Snail Products

Antibodies
Snail Antibody
Snail Antibody
NBP2-27293
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, IHC-P
Host: Rabbit Polyclonal
Snail Antibody
Snail Antibody
NBP1-80022
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Snail Antibody
Snail Antibody
NBP2-27184
Species: Hu, Mu
Applications: WB, ICC/IF, KO
Host: Rabbit Polyclonal
Lysates
Snail Overexpression Lysate
Snail Overexpression Lysate
NBL1-16265
Species: Hu
Applications: WB
Proteins
Recombinant Human Snail His P ...
Recombinant Human Snail His Protein
NBP2-22814
Species: Hu
Applications: PAGE
Snail Recombinant Protein Ant ...
Snail Recombinant Protein Antigen
NBP2-61631PEP
Species: Hu
Applications: AC
Snail Recombinant Protein Ant ...
Snail Recombinant Protein Antigen
NBP2-68727PEP
Species: Hu
Applications: AC

Description

Snail, also called SNAIL1 or SNAI1, is a zinc-finger transcription factor belonging to the Snail superfamily and encoded by the SNAI1 gene (1,2). Snail was first discovered in Drosophila and has homologs in many species including vertebrates and humans (1,2). The Snail family members includes Snail (Snail1), Slug (Snail2), and Smuc (Snail3) (1,2). In humans, Snail is expressed in a number of tissues including placenta, brain, and skeletal muscle, but is most highly expressed by the kidneys (1). Snail functions in repression of E-cadherin transcription which is associated with epithelial-mesenchymal transition (EMT) that is especially prominent during embryonic development (1-5). Along with Snail, other related EMT-inducing transcription factors (EMT-TFs) include the Twist and ZEB protein families (3). Snail is synthesized as a protein of 264 amino acids (aa) with an N-terminal SNAG domain, a serine-rich domain (SRD), nuclear export sequences (NES), and four C-terminal zinc-finger binding domains, with a theoretical molecular weight of 29 kDa (1,3). Snail activity is largely regulated through post-translational modifications such as phosphorylation, ubiquitination, and glycosylation, which impacts Snail's localization and stability, amongst other things (1-3, 5).

In addition to its role in embryonic development, Snail-induced EMT is also associated with cancer metastasis (1-5). Snail is expressed in a variety of cancer lines including breast cancer, cervical carcinoma, and colorectal carcinoma, and typically results in increased migration, invasion, and metastasis (1). Accordingly, Snail expression is also correlated with drug resistance and tumor recurrence (1-5). Chemical inhibitors that target Snail have shown some promise in reducing or eliminating Snail-induced EMT, increasing E-cadherin expression, and increasing tumor regression (1).

1. Kaufhold, S., & Bonavida, B. (2014). Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. Journal of Experimental & Clinical Cancer Research. https://doi.org/10.1186/s13046-014-0062-0

2. Wang, Y., Shi, J., Chai, K., Ying, X., & Zhou, B. P. (2013). The Role of Snail in EMT and Tumorigenesis. Current Cancer Drug Targets. https://doi.org/10.2174/15680096113136660102

3. Kang, E., Seo, J., Yoon, H., & Cho, S. (2021). The Post-Translational Regulation of Epithelial-Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22073591

4. Seo, J., Ha, J., Kang, E., & Cho, S. (2021). The role of epithelial-mesenchymal transition-regulating transcription factors in anti-cancer drug resistance. Archives of Pharmacal Research. https://doi.org/10.1007/s12272-021-01321-x

5. Baulida, J., Diaz, V. M., & Herreros, A. G. (2019). Snail1: A Transcriptional Factor Controlled at Multiple Levels. Journal of Clinical Medicine. https://doi.org/10.3390/jcm8060757

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 6615
Alternate Names
  • dJ710H13.1
  • SNAH
  • SNAI1
  • SNAIL
  • snail family zinc finger 1
  • snail homolog 1
  • SNAIL1
  • zinc finger protein SNAI1
  • Protein snail homolog 1
  • Protein sna
  • snail 1 zinc finger protein
  • SNA
  • snail 1 homolog
  • SLUGH2

Research Areas for Snail

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Phospho-Specific

PTMs for Snail

Learn more about PTMs related to Snail.

Phosphorylation
Methylation
Demethylation
Cleavage
Dephosphorylation
Ubiquitination

Bioinformatics Tool for Snail

Discover related pathways, diseases and genes to Snail. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Snail Blog Posts

Check out the latest blog posts on Snail.

    Read more.
Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...    Read more.
Understanding the relationship between HIF-1 alpha, Hypoxia and Epithelial-Mesenchymal Transition
Epithelial-mesenchymal transition (EMT) is a natural process by which epithelial cells lose their polarity and intercellular adhesion, and gain the migratory invasive properties of mesenchymal stem cells that can differentiate into a variety of cel...    Read more.
Read more Snail related blogs.