Serpin A3N Antibody [Unconjugated]

Images

 
There are currently no images for Serpin A3N Antibody (AF4709).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Serpin A3N Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Serpin A3N
Phe21-Lys418
Accession # Q91WP6
Specificity
Detects mouse Serpin A3N in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse (rm) Serpin A1, recombinant human Serpin A3 and rmSerpin A5 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
Serpina3n
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunoprecipitation 25 ug/mL
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF4709 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin A3N Antibody [Unconjugated]

  • Serpin A3N
  • Spi2

Background

Serpin A3N is a serine protease inhibitor that is structurally related to alpha 1-antichymotrypsin encoded by the SERPINA3 gene (1). Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen (2). Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B (3). Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme B-mediated killing by cytotoxic lymphocytes, providing a means to disable cell-mediated immune responses.

  1. Forsyth, S. et al. (2003) Genomics 81:336.
  2. Horvath, A. J. et al. (2004) J. Mol. Evol. 59:488.
  3. Hirst, C. E. et al. (2001) Mol. Hum. Reprod. 7:1133.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

MAB1455
Species: Hu
Applications: CyTOF-ready, Dual ISH-IHC, ICC, IHC, ICFlow, Simple Western, WB
MAB7665
Species: Hu
Applications: IHC, WB
DY4517-05
Species: Mu
Applications: ELISA
DCRP00
Species: Hu
Applications: ELISA
MAB1368
Species: Hu, Mu
Applications: CyTOF-ready, ICC, ICFlow, KO, Simple Western, WB
NBP2-52559
Species: Hu
Applications: CyTOF-ready, ELISA, Flow, IHC, IHC-P, WB
2914-HT
Species: Hu
Applications: BA
MAB4470
Species: All-Multi
Applications: ICC, IHC, WB
AF1938
Species: Hu
Applications: ICC, IP, Simple Western, WB
DHAPG0
Species: Hu
Applications: ELISA
NB300-223
Species: Bv, Ca, Ch, Eq, Hu, Mu, Po, Rt
Applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB
NBP2-61118
Species: Hu, Mu
Applications: Flow, ICC/IF, IHC, IHC-P, Simple Western, WB
H00138428-P01
Species: Hu
Applications: ELISA, AP, PA, WB
NB200-540
Species: Ec, Mu
Applications: CyTOF-ready, Flow-IC, Flow, IA, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NBP3-15868
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P, WB
D6050
Species: Hu
Applications: ELISA
MAB1417
Species: Bv, Hu, Mu
Applications: CyTOF-ready, ICC, IHC, ICFlow
210-TA
Species: Hu
Applications: BA
NBP1-81838
Species: Hu, Mu
Applications: IHC, IHC-P, WB
AF5739
Species: Hu, Mu, Rt
Applications: WB

Publications for Serpin A3N Antibody (AF4709)(18)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: IF, IHC, Immunoprecipitation, Western Blot.


Filter By Application
IF
(1)
IHC
(9)
Immunoprecipitation
(1)
Western Blot
(7)
All Applications
Filter By Species
Mouse
(18)
All Species
Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using AF4709 Applications Species
T Kaya, N Mattugini, L Liu, H Ji, L Cantuti-Ca, J Wu, M Schifferer, J Groh, R Martini, S Besson-Gir, S Kaji, A Liesz, O Gokce, M Simons CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging Nature Neuroscience, 2022;25(11):1446-1457. 2022 [PMID: 36280798] (IHC, Mouse) IHC Mouse
Y Shen, W Yang, X Xiong, X Li, Z Xiao, J Yu, F Liu, S Gui, X Xie, F Lv, L Zhao, L Hu, A Manaenko, P Xie, Q Li Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage Oxidative Medicine and Cellular Longevity, 2021;2021(0):2510847. 2021 [PMID: 36226158] (Western Blot, Mouse) Western Blot Mouse
M Kenigsbuch, P Bost, S Halevi, Y Chang, S Chen, Q Ma, R Hajbi, B Schwikowsk, B Bodenmille, H Fu, M Schwartz, I Amit A shared disease-associated oligodendrocyte signature among multiple CNS pathologies Nature Neuroscience, 2022;0(0):. 2022 [PMID: 35760863] (IHC, Mouse) IHC Mouse
S Qiu, JP Palavicini, J Wang, NS Gonzalez, S He, E Dustin, C Zou, L Ding, A Bhattachar, CE Van Skike, V Galvan, JL Dupree, X Han Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment Molecular Neurodegeneration, 2021;16(1):64. 2021 [PMID: 34526055] (IHC, Mouse) IHC Mouse
YT Ho, T Shimbo, E Wijaya, T Kitayama, S Takaki, K Ikegami, K Miyashita, Y Ouchi, E Takaki, R Yamamoto, Y Kaneda, K Tamai Longitudinal single cell transcriptomics reveals a role for Serpina3n-mediated resolution of inflammation in a mouse colitis model Cellular and Molecular Gastroenterology and Hepatology, 2021;0(0):. 2021 [PMID: 33862275] (Immunoprecipitation, Mouse) Immunoprecipitation Mouse
MM Akbor, N Kurosawa, H Nakayama, A Nakatani, K Tomobe, Y Chiba, M Ueno, M Tanaka, Y Nomura, M Isobe Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta PLoS ONE, 2021;16(3):e0248027. 2021 [PMID: 33662018] (IHC, Mouse) IHC Mouse
E Staurenghi, V Cerrato, P Gamba, G Testa, S Giannelli, V Leoni, C Caccia, A Buffo, W Noble, BG Perez-Niev, G Leonarduzz Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2 Redox Biology, 2020;39(0):101837. 2020 [PMID: 33360775] (Western Blot, Mouse) Western Blot Mouse
IS Massart, G Paulissen, A Loumaye, P Lause, SA Pötgens, MM Thibaut, E Balan, L Deldicque, A Atfi, E Louis, D Gruson, LB Bindels, MA Meuwis, JP Thissen Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia Cancers (Basel), 2020;12(11):. 2020 [PMID: 33142864] (Western Blot, Mouse) Western Blot Mouse
SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Nat Commun, 2020;11(1):4102. 2020 [PMID: 32796823] (IHC, Mouse) IHC Mouse
SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Nat Commun, 2020;11(1):4102. 2020 [PMID: 32796823] (IHC, Mouse) IHC Mouse
Show All 18 Publications.

Reviews for Serpin A3N Antibody (AF4709) (0)

There are no reviews for Serpin A3N Antibody (AF4709). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Serpin A3N Antibody (AF4709) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Serpin A3N Products

Bioinformatics Tool for Serpin A3N Antibody (AF4709)

Discover related pathways, diseases and genes to Serpin A3N Antibody (AF4709). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Serpin A3N Antibody (AF4709)

Discover more about diseases related to Serpin A3N Antibody (AF4709).
 

Pathways for Serpin A3N Antibody (AF4709)

View related products by pathway.

PTMs for Serpin A3N Antibody (AF4709)

Learn more about PTMs related to Serpin A3N Antibody (AF4709).

Blogs on Serpin A3N

There are no specific blogs for Serpin A3N, but you can read our latest blog posts.
Download our IHC Handbook

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Serpin A3N Antibody [Unconjugated] and receive a gift card or discount.

Bioinformatics

Gene Symbol Serpina3n
Uniprot