Seladin 1 Antibody [DyLight 594]

• Reactivity: Hu
• Applications: IHC, IHC-P
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 594

Seladin 1 Antibody [DyLight 594] Summary

• Immunogen: Produced in rabbits immunized with E. coli-derived Human Seladin 1 fragment.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DHCR24
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Seladin 1 Antibody [DyLight 594]

• 24-dehydrocholesterol reductaseNbla03646
• DCE
• desmosterol-to-cholesterol enzyme
• Diminuto/dwarf1 homolog
• EC 1.3.1.72
• KIAA0018SELADIN1
• seladin 1,3-beta-hydroxysterol delta-24-reductase
• seladin-1
• selective AD indicator 1,3 beta-hydroxysterol delta 24-reductase

Background

Seladin 1 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DHCR24