Serpin A3N Antibody [Unconjugated]


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Product Details

Reactivity MuSpecies Glossary
Applications WB, IP

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Serpin A3N Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse Serpin A3N
Accession # Q91WP6
Detects mouse Serpin A3N in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse (rm) Serpin A1, recombinant human Serpin A3 and rmSerpin A5 is observed.
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunoprecipitation 25 ug/mL
  • Western Blot 0.1 ug/mL
Read Publications using
AF4709 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin A3N Antibody [Unconjugated]

  • Serpin A3N
  • Spi2


Serpin A3N is a serine protease inhibitor that is structurally related to alpha 1-antichymotrypsin encoded by the SERPINA3 gene (1). Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen (2). Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B (3). Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme B-mediated killing by cytotoxic lymphocytes, providing a means to disable cell-mediated immune responses.

  1. Forsyth, S. et al. (2003) Genomics 81:336.
  2. Horvath, A. J. et al. (2004) J. Mol. Evol. 59:488.
  3. Hirst, C. E. et al. (2001) Mol. Hum. Reprod. 7:1133.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Serpin A3N Antibody (AF4709)(18)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: IF, IHC, Immunoprecipitation, Western Blot.

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Showing Publications 1 - 10 of 18. Show All 18 Publications.
Publications using AF4709 Applications Species
T Kaya, N Mattugini, L Liu, H Ji, L Cantuti-Ca, J Wu, M Schifferer, J Groh, R Martini, S Besson-Gir, S Kaji, A Liesz, O Gokce, M Simons CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging Nature Neuroscience, 2022;25(11):1446-1457. 2022 [PMID: 36280798] (IHC, Mouse) IHC Mouse
Y Shen, W Yang, X Xiong, X Li, Z Xiao, J Yu, F Liu, S Gui, X Xie, F Lv, L Zhao, L Hu, A Manaenko, P Xie, Q Li Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage Oxidative Medicine and Cellular Longevity, 2021;2021(0):2510847. 2021 [PMID: 36226158] (Western Blot, Mouse) Western Blot Mouse
M Kenigsbuch, P Bost, S Halevi, Y Chang, S Chen, Q Ma, R Hajbi, B Schwikowsk, B Bodenmille, H Fu, M Schwartz, I Amit A shared disease-associated oligodendrocyte signature among multiple CNS pathologies Nature Neuroscience, 2022;0(0):. 2022 [PMID: 35760863] (IHC, Mouse) IHC Mouse
S Qiu, JP Palavicini, J Wang, NS Gonzalez, S He, E Dustin, C Zou, L Ding, A Bhattachar, CE Van Skike, V Galvan, JL Dupree, X Han Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment Molecular Neurodegeneration, 2021;16(1):64. 2021 [PMID: 34526055] (IHC, Mouse) IHC Mouse
YT Ho, T Shimbo, E Wijaya, T Kitayama, S Takaki, K Ikegami, K Miyashita, Y Ouchi, E Takaki, R Yamamoto, Y Kaneda, K Tamai Longitudinal single cell transcriptomics reveals a role for Serpina3n-mediated resolution of inflammation in a mouse colitis model Cellular and Molecular Gastroenterology and Hepatology, 2021;0(0):. 2021 [PMID: 33862275] (Immunoprecipitation, Mouse) Immunoprecipitation Mouse
MM Akbor, N Kurosawa, H Nakayama, A Nakatani, K Tomobe, Y Chiba, M Ueno, M Tanaka, Y Nomura, M Isobe Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta PLoS ONE, 2021;16(3):e0248027. 2021 [PMID: 33662018] (IHC, Mouse) IHC Mouse
E Staurenghi, V Cerrato, P Gamba, G Testa, S Giannelli, V Leoni, C Caccia, A Buffo, W Noble, BG Perez-Niev, G Leonarduzz Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2 Redox Biology, 2020;39(0):101837. 2020 [PMID: 33360775] (Western Blot, Mouse) Western Blot Mouse
IS Massart, G Paulissen, A Loumaye, P Lause, SA Pötgens, MM Thibaut, E Balan, L Deldicque, A Atfi, E Louis, D Gruson, LB Bindels, MA Meuwis, JP Thissen Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia Cancers (Basel), 2020;12(11):. 2020 [PMID: 33142864] (Western Blot, Mouse) Western Blot Mouse
SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Nat Commun, 2020;11(1):4102. 2020 [PMID: 32796823] (IHC, Mouse) IHC Mouse
SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Nat Commun, 2020;11(1):4102. 2020 [PMID: 32796823] (IHC, Mouse) IHC Mouse
Show All 18 Publications.

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Gene Symbol Serpina3n