Recombinant Human IGF-I/IGF-1 Protein, CF

Recombinant Human IGF-I/IGF-1 (Catalog # 291-G1) stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.3‑1.5 ng/mL.

1 μg/lane of Recombinant Human IGF-I/IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.

MALDI-TOF analysis of Recombinant Human IGF-I/IGF-1.The major peak corresponds to the calculated molecular mass, 7650 Da. The minor peak at 7873 is a matrix-associated artifact of the MALDI-TOF.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human IGF-I/IGF-1 Protein, CF Summary

• Details of Functionality: Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED₅₀ for this effect is 0.3-1.5 ng/mL.
• Source: E. coli-derived human IGF-I/IGF-1 protein
  Gly49-Ala118
• Accession #: P05019
• N-terminal Sequence: Gly49
• Protein/Peptide Type: Recombinant Proteins
• Gene: IGF1
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 7.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 7 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 200 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IGF-I/IGF-1 Protein, CF

• IBP1
• IGF1
• IGF-1
• IGF1A
• IGFI
• IGF-I
• IGF-IA
• IGF-IB
• insulin-like growth factor 1 (somatomedin C)
• insulin-like growth factor 1
• insulin-like growth factor I
• insulin-like growth factor IA
• insulin-like growth factor IB
• Mechano growth factor
• MGF
• Somatomedin A
• Somatomedin C
• somatomedin-C

Background

Insulin-like growth factor I (IGF-I or IGF-1), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C‑terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-1 protein is identical between isoforms and is generated by proteolytic removal of the N- and C‑terminal regions. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II/IGF-2. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4‑7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half‑life and modulating its interactions with receptors (10).

1. Philippou, A. et al. (2007) In Vivo 21:45.
2. Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275.
3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.

Publications for IGF-I/IGF-1 (291-G1)(209)

Publications using 291-G1

• Maylem, ERS;Spicer, LJ;Batalha, IM;Sch�tz, LF; Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells Domestic animal endocrinology 2023-04-25 [PMID: 37167929] (Bioassay, Bovine)
• CA Hayes, NI Morgan, KC Thomas, MJ Pushie, A Vijayasank, BG Ashmore, K Wontor, MA De Leon, NM Ashpole Neuronal and Astrocyte Insulin-like Growth Factor-1 Signaling Differentially Modulates Ischemic Stroke Damage bioRxiv : the preprint server for biology, 2023-04-02;0(0):. 2023-04-02 [PMID: 37034764] (Bioassay, Mouse)
• AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G&gt;A (p.D249N) autosomal dominant mutation in TUBB4A Stem Cell Research, 2023-03-26;69(0):103083. 2023-03-26 [PMID: 37003180] (Bioassay, Human)
• NB Campbell, Y Patel, TL Moore, M Medalla, E Zeldich Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome International Journal of Molecular Sciences, 2023-02-09;24(4):. 2023-02-09 [PMID: 36834891] (Bioassay, Human)
• EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar Pervasive environmental chemicals impair oligodendrocyte development bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798415] (Bioassay, Human, Mouse)
• HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective bioRxiv : the preprint server for biology, 2023-02-10;0(0):. 2023-02-10 [PMID: 36798313] (Bioassay, Human)
• PY Su, W Lee, J Zernant, SH Tsang, T Nagasaki, B Corneo, R Allikmets Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture Oncogene, 2022-11-14;65(0):102973. 2022-11-14 [PMID: 36455383] (Bioassay, Human)
• C Bueno, M Blanquer, D García-Ber, S Martínez, JM Moraleda Binucleated human bone marrow-derived mesenchymal cells can be formed during neural-like differentiation with independence of any cell fusion events Scientific Reports, 2022-11-30;12(1):20615. 2022-11-30 [PMID: 36450873] (Bioassay, Human)
• ESY Ng, N Kady, J Hu, A Dave, Z Jiang, J Pei, MB Gorin, A Matynia, RA Radu Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration Cells, 2022-11-02;11(21):. 2022-11-02 [PMID: 36359858] (Bioassay, Human)
• M Ridenour, LJ Spicer, JL Grindstaff Insulin-like growth factor 1 and the hormonal mediation of sibling rivalry General and comparative endocrinology, 2022-11-07;330(0):114163. 2022-11-07 [PMID: 36356644] (Bioassay, Eastern Bluebirds)
• F Fang, L Xu, L Liang, M Qu, H Yao, W Yue, L Chen, D Chen, Z Fan, L He, X Nan, H Zhang, X Xie, X Pei The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation Cell Death & Disease, 2022-10-21;13(10):886. 2022-10-21 [PMID: 36270980] (Bioassay, Human)
• T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro Nature Communications, 2022-09-15;13(1):5427. 2022-09-15 [PMID: 36109497] (Cell Culture, Mouse)
• Z Liu, D Meng, J Wang, H Cao, P Feng, S Wu, N Wang, C Dang, P Hou, P Xia GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway Cell Death & Disease, 2022-08-30;13(8):751. 2022-08-30 [PMID: 36042202] (Bioassay, Human)
• Y Tang, DJ Kwiatkowsk, EP Henske Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment Nature Communications, 2022-08-26;13(1):5018. 2022-08-26 [PMID: 36028490] (Bioassay, Mouse)
• S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay Nature Communications, 2022-08-25;13(1):5003. 2022-08-25 [PMID: 36008413] (Bioassay, Mouse)
• LJ Spicer, JR Evans, NB Schreiber Hormone regulation of thrombospondin-1 mRNA in porcine granulosa cells in vitro Oncogene, 2022-07-26;244(0):107048. 2022-07-26 [PMID: 35914333] (Bioassay, Porcine)
• C Nunes, L Depestel, L Mus, KM Keller, L Delhaye, A Louwagie, M Rishfi, A Whale, N Kara, SR Andrews, F Dela Cruz, D You, A Siddiquee, CT Cologna, S De Craemer, E Dolman, C Bartenhage, F De Vloed, E Sanders, A Eggermont, SL Bekaert, W Van Loocke, JW Bek, G Dewyn, S Loontiens, G Van Isterd, B Decaesteke, L Tilleman, F Van Nieuwe, V Vermeirsse, C Van Neste, B Ghesquiere, S Goossens, S Eyckerman, K De Preter, M Fischer, J Houseley, J Molenaar, B De Wilde, SS Roberts, K Durinck, F Speleman RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition Science Advances, 2022-07-13;8(28):eabn1382. 2022-07-13 [PMID: 35857500] (Bioassay, Human)
• IB Kim, T Lee, J Lee, J Kim, S Lee, IG Koh, JH Kim, JY An, H Lee, WK Kim, YS Ju, Y Cho, SJ Yu, SA Kim, M Oh, DW Han, E Kim, JK Choi, HJ Yoo, JH Lee Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder Oncogene, 2022-07-15;0(0):. 2022-07-15 [PMID: 35840799] (Bioassay, Human)
• MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-02-21;31(0):100852. 2022-02-21 [PMID: 35782608] (Bioassay, Human)
• V Kheirollah, A Khadim, G Kiliaris, M Korfei, MM Barroso, I Alexopoulo, AI Vazquez-Ar, M Wygrecka, C Ruppert, A Guenther, W Seeger, S Herold, E El Agha Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis Cells, 2022-06-20;11(12):. 2022-06-20 [PMID: 35741102] (Bioassay, Human)
• MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor Biomolecules, 2022-06-18;12(6):. 2022-06-18 [PMID: 35740973] (Bioassay, Human)
• M Berlak, E Tucker, M Dorel, A Winkler, A McGearey, E Rodriguez-, BM da Costa, K Barker, E Fyle, E Calton, S Eising, K Ober, D Hughes, E Koutrouman, P Carter, R Stankunait, P Proszek, N Jain, C Rosswog, H Dorado-Gar, JJ Molenaar, M Hubank, G Barone, J Anderson, P Lang, HE Deubzer, A Künkele, M Fischer, A Eggert, C Kloft, AG Henssen, M Boettcher, F Hertwig, N Blüthgen, L Chesler, JH Schulte Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells Molecular Cancer, 2022-06-10;21(1):126. 2022-06-10 [PMID: 35689207] (Bioassay, Human)
• E Metzler, H Escobar, DY Sunaga-Fra, S Sauer, S Diecke, S Spuler Generation of hiPSC-Derived Skeletal Muscle Cells: Exploiting the Potential of Skeletal Muscle-Derived hiPSCs Biomedicines, 2022-05-23;10(5):. 2022-05-23 [PMID: 35625941] (Bioassay, Human)
• KMA De Kleijn, KR Straasheij, WA Zuure, GJM Martens Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids Biomedicines, 2022-04-29;10(5):. 2022-04-29 [PMID: 35625761] (Bioassay, Human)
• FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus Cell Transplantation, 2022-01-01;31(0):9636897221101. 2022-01-01 [PMID: 35596532] (Bioassay, Human)
• SA Luff, JP Creamer, S Valsoni, C Dege, R Scarfò, A Dacunto, S Cascione, LN Randolph, E Cavalca, I Merelli, SA Morris, A Ditadi, CM Sturgeon Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells Nature Cell Biology, 2022-04-28;0(0):. 2022-04-28 [PMID: 35484246] (Bioassay, Human)
• Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)
• SL Pereira, ME Shoemaker, S Gawel, GJ Davis, M Luo, VA Mustad, JT Cramer Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia Nutrients, 2022-03-11;14(6):. 2022-03-11 [PMID: 35334853] (Bioassay, Human)
• L Zhu, D Retana, P García-Góm, L Álvaro-Esp, N Priego, M Masmudi-Ma, N Yebra, L Miarka, E Hernández-, C Blanco-Apa, S Martínez, C Sobrino, N Ajenjo, MJ Artiga, E Ortega-Pai, R Torres-Rui, S Rodríguez-, RENACER, R Soffietti, L Bertero, P Cassoni, T Weiss, J Muñoz, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, O Toldos, Y Ruano, L Alcázar, G Blasco, J Fernández-, E Caleiras, M Lafarga, D Megías, O Graña-Cast, C Nör, MD Taylor, LS Young, D Varešlija, N Cosgrove, FJ Couch, L Cussó, M Desco, S Mouron, M Quintela-F, M Weller, J Pastor, M Valiente A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis Embo Molecular Medicine, 2022-02-17;0(0):e14552. 2022-02-17 [PMID: 35174975] (Bioassay, Human)
• KN Lin, K Zhang, W Zhao, SY Huang, H Li Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells International Journal of Molecular Sciences, 2022-01-28;23(3):. 2022-01-28 [PMID: 35163437] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021-12-23;59(0):102635. 2021-12-23 [PMID: 35074682] (Bioassay, Human)
• AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)
• KD Abu-Bonsra, DF Newgreen, M Dottori Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds Cells, 2021-10-26;10(11):. 2021-10-26 [PMID: 34831120] (Bioassay, Human)
• AN Holowatyj, B Gigic, CA Warby, J Ose, T Lin, P Schrotz-Ki, CM Ulrich, JJ Bernard The Use of Human Serum Samples to Study Malignant Transformation: A Pilot Study Cells, 2021-10-06;10(10):. 2021-10-06 [PMID: 34685650] (Bioassay, Human)
• W M Kholosy, M Derieppe, F van den Ha, K Ober, Y Su, L Custers, L Schild, L M J van Zo, L M Wellens, H R Ariese, CL Szanto, J Wienke, MP Dierselhui, D van Vuurde, EM Dolman, JJ Molenaar Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies Journal of personalized medicine, 2021-08-30;11(9):. 2021-08-30 [PMID: 34575646] (Bioassay, Human)
• PR Gajjala, RK Kasam, D Soundarara, D Sinner, SK Huang, AG Jegga, SK Madala Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis JCI Insight, 2021-10-22;0(0):. 2021-10-22 [PMID: 34520400] (Bioassay, Human, Mouse)
• AM Thiebaut, I Buendia, V Ginet, E Lemarchand, MB Boudjadja, Y Hommet, L Lebouvier, C Lechevalli, M Maillasson, E Hedou, N Déglon, F Oury, M Rubio, J Montaner, J Puyal, D Vivien, BD Roussel Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia Autophagy, 2021-09-14;0(0):1-21. 2021-09-14 [PMID: 34520334] (Bioassay, Human)
• G Iannello, A Patel, D Sirabella, B Corneo, V Thaker Generation of the iPSC line CUIMCi003-A derived from a patient with severe early onset obesity Stem Cell Research, 2021-06-21;54(0):102432. 2021-06-21 [PMID: 34214899] (Bioassay, Human)
• KMA Abdel-Raou, R Rezgui, C Stefanini, JCM Teo, N Christofor Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands Biology, 2021-06-16;10(6):. 2021-06-16 [PMID: 34208436] (Cell Culture, Human)
• L Wang, M Yang, H Jin PI3K/AKT phosphorylation activates ERRalpha by upregulating PGC?1alpha and PGC?1beta in gallbladder cancer Molecular Medicine Reports, 2021-06-29;24(2):. 2021-06-29 [PMID: 34184087] (Bioassay, Human)
• C Qiao, W Huang, J Chen, W Feng, T Zhang, Y Wang, D Liu, X Ji, M Xie, M Sun, D Fan, K Wu, L Xia IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R Cell Death & Disease, 2021-06-01;12(6):564. 2021-06-01 [PMID: 34075028] (Bioassay, Human)
• J Borsoi, M Morato-Mar, F de Araújo, L Assis Pere, LE Farinha-Ar, R Delgado Sa, AB Alvarez Pe, L Veiga Pere Generation of two human induced pluripotent stem cell (hiPSC) lines derived from unrelated Marfan Syndrome patients Stem Cell Research, 2021-05-25;54(0):102407. 2021-05-25 [PMID: 34062330] (Bioassay, Human)
• C de O Mende, C Lopes-Siqu, F Pettito-As, M Pereira-Ol, MP de Oliveir, C Pirmez, AM Da-Cruz, H Goto Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis Journal of Immunology Research, 2021-03-29;2021(0):6657785. 2021-03-29 [PMID: 33860062] (Bioassay, L. braziliensis)
• M Chiara Per, N Bellitto, ERS Maylem, F Caloni, LJ Spicer Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in�vitro Theriogenology, 2021-03-28;168(0):1-12. 2021-03-28 [PMID: 33826978] (Bioassay, Feline)
• X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment Cell Reports, 2021-03-02;34(9):108802. 2021-03-02 [PMID: 33657377] (Bioassay, Human)
• J Sheff, P Wang, P Xu, M Arbour, L Masson, H van Faasse, G Hussack, K Kemmerich, E Brunette, D Stanimirov, JJ Hill, J Kelly, F Ni Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor Scientific Reports, 2021-02-19;11(1):4284. 2021-02-19 [PMID: 33608571] (Surface Plasmon Resonance, Human)
• E Solomon, K Davis-Ande, B Hovde, S Micheva-Vi, JF Harris, S Twary, R Iyer Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation BMC molecular and cell biology, 2021-02-18;22(1):13. 2021-02-18 [PMID: 33602141] (Bioassay, Human)
• M Mohrin, J Liu, J Zavala-Sol, S Bhargava, J Maxwell Tr, A Brito, D Hu, D Brooks, G Koukos, L Alabdulaal, JS Paw, K Hake, G Kolumam, ML Bouxsein, R Baron, Y Kutskova, A Freund Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells Aging Cell, 2021-02-09;0(0):e13313. 2021-02-09 [PMID: 33561324] (Bioassay, Human)
• CC Zuliani, II Damas, KC Andrade, CB Westin, ÂM Moraes, IB Coimbra Chondrogenesis of human amniotic fluid stem cells in Chitosan-Xanthan scaffold for cartilage tissue engineering Scientific Reports, 2021-02-04;11(1):3063. 2021-02-04 [PMID: 33542256] (Bioassay, Human)
• C Phoomak, W Cui, TJ Hayman, SH Yu, P Zhao, L Wells, R Steet, JN Contessa The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress Science Advances, 2021-01-15;7(3):. 2021-01-15 [PMID: 33523898] (Bioassay, Human)
• C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response Cell Stem Cell, 2021-01-04;28(2):331-342.e5. 2021-01-04 [PMID: 33450186] (Bioassay, Human)
• S Krueger, A Riess, A Jonitz-Hei, A Weizel, A Seyfarth, H Seitz, R Bader Establishment of a New Device for Electrical Stimulation of Non-Degenerative Cartilage Cells In Vitro International Journal of Molecular Sciences, 2021-01-01;22(1):. 2021-01-01 [PMID: 33401406] (Bioassay, Human)
• 2020-12-17;0(0):. 2020-12-17 [PMID: 33348564] (Cell Culture, Human)
• A Andueza, S Kumar, J Kim, DW Kang, HL Mumme, JI Perez, N Villa-Roel, H Jo Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study Cell Reports, 2020-12-15;33(11):108491. 2020-12-15 [PMID: 33326796] (Cell Culture, Human)
• L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy Nat Commun, 2020-11-17;11(1):5842. 2020-11-17 [PMID: 33203880] (Cell Culture, Human)
• KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function Cell Stem Cell, 2020-10-21;0(0):. 2020-10-21 [PMID: 33091368] (Bioassay, Mouse)
• NV Hewawasam, F Lhaf, HA Taylor, K Viloria, A Austin, A King, P Jones, L Jones, MD Turner, NJ Hill Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress Sci Rep, 2020-09-25;10(1):15741. 2020-09-25 [PMID: 32978479] (Bioassay, Mouse)
• Z Sun, K Wu, L Gu, L Huang, Q Zhuge, S Yang, Z Wang IGF-1R stimulation alters microglial polarization via TLR4/NF-kappaB pathway after cerebral hemorrhage in mice Brain Res. Bull., 2020-08-29;0(0):. 2020-08-29 [PMID: 32871240] (Bioassay, Mouse)
• S Riccetti, A Sinigaglia, G Desole, N Nowotny, M Trevisan, L Barzon Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells Viruses, 2020-08-12;12(8):. 2020-08-12 [PMID: 32806715] (Bioassay, Human)
• DP Ha, AS Lee Insulin-like growth factor 1-receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis Cell. Signal., 2020-08-14;75(0):109736. 2020-08-14 [PMID: 32805346] (Bioassay, Mouse)
• HJ Byeon, JY Kim, J Ko, EJ Lee, K Don, JS Yoon Protein tyrosine phosphatase 1B as a therapeutic target for Graves&#039; orbitopathy in an in vitro model PLoS ONE, 2020-08-06;15(8):e0237015. 2020-08-06 [PMID: 32760098] (Bioassay, Cell Culture, Human)
• Y Nanki, T Chiyoda, A Hirasawa, A Ookubo, M Itoh, M Ueno, T Akahane, K Kameyama, W Yamagami, F Kataoka, D Aoki Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing Sci Rep, 2020-07-28;10(1):12581. 2020-07-28 [PMID: 32724113] (Bioassay, Human)
• ST Chen, WJ Lai, WJ Zhang, QP Chen, LB Zhou, KF So, LL Shi Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons Neural Regen Res, 2020-12-01;15(12):2335-2343. 2020-12-01 [PMID: 32594058] (Bioassay, Human)
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• Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1. J Biol Chem, 2015-01-07;290(9):5438-48. 2015-01-07 [PMID: 25568321] (Cell Culture, Human)
• Lee H, Lee J, Lee S, Cho H, Song H, Jeong D, Seo Y, Shin S, Joung J, Kwon Y, Choi Y, Park W, Lee H, Seol H, Shim Y, Joo K, Nam D Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy. Clin Cancer Res, 2014-12-30;21(5):1172-82. 2014-12-30 [PMID: 25549722] (Bioassay, Human)
• Crosley , Erin J, Dunk , Caroline, Beristain , Alexande, Christians , Julian K IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells. Reprod Biol Endocrinol, 2014-12-04;12(0):123. 2014-12-04 [PMID: 25475528] (Bioassay, Human)
• Li H, Xu L, Zhao L, Ma Y, Zhu Z, Liu Y, Qu X Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3beta and ZEB2 in the BGC-823 gastric cancer cell line. Oncol Lett, 2014-11-07;9(1):143-148. 2014-11-07 [PMID: 25435948] (Bioassay, Human)
• Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation. J Biol Chem, 2014-11-12;290(1):467-77. 2014-11-12 [PMID: 25391655] (Bioassay, Human)
• Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma. Cancer Res, 2014-09-30;74(24):7418-29. 2014-09-30 [PMID: 25269480] (Bioassay, Human)
• Drexler A, Pietri J, Pakpour N, Hauck E, Wang B, Glennon E, Georgis M, Riehle M, Luckhart S Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. PLoS Pathog, 2014-06-26;10(6):e1004231. 2014-06-26 [PMID: 24968248] (In Vivo, Insect)
• Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes. Stem Cell Reports, 2014-04-24;2(5):648-61. 2014-04-24 [PMID: 24936452] (Bioassay, Human)
• Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res, 2014-06-16;74(16):4458-69. 2014-06-16 [PMID: 24934808] (Bioassay, Human)
• Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem Cells, 2014-10-01;32(10):2714-23. 2014-10-01 [PMID: 24916783] (Bioassay, Human)
• Li H, Xu L, Li C, Zhao L, Ma Y, Zheng H, Li Z, Zhang Y, Wang R, Liu Y, Qu X Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells. Mol Cancer, 2014-06-02;13(0):136. 2014-06-02 [PMID: 24885194] (Bioassay, Human)
• Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, Monti E Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. Br J Cancer, 2014-05-22;110(12):2865-73. 2014-05-22 [PMID: 24853185] (Bioassay, Human)
• Wang , Lu-Kai, Hsiao , Tzu-Hung, Hong , Tse-Ming, Chen , Hsuan-Yu, Kao , Shih-Han, Wang , Wen-Lung, Yu , Sung-Lia, Lin , Ching-We, Yang , Pan-Chyr MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. PLoS ONE, 2014-05-09;9(5):e96765. 2014-05-09 [PMID: 24816813] (Bioassay, Human)
• Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype. Gene Ther, 2014-05-08;21(7):662-72. 2014-05-08 [PMID: 24807808] (Bioassay, Human)
• Wang , Lin, Cao , Lan, Shansky , Janet, Wang , Zheng, Mooney , David, Vandenburgh , Herman Minimally invasive approach to the repair of injured skeletal muscle with a shape-memory scaffold. Mol Ther, 2014-04-28;22(8):1441-9. 2014-04-28 [PMID: 24769909] (In Vivo, Mouse)
• Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells. PLoS ONE, 2014-03-04;9(3):e89064. 2014-03-04 [PMID: 24594907] (Bioassay, Human)
• Rawnaq T, Dietrich L, Wolters-Eisfeld G, Uzunoglu F, Vashist Y, Bachmann K, Simon R, Izbicki J, Bockhorn M, Gungor C The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer. Mol Cancer Res, 2014-02-24;12(5):670-80. 2014-02-24 [PMID: 24567526] (Bioassay, Human)
• Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab, 2014-02-04;19(2):209-20. 2014-02-04 [PMID: 24506864] (Bioassay, Mouse)
• Liang Z, Diepstra A, Xu C, van Imhoff G, Plattel W, Van Den Berg A, Visser L Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma. PLoS ONE, 2014-01-28;9(1):e87474. 2014-01-28 [PMID: 24489919] (Bioassay, Human)
• Belzile , Jean-Phi, Stark , Thomas J, Yeo , Gene W, Spector , Deborah Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA. J Virol, 2014-01-22;88(8):4021-39. 2014-01-22 [PMID: 24453373] (Bioassay, Human)
• Shen X, Zhang Y, Feng Y, Zhang L, Li J, Xie Y, Luo X Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway. Int J Oncol, 2014-01-08;44(3):791-6. 2014-01-08 [PMID: 24402647] (Bioassay, Human)
• Elloul , Sivan, Kedrin , Dmitriy, Knoblauch , Nicholas, Beck , Andrew H, Toker , Alex The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Mol Cancer Res, 2013-11-22;12(3):464-76. 2013-11-22 [PMID: 24269953] (Bioassay, Human)
• Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2013-11-19;2(0):e00940. 2013-11-19 [PMID: 24252877] (Bioassay, Human)
• Hung C, Rohani M, Lee S, Chen P, Schnapp L Role of IGF-1 pathway in lung fibroblast activation. Respir Res, 2013-10-08;14(0):102. 2013-10-08 [PMID: 24103846] (Cell Culture, Mouse)
• Tucker , Budd A, Mullins , Robert F, Streb , Luan M, Anfinson , Kristin, Eyestone , Mari E, Kaalberg , Emily, Riker , Megan J, Drack , Arlene V, Braun , Terry A, Stone , Edwin M Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. Elife, 2013-08-27;2(0):e00824. 2013-08-27 [PMID: 23991284] (Bioassay, Human)
• Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol, 2013-04-21;31(5):440-7. 2013-04-21 [PMID: 23604284] (Bioassay, Human)
• Buchholz , David E, Pennington , Britney, Croze , Roxanne, Hinman , Cassidy, Coffey , Peter J, Clegg , Dennis O Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Transl Med, 2013-04-18;2(5):384-93. 2013-04-18 [PMID: 23599499] (Bioassay, Human)
• Bell A, Satchwell T, Heesom K, Hawley B, Kupzig S, Hazell M, Mushens R, Herman A, Toye A Protein distribution during human erythroblast enucleation in vitro. PLoS ONE, 2013-04-02;8(4):e60300. 2013-04-02 [PMID: 23565219] (Cell Culture, Human)
• Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro. BMC Cancer, 2013-04-01;13(0):170. 2013-04-01 [PMID: 23548153] (Bioassay, Human)
• Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci, 2013-02-26;126(0):1832-44. 2013-02-26 [PMID: 23444369] (Bioassay, Human)
• Tucker B, Anfinson K, Mullins R, Stone E, Young M Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem Cells Transl Med, 2012-12-27;2(1):16-24. 2012-12-27 [PMID: 23283489] (Bioassay, Human)
• Logan J, Sophocleous A, Marino S, Muir M, Brunton V, Idris A Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis. J Bone Miner Res, 2013-05-01;28(5):1229-42. 2013-05-01 [PMID: 23239200] (Bioassay, Mouse)
• Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 2012-11-27;21(1):228-39. 2012-11-27 [PMID: 23183535] (Bioassay, Human)
• Zelinka C, Scott M, Volkov L, Fischer A The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1. PLoS ONE, 2012-09-04;7(9):e44477. 2012-09-04 [PMID: 22973454] (In Vivo, Chicken)
• Aad , Pauline, Echternkamp , Sherrill, Sypherd , David D, Schreiber , Nicole B, Spicer , Leon J The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Biol Reprod, 2012-10-04;87(4):79. 2012-10-04 [PMID: 22811575] (Bioassay, Bovine)
• Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c. Stem Cells, 2012-07-01;30(7):1455-64. 2012-07-01 [PMID: 22495904] (Bioassay, Human)
• Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant, 2011-12-21;21(6):1321-39. 2011-12-21 [PMID: 22195604] (Cell Culture, Human)
• Laranjeira AB, de Vasconcellos JF, Sodek L, Spago MC, Fornazim MC, Tone LG, Brandalise SR, Nowill AE, Yunes JA IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase. Leukemia, 2011-10-18;26(5):1001-11. 2011-10-18 [PMID: 22005787] (Bioassay, Human)
• Iozzo RV, Buraschi S, Genua M Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J. Biol. Chem., 2011-08-12;286(40):34712-21. 2011-08-12 [PMID: 21840990] (Bioassay, Human)
• Walsh L, Damjanovski S IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-beta1 resulting in epithelial to mesenchymal transition. Cell Commun Signal, 2011-05-02;9(1):10. 2011-05-02 [PMID: 21535875] (Cell Culture, Human)
• Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol. Cancer Ther., 2010-03-02;9(3):706-17. 2010-03-02 [PMID: 20197390] (Bioassay, Human)
• Fischer AJ, Scott MA, Zelinka C, Sherwood P A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Muller glia. Glia, 2010-04-15;58(6):633-49. 2010-04-15 [PMID: 19941335] (In Vivo, Chicken)
• Banziger-Tobler NE, Halin C, Kajiya K, Detmar M Growth hormone promotes lymphangiogenesis. Am. J. Pathol., 2008-06-26;173(2):586-97. 2008-06-26 [PMID: 18583315] (Western Blot)
• Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, Lee CT, Shinomura Y, Carbone DP, Imai K Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol. Cancer Ther., 2008-06-01;7(6):1483-93. 2008-06-01 [PMID: 18566219] (Bioassay, Human)
• Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008-06-05;2(6):602-12. 2008-06-05 [PMID: 18522853] (Bioassay, Human)
• Gonzalez RM, Seurynck-Servoss SL, Crowley SA Development and validation of sandwich ELISA microarrays with minimal assay interference. J. Proteome Res., 2008-04-19;7(6):2406-14. 2008-04-19 [PMID: 18422355] (ELISA (Standard))
• Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol., 2008-01-01;214(1):85-95. 2008-01-01 [PMID: 17992660] (Bioassay, Human)
• Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol. Biol. Cell, 2007-07-18;18(10):3764-75. 2007-07-18 [PMID: 17634284] (Bioassay, Mouse)
• Spicer LJ, Aad PY Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol. Reprod., 2007-03-14;77(1):18-27. 2007-03-14 [PMID: 17360960] (Bioassay, Bovine)
• Sheen-Chen SM, Ho HT, Chia-Pei L, Hung KS, Eng HL The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat. Dig. Dis. Sci., 2006-11-11;51(12):2220-4. 2006-11-11 [PMID: 17103039] (In Vivo, Rat)
• Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am. J. Physiol. Heart Circ. Physiol., 2006-10-20;292(2):H1095-104. 2006-10-20 [PMID: 17056665] (Bioassay, Canine, Human)
• Anderson BC, Christiansen SP, Grandt S, Grange RW, McLoon LK Increased extraocular muscle strength with direct injection of insulin-like growth factor-I. Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2461-7. 2006-06-01 [PMID: 16723457] (In Vivo, Rabbit)
• Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006-05-11;126(9):2096-105. 2006-05-11 [PMID: 16691197] (Bioassay, Human)
• Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells. J. Endocrinol., 2006-05-01;189(2):329-39. 2006-05-01 [PMID: 16648300] (Bioassay, Bovine)
• Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006-06-01;53(8):845-57. 2006-06-01 [PMID: 16586492] (Bioassay, Human)
• Larsen PH, DaSilva AG, Conant K, Yong VW Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice. J. Neurosci., 2006-02-22;26(8):2207-14. 2006-02-22 [PMID: 16495447] (Bioassay, Mouse)
• Hanley MB, Napolitano LA, McCune JM Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells, 2005-06-13;23(8):1170-9. 2005-06-13 [PMID: 15955828] (Bioassay, Human)
• Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E Insulin growth factor-1 protects against excitotoxicity in the rat striatum. Neuroreport, 2004-10-05;15(14):2251-4. 2004-10-05 [PMID: 15371744] (In Vivo, Rat)
• Gahr SA, Kocamis H, Richter JJ, Killefer J The effects of in ovo rhIGF-I administration on expression of the growth hormone secretagogue receptor (GHSR) during chicken embryonic development. Growth Dev Aging, 2004-01-01;68(1):3-10. 2004-01-01 [PMID: 15307660] (In Vivo, Chicken)
• Brenner N, Huning M, Stange R Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif. Tissue Int., 2004-04-01;74(4):388-97. 2004-04-01 [PMID: 15255077] (In Vivo, Rat)
• Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats. Bone, 2004-05-01;34(5):862-8. 2004-05-01 [PMID: 15121018] (In Vivo, Rat)
• Studer RK, Bergman R, Stubbs T, Decker K Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther., 2003-11-07;6(1):R56-R64. 2003-11-07 [PMID: 14979938] (Bioassay, Rabbit)
• Oropeza A, Wrenzycki C, Herrmann D, Hadeler KG, Niemann H Improvement of the developmental capacity of oocytes from prepubertal cattle by intraovarian insulin-like growth factor-I application. Biol. Reprod., 2004-02-06;70(6):1634-43. 2004-02-06 [PMID: 14766727] (In Vivo, Bovine)
• Loeser RF, Carlson CS, Del Carlo M, Cole A Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum., 2002-09-01;46(9):2349-57. 2002-09-01 [PMID: 12355482] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene, 2002-08-22;21(37):5673-83. 2002-08-22 [PMID: 12173037] (Bioassay, Human)
• Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest. Ophthalmol. Vis. Sci., 2002-07-01;43(7):2462-7. 2002-07-01 [PMID: 12091451] (In Vivo, Mouse)
• Loeser RF, 2018, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. e0194453, 2000-09-01;43(9):2110-20. 2000-09-01 [PMID: 11014363] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Deleu S, Pirson I, Clermont F, Nakamura T, Dumont JE, Maenhaut C Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli. J. Cell. Physiol., 1999-11-01;181(2):342-54. 1999-11-01 [PMID: 10497313] (Bioassay, Canine)

Bioinformatics

• Gene Symbol: IGF1
• Uniprot:
  • P05019()