol Med Rep, 2019;19(5):4019-4026. 2019 [PMID: 30942438] (Bioassay, Human)
• CA Conover, LK Bale, RL Frye, HV Schaff Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes Physiol Rep, 2019;7(4):e14006. 2019 [PMID: 30809969] (Bioassay, Human)
• S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation JCI Insight, 2019;0(0):. 2019 [PMID: 30721154] (Bioassay, Human)
• KA Rankin, F Mei, K Kim, YA Shen, SR Mayoral, C Desponts, DS Lorrain, AJ Green, SE Baranzini, JR Chan, R Bove Selective estrogen receptor modulators enhance CNS remyelination independent of estrogen receptors J. Neurosci., 2019;0(0):. 2019 [PMID: 30696729] (Bioassay, Human)
• G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, Z Hou, Z Cai, G Jin, CC Hsu, YH Wang, J Hu, TY Chen, H Li, MG Lee, HK Lin SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis Nat. Cell Biol., 2019;0(0):. 2019 [PMID: 30692626] (Bioassay, Human)
• LP Foltz, SE Howden, JA Thomson, DO Clegg Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9 Int J Mol Sci, 2018;19(12):. 2018 [PMID: 30572641] (Bioassay, Human)
• J Li, J Zheng Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in�vitro Mol Med Rep, 2019;19(2):821-830. 2019 [PMID: 30569095] (Bioassay, Human)
• M Osipovitch, A Asenjo Mar, JN Mariani, A Cornwell, S Dhaliwal, L Zou, D Chandler-M, S Wang, X Li, SJ Benraiss, R Agate, A Lampp, A Benraiss, MS Windrem, SA Goldman Human ESC-Derived Chimeric Mouse Models of Huntington&#039;s Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation Cell Stem Cell, 2018;0(0):. 2018 [PMID: 30554964] (Bioassay, Human)
• R Negoro, K Takayama, K Kawai, K Harada, F Sakurai, K Hirata, H Mizuguchi Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies Stem Cell Reports, 2018;0(0):. 2018 [PMID: 30472010] (Bioassay, Human)
• B Decaesteke, G Denecker, C Van Neste, EM Dolman, W Van Loocke, M Gartlgrube, C Nunes, F De Vloed, P Depuydt, K Verboom, D Rombaut, S Loontiens, J De Wyn, WM Kholosy, B Koopmans, AHW Essing, C Herrmann, D Dreidax, K Durinck, D Deforce, F van Nieuwe, A Henssen, R Versteeg, V Boeva, G Schleierma, J van Nes, P Mestdagh, S Vanhauwaer, JH Schulte, F Westermann, JJ Molenaar, K De Preter, F Speleman TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets Nat Commun, 2018;9(1):4866. 2018 [PMID: 30451831] (Bioassay, Human)
• TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer Mol. Cancer Ther., 2018;0(0):. 2018 [PMID: 30404927] (Bioassay, Human)
• IF LaRocque-d, JDB Rocha, MP Nunes, PAV Oliveira, DO Nascimento, L Freire-de-, CM Takiya, A Morrot, D Decote-Ric, JO Previato, GA DosReis, L Mendonça-P, CG Freire-de- Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection Sci Rep, 2018;8(1):16378. 2018 [PMID: 30401972] (Bioassay, Human)
• H Takeuchi, S Inagaki, W Morozumi, Y Nakano, Y Inoue, Y Kuse, T Mizoguchi, S Nakamura, M Funato, H Kaneko, H Hara, M Shimazawa VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush Sci Rep, 2018;8(1):16443. 2018 [PMID: 30401804] (Bioassay, Human)
• N Brookhouse, P Zhang, R Caselli, JJ Kim, DA Brafman Generation and characterization of two human induced pluripotent stem cell (hiPSC) lines homozygous for the Apolipoprotein e4 (APOE4) risk variant-Alzheimer&#039;s disease (ASUi005-A) and healthy non-demented control (ASUi006-A) Stem Cell Res, 2018;32(0):145-149. 2018 [PMID: 30296667] (Bioassay, Human)
• LC Reis, EM Ramos-Sanc, F Petitto-As, AH Nerland, M Hernandez-, F Selheim, LM Floeter-Wi, H Goto Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection Mediators Inflamm., 2018;2018(0):9787128. 2018 [PMID: 30150896] (Mouse)
• YY Lin, Y Chien, JH Chuang, CC Chang, YP Yang, YH Lai, WL Lo, KH Chien, TI Huo, CY Wang Development of a Graphene Oxide-Incorporated Polydimethylsiloxane Membrane with Hexagonal Micropillars Int J Mol Sci, 2018;19(9):. 2018 [PMID: 30149618] (Bioassay, Human)
• S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington&#039;s disease patients Nat Commun, 2018;9(1):2886. 2018 [PMID: 30038412] (Bioassay, Human)
• FC Yang, J Draper, PG Smith, JL Vivian, SM Shapiro, JA Stanford Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain Cell Transplant, 2018;0(0):9636897187663. 2018 [PMID: 29845869] (Bioassay, Human)
• MK Shanmugam, KS Ahn, JH Lee, R Kannaiyan, N Mustafa, KA Manu, KS Siveen, G Sethi, WJ Chng, AP Kumar Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma Front Pharmacol, 2018;9(0):365. 2018 [PMID: 29773987] (Bioassay, Human)
• S Nagel, C Pommerenke, C Meyer, M Kaufmann, RAF MacLeod, HG Drexler Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma Oncotarget, 2018;9(18):14338-14353. 2018 [PMID: 29581848] (Bioassay, Human)
• CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality Genes Dev., 2018;32(5):373-388. 2018 [PMID: 29555651] (Bioassay, Human)
• R Ma, Q Li, Z Wang, Y Yuan, L Gan, J Qian Modulation of hyaluronan polymer size regulates proliferation of perimysial fibroblasts in thyroid eye disease Biochem. Biophys. Res. Commun., 2018;0(0):. 2018 [PMID: 29421653] (Bioassay, Human)
• G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction EBioMedicine, 2018;28(0):287-302. 2018 [PMID: 29396297] (Bioassay, Human)
• A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, H Wang, M Fenner, S Tse, A Marks, C Nchako, AH Brivanlou Chromosomal instability during neurogenesis in Huntington&#039;s disease Development, 2018;145(2):. 2018 [PMID: 29378824] (Differentiation, Human)
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• Sheen-Chen SM, Ho HT, Chia-Pei L, Hung KS, Eng HL The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat. Dig. Dis. Sci., 2006;51(12):2220-4. 2006 [PMID: 17103039] (In Vivo, Rat)
• Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am. J. Physiol. Heart Circ. Physiol., 2006;292(2):H1095-104. 2006 [PMID: 17056665] (Bioassay, Canine)
• Anderson BC, Christiansen SP, Grandt S, Grange RW, McLoon LK Increased extraocular muscle strength with direct injection of insulin-like growth factor-I. Invest. Ophthalmol. Vis. Sci., 2006;47(6):2461-7. 2006 [PMID: 16723457] (In Vivo, Rabbit)
• Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006;126(9):2096-105. 2006 [PMID: 16691197] (Bioassay, Human)
• Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells. J. Endocrinol., 2006;189(2):329-39. 2006 [PMID: 16648300] (Bioassay, Bovine)
• Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006;53(8):845-57. 2006 [PMID: 16586492] (Bioassay, Human)
• Larsen PH, DaSilva AG, Conant K, Yong VW Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice. J. Neurosci., 2006;26(8):2207-14. 2006 [PMID: 16495447] (Bioassay, Mouse)
• Hanley MB, Napolitano LA, McCune JM Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells, 2005;23(8):1170-9. 2005 [PMID: 15955828] (Bioassay, Human)
• Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E Insulin growth factor-1 protects against excitotoxicity in the rat striatum. Neuroreport, 2004;15(14):2251-4. 2004 [PMID: 15371744] (In Vivo, Rat)
• Gahr SA, Kocamis H, Richter JJ, Killefer J The effects of in ovo rhIGF-I administration on expression of the growth hormone secretagogue receptor (GHSR) during chicken embryonic development. Growth Dev Aging, 2004;68(1):3-10. 2004 [PMID: 15307660] (In Vivo, Chicken)
• Brenner N, Huning M, Stange R Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif. Tissue Int., 2004;74(4):388-97. 2004 [PMID: 15255077] (In Vivo, Rat)
• Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats. Bone, 2004;34(5):862-8. 2004 [PMID: 15121018] (In Vivo, Rat)
• Studer RK, Bergman R, Stubbs T, Decker K Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther., 2004;6(1):R56-R64. 2004 [PMID: 14979938] (Bioassay, Rabbit)
• Oropeza A, Wrenzycki C, Herrmann D, Hadeler KG, Niemann H Improvement of the developmental capacity of oocytes from prepubertal cattle by intraovarian insulin-like growth factor-I application. Biol. Reprod., 2004;70(6):1634-43. 2004 [PMID: 14766727] (In Vivo, Bovine)
• Loeser RF, Carlson CS, Del Carlo M, Cole A Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum., 2002;46(9):2349-57. 2002 [PMID: 12355482] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene, 2002;21(37):5673-83. 2002 [PMID: 12173037] (Bioassay, Human)
• Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest. Ophthalmol. Vis. Sci., 2002;43(7):2462-7. 2002 [PMID: 12091451] (In Vivo, Mouse)
• Loeser RF, 2018, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum., 2000;43(9):2110-20. 2000 [PMID: 11014363] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Deleu S, Pirson I, Clermont F, Nakamura T, Dumont JE, Maenhaut C Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli. J. Cell. Physiol., 1999;181(2):342-54. 1999 [PMID: 10497313] (Bioassay, Canine)

Bioinformatics

• Gene Symbol: IGF1
• Uniprot:
  • P05019()