SHP/NR0B2/Nuclear Receptor SHP Products

Antibodies
SHP/NR0B2/Nuclear Receptor SH ...
SHP/NR0B2/Nuclear Receptor SHP Ant...
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
SHP/NR0B2/Nuclear Receptor SH ...
SHP/NR0B2/Nuclear Receptor SHP Ant...
NBP1-33597
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
SHP/NR0B2/Nuclear Receptor SH ...
SHP/NR0B2/Nuclear Receptor SHP Ant...
PP-N7519-00
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
SHP/NR0B2/Nuclear Receptor SH ...
SHP/NR0B2/Nuclear Receptor SHP Ove...
H00008431-T01
Species: Hu
Applications: WB
SHP/NR0B2/Nuclear Receptor SH ...
SHP/NR0B2/Nuclear Receptor SHP Ove...
NBL1-13765
Applications: WB
Proteins
Recombinant Human SHP/NR0B2/N ...
Recombinant Human SHP/NR0B2/Nuclea...
H00008431-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
SHP/NR0B2/Nuclear Receptor SH ...
SHP/NR0B2/Nuclear Receptor SHP RNAi
H00008431-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway. SHP expression has been documented in human liver, adrenal, spleen, and pancreas. ESTs have been isolated from cancerous human kidney, lung, and stomach, as well as normal human heart, kidney, liver, and liver/spleen. Caution: The nuclear receptor SHP should not be confused with the tyrosine phosphatases SHP-1 and SHP-2.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 8431
Alternate Names
  • Small heterodimer partner
  • nuclear receptor subfamily 0 group B member 2
  • Orphan nuclear receptor SHP
  • SHPSHP1
  • FLJ17090
  • nuclear receptor subfamily 0, group B, member 2

Research Areas for SHP/NR0B2/Nuclear Receptor SHP

Find related products by research area and learn more about each of the different research areas below.

GPCR

PTMs for SHP/NR0B2/Nuclear Receptor SHP

Learn more about PTMs related to SHP/NR0B2/Nuclear Receptor SHP.

Demethylation
Phosphorylation
Deacetylation
Methylation

Bioinformatics Tool for SHP/NR0B2/Nuclear Receptor SHP

Discover related pathways, diseases and genes to SHP/NR0B2/Nuclear Receptor SHP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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