Snail Antibody

Images

 
Immunohistochemistry-Paraffin: Snail Antibody [NBP2-27293] - analysis of Snail Antibody in formalin-fixed, paraffin-embedded human kidney tissue using this antibody at 5 ug/ml.
Simple Western: Snail Antibody [NBP2-27293] - Simple Western lane view shows a specific band for SNAIL in 0.5 mg/ml of MCF-7 lysate. This experiment was performed under reducing conditions using the 12-230 kDa ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Simple Western, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Snail Antibody Summary

Immunogen
A portion of amino acids 1-60 of human SNAI1 was used as the immunogen.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SNAI1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Simple Western 1:1000
  • Immunohistochemistry-Paraffin 5ug/ml
Application Notes
In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size. Use in Western blot reported in scientific literature (PMID 28260923).
Publications
Read Publications using
NBP2-27293 in the following applications:

  • 1 publication
  • WB
    2 publications

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human, 94% homologous in mouse and rat. It is 61% homologous with human SNAI2 protein.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for Snail Antibody

  • Protein sna
  • Protein snail homolog 1
  • SLUGH2
  • SNA
  • SNAH
  • SNAHdJ710H13.1
  • SNAI1
  • snail 1 (drosophila homolog), zinc finger protein
  • snail 1 homolog
  • snail 1 zinc finger protein
  • snail 1, zinc finger protein
  • snail homolog 1 (Drosophila)
  • Snail
  • zinc finger protein SNAI1

Background

Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor which down regulates the expression of ectodermal gene within the mesoderm and thus functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stroma may be a new putative prognosis marker for colon tumors. In recent studies SNAI1 is found to be potential target for proteasome degradation by hypoxia-controlled FBXL14 ubiquitin ligase targets.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Snail Antibody (NBP2-27293)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC-P, WB.


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IHC-P
(1)
WB
(2)
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Filter By Species
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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Snail Antibody (NBP2-27293). (Showing 1 - 2 of 2 FAQs).

  1. There are many kinds of antibodies you supply against SNAIL. Could you give me your recommendation? Which is the best for the IHC-P experiments the species of my samples to be tested is human.
    • Our SNAIL antibody with catalog # NBP1-19529 has been successfully validated for IHC-P in paraffin-embedded human lung carcinoma tissue and I would highly recommend you to use the same for your samples too. The working dilutions of this antibody for IHC-P ranges from 1:50 - 1:200 and beside IHC, you can use this antibody for Western Blot and Immunofluorescence also.
  2. Could you please let me know the secondary antibody recommended for this particular primary antibody (Catalog NumberNBP2-27293) so that I could order both primary & secondary antibodies.
    • Our SNAIL antibody with catalogue number NBP2-27293 is a rabbit polyclonal, and as such you would require an anti-rabbit secondary to detect it. You can see our full range of anti-rabbit secondary antibodies at the following link, and by using the search filters at the left hand side of the webpage you can select a suitably conjugated product for your research: View Secondary Antibodies

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Snail Antibody (NBP2-27293)

Discover related pathways, diseases and genes to Snail Antibody (NBP2-27293). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Snail Antibody (NBP2-27293)

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Research Areas for Snail Antibody (NBP2-27293)

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Blogs on Snail.

Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...  Read full blog post.

Understanding the relationship between HIF-1 alpha, Hypoxia and Epithelial-Mesenchymal Transition
Epithelial-mesenchymal transition (EMT) is a natural process by which epithelial cells lose their polarity and intercellular adhesion, and gain the migratory invasive properties of mesenchymal stem cells that can differentiate into a variety of cel...  Read full blog post.

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Bioinformatics

Gene Symbol SNAI1
Entrez
Uniprot